Clinical trials: Xerostomia Due to Radiotherapy
Head and Neck Cancer (H&N), Oral Mucositis (Ulcerative) Due to Radiation
Oral Care Program for Mouth Side Effects During Head and Neck Radiation Therapy
People having radiation therapy to the head and neck often develop painful mouth problems - mouth sores, dry mouth, mouth pain, trouble eating and drinking, and changes in taste.
- Conditions
- Head and Neck Cancer (H&N), Oral Mucositis (Ulcerative) Due to Radiation, Stomatitis (Oral Mucositis), Xerostomia Due to Radiotherapy
- Trial name
- OSEM (NCT07885033)
- Testing
- ORAL CARE PRODUCT KIT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- UNCANCER LLC
Xerostomia Due to Radiotherapy (Disorder)
Screening of Biomarkers and Related Mechanisms for RIX
A large number of patients undergoing radiotherapy and chemotherapy are suffering from dry mouth. Due to reduced saliva secretion, patients may experience symptoms such as difficulty chewing and swallowing.
- Trial name
- RIX (NCT07170358)
- Testing
- Radiation Therapy
- Where
- 4 sites in China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Xerostomia Due to Radiotherapy (Disorder)
Screening of Biomarkers and Related Mechanisms for RIX
A large number of patients undergoing radiotherapy and chemotherapy are suffering from dry mouth. Due to reduced saliva secretion, patients may experience symptoms such as difficulty chewing and swallowing.
- Trial name
- RIX (NCT06700863)
- Testing
- Radiation Therapy
- Where
- 4 sites in China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Head and Neck Cancer, Xerostomia Due to Radiotherapy
MRI - Guided Adaptive RadioTHerapy for Reducing XerostomiA in Head and Neck Cancer (MARTHA-trial)
Radiotherapy is the main treatment for locally advanced squamous cell carcinoma of the head and neck (SCCHN). Many advances regarding tumor control and patient survival have been made over the past decades.
- Trial name
- MARTHA (NCT03972072)
- Testing
- Pre-defined MR-linac based IGRT and plan adaptation protocol, salivary flow measurements
- Where
- Switzerland
- Volunteers
- 49 people
- Sponsor
- Panagiotis Balermpas
Xerostomia Due to Hyposecretion of Salivary Gland, Xerostomia Due to Radiotherapy
Repeated Mesenchymal Stem Cell Therapy for Radiation-Induced Hyposalivation and Xerostomia in Head and Neck Cancer Survivors
Dry mouth leads to debilitating symptoms 24/7. The two primary causes for dry mouth are Sjögrens disease and after radiotherapy of a head and neck cancer.
- Conditions
- Xerostomia Due to Hyposecretion of Salivary Gland, Xerostomia Due to Radiotherapy, Sjögren´s Syndrome
- Trial name
- MESRIX-more (NCT07290946)
- Testing
- ALLOGENEIC AND EXPANDED ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELLS
- Volunteers
- 100 people
- Sponsor
- Christian von Buchwald
Radiotherapy Side Effect, Xerostomia Due to Radiotherapy
Prevalence of Late Xerostomia and Hyposalivation with Associated Risk Factors in Survivors of Head and Neck Cancer After Radiotherapy: a Multi-centric Cross-sectional Study
The study titled "Prevalence of Late Xerostomia and Hyposalivation with Associated Risk Factors in Survivors of Head and Neck Cancer After Radiotherapy" is a multi-centric cross-sectional study conducted in Egypt.
- Conditions
- Radiotherapy Side Effect, Xerostomia Due to Radiotherapy, Xerostomia Due to Radiotherapy (Disorder)
- Trial name
- NCT06851572
- Where
- Egypt
- Volunteers
- 260 people
- Sponsor
- Ain Shams University
Head and Neck Cancer, Oropharynx Cancer
Functional Sparing of Salivary Glands Using MRI Sialography for Patients Undergoing Definitive Radiation Therapy for Head and Neck Cancers of the Oropharynx
The proposed study is an attempt to improve patient xerostomia (dry mouth) after definitive radiation therapy treatment for head and neck cancer.
- Conditions
- Head and Neck Cancer, Oropharynx Cancer, Xerostomia Due to Radiotherapy
- Trial name
- NCT03418792
- Testing
- Parotid-Sparing Head & Neck Radiation Guided by MRI Sialography
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Radiation-Induced Parotid Gland Hypofunction, Xerostomia Due to Radiotherapy
A Phase 1 Open-Label, Dose Escalation Study to Determine the Optimal Dose, Safety, and Activity of AAV2hAQP1 in Subjects With Radiation-Induced Parotid Gland Hypofunction and Xerostomia
Open-label, non-randomized, dose escalation trial of AAV2hAQP1 administered via Stensen's duct to a single or both parotid glands in subjects with radiation-induced xerostomia The objectives are to evaluate the safety and…
- Conditions
- Radiation-Induced Parotid Gland Hypofunction, Xerostomia Due to Radiotherapy, Head and Neck Cancer
- Trial name
- NCT04043104
- Testing
- AAV2hAQP1: 1 x 10^11 vg/gland (single gland), AAV2hAQP1: 3 x 10^10 vg/gland (both glands), AAV2hAQP1: 3 x 10^11 vg/gland (single gland)
- Where
- 6 sites in United States, Canada
- Volunteers
- 24 people
- Sponsor
- MeiraGTx UK II Ltd
Xerostomia Due to Radiotherapy, Hyposalivation
Allogeneic Mesenchymal Stem Cells for Radiation-induced Hyposalivation and Xerostomia/Dry Mouth
An investigator-initiated, non-randomized, open label study to investigate the safety, feasibility and tolerability of intraglandular injection of allogeneic mesenchymal stem/stromal cells (MSCs) into the submandibular and…
- Conditions
- Xerostomia Due to Radiotherapy, Hyposalivation, Xerostomia, Oropharynx Cancer
- Trial name
- MESRIX-SAFETY (NCT03874572)
- Testing
- Allogeneic adipose derived stem/stromal cells
- Where
- 2 sites in Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Radiation Toxicity, Xerostomia Due to Radiotherapy
Mesenchymal Stem Cells for Radiation-induced Xerostomia
A prospective study for long-term follow-up (LTFU) to evaluate safety and efficacy in subjects who participated in the Phase 1/2 randomized placebo-controlled trial MESRIX.
- Conditions
- Radiation Toxicity, Xerostomia Due to Radiotherapy, Dry Mouth, Hyposalivation
- Trial name
- NCT03876197
- Testing
- Autologous adipose-derived mesenchymal stem/stromal cells
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Xerostomia Due to Radiotherapy
Clinical Trial to Evaluate the Effect and Safety of MSV in Xerostomy
Phase II not controlled, open-label, prospective, single center clinical trial
- Trial name
- NCT03743155
- Testing
- mesenchymal cells
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Institut de Terapia Regenerativa Tissular
Xerostomia, Xerostomia Due to Radiotherapy
Finger-prick Autologous Blood (FAB) for Use in Dry Mouth
This is a feasibility study that will assess the efficacy of using autologous blood to treat moderate to severe dry mouth. Dry mouth has been estimated to affect up to 64.8% of the general population (Navazesh et al., 2009) and…
- Conditions
- Xerostomia, Xerostomia Due to Radiotherapy, Xerostomia Due to Hyposecretion of Salivary Gland
- Trial name
- NCT03530735
- Testing
- Finger-prick Autologous Blood (FAB)
- Volunteers
- 20 people
- Sponsor
- Bedford Hospital NHS Trust
Xerostomia Due to Radiotherapy (Disorder)
Stromal Vascular Fraction for Treatment of Xerostomia
Prospective, single center, double armed, randomized treatment with observation only (standard of care) control group. Subjects receiving study treatment will have 6 months of study follow-up.
- Trial name
- NCT03061110
- Testing
- Stromal Vascular Fraction, Usual Care
- Where
- United States
- Sponsor
- Midwestern Regional Medical Center