Clinical trials: Well Aging
Anhedonia, Depression
Sleep and Healthy Aging Research on Depression for Younger Women
Compelling evidence indicates inflammation plays a role in depression, but potential mechanisms linking inflammation to depression, such as dysregulated reward processing, are poorly understood.
- Trial name
- NCT03848715
- Testing
- Endotoxin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Alzheimer Disease 2 Due to Apoe4 Isoform, Healthy Aging
Dementia Risk and Dynamic Response to Exercise
Research suggests that physical exercise supports brain health and cognition as we age. The goal of this project is to examine the specific changes in brain blood flow and biological factors in the blood immediately after…
- Trial name
- DYNAMIC (NCT04009629)
- Testing
- Moderate Intensity Aerobic Exercise
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Aging, Mild Cognitive Impairment
Enhancing Quality of Life for Older Adults With and Without Mild Cognitive Impairment (MCI) Through Social Engagement Over Video Technology
The goal of this randomized controlled trial is to rigorously assess the efficacy of an 8-week social engagement OneClick intervention.
- Conditions
- Aging, Mild Cognitive Impairment, Aging Well
- Trial name
- NCT05380180
- Testing
- OneClick Social Engagement Intervention, OneClick Social Engagement Intervention Extension
- Where
- 2 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Healthy Aging
What Makes People Better at Retrieving Difficult Words?
This study is being conducted to learn more about how various personal and situational characteristics are related to the ability to produce words in response to definitions.
- Trial name
- NCT05066750
- Testing
- Mindful breathing, Control video
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Colorado Springs
Sedentary Lifestyle
Healthy Aging Resources to Thrive (HART)
Healthy Aging Resources to Thrive (HART) uses a rigorous two-stage randomized control design, adapted and refined based on pilot studies, to test a novel intervention to reduce sitting time in older adults.
- Trial name
- HART (NCT03739762)
- Testing
- i-STAND, Healthy Living control
- Where
- United States
- Volunteers
- 283 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Physical Inactivity
Intergenerational Behavioral Intervention to Enhance Physical Activity in Older Adults at Risk for Alzheimer's Disease
This is a four-week pilot randomized controlled trial of a behavioral intervention in older adults at risk for Alzheimer's disease. Older participants are a subgroup from the PREVENT-AD longitudinal cohort.
- Trial name
- HABS (NCT06038643)
- Testing
- Motivational behavioural intervention and daily activities monitoring, Active Control
- Where
- Canada
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Aging, Mild Cognitive Impairment
Internet-based Conversational Engagement Clinical Trial
The study aims to randomize 320 (160 Caucasian, 160 African American) socially isolated adults 75+ years old (50:50 split between those with normal cognition and mild cognitive impairment (MCI)) recruited from the community to…
- Trial name
- I-CONECT (NCT02871921)
- Testing
- Conversational Engagement
- Where
- 2 sites in United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Social Isolation, Loneliness
Engage Coaching for Latinos
This study asks: "what behavioral strategies are needed to help socially disconnected Hispanic/Latino caregivers with significant barriers to increasing connectedness?" This study uses a mixed methods approach to adapt a brief…
- Conditions
- Social Isolation, Loneliness, Caregiver Burnout
- Trial name
- NCT04875065
- Testing
- Engage coaching
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Rochester
Hearing Loss
Evaluation of the Benefits for Overall Health Following Cochlear Implant Treatment in the Elderly Population
The purpose of this study is to show that cochlear implant treatment improves the overall health related quality of life and general well-being in elderly individuals.
- Trial name
- NCT03072862
- Testing
- Commercial Nucleus Cochlear Implant Systems
- Where
- 8 sites in France, Israel and 2 more
- Volunteers
- 100 people
- Sponsor
- Cochlear
Healthy Aging
Using Teleneuropsychology to Optimize Cognition in Healthy Aging: the Web-based Breakfast Game
Executive control processes involve initiate, coordinate, synchronize, and regulate elemental cognitive functions for the conduct of goal-directed behavior.
- Trial name
- NCT05506852
- Testing
- Web-based training strategy, Web-based regular training (no strategy)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Columbia University
Social Isolation, Aging
A Personalized Health Behavior System
The objectives of this study are to examine the usability and efficacy, for diverse older adults, of a new tablet-based dynamic system: the Fittle Senior System (FSS) that will provide: (1) personalized behavior-change programs…
- Conditions
- Social Isolation, Aging, Physical Activity
- Trial name
- FITTLESenior (NCT03538158)
- Testing
- Intervention Condition, Control Condition
- Where
- 2 sites in United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Mild Cognitive Impairment, Healthy Aging
SHARE(D) Stage II: Alzheimer's Risk Disclosure Protocol Piloting
The goal of this study is to test efficacy and safety of person-centered, culturally-informed protocols for disclosure of different combinations of Alzheimer's dementia risk factors.
- Trial name
- SHARE(D) (NCT04309500)
- Testing
- Personalized DAT Risk Disclosure Protocol
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Loneliness, Social Isolation
The Emotional, Physical and Cognitive Benefits of Purposeful Green Space Activities on Seniors
This project explores if various nature based activities can lead to acute improvements in emotional, physical and cognitive health outcomes and encouraging senior center (JABA) service users to return to a safe environment.
- Conditions
- Loneliness, Social Isolation, Mood, Well Aging
- Trial name
- NCT04913363
- Testing
- Green space
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Mild Cognitive Impairment, MCI
Effects of Methylene Blue in Healthy Aging, Mild Cognitive Impairment and Alzheimer's Disease
A double-blind, placebo-controlled study that aims to investigate the effect of 2-week and 12-week administration of USP methylene blue (MB) on cerebral blood flow, functional connectivity, memory and attention cognitive…
- Conditions
- Mild Cognitive Impairment, MCI, Aging, Alzheimer's Disease
- Trial name
- MB2 (NCT02380573)
- Testing
- Methylene Blue, FD&C Blue # 2, Phenazopyridine hydrochloride
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Healthy Aging, Alzheimer Disease
Acute Exercise and the Cerebral Metabolic Response in Aging and Alzheimer's Disease
The overall goal is to characterize the acute exercise response as it relates to brain glucose metabolism in aging and Alzheimer's Disease (AD).
- Trial name
- AEROBIC (NCT04299308)
- Testing
- Aerobic Exercise
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Healthy Aging
What Makes People Better at Describing Photographs?
This study is being conducted to learn more about how various personal and situational characteristics are related to the ability to provide verbal descriptions of photographs.
- Trial name
- NCT05444114
- Testing
- Mental Exercise
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of Colorado, Colorado Springs
Sedentary Lifestyle
Sedentary Behavior Interrupted Randomized Controlled Trial (P2)
Epidemiological findings indicate that older adults do not meet physical activity (PA) guidelines \& spend up to 11 hrs/day sitting.
- Trial name
- NCT03473145
- Testing
- Health Coaching, activPAL inclinometer, Tools to Prompt Standing or Prompt Sit-to-Stand Transitions.
- Where
- United States
- Volunteers
- 407 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Healthy Aging
Beta-glucan and Immune Response to Influenza Vaccine
This trial in healthy adults will determine the effects of beta-glucan, a dietary fiber supplement isolated from baker's yeast, on immune response to the influenza vaccine.
- Trial name
- M-Unity (NCT05074303)
- Testing
- Influenza Vaccine, Beta-glucan
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Florida
Aged, Older Adults
danceSing Care Evaluation: Testing the Feasibility
The investigators wanted to find out if digital music and movement resources could be delivered in care homes. They rolled out a 12-week programme to 10 care homes and had 47 care home residents participate in the research.
- Conditions
- Aged, Older Adults, Healthy Aging, Aging
- Trial name
- NCT05559203
- Testing
- danceSing Care
- Where
- United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Stirling