Clinical trials: in Benin
Erythema Nodosum Leprosum
Efficacy and Safety Study of Dovramilast in People With Leprosy Type 2 Reaction
Dovramilast has not been approved for leprosy type 2 reaction (erythema nodosum leprosum, ENL) or any other disease anywhere in the world.
- Trial name
- NCT07172659
- Testing
- Dovramilast, Prednisolone, Thalidomide
- Where
- 6 sites in United States, Benin and 4 more
- Volunteers
- 45 people
- Sponsor
- Medicines Development for Global Health
Red Blood Cell Disorder
Pathophysiological Explorations of Red Blood Cells
GR-Ex is a program labelled by Labex (Laboratory of Excellence) by the French Ministry of Higher Education and Research. This program aims to develop the means to improve knowledge in the physiology and pathologies of…
- Trial name
- GR-Ex (NCT03541525)
- Testing
- Biological sampling
- Where
- 25 sites in Benin, France and 1 more
- Volunteers
- 3,750 people, healthy volunteers welcome
- Sponsor
- Imagine Institute
Severe Malaria, Severe Anaemia
Post-discharge Malaria Chemoprevention Implementation Trial in Benin
The proposed research aims to conduct implementation trials in Benin, co-designed with national stakeholders, to evaluate different delivery strategies for optimizing health system delivery of post-discharge malaria…
- Trial name
- PDMC-SL (NCT06601712)
- Testing
- Adherence support strategy A, Adherence support strategy B, Control
- Where
- 2 sites in Benin
- Volunteers
- 648 people
- Sponsor
- Institut de Recherche Clinique du Benin
Stroke, Medication Adherence
Stroke Minimization Through Additive Anti-atherosclerotic Agents in Routine Treatment II Study (SMAART II)
The overall objective of the Stroke Minimization through Additive Anti-atherosclerotic Agents in Routine Treatment II (SMAART-II) is to deploy a hybrid study design to firstly, demonstrate the efficacy of a polypill (Polycap ®)…
- Trial name
- NCT05963568
- Testing
- Polycap
- Where
- 4 sites in Benin, Ghana and 2 more
- Volunteers
- 1,000 people
- Sponsor
- Northern California Institute of Research and Education
Type 2 Diabetes
Culturally Tailored Nutrition Therapy to Improve Dietary Adherence of Type 2 Diabetes Patients in Benin, Africa
The clinical trial aims to assess the effectiveness of the Objectif Santé Diabète Benin (OSanDiaBé), a culturally tailored medical nutrition therapy (MNT), in enhancing diabetes management and nutrition choices.
- Trial name
- OSanDiaBé (NCT07145684)
- Testing
- A culturally tailored medical nutrition therapy
- Where
- Benin
- Volunteers
- 64 people
- Sponsor
- University of Arizona
Tuberculosis Infection, Latent
Shorter and Safer Treatment Regimens for Latent TB
Our study rationale is based on: 1. Tuberculosis Preventive Treatment (TPT) is given to healthy people and needs to be safe; 2. Tuberculosis Preventive Treatment (TPT) with shorter regimens are superior with respect to…
- Trial name
- SSTARLET (NCT06498414)
- Testing
- rifampin standard arm, rifampin double dose, levofloxacin and rifapentine
- Where
- 14 sites in Benin, Brazil and 3 more
- Volunteers
- 1,800 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Latent Tuberculosis
Assessment of the Safety, Tolerability, and Effectiveness of Rifapentine Given Daily for LTBI
This study is conducted to compare the safety and effectiveness of a novel short 6-week regimen of daily rifapentine (6wP, experimental arm) with a comparator arm of 12-16 weeks of rifamycin-based treatment (standard of care…
- Trial name
- ASTERoiD (NCT03474029)
- Testing
- Rifapentine daily for 6 weeks, Rifapentine and Isoniazid weekly for 12 weeks, Rifampin and Isoniazid daily for 12 weeks
- Where
- 21 sites in United States, Australia and 6 more
- Volunteers
- 3,400 people
- Sponsor
- Centers for Disease Control and Prevention
Surgery, Inpatients
EMUs: Enhanced Monitoring Using Sensors After Surgery
Patients can become critically unwell following surgical operations. Delay in recognition of this deterioration can result in patient harm and even death.
- Trial name
- EMUs (NCT06565559)
- Testing
- Wearable Wireless Sensor
- Where
- 17 sites in Benin, Ghana and 6 more
- Volunteers
- 1,332 people
- Sponsor
- University of Edinburgh
Helminthiasis, Filariasis
Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH)
Over 1.5 billion people are infected with soil-transmitted helminths (STH). Global STH guidelines recommend MDA (mass drug administration) of albendazole or mebendazole to targeted populations, including pre-school age children…
- Trial name
- NCT03014167
- Testing
- Albendazole
- Where
- 3 sites in Benin, India and 1 more
- Volunteers
- 357,716 people, healthy volunteers welcome
- Sponsor
- University of Washington
Bacterial Infections
Diagnostic Evaluation Study of the BactInsight Blood Culture System in West-Africa
Diagnosis of bloodstream infections (BSI) is done by sampling blood in blood culture bottles that are checked for growth in the microbiology laboratory.
- Trial name
- SIMBLE-FIELD (NCT05722184)
- Testing
- BactInsight blood culture system
- Where
- 2 sites in Benin
- Volunteers
- 1,724 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Tuberculosis, Pulmonary, Undernutrition
The INSTITUT Study Tuberculosis Nutritional Support
Undernutrition is a leading global risk factor of tuberculosis (TB) and a prevalent comorbidity associated with TB. In Benin, the National TB Program systematically provides nutritional support to all persons with TB (PWTB)…
- Trial name
- INSTITUT (NCT06084715)
- Testing
- Nutritional support
- Where
- 2 sites in Benin, Togo
- Volunteers
- 769 people
- Sponsor
- Boston Medical Center
Pregnancy Related
Evaluation of Electronic Pregnancy Registers and Mobile Applications for Monitoring Pregnancy Outcomes ( EVAPREAP )
Monitoring pregnancy outcomes during pregnancy is very important in assessing the effectiveness of interventions. This study aims to create pregnancy registers and evaluate pregnancy mobile applications as a potential tool for…
- Trial name
- NCT06225739
- Testing
- Electronic pregnancy register, In-depth interviews and focus group discussions
- Where
- 4 sites in Benin, Burkina Faso and 2 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- European Vaccine Initiative
Post-operative Complications
Reducing Deaths After Surgery in Low- and Middle-income Countries: A Pilot Cluster Randomised Trial
SurgPASS is a pilot randomised cluster trial utilising a pre-operative checklist with the aim of reducing deaths after surgery. If SurgPASS is successful, the intervention will be implemented in a separate full-scale cluster…
- Trial name
- SurgPASS (NCT06932653)
- Testing
- SurgPASS - intervention
- Where
- 5 sites in Benin, Ghana and 3 more
- Volunteers
- 300 people
- Sponsor
- University of Birmingham
Appendicitis, Appendectomy
A Global Prospective Cohort Study on Outcomes of Appendicectomy for Appendicitis
This study aims to assess and improve the global management of appendicitis, the most common emergency surgery, by examining various aspects of emergency care systems worldwide.
- Trial name
- AlliGatOr (NCT06774001)
- Testing
- Appendicectomy
- Where
- 7 sites in Benin, Ghana and 5 more
- Volunteers
- 14,000 people
- Sponsor
- University of Birmingham
Tuberculosis, Lower Resp Tract Infection
Triage UltraSound in Tb Endemic Regions
In Sub-Saharan Africa, lower respiratory tract infections (LRTIs) and tuberculosis (TB) jointly are the leading cause of overall mortality.
- Conditions
- Tuberculosis, Lower Resp Tract Infection, Pneumonia
- Trial name
- TrUST (NCT05423847)
- Testing
- POCUS
- Where
- 3 sites in Benin, Mali and 1 more
- Volunteers
- 504 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Malaria, Anemia
Efficacy of Two Dual Active Ingredient Long Lasting Insecticidal Nets for Control of Malaria Transmitted by Pyrethroid Resistant Vectors in Benin
The massive scale-up of Long Lasting Insecticidal Nets (LLIN) has led to a major reduction in malaria burden (up to 50%) in many sub-Saharan African countries.
- Trial name
- NNP (NCT03931473)
- Testing
- Bed nets
- Where
- Benin
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Surgical Site Infection
A Stratified, Multi-ARm, muLti-site Randomised Platform Trial Aiming to Reduce the INcidence of Post-operative SSI
MARLIN is a stratified, multi-arm, multi-stage factorial randomised platform trial aiming to reduce the incidence of post-operative surgical site infection (SSI).
- Trial name
- MARLIN (NCT06465901)
- Testing
- Chlorhexidine Gluconate 2.0% to 4.0% (e.g. Hibiscrub) preoperative shower, Intraoperative wound wash (e.g. Granudacyn), DACC surgical wound dressing (e.g. Leukomed Sorbact)
- Where
- 7 sites in Benin, Ghana and 5 more
- Volunteers
- 10,092 people
- Sponsor
- University of Birmingham
Buruli Ulcer
Beta-Lactam Containing Regimen for the Shortening of Buruli Ulcer Disease Therapy
Buruli ulcer (BU) is a skin Neglected Tropical Disease (NTD) that is caused by Mycobacterium ulcerans. It affects skin, soft tissues and bones causing long-term morbidity, stigma and disability.
- Trial name
- BLMs4BU (NCT05169554)
- Testing
- Standard [RC8]: rifampicin plus clarithromycin (RC) therapy for 8 weeks., Investigational [RCA4]: standard (RC) plus amoxicillin/clavulanate (A) for 4 weeks.
- Where
- 3 sites in Benin
- Volunteers
- 140 people
- Sponsor
- Fundacion Agencia Aragonesa para la Investigacion y Desarrollo (ARAID)
COVID-19, SARS CoV 2 Infection
STREngthening COronavirus Disease 2019 (COVID-19) Surveillance in Africa
The aim of this observational study was to develop, with the intended users, an epidemic surveillance and response system that will be effective, sensitive, coordinated and appropriate.
- Conditions
- COVID-19, SARS CoV 2 Infection, COVID-19 Pandemic
- Trial name
- STREESCO (NCT06170320)
- Where
- Benin
- Volunteers
- 7,000 people
- Sponsor
- Institut de Recherche pour le Developpement
Stroke, Acute
Effectiveness of High-intensity Aerobic Interval Training on Impairments and Activity Limitations in the Acute Phase of Stroke in Benin
This clinical trial aims to examine the effects of combining HIIT on a semi-recumbent cycle ergometer (HIIT-RCE) with conventional physiotherapy on impairments and activity limitations in early subacute stroke.
- Trial name
- NCT06179173
- Testing
- HIIT-RCE, Conventional physiotherapy
- Where
- Benin
- Volunteers
- 40 people
- Sponsor
- Hasselt University