Clinical trials: in Vitro Activation
Infertility, Male
Selection of Non Apoptotic Human Sperm for in Vitro Fertilization by Using Magnetic Activated Cell Sorting (MACS)
This clinical study has been organised to help improve the embryo quality in couples having high rate of sperm showing apoptotic signs.
- Trial name
- MACS-HS (NCT03988361)
- Testing
- Magnetic Activated Cell Sorting
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Immunosuppression, Kidney Transplantation
The Differential Effects of 3 Different Immunosuppressive
The study is a laboratory investigation comparing the regulatory effects of different immunosuppressive therapies in an in vitro human MLR assay of selecting specific immunosuppressive therapy to promote a regulatory profile and…
- Trial name
- NCT00729248
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Northwestern University
Activation of Primordial Follicles
In Vitro Follicle Activation in Patient With Premature Ovarian Failure Under 36 Years Old
This is a clinical trial that the investigators aim to validate In-vitro Activation (IVA) treatment protocol, which was previously defined by Kazuhiro Kawamura (MD) and Aaron Hsueh (PhD), in Turkish patient with Premature Ovarian…
- Trial name
- NCT04131244
- Testing
- In vitro activation of primordial follicles by PTEN inhibitor and AKT stimulator
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Hacettepe University
Primary Ovarian Insufficiency, Infertility
In Vitro Follicle Activation
The purpose of this study is to evaluate the effectiveness of an experimental treatment, known as in vitro activation (IVA) of dormant ovarian follicles, for infertility in women diagnosed with primary ovarian insufficiency (POI).
- Trial name
- IVA (NCT02496598)
- Testing
- In Vitro Follicle Activation (IVA), Follicle Activation
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- National Foundation for Fertility Research
Infertility, Male
To Study the Effect of Magnetic Activated Sperm Sorting on the Outcome of in Vitro Fertilization-embryo Transplantation
Recent studies have evaluated the use of magnetic-activated sperm sorting (MASS) to reduce apoptotic spermatozoa and improve the outcome of infertile male with assisted reproductive technology (ART).
- Trial name
- MASS (NCT03968367)
- Testing
- Magnetic activated sperm sorting
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Li-jun Ding
Acute Myeloid Leukemia
Natural Killer Cells Infusion for Treating Acute Myeloid Leukemia Patients With Minimal Residual Disease
This trial will evaluate the effectiveness and safety of haploid donor-derived in vitro activated natural killer(NK) cells infusion for Treating acute myeloid leukemia Patients With minimal residual disease.
- Trial name
- NCT04209712
- Testing
- haploid allogeneic NK cell therapy
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China
Infertility, Female, Oocyte Maturation
Second Phase of the Pilot Study for Obtaining Mature Oocytes by in Vitro Maturation in Oocyte-donor Women
In vitro maturation (IVM) is a technique for obtaining potentially fertilizable oocytes from immature oocytes. An oocyte must be mature both nuclearly and cytoplasmically in order to be competent in the reproductive process.
- Trial name
- MIVODON-II (NCT06103383)
- Testing
- Controlled ovarian stimuation, Oocyte pick up, Oocyte in vitro maturation
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Melanoma, Kidney Cancer
Determining the Lymphokine Activated Killer (LAK) Cytotoxicity Present in Patients Undergoing Interleukin-2 Therapy
Therapy with Interleukin-2 stimulates lymphocytes in humans to become Lymphokine-activated Killer cells (LAK). This study will determine if these killer cells are able to kill certain standard cell-lines in the laboratory.
- Trial name
- LAK (NCT01068470)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Loma Linda University
ARDS (Acute Respiratory Distress Syndrome)
Lung Injury is One of the Primary Causes of Morbidity and Mortality in Critically Ill Patients. These Patients Will be Monitored for: 1) Immune Cell Activation 2) Blood-based Biomarkers. In Vitro Models Derived From These Samples Will be Treated With Novel Agent PIP-2 to Evaluate Its Efficacy.
Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) is a condition where high levels of inflammation damage the lung. This is a highly morbid condition with no specific pharmacologic therapies.
- Trial name
- ALI/ARDS (NCT07125079)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Pennsylvania
in Vitro Fertilization
AOA Versus Non-AOA in Low Prognosis Patients by the POSEIDON Criteria
Poor ovarian response (POR) remains one of the significant challenges of Assisted Reproductive Technology (ART). Facing difficulties related to clinical practice, optimizing the embryo culture process is necessary to improve the…
- Trial name
- NCT05402605
- Testing
- ICSI with AOA, ICSI without AOA
- Where
- Vietnam
- Volunteers
- 528 people
- Sponsor
- Mỹ Đức Hospital
in Vitro Activation, Dormant Follicle
In Vitro Activation of Dormant Follicles for Patients With Primary Ovarian Insufficiency
In this study, the investigators used the newly developed technique i.e. in vitro activation of dormant follicles (IVA) to promote ovarian follicle growth much more efficiently than natural, in vivo process for women with Primary…
- Conditions
- in Vitro Activation, Dormant Follicle, Primary Ovarian Insufficiency, Ovarian Resistance Syndrome
- Trial name
- IVADFPOI (NCT02322060)
- Testing
- Ovariotomy, Activate dormant follicles, Ovary tissue transplantation
- Where
- China
- Volunteers
- 35 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
HIV Infections
A Phase I Study of Autologous, Activated CD8(+) Lymphocytes Expanded In Vitro and Infused With or Without Recombinant Interleukin-2 to Patients With AIDS or Severe ARC
1) To determine whether it is possible to remove and culture (increase in number and activate) in the laboratory, CD8(+) lymphocytes (white blood cells) from HIV-infected patients receiving zidovudine (AZT); 2) To determine the…
- Trial name
- NCT00000680
- Testing
- Zidovudine, Aldesleukin
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hemophilia A
Impact of Emicizumab on Activated Clotting Time Using the i-STAT Alinity Analyzer
Emicizumab (Hemlibra®) is a subcutaneous hemostatic treatment approved in 2019 for the prophylaxis in severe hemophilia A. Emicizumab is a bispecific monoclonal antibody mimicking factor VIIIa that provides a constant level of…
- Trial name
- EMISTAT (NCT05856903)
- Testing
- ACT
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Menopause, Menopause Ovarian Failure
Stem Cell Therapy and Growth Factor Ovarian in Vitro Activation
SEGOVA procedure includes - Stem cell therapy, G - Growth factor Platelet Plasma Rich therapy and in Vitro Activation of the ovaries.
- Conditions
- Menopause, Menopause Ovarian Failure, Ovarian Failure, Premature Ovarian Failure
- Trial name
- SEGOVA (NCT04009473)
- Testing
- SEGOVA procedure
- Where
- 3 sites in Malta, North Macedonia and 1 more
- Volunteers
- 100 people
- Sponsor
- Forever Young d.o.o.
Pulpitis - Irreversible
Correlation Between Postoperative Pain and Apical Extrusion of Different Irrigation Activation Techniques
The aim of this clinical trial is : To evaluate effect of different techniques of irrigant activation: 1. LASER activation 2. sonic activation 3. ultrasonic activation 4. passive needle irrigation On: 1.
- Trial name
- NCT06573710
- Testing
- sonic activator, LASER activation, Ultrasonic activation
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Prostate Hyperplasia, Coagulation; Intravascular
The Effect of Human Prostate Tissue on Platelet Activation
Transurethral resection of the prostate (TURP) is a common and standard urological surgical procedure for managing benign prostatic hyperplasia (BPH).
- Conditions
- Prostate Hyperplasia, Coagulation; Intravascular, Thrombotic Disorder
- Trial name
- NCT05059431
- Volunteers
- 8 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Congenital Heart Disease, Fibrinolysis
Determination of the Minimal Concentration of Antifibrinolytics Required to Inhibit t-PA-activated Fibrinolysis
Lysine analogs, like tranexamic acid (TXA) or epsilon aminocaproic acid (EACA), are antifibrinolytic agents routinely administered in children undergoing different surgeries associated with a high bleeding risk (e.g.
- Conditions
- Congenital Heart Disease, Fibrinolysis, Rotational Thromboelastometry
- Trial name
- NCT02352675
- Testing
- Intraoperative Blood Sample
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Children's Hospital
Food Allergy
Basophile Activation Testing (BAT) in Hazelnut Allergy (Hazelnut BAT Study)
The proposed study intends to compare the outcome of food challenge in hazelnut allergic patients with the outcome of basophile activation tests using hazelnut extract and components.
- Trial name
- NCT03079206
- Testing
- Food challenge, skin testing, blood sampling
- Where
- Switzerland
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Infertility, Hyperstimulation Syndrome, Ovaian
Vascular Cell Activation, Cell-Derived Microparticles and In Vitro Fertilisation, and In Vitro Fertilisation
Introduction: Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic phenomenon, poorly understood and difficult to predict, complicating intense ovarian stimulation cycle.
- Conditions
- Infertility, Hyperstimulation Syndrome, Ovaian, Thrombosis
- Trial name
- PREDHSO (NCT03051230)
- Volunteers
- 50 people
- Sponsor
- Poissy-Saint Germain Hospital
Infertility (IVF Patients), Infertile Females or Females with Ovarian Insufficiency
Evaluation of Pregnancy Outcome with Usage of Drug-free In-vitro Activation of Follicles Ovary
This study is the pilot study to evaluate the effect of Drug-free in vitro activation to improve the outcomes of IVF in poor responder women
- Trial name
- NCT06769789
- Testing
- Drug free invitro activation Ovary
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Malihe Mahmoudinia