Clinical trials: Worm Infestation
Malnutrition, Worm Infestation
Deworming and Vitamin A (DEVTA) Prepilot Study
Background. More than a third of the world's population is infected with intestinal nematodes. A majority of these infections occur in children.
- Conditions
- Malnutrition, Worm Infestation, Under-Fives
- Trial name
- NCT00396500
- Testing
- Albendazole (400 mg) and/or Vitamin a
- Where
- India
- Volunteers
- 4,000 people
- Sponsor
- King George's Medical University
Neurocysticercosis
Sub Arachnoid Neurocysticercosis Treatment Outcome (SANTO)
Taenia solium neurocysticercosis (NCC) is a parasitic infection causing much neurological disease in most of the world. When parasites locate in the cavities around the brain (subarachnoid NCC, SANCC), it becomes an aggressive…
- Trial name
- SANTO (NCT02947581)
- Testing
- Albendazole and praziquantel
- Where
- 2 sites in Peru
- Volunteers
- 107 people
- Sponsor
- Universidad Peruana Cayetano Heredia
Soil Transmitted Helminths, Schistosomiasis Mansoni
Evaluation of an AI-DP for STH Deworming Programs: a Study Protocol
The goal of this observational study is to test a new AI diagnostic tool for detection, specification and quantification of parasitic infections (Ascaris, Trichuris, hookworm and S.
- Trial name
- KAKADU (NCT06055530)
- Testing
- Artificial Intelligence Digital Pathology
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Enaiblers AB
Schistosomiasis, Bilharziasis
Clinical Trial of Bilhvax,a Vaccine Candidate Against Schistosomiasis
The purpose of this clinical study is to evaluate safety and immunogenicity in adult healthy volunteers of the vaccine candidate against schistosomiasis named Bilhvax.
- Conditions
- Schistosomiasis, Bilharziasis, Urinary Schistosomiasis
- Trial name
- Bilhvax1a (NCT01512277)
- Testing
- rSh28GST
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Neurocysticercosis
Corticosteroids to Reduce Frequency of Seizures in Neurocysticercosis Patients
The purpose of this study is to determine whether a short course of increased corticosteroid dosing with tapered dosing decreases seizure frequency as compared to standard corticosteroid dosing in patients with neurocysticercosis…
- Trial name
- NCT00290823
- Testing
- Albendazole, Dexamethasone, Omeprazole
- Where
- Peru
- Volunteers
- 110 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Rabies in Animals, Worms; Intestine
Integrating Community Interventions to Eliminate Neglected Tropical Diseases
The overarching goal of this project is the elimination of two neglected tropical diseases (NTD): soil-transmitted helminthiasis and rabies.
- Trial name
- NCT03667079
- Testing
- integrated delivery of deworming and vaccination, Mass deworming only, Mass vaccination of dogs
- Where
- United States
- Volunteers
- 28,143 people, healthy volunteers welcome
- Sponsor
- Washington State University
Helminth Infections
A Study to Assess the Efficacy and Safety of Mebendazole for the Treatment of Helminth Infections in Pediatric Participants
The purpose of this study is to evaluate the efficacy and safety of mebendazole compared with placebo in pediatric participants with Helminth infections.
- Trial name
- NCT02034162
- Testing
- Mebendazole
- Where
- 3 sites in Ethiopia, Rwanda
- Volunteers
- 295 people
- Sponsor
- Janssen Research & Development, LLC
Malaria,Falciparum, Neglected Tropical Diseases
Adjunctive Ivermectin Mass Drug Administration for Malaria Control
This is a cluster-randomized placebo-controlled clinical trial to evaluate the additive benefit of Ivermectin (IVM) (or Placebo) mass drug administration (MDA) to dihydroartemisinin-piperaquine (DP) MDA for malaria control in a…
- Conditions
- Malaria,Falciparum, Neglected Tropical Diseases, Strongyloidiasis, Lymphatic Filariasis
- Trial name
- MATAMAL (NCT04844905)
- Testing
- Ivermectin, Dihydroartemisinin-piperaquine
- Where
- Guinea-Bissau
- Volunteers
- 24,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Schistosoma Mansoni
Schistosoma Mansoni in Mwanza Region, Tanzania
The objective of this study is to determine the strategy for mass drug administration (MDA) which provides the greatest reductions in prevalence and intensity of Schistosoma mansoni in school-aged children after 4 years of…
- Trial name
- SCORE_PAR (NCT02162875)
- Testing
- Praziquantel
- Where
- Tanzania
- Volunteers
- 37,500 people
- Sponsor
- DBL -Institute for Health Research and Development
Hookworm Infections
Efficacy of Na-GST-1/Alhydrogel Hookworm Vaccine Assessed by Controlled Challenge Infection
This study evaluates the efficacy, safety and immunogenicity of different formulations of the Na-GST-1 hookworm vaccine using a controlled human hookworm infection model in healthy, hookworm-naive adults.
- Trial name
- NCT03172975
- Testing
- Na-GST-1/Alhydrogel, Na-GST-1/Alhydrogel + CPG 10104, Na-GST-1/Alhydrogel + GLA-AF
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Lymphedema, Lymphatic Filariasis
A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka
Current lymphedema management protocols are based on the use of simple measures of hygiene (regular washing with soap and water, skin and nail care), use of topical antibiotics or antifungal agents, exercise and footwear.
- Conditions
- Lymphedema, Lymphatic Filariasis, Filariasis
- Trial name
- LeDoxy-SL (NCT02929134)
- Testing
- Doxycycline
- Where
- Sri Lanka
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- The Task Force for Global Health
Filariasis
Safety, Tolerability and PK of Multiple-ascending Doses of Emodepside
The study evaluates safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of emodepside, after administration as a Liquid Service Formulation (LSF), over 10 days, in healthy male caucasian subjects.
- Trial name
- NCT03383614
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Drugs for Neglected Diseases
Strongyloidiasis
Multiple Versus Single Dose of Ivermectin for the Treatment of Strongyloidiasis
Ivermectin is currently the best drug to cure strongyloidiasis, but the "standard" single dose of 200 mcg/kg is probably not enough to guarantee cure.
- Trial name
- STRONGTREAT (NCT01570504)
- Testing
- Ivermectin
- Where
- 9 sites in Italy, Spain and 1 more
- Volunteers
- 312 people
- Sponsor
- Centro per le Malattie Tropicali
Onchocerciasis
Emodepside Phase II Trial for Treatment of Onchocerciasis
The trial evaluates safety, tolerability, pharmacodynamics, pharmacokinetics, dose-response, and efficacy of emodepside tablets, administrated as a range of dose regimens, in adults infected with Onchocerca Volvulus.
- Trial name
- NCT05180461
- Testing
- emodepside, ivermectin
- Where
- 3 sites in Democratic Republic of the Congo, Ghana
- Volunteers
- 578 people
- Sponsor
- Drugs for Neglected Diseases
Latent Tuberculosis, Diabete Mellitus
Comorbidities and Coinfections in Latent TB
Approximately 2 billion people worldwide are infected with Mycobacterium tuberculosis (TB), with 90% of individuals having latent infection (LTBI).
- Conditions
- Latent Tuberculosis, Diabete Mellitus, Malnutrition, Helminth Infection
- Trial name
- COMBINE-TB (NCT04642755)
- Where
- India
- Volunteers
- 300 people
- Sponsor
- Tuberculosis Research Centre, India
Trichuriasis, Ascariasis
Efficacy and Safety of MOX/ALB Co-administration
This study is a double-blind randomized controlled superiority trial aiming at providing evidence on the efficacy and safety of co-administered moxidectin and albendazole versus albendazole monotherapy (standard of care) against…
- Conditions
- Trichuriasis, Ascariasis, Hookworm Infections
- Trial name
- NCT04726969
- Testing
- Moxidectin 2 mg Oral Tablet, Albendazole 400 mg Oral Tablet, Ivermectin 3 mg Oral Tablet
- Where
- Côte d’Ivoire
- Volunteers
- 255 people
- Sponsor
- Jennifer Keiser
Schistosoma Mansoni
A Randomised Trial of Artesunate-sulfamethoxypyrazine/Pyrimethamine Versus Praziquantel for the Treatment of S. Mansoni
The purpose of this study is to determine the comparative efficacy of artesunate plus sulfamethoxypyrazine-pyrimethamine versus Praziquantel in the treatment of school children infected with S.mansoni in western Kenya.
- Trial name
- NCT01054651
- Testing
- Artesunate+Sulfamethoxypyrazine/pyrimethamine, Praziquantel
- Where
- Kenya
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Kenya Medical Research Institute
Fibrosis
HIV Accelerated Liver Disease in Uganda
Background: Liver disease is a leading cause of death in people who have the human immunodeficiency virus (HIV). It especially affects those who have both HIV and hepatitis B or C viruses.
- Trial name
- NCT01524562
- Where
- United States
- Volunteers
- 786 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Trichinellosis
Efficacy and Safety of Silodosin in the Treatment of Lower Urinary Tract Symptoms in Taiwanese Population.
To evaluate the therapeutic effects and safety of silodosin in the patients of acute brain injury with lower urinary tract symptoms.
- Trial name
- NCT06332235
- Testing
- Silodosin 8 mg
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Schistosomiasis Haematobia
Nanobody-based Schistosomiasis Urine Test Kit Research
This study aims to develop and evaluate a nanobody-based urine diagnostic test for Schistosoma haematobium infection through IPSE antigen detection.
- Trial name
- NCT07500740
- Testing
- Because this is an observational study, participants are not assigned an intervention as part of the study.
- Where
- Tanzania
- Volunteers
- 2,500 people
- Sponsor
- Pemba Ministry of Health Zanzibar