Clinical trials: type1diabetes
type1diabetes
Accuracy of a Continuous Ketone Monitoring (CKM) System in Individuals With Type 1 Diabetes on Insulin Pump Therapy.
The goal of this 14-day randomized pilot trial is to assess the accuracy of a continuous ketone monitoring (CKM) system when compared to standard point-of-care capillary ketone monitors in individuals with type 1 diabetes on…
- Trial name
- CKM 1 (NCT06420518)
- Testing
- Ketogenic diets, 8-hour insulin-suspension period
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- McGill University
Type1diabetes
Investigational Extended Wear Insulin Infusion Set in People With Type 1 Diabetes
The purpose of this study is to collect clinical data to support a 7-day wear of the Extended Wear Infusion Set (EWIS). Participants will be asked to: 1.
- Trial name
- NCT06273124
- Testing
- SteadiSet Extended Wear Infusion Set
- Where
- 15 sites in United States
- Volunteers
- 260 people
- Sponsor
- Tandem Diabetes Care, Inc.
type1diabetes
Sexual Dimorphism in Cardiovascular Autonomic Neuropathy in Patients With Type 1 Diabetes
Sex might interact with cardioautonomic neuropathy (CAN) in the development of macrovascular disease in patients with type 1 diabetes (T1D).
- Trial name
- NCT04950634
- Where
- Spain
- Volunteers
- 320 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Diabetes Complications, type1diabetes
Early Detection of Long-term Diabetic Complications in Children and Adolescents With Type 1 Diabetes
Aims: To investigate early markers of long-term diabetic complications and the association to an extended glucose metabolic profile comprising glucose control (current and past), glucose variability and insulin sensitivity in…
- Conditions
- Diabetes Complications, type1diabetes, Children, Only, Diabetic Neuropathies
- Trial name
- NCT05159856
- Where
- Denmark
- Volunteers
- 400 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type1diabetes
4T Sustainability Program
The goal of the 4T program is to implement proven methods and emerging diabetes technology into clinical practice to sustain tight glucose control from the onset of type 1 diabetes (T1D) and optimize patient-reported and…
- Trial name
- NCT06314048
- Testing
- CGM and RPM
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Stanford University
Type1diabetes, Therapeutic Play
The Effect of Therapeutic Play on Anxiety and Fear Levels in Children With Diabetes
The study will be conducted using a randomized controlled method. Children with type 1 diabetes who are admitted to the Pediatric Endocrinology Service will be divided into two groups by randomization method.
- Conditions
- Type1diabetes, Therapeutic Play, Fear State, Anxiety State
- Trial name
- NCT06418269
- Testing
- Therapeutic Play
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Type1diabetes
Gluten and Amylase Trypsin Inhibitors (ATI) Free Diet
Siblings of those with type 1 diabetes are at an increased risk of developing the disease themselves. Through prior research, the investigators have found that siblings as well as those with type 1 diabetes have a general level…
- Trial name
- NCT03443180
- Testing
- Gluten and Amylase Trypsin Inhibitors (ATI)-free diet
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Type1diabetes
Bridging the Gap to Adult Diabetes Care
Adolescents with type 1 diabetes face particular challenges related to having a chronic illness that requires daily intensive self-management and medical follow-up during a period when their social, developmental, educational…
- Trial name
- NCT03781973
- Testing
- Data platform +Quality Performance feedback reports
- Where
- 5 sites in Canada
- Volunteers
- 484 people
- Sponsor
- The Hospital for Sick Children
Type1diabetes, Type2diabetes
Assessment of Pancreatic Beta Cell Mass and Function by Positron Emission Tomography Imaging in Human Diabetes Mellitus
The goals of this project are to build an experimental tool to dissect out in vivo pancreatic beta cell mass (BCM) and beta cell function (BCF) and to assess for the first time these two determinants of beta cell functional mass…
- Conditions
- Type1diabetes, Type2diabetes, Pre Diabetes, Hyperinsulinism
- Trial name
- NCT05662189
- Testing
- 68Ga-exendin-4, mixed meal test
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
type1diabetes
The Breakfast Rise, Education and Knowledge Study
The study proposes to recruit 90 children and young people who have type 1 diabetes (T1D) and who regularly use Dexcom continuous glucose monitoring (CGM).
- Trial name
- BREAK (NCT05698875)
- Testing
- Breakfast meals
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- University of Stirling
Type1diabetes
Wharton´s Jelly Derived Mesenchymal Stromal Cell Repeated Treatment of Adult Patients Diagnosed with Type I Diabetes
An open label, parallel single centre trial of Wharton's Jelly derived allogenic mesenchymal stromal cells repeated treatment to preserve endogenous insulin production in adult patients diagnosed with type 1 diabetes
- Trial name
- NCT03973827
- Testing
- ProTrans, Control
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- NextCell Pharma Ab
type1diabetes
Feasibility Trial of a Mindfulness Based Intervention in Youth With Type 1 Diabetes
Type 1 diabetes (T1D) is one of the most common chronic illnesses of childhood. The involved treatment regimen, including daily insulin administration/pump management, frequent blood glucose checks, and careful track-ing of food…
- Trial name
- BREATHE-T1D (NCT05268393)
- Testing
- BREATHE-T1D
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Children's National Research Institute
Type1diabetes
A Cognitive Behavioral Intervention to Reduce Fear of Hypoglycemia in Young Adults With Type 1 Diabetes
This study is being conducted to determine the feasibility of a cognitive behavioral therapy intervention to reduce fear of hypoglycemia and improve glucose levels in young adults with type 1 diabetes.
- Trial name
- FREE (NCT03165786)
- Testing
- FREE
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Illinois at Chicago
Severe Hypoglycemia, Type1diabetes
Longitudinal Study of the GLUcagon REsponse to Hypoglycemia in Children and Adolescents With New-onset Type 1 DIAbetes
The GLUREDIA study investigates the counter-regulatory response (CRR) during hypoglycemia in children with type 1 diabetes (T1D).
- Trial name
- GLUREDIA (NCT06770621)
- Testing
- Insulin-induced hypoglycemia test, Glucagon profile, Biological sample once
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Type1diabetes
Type 1 Diabetes Management Using a Very Low Carbohydrate Versus Standard Diet
Despite major technological advances, management of type one diabetes mellitus (T1D) remains suboptimal, putting millions of people at risk for immediate and long-term complications.
- Trial name
- NCT03710928
- Testing
- very low carbohydrate diet, standard carbohydrate diet
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Boston Children's Hospital
Type1diabetes
Very Low Carbohydrate Diets and Glucagon Response in T1DM
Despite major technological advances, management of type one diabetes mellitus (T1D) remains suboptimal, putting millions of people at risk for immediate and long-term complications.
- Trial name
- NCT04200391
- Testing
- Very low carbohydrate diet
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Boston Children's Hospital
Type1diabetes
Effects of Ketosis on Brain Function in Patients With T1DM
The scientific goal of this study is to examine the effects of a ketogenic diet on hypoglycemia tolerance and brain function in people with type 1 diabetes mellitus (T1D) and to clarify the mechanistic role of ketones in this…
- Trial name
- NCT04219709
- Testing
- Very low carbohydrate diet, Standard carbohydrate diet
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Boston Children's Hospital
Type1diabetes
First-in-human Safety Study of Hypoimmune Pancreatic Islet Transplantation in Adult Subjects With Type 1 Diabetes
The current study tests the hypothesis whether genetically modified Langerhans islet cells containing insulin-producing cells from a deceased organ donor can 1. be transplanted safely and 2.
- Trial name
- NCT06239636
- Testing
- UP421
- Where
- Sweden
- Volunteers
- 2 people
- Sponsor
- Per-Ola Carlsson
Type1diabetes, Metabolic Syndrome
The Effect of Exercise on Metabolic Parameters, Anthropometric Measurement Values and Quality of Life
This study was planned as a randomized controlled experimental study to determine the effect of exercise with Augmented Reality Glasses (AR) on metabolic parameters, anthropometric measurement values and quality of life in…
- Conditions
- Type1diabetes, Metabolic Syndrome, Nursing Caries
- Trial name
- NCT05737654
- Testing
- Exercise with augmented reality glasses
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- TC Erciyes University
Type1diabetes, Hypoglycemia
The Effect of Glucose-dependent Insulinotropic Polypeptide on the Alpha Cell Response to Hypoglycaemia in Patients with Type 1 Diabetes
The goal of this clinical trial is to evaluate the effects of the hormone glucose-dependent insulinotropic polypeptide (GIP) and its two isoforms, GIP[1-30] and GIP[1-42], in patients with type 1 diabetes.
- Conditions
- Type1diabetes, Hypoglycemia, Type 1 Diabetes
- Trial name
- GIPHYPO (NCT06137586)
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- University Hospital, Gentofte, Copenhagen