Clinical trials: Working Memory
Working Memory, Mild to Moderate Depression
Cross-over Study on the Influence of Fampridine on Working Memory in Mild to Moderate Depression
Cognitive deficits, including working memory deficits, are often present in depression and there are currently no effective pharmacological treatments targeting working memory deficits. Papassotiropoulos et al.
- Trial name
- FamD_2025 (NCT06751784)
- Testing
- Fampridine SR
- Where
- Switzerland
- Volunteers
- 38 people
- Sponsor
- University of Basel
Working Memory, Consolidation/Recconsolidation Memory
Theories of Working Memory and Consolidation/RECOnsolidation in the Process of Resorption of Post-traumatic Symptoms.
EMDR is a psychotherapeutic approach recommended by the World Health Organization (WHO) for the treatment of disorders such as post-traumatic stress disorder, anxiety, depression and, more generally, psychological distress.
- Conditions
- Working Memory, Consolidation/Recconsolidation Memory, Eye Movement Desensitization and Reprocessing, Alterning Bilateral Stimulation
- Trial name
- NCT06469333
- Testing
- Eye movements (EM), Auditory stimulations, Tactile stimulations
- Where
- France
- Volunteers
- 154 people
- Sponsor
- University of Lorraine
Working Memory
Modulation of Brain Oscillations Underlying Working Memory
This study will use novel transcranial alternating current stimulation (tACS) protocols and electroencephalography (EEG) to modulate and measure brain oscillations that underlie working memory.
- Trial name
- NCT05923606
- Testing
- Active tACS
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cognitive Function, Working Memory
Effects of Park Golf on Working Memory and Prefrontal Cortex Activation in Older Adults
This study investigates whether a park golf program can improve working memory and prefrontal cortex activity in community-dwelling older adults.
- Trial name
- NCT07807631
- Testing
- Park Golf Program, Health Education Program
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Gwangju Health University
Working Memory
Traveling-wave Transcranial Electric Stimulation
This study will assess the impact of traveling wave transcranial alternating current stimulation (tACS) on working memory performance in adults.
- Trial name
- TravelingTES (NCT05399381)
- Testing
- Transcranial alternating current stimulation (tACS)
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Working Memory, Epilepsy
Causal Role of Top-Down Theta Oscillations in Prioritization
Purpose: The purpose of this pilot study is to investigate the dynamics between theta and alpha oscillations in the control of working memory.
- Trial name
- NCT06252532
- Testing
- Direct cortical stimulation (DCS) Alpha, Direct cortical stimulation (DCS) Theta, Direct cortical stimulation (DCS) In-Phase Theta
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of North Carolina, Chapel Hill
Healthy Volunteers, Working Memory Task
Non-invasive Optical Low-frequency Oscillation Study of the Prefrontal Cortex Based on fNIRS
The investigators aimed to investigate the effects of different cognitive load tasks (1-back, 2-back, 3-back) on low-frequency oscillations (LFOs) in the prefrontal cortex of healthy young individuals, analyze the relationship…
- Conditions
- Healthy Volunteers, Working Memory Task, Cognition
- Trial name
- NCT07759648
- Testing
- N-back Visual working memory task
- Where
- China
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College
Schizophrenia, Working Memory
tACS for Working Memory in Schizophrenia
This study is a randomized, single-blind, sham-controlled crossover trial enrolling 30 schizophrenia patients, each receiving one active and one sham tACS session (7-day washout), targeting P3/P4 at individual alpha frequency…
- Trial name
- NCT07701343
- Testing
- transcranial alternating current stimulation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Central South University
Executive Functions (EF), Working Memory
Beyond Aerobic Fitness: Effects of Coordination and Aerobic Exercise on Executive Functions in School-Aged Children
This randomized controlled trial aims to compare the effects of aerobic exercise and coordination-based exercise on executive functions in school-aged children aged 10 to 12 years.
- Conditions
- Executive Functions (EF), Working Memory, Selective Attention
- Trial name
- NCT07658404
- Testing
- Aerobic Exercise Program, Coordination Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Istanbul Gelisim University
Cognitive Rehabilitation, Brain Injuries
Hypnosis in Working Memory Rehabilitation
Establishment of effective, efficient, and evidence-based interventions in rehabilitation of working memory (WM) deficits after acquired brain injury (ABI) is sorely needed.
- Conditions
- Cognitive Rehabilitation, Brain Injuries, Cognitive Impairment, Working Memory
- Trial name
- NCT05287542
- Testing
- Hypnotic suggestion, Mindfulness
- Where
- Norway
- Volunteers
- 90 people
- Sponsor
- Sunnaas Rehabilitation Hospital
Working Memory
NIMH K23: Modulation of Frontoparietal Dynamics in Adolescent Working Memory Deficits
Working memory (WM) deficits are a transdiagnostic feature of adolescent psychopathology that substantially contribute to poor clinical and functional outcomes.
- Trial name
- NCT05662280
- Testing
- Active Intermittent Theta Burst Stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Bradley Hospital
Working Memory, Inhibitory Control
BID WM Digital Intervention in Aging
The goal of this clinical trial is to learn if engaging with an digital intervention may improve cognitive function. The main questions it aims to answer are: 1.
- Conditions
- Working Memory, Inhibitory Control, Mild Cognitive Impairment (MCI), Aging
- Trial name
- NCT06918704
- Testing
- Coherence, Worder
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Working Memory, Epilepsy
Modulating Oscillations and Working Memory in Patients With Subdural Electrodes
Purpose: To investigate whether rhythmic direct electrical stimulation (DES) causes entrainment of endogenous neural oscillatory activity and whether such activity improve cognition.
- Trial name
- NCT03111290
- Testing
- Direct Cortical Stimulation
- Sponsor
- University of North Carolina, Chapel Hill
Alzheimer Disease, Working Memory
Induction and Stabilization of Gamma Oscillations With 40 Hz External Brain Stimulation
The goal of the present studies is to develop and validate novel stimulation protocols for the entrainment of gamma oscillations, which are associated with many cognitive functions and critically involved in cognitive impairment…
- Conditions
- Alzheimer Disease, Working Memory, EEG Brain Oscillations
- Trial name
- NCT06680154
- Testing
- Transcranial alternating current stimulation, Theta burst stimulation
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The National Brain Mapping Laboratory (NBML)
Cognitive Assessment, Working Memory
Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure.
The proposed project will evaluate the synergistic effects of a nutritional formulation, 'Think Tank' on cognitive performance following exposure to a psychological and physical stressor.
- Conditions
- Cognitive Assessment, Working Memory, Executive Function (Cognition), Sustained Attention
- Trial name
- NCT07319117
- Testing
- Skoshify 'Think Tank' Formulation
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Leeds Beckett University
Working Memory
Non-Invasive Brain Stimulation to Control Large-Scale Brain Networks
This project will assess the feasibility of traveling wave transcranial alternating current stimulation (tACS) to modify working memory performance and large-scale brain connectivity in surgical epilepsy patients.
- Trial name
- NCT04680481
- Testing
- Transcranial alternating current stimulation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Minnesota
ADHD With Working Memory Deficits
Brain Stimulation for Working Memory Deficits in Adolescents With ADHD
Working memory (WM) is the foundational cognitive control process of holding information 'in mind' to execute goal-directed behaviors. WM deficits are an established component of ADHD.
- Trial name
- NCT03480737
- Testing
- Magstim Super Rapid2 stimulator, 10 Hz condition, Magstim Super Rapid2 stimulator, iTBS condition
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Bradley Hospital
Cognitive Performance, Executive Function (Cognition)
Exploring the Cognitive Benefits of a Blackcurrant-Based Supplement in Normobaric Hypoxia
This study investigates the cognitive effects of Ārepa, a blackcurrant-based drink, under simulated high-altitude conditions (4,500m normobaric hypoxia for ~180 minutes).
- Conditions
- Cognitive Performance, Executive Function (Cognition), Working Memory, Hypoxia Induced Cognitive Impairment
- Trial name
- NCT07166835
- Testing
- Nootropics (ginkgo biloba, nicergoline, piracetam, or others)
- Where
- United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Leeds Beckett University
Postoperative Cognitive Dysfunction, Cognitive Impairment
Cognitive Changes After Major Joint Replacement - Full Trial (Cognigram 2)
Patients assume that cognitive performance rapidly returns to baseline after anesthesia and surgery. Several studies have shown that one week after major non-cardiac surgery about 27% of patients have postoperative cognitive…
- Conditions
- Postoperative Cognitive Dysfunction, Cognitive Impairment, Mild Cognitive Impairment, Delirium
- Trial name
- NCT03147937
- Testing
- Cognitive Testing
- Where
- Canada
- Volunteers
- 505 people
- Sponsor
- Dr. Stephen Choi
Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder
Network Control TMS fMRI
This study uses different types of functional magnetic resonance imagining (fMRI) to generate individual transcranial magnetic stimulation (TMS) targets.
- Conditions
- Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder, Working Memory
- Trial name
- NCT05736458
- Testing
- Transcranial Magnetic Stimulation (TMS), High controllability TMS target
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania