Clinical trials: Weight Gain, open to volunteers
Psychosis
A Probiotic Strategy for Antipsychotic-induced Metabolic Dysfunction
Antipsychotic drugs are used to treat a range of psychiatric disorders including schizophrenia, bipolar disorders, and psychotic depression.
- Trial name
- MetaboMicrobe (NCT06729671)
- Testing
- Bifidobacterium longum APC1472 hydroxypropylmethylcellulose (HPMC) capsule, maltodextrin
- Where
- 2 sites in Ireland
- Volunteers
- 70 people
- Sponsor
- University College Cork
Overweight or Obesity
NDPP-NextGen: A Clinical Trial to Reduce Intergenerational Obesity and Diabetes Risks
The goal of this clinical trial is to test an enhanced version of the National Diabetes Prevention Program (NDPP-NextGen) that is tailored to young women in childbearing years.
- Trial name
- NCT05674799
- Testing
- NDPP-NextGen
- Where
- United States
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Hemodialysis Patient
A Theory-based Fluid Self-management Program
This study aims to evaluate the efficacy of an intervention guided by the IFSMT, in which structured education and digitally delivered reinforcement strategies are designed to enhance self-management processes, including…
- Trial name
- NCT07677605
- Testing
- A Theory-based fluid self-management program
- Where
- Indonesia
- Volunteers
- 160 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Weight Gain, Weight Loss
Nutritional Responses to Acute Exercise Performed on the LipoxMax in Obese Adolescents
Primarily over the past 20 years, it has been shown that physical activity not only leads to energy expenditure but can also indirectly influence energy intake and feelings of hunger in both lean and obese adults, suggesting that…
- Conditions
- Weight Gain, Weight Loss, Eating Attitudes, Obese Adolescents
- Trial name
- LipoxAPP (NCT07844330)
- Testing
- The participants in this study are adolescents with obesity (with a Body Mass Index above the 95th percentile on international growth charts)
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Centre Hospitalier Emile Roux
Healthy
Revealing Microbiome Association With (Plant-based) Diet in Freshman
Aim of the study is to evaluate the impact of a vegan vs. vegetarian dietary pattern compared to an omnivore diet on body weight, saliva and stool microbiome profiles, as well as saliva, urine and plasma metabolome profile…
- Trial name
- Freshman (NCT04598022)
- Testing
- cross-sectional observation, cross-sectional follow-up observation
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Kiel
Intellectual Disability, Developmental Disability
Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability
People with IDD (intellectual and developmental disability) have very high rates of obesity and die prematurely from cardiometabolic disease.
- Conditions
- Intellectual Disability, Developmental Disability, Obesity
- Trial name
- METIDD (NCT05744479)
- Testing
- Metformin, Lifestyle Intervention
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Centre for Addiction and Mental Health
Schizophrenia Disorder, Metabolic Syndrome
Efficacy and Safety of Semaglutide Versus Placebo on Cardiometabolic Profile in Patients With Schizophrenia With Metabolic Syndrome
Patients with schizophrenia on second-generation antipsychotics have a high burden of metabolic syndrome and elevated cardiovascular risk, with few effective treatment options.
- Conditions
- Schizophrenia Disorder, Metabolic Syndrome, Antipsychotic-induced Weight Gain, Cardiovascular Risk
- Trial name
- NCT07770282
- Testing
- Semaglutide + TAU
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Excessive Weight Gain
A Study of Niacin Regulation
Adults who gain most of their excess weight in the abdominal area typically do not respond to things that "turn off" fat cells the same way as lean people.
- Trial name
- NCT06175403
- Testing
- Niacin
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy Volunteer, Weight Gain
Early Metabolic Effects of Antiretroviral Drugs in Healthy volUnteers: a Phase 2 Randomized Study
Background: People with HIV take drugs to keep the amount of virus in their body low. One type of these drugs, called integrase strand transfer inhibitors (INSTIs), can cause weight gain over time.
- Conditions
- Healthy Volunteer, Weight Gain, Metabolic Effects, Integrase Strand Transfer Inhibitors
- Trial name
- NCT05652478
- Testing
- Dolutegravir (DTG) AND Tenofovir alafenamide (TAF), Tenofovir Disoproxil Fumarate, Dolutegravir
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Disability Physical, Wheelchair
Fast In-Bed Tracking (FIT) System Lifestyle Intervention is a Clinical Trial of a Bed Scale Device. Overweight Wheelchair Users Will Complete a Weight Loss Program, Half Get Scales at Baseline, Half at Month 6 Those Who Receive the Bed Scales at Baseline Are Expected to Have Increased Weight Loss
This project will complete the final design and development steps to commercialize the Fast In-Bed Tracking (FIT) Platform, which is an e-Health and wellness Internet of Things (IoT) monitoring system that can be integrated into…
- Conditions
- Disability Physical, Wheelchair, Obesity; Overweight
- Trial name
- NCT07141342
- Testing
- The Fast In-Bed Tracking System (FIT) Weight Scale, Group Lifestyle Balance Adapted for Individuals with Impaired Mobility (GLB-AIM) intervention
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Jonathan Pearlman
Gestational Weight Gain, Overweight and Obesity
Healthy Mom Zone Gestational Weight Gain Management Intervention 2.0
The goal of this clinical trial is to see if the enhanced HMZ 2.0 intervention with new control system/digital platform to regulate gestational weight gain (GWG) and impact maternal-infant outcomes while collecting implementation…
- Conditions
- Gestational Weight Gain, Overweight and Obesity, Pregnancy, Energy Balance
- Trial name
- HMZ Two (NCT05807594)
- Testing
- HMZ 2.0 Intervention, Attention Control Intervention
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Penn State University
Antipsychotic Induced Weight Gain
: EFFECT OF PROBIOTIC SUPPLEMENTATION ON ATYPICAL ANTIPSYCHOTIC INDUCED WEIGHT GAIN IN PATIENTS ATTENDING PSYCHIATRIC CLINICS AT AINSHAMS UNIVERSITY HOSPITALS (A RANDOMIZED CONTROLLED TRIAL)
the goal of the study is to improve the quality of life of patients on antipsychotic medications and increase the rate of compliance to treatment.
- Trial name
- NCT06936137
- Testing
- lactobacillus LS
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Ain Shams University
Weight Gain, Body Mass Index
"Effects of High-Calorie Diets VS High-Calorie Formulas on Weight Gain in Children With Congenital Heart Disease "
This study is a randomized controlled trial designed to evaluate the effects of high-calorie diets and specialized nutritional formulas on weight gain and clinical outcomes in underweight children aged 1 to 5 years with…
- Conditions
- Weight Gain, Body Mass Index, Pediatric Nutrition, Congenital Heart Disease
- Trial name
- NCT07552688
- Testing
- High-Calorie Specialized Nutritional Formula, education program, High-Calorie Diet
- Where
- 2 sites in Iraq
- Volunteers
- 75 people
- Sponsor
- Aryan Najmadin Nasradin
Pregnancy Related, Weight Gain
HealthyPregnancy - Digital Support for Pregnant Women with a BMI At 25 or Above (BMI≥25)
The study aims to examine the effectiveness of a digital care guide offering support and information on diet, physical exercise and mental well-being on pregnancy weight gain among pregnant women with a BMI at 25 or above in a…
- Trial name
- NCT06734910
- Testing
- HealthyPregnancy
- Where
- 2 sites in Denmark
- Volunteers
- 450 people
- Sponsor
- Center for Clinical Research and Prevention
Obesity, Morbid, Weight Gain
DIStal gastriC Bypass OUtcome in Revision SurgEry After Roux-en-y Gastric Bypass
This study is designed as a prospective multicenter randomized controlled clinical trial comparing two surgical techniques of distal gastric bypass (DGB) in revisional surgery following failed Roux-en-Y gastric bypass.
- Trial name
- DISCOURSE (NCT04894838)
- Testing
- Distal gastric bypass
- Where
- 8 sites in Netherlands
- Volunteers
- 150 people
- Sponsor
- St. Antonius Hospital
Breast Cancer, Insomnia
The Effects of Treating Insomnia on Behavioral Weight Loss Outcomes in Survivors of Breast Cancer
The investigators propose a randomized controlled clinical trial in 250 women with a history of early stage breast cancer who are overweight or obese with insomnia to test whether a brief, cognitive-behavioral intervention for…
- Conditions
- Breast Cancer, Insomnia, Weight Gain
- Trial name
- COIN (NCT05780814)
- Testing
- Cognitive-Behavioral Therapy for Insomnia (CBT-I), Sleep Education Control (EDU)
- Where
- 4 sites in United States
- Volunteers
- 250 people
- Sponsor
- Johns Hopkins University
Weight Gain During Pregnancy
BUMP2.0 Feasibility Study
Most women in the UK gain more weight than recommended during pregnancy, which puts them and their babies at risk of medical complications.
- Trial name
- NCT06882837
- Testing
- BUMP app
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Oxford
Lifestyle, Healthy, Pregnancy Related
A Nutrition and Exercise Lifestyle Intervention Program Participant Choice Approach
Interventions that target excessive gestational weight gain (EGWG) with nutrition and exercise behavior change struggle with low program adherence.
- Conditions
- Lifestyle, Healthy, Pregnancy Related, Adherence, Treatment, Nutrition, Healthy
- Trial name
- NELIP (NCT06187675)
- Testing
- Nutrition and Exercise Lifestyle Intervention Program
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Childhood Obesity
Josef Ressel Centre Perinatal Programming
Background: Metabolic imprinting through early childhood nutrition seems to play an important role in the aetiology of obesity. Overweight at age two and later in life is associated with excessive weight gain as early as three…
- Trial name
- JRP (NCT03634930)
- Testing
- observation
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Moenie van der Kleyn
Obesity and Obesity-related Medical Conditions
Weight Changes After Incretin-mimetics
The goal of this study is to identify people at risk of weight regain after stopping an injectable weight loss drug. The main question the investigators aim to answer is: Can weight regain be predicted by measuring circulating…
- Trial name
- NCT06795360
- Testing
- discontinuation of weight loss medication
- Volunteers
- 52 people
- Sponsor
- Medical College of Wisconsin