Clinical trials: Xerostomia Due to Hyposecretion of Salivary Gland
Xerostomia Due to Radiotherapy, Hyposalivation
Allogeneic Mesenchymal Stem Cells for Radiation-induced Hyposalivation and Xerostomia/Dry Mouth
An investigator-initiated, non-randomized, open label study to investigate the safety, feasibility and tolerability of intraglandular injection of allogeneic mesenchymal stem/stromal cells (MSCs) into the submandibular and…
- Conditions
- Xerostomia Due to Radiotherapy, Hyposalivation, Xerostomia, Oropharynx Cancer
- Trial name
- MESRIX-SAFETY (NCT03874572)
- Testing
- Allogeneic adipose derived stem/stromal cells
- Where
- 2 sites in Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Xerostomia Due to Radiotherapy
Clinical Trial to Evaluate the Effect and Safety of MSV in Xerostomy
Phase II not controlled, open-label, prospective, single center clinical trial
- Trial name
- NCT03743155
- Testing
- mesenchymal cells
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Institut de Terapia Regenerativa Tissular
Xerostomia
Dry Mouth Toothpaste Study - Comparing Two Toothpastes With Arginine
This is a clinical investigation to measure the changes in the oral environment resulting from a 3 month exposure to an arginine containing toothpaste. This study is a double blind, randomized controlled, parallel design.
- Trial name
- NCT06365047
- Testing
- 8% Arginine toothpaste, 1000 ppm F toothpaste
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Tufts University
Psychiatric Disorders, Xerostomia Due to Hyposecretion of Salivary Gland
This Present Study Can be Used by Clinicians Who Treat Psychiatric Patients: Dentists Might Expect Xerogenic Side Effects of Specific Psychiatric Drugs Which Can Affect Dental Treatment, and the Results Can Help Psychiatrist to Choose the Less Xerogenic Psychiatric Medication
The goal of this observational study is to learn about the effects of psychiatric drug therapies on intra- and extra-oral sicca symptoms and salivation.
- Trial name
- NCT06920472
- Volunteers
- 361 people
- Sponsor
- Semmelweis University
Xerostomia, Xerostomia Due to Radiotherapy
Finger-prick Autologous Blood (FAB) for Use in Dry Mouth
This is a feasibility study that will assess the efficacy of using autologous blood to treat moderate to severe dry mouth. Dry mouth has been estimated to affect up to 64.8% of the general population (Navazesh et al., 2009) and…
- Conditions
- Xerostomia, Xerostomia Due to Radiotherapy, Xerostomia Due to Hyposecretion of Salivary Gland
- Trial name
- NCT03530735
- Testing
- Finger-prick Autologous Blood (FAB)
- Volunteers
- 20 people
- Sponsor
- Bedford Hospital NHS Trust
Xerostomia Due to Radiotherapy (Disorder)
Screening of Biomarkers and Related Mechanisms for RIX
A large number of patients undergoing radiotherapy and chemotherapy are suffering from dry mouth. Due to reduced saliva secretion, patients may experience symptoms such as difficulty chewing and swallowing.
- Trial name
- RIX (NCT07170358)
- Testing
- Radiation Therapy
- Where
- 4 sites in China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Xerostomia Due to Hyposecretion of Salivary Gland
Hyaluronic Acid in the Treatment of Hyposalivation
The goal of this clinical trial is to learn if drug containing non-crosslinked hyaluronic acid and amino acids solution (Sunecos-200) works to treat hyposalivation in adults.
- Trial name
- NCT07309588
- Testing
- Sunecos-200 Injectable Hyaluronic acid and amino acids solution
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Poznan University of Medical Sciences
Xerostomia Due to Hyposecretion of Salivary Gland
Salivary Markers in Patients With Xerostomia
The purpose of this study was to investigate the salivary levels of inflammatory and their association with oral health in xerostomía patient
- Trial name
- NCT03156569
- Testing
- Analysis of the saliva
- Where
- 2 sites in Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Xerostomia Due to Hyposecretion of Salivary Gland
Chamomile Effect on Xerostomia Associated With End-stage Renal Disease in Elderly
Background and Objectives: Chronic hemodialysis causes changes in blood chemistry as well as dry mouth, due to removal of excess fluids. Dry mouth is due to hyposalivation or change in saliva composition.
- Trial name
- NCT06114797
- Testing
- Chamomile, Saline mouthwash
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Ain Shams University
Dry Eye, Sjogren's Syndrome
Comparative Study of Thymosin Beta 4 Eye Drops vs. Vehicle in the Treatment of Severe Dry Eye
Severe dry eye is a debilitating ocular disease resulting in loss of vision, reduced day-to-day function and significant discomfort.
- Conditions
- Dry Eye, Sjogren's Syndrome, Graft vs. Host Disease
- Trial name
- NCT01393132
- Testing
- Thymosin Beta 4 eye drops, Vehicle Control
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Michigan Cornea Consultants, PC
Xerostomia Due to Radiotherapy (Disorder)
Screening of Biomarkers and Related Mechanisms for RIX
A large number of patients undergoing radiotherapy and chemotherapy are suffering from dry mouth. Due to reduced saliva secretion, patients may experience symptoms such as difficulty chewing and swallowing.
- Trial name
- RIX (NCT06700863)
- Testing
- Radiation Therapy
- Where
- 4 sites in China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Radiation Toxicity, Xerostomia Due to Radiotherapy
Mesenchymal Stem Cells for Radiation-induced Xerostomia
A prospective study for long-term follow-up (LTFU) to evaluate safety and efficacy in subjects who participated in the Phase 1/2 randomized placebo-controlled trial MESRIX.
- Conditions
- Radiation Toxicity, Xerostomia Due to Radiotherapy, Dry Mouth, Hyposalivation
- Trial name
- NCT03876197
- Testing
- Autologous adipose-derived mesenchymal stem/stromal cells
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Radiotherapy Side Effect, Xerostomia Due to Radiotherapy
Prevalence of Late Xerostomia and Hyposalivation with Associated Risk Factors in Survivors of Head and Neck Cancer After Radiotherapy: a Multi-centric Cross-sectional Study
The study titled "Prevalence of Late Xerostomia and Hyposalivation with Associated Risk Factors in Survivors of Head and Neck Cancer After Radiotherapy" is a multi-centric cross-sectional study conducted in Egypt.
- Conditions
- Radiotherapy Side Effect, Xerostomia Due to Radiotherapy, Xerostomia Due to Radiotherapy (Disorder)
- Trial name
- NCT06851572
- Where
- Egypt
- Volunteers
- 260 people
- Sponsor
- Ain Shams University
Xerostomia Due to Hyposecretion of Salivary Gland, pH
Efficacy of a Dietary Supplement (Aqualief®) in Xerostomic Patients
Xerostomia is defined as the subjective complaint of dry mouth. Symptoms of dry mouth may range from mild oral discomfort to significant oral disease that can compromise patients' health, dietary intake and quality of life.
- Conditions
- Xerostomia Due to Hyposecretion of Salivary Gland, pH, Saliva, Quality of Life
- Trial name
- Aqualief (NCT03612414)
- Testing
- Aqualief
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Università degli Studi dell'Insubria
Thirst in Intensive Care Unit (ICU) Practice, Thirst; Due to Deprivation of Water
The Effect of Cold Water Spray Application on Dry Mouth and Thirst Symptoms and Comfort of Patients After Endonasal Endoscopic Surgery After Admission to Intensive Care Unit
The aim of this observational study was to evaluate the effect of cold water spray application on dry mouth and thirst symptoms and comfort of patients who underwent endonasal endoscopic pituitary surgery in neurosurgery in the…
- Conditions
- Thirst in Intensive Care Unit (ICU) Practice, Thirst; Due to Deprivation of Water, Thirst, Dry Mouth
- Trial name
- NCT06763133
- Testing
- Cold Water Spray Application, Clinical routine practice
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Xerostomia Due to Radiotherapy (Disorder)
Stromal Vascular Fraction for Treatment of Xerostomia
Prospective, single center, double armed, randomized treatment with observation only (standard of care) control group. Subjects receiving study treatment will have 6 months of study follow-up.
- Trial name
- NCT03061110
- Testing
- Stromal Vascular Fraction, Usual Care
- Where
- United States
- Sponsor
- Midwestern Regional Medical Center
Xerostomia Due to Hyposecretion of Salivary Gland, Diabetes Mellitus, Type 2
The Artificial Saliva Spray Reduces Xerostomia in Diabetes Type II
In diabetes Type II the xerostomia is a quite frequent symptom. In evaluating the activity of an artificial saliva spray compared to a water gel in patients with Diabetes Type II patients had to follow a three day treatment with…
- Trial name
- NCT03452085
- Testing
- artificial saliva spray (AS), maritime throat spray (TT)
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Certmedica International GmbH
Radiation-Induced Parotid Gland Hypofunction, Xerostomia Due to Radiotherapy
A Phase 1 Open-Label, Dose Escalation Study to Determine the Optimal Dose, Safety, and Activity of AAV2hAQP1 in Subjects With Radiation-Induced Parotid Gland Hypofunction and Xerostomia
Open-label, non-randomized, dose escalation trial of AAV2hAQP1 administered via Stensen's duct to a single or both parotid glands in subjects with radiation-induced xerostomia The objectives are to evaluate the safety and…
- Conditions
- Radiation-Induced Parotid Gland Hypofunction, Xerostomia Due to Radiotherapy, Head and Neck Cancer
- Trial name
- NCT04043104
- Testing
- AAV2hAQP1: 1 x 10^11 vg/gland (single gland), AAV2hAQP1: 3 x 10^10 vg/gland (both glands), AAV2hAQP1: 3 x 10^11 vg/gland (single gland)
- Where
- 6 sites in United States, Canada
- Volunteers
- 24 people
- Sponsor
- MeiraGTx UK II Ltd
Dentin Sensitivity, Xerostomia
Effect of a Self-adhering Material in Dental Hypersensitivity
Aim: To compare the desensitizing capacity of Vertise Flow™ (VF), a new self adhering material, in the treatment of dentine hypersensitivity (DH) in patients who are xerostomic due to radiotherapy for head and neck cancer.
- Trial name
- NCT02766127
- Testing
- Veritise Flow, Universal Dentin Sealant, Clearfil Protect Bond
- Where
- Italy
- Volunteers
- 17 people
- Sponsor
- Università degli Studi di Sassari
Head and Neck Cancer (H&N), Oral Mucositis (Ulcerative) Due to Radiation
Oral Care Program for Mouth Side Effects During Head and Neck Radiation Therapy
People having radiation therapy to the head and neck often develop painful mouth problems - mouth sores, dry mouth, mouth pain, trouble eating and drinking, and changes in taste.
- Conditions
- Head and Neck Cancer (H&N), Oral Mucositis (Ulcerative) Due to Radiation, Stomatitis (Oral Mucositis), Xerostomia Due to Radiotherapy
- Trial name
- OSEM (NCT07885033)
- Testing
- ORAL CARE PRODUCT KIT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- UNCANCER LLC