Clinical trials: Wellness
Edentulous Mouth, Edentulous Jaw
Canine Guidance vs Bilateral Balanced Occlusion in Complete Denture
The objective of this study is to compare the canine guidance (CG) and bilateral balanced occlusion (BBO) on denture satisfaction and kinesiographic parameters of complete denture wearers, by means of a cross-over trial.
- Trial name
- NCT01420536
- Testing
- Occlusal scheme
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- University of Sao Paulo
HIV-1-infection
Population Effectiveness of Dolutegravir Implementation in Sub-Saharan Africa
This is a prospective observational cohort study enrolling participants in South Africa and Uganda who are prescribed an HIV treatment regimen containing lamivudine, tenofovir, and dolutegravir, which is known as TLD.
- Trial name
- DISCO (NCT04066036)
- Testing
- This is an observational study only.
- Where
- 2 sites in South Africa, Uganda
- Volunteers
- 999 people
- Sponsor
- Massachusetts General Hospital
Autism, Trauma
A Pilot Participatory Program Evaluation of a Virtual Trauma Support Program for Autistic Adults
The goal of this single-group clinical trial is to learn about the initial efficacy and feasibility of telehealth-delivered Written Exposure Therapy (WET) for autistic adults with traumatic stress symptoms.
- Conditions
- Autism, Trauma, Posttraumatic Stress Disorder, Posttraumatic Stress Symptom
- Trial name
- NCT05862467
- Testing
- Written Exposure Therapy (WET) via telehealth
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Wyoming
Alcoholism
Examination of Zinc, S-adenosylmethionine, and Combination Therapy Versus Placebo in Alcoholics
This is a randomized, placebo controlled trial of dietary zinc and S-adenosylmethionine (SAMe) in otherwise healthy alcoholic US Veterans.
- Trial name
- ExZACTO (NCT01899521)
- Testing
- Bronchoscopy, Zinc sulfate 220 mg once daily, S-adenosylmethionine 400 mg twice daily
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- VA Office of Research and Development
Mental Health Disorder
Arena Labs - Improving Clinician Well Being
To determine the efficacy of the asynchronous performance coaching platform, Arena Strive at changing measures of physiological resilience, professional fulfillment, burnout, and self-valuation in full time clinicians.
- Trial name
- NCT05653700
- Testing
- Arena Strive, Control Cohort
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Chronic Kidney Diseases, Apolipoprotein L1
APOL1 Genetic Testing Program for Living Donors
Living donor (LD) kidney transplantation is the optimal treatment for patients with end-stage kidney disease (ESKD). However, LDs take on a higher risk of future ESKD themselves.
- Conditions
- Chronic Kidney Diseases, Apolipoprotein L1, Kidney Transplantation
- Trial name
- NCT04910867
- Testing
- Components of Genetic Counseling, APOL1 genetic testing, EHR integration
- Where
- 2 sites in United States
- Volunteers
- 280 people
- Sponsor
- Northwestern University
Breast Screening
Are Text Message Reminders an Effective Intervention for Improving the Uptake of Breast Screening?
Breast Cancer is the single most common cancer, and the third leading cause of cancer cancer deaths, in the United Kingdom. Breast screening is able to detect breast cancer in the early stages of development, during which time it…
- Trial name
- NCT01977599
- Testing
- Text Message Reminder for Breast Screening Appointment
- Where
- United Kingdom
- Volunteers
- 2,240 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Nicotine Dependence
Trial on the Effectiveness of Mindfulness Training for Smokers
The Mindfulness Training for Smokers study follows a randomized controlled design with 240 total participants. Both the study group and the control group will be enrolled in the Wisconsin Tobacco Quit Line and will receive four…
- Trial name
- MTS (NCT01093599)
- Testing
- Quit Line plus MTS, Quit Line Only
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- University of Wisconsin, Madison
HIV Infections
AmbassADDOrs for Health Study
The goal of the study is to evaluate Malkia Klabu ("Queen Club") in Tanzania, a loyalty program intervention that creates adolescent girls and young women (AGYW)-friendly drug shops where AGYW can access HIV prevention services…
- Trial name
- ADDO (NCT05357144)
- Testing
- Loyalty card program at drug shops & supply of HIVST and SRH products, Comparison drug shops
- Where
- 2 sites in Tanzania
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Substance Use Disorders, HIV
Implementing Technology-Assisted Drug Treatment and Relapse Prevention in Federally Qualified Health Centers (FQHCs)
Implementing a mobile-phone based system for drug use disorders in primary care settings.
- Trial name
- Seva (NCT01963234)
- Testing
- Seva
- Where
- 3 sites in United States
- Volunteers
- 439 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Preventive Health Services (PREV HEALTH SERV)
Presumptively Initiating Vaccines and Optimizing Talk With Motivational Interviewing (PIVOT With MI)
The overall goal of this project is to determine whether a novel and innovative provider communication strategy is effective in improving vaccine acceptance among vaccine-hesitant parents (VHPs) and visit experience among VHPs…
- Trial name
- NCT03885232
- Testing
- Experimental: PIVOT with MI, Active Comparator: Control
- Where
- 2 sites in United States
- Volunteers
- 17,446 people
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 2, Hypertension
Motivational Interviewing (MI) Intervention to Improve Adherence
The purpose of this study is to examine the effectiveness of a telephone motivational interviewing intervention by pharmacy students in enhancing adherence to angiotensin converting enzyme inhibitors (ACEI)/ angiotensin receptor…
- Trial name
- MI (NCT03985098)
- Testing
- Motivational interviewing intervention arm
- Where
- United States
- Volunteers
- 727 people
- Sponsor
- University of Houston
Skin Diseases, Telemedicine
Impact of Teledermatology on Health Services Outcomes in the Department of Veterans Affairs
This study compares store and forward teledermatology with the conventional clinic-based consult process. Our primary objective is to determine whether the mean change in quality of life, as rated by the subscale scores and…
- Conditions
- Skin Diseases, Telemedicine, Quality of Life
- Trial name
- NCT00488293
- Testing
- Store and forward teledermatology
- Where
- 2 sites in United States
- Volunteers
- 392 people
- Sponsor
- US Department of Veterans Affairs
Hospitalization, Child Health
Comparative Effectiveness of Direct Admission & Admission Through Emergency Departments for Children
At a national level, emergency departments (EDs) serve as the portal of hospital admission for 75% of hospitalized children. The remainder occur via direct admission, defined as admission to hospital without first receiving care…
- Trial name
- NCT04192799
- Testing
- Direct admission, ED admission
- Where
- 3 sites in United States
- Volunteers
- 1,997 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Dementia, Alzheimer Disease
Community-based Brain Health Program to Address Dementia Risk
This is a validation study to evaluate the acceptability, feasibility and preliminary efficacy of the Brain Health Program, a multimodal curriculum covering dementia risk factors and evidence-based change interventions.
- Trial name
- C-BBHP (NCT05529706)
- Testing
- Brain Health Program
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Posit Science Corporation
Pulmonary Disease, Chronic Obstructive
A Study Using US Medical and Pharmacy Claim Records to Compare the Resource Use, Cost, and Outcomes of People With COPD Who Take Either Tiotropium + Olodaterol or Fluticasone + Umeclidinium + Vilanterol
The purpose of this study is to estimate disease-related and all-cause burden and clinical outcomes of interest following initiation of chronic obstructive lung disease (COPD) maintenance therapy with Tiotropium…
- Trial name
- NCT05127304
- Testing
- Trelegy Ellipta, Stiolto Respimat, Furoate/Umeclidinium/Vilanterol
- Where
- United States
- Volunteers
- 11,316 people
- Sponsor
- Boehringer Ingelheim
Stress, Carer Stress Syndrome
Tailored Health Self-Management Interventions for Highly Distressed Caregivers: Family Members of Persons With Dementia
How do different health self-management interventions (resourcefulness training or biofeedback training) compare to usual care (dementia education) in affecting the health risks, and physical and mental health, of family…
- Conditions
- Stress, Carer Stress Syndrome, Dementia, Alzheimer Disease
- Trial name
- NCT04247347
- Testing
- Biofeedback Training, Dementia Education, Resourcefulness Training
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Periodontal Diseases, Dental Plaque
Oral Health Literacy Tailored Communication
The purpose of this study to investigate attitude, oral health literacy and psychological factors in order to evaluate if these factors are important for oral health in adults.
- Conditions
- Periodontal Diseases, Dental Plaque, Dental Calculus, Sialorrhea
- Trial name
- NCT01118143
- Testing
- Tailored oral health literacy instruction
- Where
- 2 sites in Norway
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- University of Tromso
High Grade Anal Canal Squamous Intraepithelial Neoplasia, Human Immunodeficiency Virus
Development of a Health-Related Symptom Index for Participants With and Either Treated or Monitored for Anal High-Grade Squamous Intraepithelial Lesions
This trial develops a health-related symptom index for participants with and either treated or monitored for anal high-grade squamous intraepithelial lesions.
- Trial name
- NCT04276935
- Testing
- Interview, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- AIDS Malignancy Consortium
Complication of Cardiac Defibrillator
Health Economic Evaluation of Remote Follow up for Implantable Cardioverter Defibrillator (ICD) Patients
The purpose of the study is to define the economic value of implantable cardioverter defibrillator (ICD) remote monitoring for hospitals, third payers and patients in Italy.
- Trial name
- TARIFF (NCT01075516)
- Where
- 6 sites in Italy
- Volunteers
- 209 people
- Sponsor
- Abbott Medical Devices
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