Clinical trials: type1diabetes
Type1diabetes, Type2diabetes
Assessment of Pancreatic Beta Cell Mass and Function by Positron Emission Tomography Imaging in Human Diabetes Mellitus
The goals of this project are to build an experimental tool to dissect out in vivo pancreatic beta cell mass (BCM) and beta cell function (BCF) and to assess for the first time these two determinants of beta cell functional mass…
- Conditions
- Type1diabetes, Type2diabetes, Pre Diabetes, Hyperinsulinism
- Trial name
- NCT05662189
- Testing
- 68Ga-exendin-4, mixed meal test
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Type1diabetes
Safety of Closed-loop Hybrid Insulin Administration During Ramadan Fasting in People Living With Type 1 Diabetes
Fasting in Ramadan is not recommended for people with type 1 diabetes. The main risk associated with fasting is dysglycemia (hypoglycemia, hyperglycemia, diabetic ketosis) and dehydration.
- Trial name
- RAMDAM (NCT05747352)
- Testing
- closed-loop hybrid insulin administration
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Centre Hospitalier Sud Francilien
type1diabetes
Motivational Interviewing to Improve Self Management in Youth With Type 1 Diabetes
A brief, nurse-led educational intervention using motivational interviewing substantially improved general and disease-specific self-management skills in youth with type 1 diabetes.
- Trial name
- NCT04798937
- Testing
- Motivational interviewing
- Where
- Tunisia
- Volunteers
- 66 people
- Sponsor
- Université de Sousse
Type1diabetes
Sublingual Microcirculation in Children with Compensated T1D Using the SDF Method
The main goal of the study is to describe the sublingual microcirculation of children with type 1 diabetes mellitus (T1D) with stable and satisfactory treatment of the disease and to compare it with previously measured parameters…
- Trial name
- NCT05958264
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- Vlasta Krausová
Type1diabetes
Thrive With Type 1 Diabetes 2026
This study aims to learn whether a cognitive behavioral intervention can improve lifestyle and glucose targets for adults with type 1 diabetes.
- Trial name
- NCT07522866
- Testing
- TranS-C Intervention Arm, Attention Control Enhanced Usual Care (EUC) Arm
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Emory University
type1diabetes
Sexual Dimorphism in Cardiovascular Autonomic Neuropathy in Patients With Type 1 Diabetes
Sex might interact with cardioautonomic neuropathy (CAN) in the development of macrovascular disease in patients with type 1 diabetes (T1D).
- Trial name
- NCT04950634
- Where
- Spain
- Volunteers
- 320 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
type1diabetes
Response to BNT162b2 Vaccine in Adolescents With Type 1 Diabetes
Adolescents with type 1 diabetes may be at increased risk for severe coronavirus disease-2019 (COVID-19) and are therefore prioritized for access to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination.
- Trial name
- NCT05620251
- Testing
- Blood test
- Where
- Turkey (Türkiye)
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Type1diabetes
Two Narrative Medicine Interventions in Type 1 Diabetes
a randomized prospective study aims at comparing the impact of a "living theater" session with a simple "writing workshop " on emotional distress (Problem Areas in Diabetes Questionnaire PAID) and illness perception ( Illness…
- Trial name
- NCT03365349
- Testing
- participating in a session of "living theatre", writing workshop
- Volunteers
- 87 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type1diabetes
The Impact of a Predictive Hypoglycaemia Alert Function in Physical Activity for People With T1DM
Observational, within-subject, crossover study To assess the impact of Dexcom G6 RT-CGM with a predictive hypoglycaemia alert function on the frequency, duration and severity of hypoglycaemia occurring before, during and after…
- Trial name
- PACE (NCT04142944)
- Testing
- Dexcom G6 with alert, Dexcom G6 without alert
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Imperial College London
Type1diabetes
Development of Predictive Biomarkers
Investigators aim to further the understanding of the various factors that govern the progression of beta-cell death in individuals recently diagnosed with Type 1 diabetes (T1D).
- Trial name
- NCT03423862
- Testing
- Mixed Meal Tolerance Test
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical College of Wisconsin
Type1diabetes
Petit Cactus Study
The goal of this trial is to test a newly developed carbohydrate counting mobile application (named Petit Cactus) with photo recognition, for people with type 1 diabetes. To evaluate Petit Cactus, our objectives are: 1.
- Trial name
- NCT07380802
- Testing
- Petit Cactus
- Where
- Canada
- Volunteers
- 73 people
- Sponsor
- McGill University
Type1diabetes
Evaluation of the Accuracy and Safety of A Novel Real-Time Continuous Glucose Monitoring System
The study is to evaluate the accuracy and safety of a novel real-time CGM system among adult patients with type 1 diabetes mellitus with respect to YSI reference venous plasma sample measurements.
- Trial name
- NCT07092761
- Testing
- GS3 CGM
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Henan University of Science and Technology
Type1diabetes
A Cognitive Behavioral Intervention to Reduce Fear of Hypoglycemia in Young Adults With Type 1 Diabetes
This study is being conducted to determine the feasibility of a cognitive behavioral therapy intervention to reduce fear of hypoglycemia and improve glucose levels in young adults with type 1 diabetes.
- Trial name
- FREE (NCT03165786)
- Testing
- FREE
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Illinois at Chicago
Short Sleep Phenotype, Type1diabetes
A Sleep Intervention in Type 1 Diabetes
Insufficient sleep and sleep irregularity (variability in sleep duration) are increasingly recognized as important contributors to glucose control and diabetes distress in type 1 diabetes (T1D).
- Trial name
- NCT03617770
- Testing
- Sleep Opt-In, Healthy Living
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Illinois at Chicago
Type1diabetes
Assay for the Pancreatic Polypeptide: an Help for Clinical Practice Guidelines in Classification of the Diabetes
The purpose of this study is to evaluate global endocrine function within type 1 and type 3c diabetic patients, helping pancreatic polypeptide measurement.
- Trial name
- DIAPP (NCT03396146)
- Testing
- 12 ml total blood tubes volume, Fecal sample
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 1 Diabetes, type1diabetes
Reducing Innate Inflammation in New Onset Type 1 Diabetes
This study aims to determine whether Lactiplantibacillus plantarum 299v (Lp299v) supplementation will reduce systemic inflammation and prolong residual beta cell function in individuals newly diagnosed with Type 1 diabetes.
- Conditions
- Type 1 Diabetes, type1diabetes, Type 1 Diabetes Mellitus
- Trial name
- NCT04335656
- Testing
- Lactiplantibacillus plantarum
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Medical College of Wisconsin
Type1diabetes
Specialized Technology Education for Pumps & Pens in Underserved Populations With Diabetes
Lower socioeconomic status (SES) individuals with type 1 diabetes have poorer outcomes than wealthier patients and part of this disparity comes from a lack of tools and knowledge about how to teach these patients on the…
- Trial name
- STEPP-UP (NCT04550585)
- Testing
- Education: Session 1 - Basics of type 1 management, Session 2 - Carbohydrate counting, Education: Session 3 - Insulin self- adjustment
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Southern California
Type1diabetes
Metabolic Profiling of Type 1 Diabetes Mellitus in Children and Adolescents
The aim of this study was to look for discriminating variation in the concentrations of small-molecule metabolites in the plasma of T1DM children compared with non-diabetic matched controls using proton nuclear magnetic resonance…
- Trial name
- T1DM (NCT03014908)
- Testing
- Blood sampling
- Where
- Belgium
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Type1diabetes
First-in-human Safety Study of Hypoimmune Pancreatic Islet Transplantation in Adult Subjects With Type 1 Diabetes
The current study tests the hypothesis whether genetically modified Langerhans islet cells containing insulin-producing cells from a deceased organ donor can 1. be transplanted safely and 2.
- Trial name
- NCT06239636
- Testing
- UP421
- Where
- Sweden
- Volunteers
- 2 people
- Sponsor
- Per-Ola Carlsson
Type1diabetes
Mobile Physical Activity for Type 1 Diabetes
The study is the formative observation stage of behavioral intervention development. Sedentary adults with type 1 diabetes will be given access to a mobile application that incorporates biosensor feedback, teleconsultation, and…
- Trial name
- NCT04204733
- Testing
- Mobile application
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University