Weight GainLipoxAPPNCT07844330
Nutritional Responses to Acute Exercise Performed on the LipoxMax in Obese Adolescents
A study testing The participants in this study are adolescents with obesity (with a Body Mass Index above the 95th percentile on international growth charts) in people with Weight Gain and Weight Loss, run by Centre Hospitalier Emile Roux at 1 site in France.
Trial summary
Primarily over the past 20 years, it has been shown that physical activity not only leads to energy expenditure but can also indirectly influence energy intake and feelings of hunger in both lean and obese adults, suggesting that physical activity has a dual effect on energy balance. Read more about this study
- Who is it for?
- Ages 12 to 16 years
- Conditions the study is for
- Weight Gain, Weight Loss, Eating Attitudes
- What is being tested?
- The participants in this study are adolescents with obesity (with a Body Mass Index above the 95th percentile on international growth charts)
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 18 participants
- Where
- 1 siteFrance
- Study dates
- 1 Sep 2026to 30 Sep 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 12 to 16 years
- All sexes
- No healthy volunteers
- Child
Who may be able to join
- Adolescents aged 12 to 16 (inclusive), at Tanner stage 3-5,
- With obesity defined as a body mass index (BMI) above the 95th percentile according to international growth charts,
- Adolescents enrolled in the social security system or an equivalent program,
- Adolescents who have been informed and have provided written consent to participate in the study
Who cannot join
- Refusal to participate in the study,
- Refusal of consent by legal guardians,
- Regular use of tobacco or alcohol,
- Special dietary restrictions,
- Participation in regular and intense physical and sports activities,
- Medical or surgical history deemed by the investigator to be incompatible with the study,
Show all 15Show fewer
- Diabetes, or any other condition that limits the application of either strategy in the trial,
- Adolescents currently following a calorie-restricted diet or a weight-loss program involving physical activity at the time of enrollment or within the past 6 months,
- Taking medications that may interfere with the study results,
- Adolescents with cardiovascular problems; this refers to participants with a history of cardiovascular and/or neurovascular disease, as well as those with cardiovascular and/or neurovascular risk factors (excluding obesity or being overweight),
- Surgery within the previous 3 months,
- Adolescents who are currently excluded from another study,
- Pregnant or breastfeeding adolescents,
- Adolescents under guardianship, conservatorship, or judicial protection,
- Parents under conservatorship, guardianship, or judicial protection
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Primarily over the past 20 years, it has been shown that physical activity not only leads to energy expenditure but can also indirectly influence energy intake and feelings of hunger in both lean and obese adults, suggesting that physical activity has a dual effect on energy balance.
Studies in children and adolescents are less common, but it now seems clear that their energy intake is affected by physical exercise ) depending on their weight status.
Read the detailed description
Our team has indeed demonstrated the appetite-suppressing effects of moderate- to vigorous-intensity exercise (>65% of maximum capacity) in obese adolescents, regardless of gender. While research conducted to date has primarily focused on identifying the characteristics of exercise that can influence food intake in these adolescents-such as the type, intensity, or duration of exercise-it appears that, beyond physical exercise itself, the energy substrates utilized during exercise may play a crucial role.
In adults-whether of normal weight, overweight, or obese-the scientific literature highlights not only the energy expenditure generated by physical exercise but also the vital role played by the type of energy substrate used to fuel this expenditure. Indeed, while physical exercise that primarily promotes lipid oxidation does not appear to significantly impact eating behavior at the next meal, carbohydrate utilization, on the other hand, appears to have a rather appetite-stimulating effect. Although this nutritional impact of the types of energy substrates utilized during physical exercise is crucial for better guiding our recommendations for adapted physical activity, it remains unexplored in adolescents at this time. Recently, based on a secondary analysis, our team suggested a positive correlation between energy expenditure during a 30-minute cycling exercise and subsequent food intake in adolescents with obesity. In that study, carbohydrate oxidation in particular showed a positive relationship with the adolescents' food intake at the next meal. These preliminary results led to a study dedicated to this question; however, that study unfortunately did not replicate this relationship and appears to indicate that carbohydrate utilization during acute exercise is not involved in short-term dietary regulation in these adolescents.
However, that study had focused its design on an exercise regimen that promotes carbohydrate utilization, and the potential role of fat oxidation remains unexplored in this population. In overweight adults, Javernaud and colleagues previously demonstrated that exercise targeting the maximum lipid oxidation point (known as Lipoxmax) reduced feelings of hunger in the hours following the workout while improving participants' satiety. While prescribing physical exercise as a key component of pediatric obesity management is considered essential for optimizing treatment outcomes, the potential impact of exercise performed at Lipoxmax on food intake remains unexplored in this population.
Thus, in this context, the objective of this study is to explore the effects of a single session of exercise performed at the maximum lipid oxidation point (Lipoxmax) on dietary control in adolescents with obesity.
- Conditions
- Weight Gain, Weight Loss, Eating Attitudes, Obese Adolescents
- Being tested
- The participants in this study are adolescents with obesity (with a Body Mass Index above the 95th percentile on international growth charts)
- Medical subject headings
- Weight Gain, Weight Loss
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
The participants in this study are adolescents with obesity (with a Body Mass Index above the 95th percentile on international growth charts)Other
This study aims to understand how physical exercise performed at a specific intensity that promotes fat utilization (called LipoxMax) influences food intake, hunger, and food preferences in adolescents with obesity. Following an initial screening visit to verify eligibility criteria and assess dietary habits, participants undergo a measurement visit at Clermont-Ferrand University Hospital, which includes anthropometric assessments (height, weight, waist and hip circumferences), body composition measurements (body fat, muscle mass, bone structure), and a bicycle ergometer test to determine their LipoxMax intensity. The adolescents then undergo two experimental visits at the AME2P laboratory in Clermont-Ferrand, conducted in random order and spaced at least five days apart. At each visit, they arrive having fasted, consume a standardized breakfast, and then rest until 11:00 a.m. They then either rest for 40 minutes (control condition) or perform a 40-minute exercise session at LipoxMax.
| Study group | Role | What they receive |
|---|---|---|
| Intervention | Other | The participants in this study are adolescents with obesity (with a Body Mass Index above the 95th percentile on international growth charts). Receives: Other: The participants in this study are adolescents with obesity (with a Body Mass Index above the 95th percentile on international growth charts) |
What is being measured
The primary outcome is the main question the study is designed to answer.
ad libitum food intake in response to exercise
Method: Meta-Max Indirect Calorimetry
The following will be measured here: energy expenditure in kcal/min based on oxygen consumption, as well as fat and carbohydrate utilization based on the respiratory quotient (VCO2/VO2), in mg/min.
Measured: 3 months
Secondary outcomes (2)
Feelings of hunger in response to exercise
Method: HUNGER SENSATION QUESTIONNAIRE
Patients will have to answer 4 questions with answer situated in between "not at all" and "Very much". The questions are: Are you hungry? Do you feel satiated? How much could you eat again? Would you like to eat something?
Measured: 3 months
Hedonic response as measured by food liking and wanting
Their relationship with food will be investigated 15 min before the test meal and then 1 hour after, using the Leeds Foods Preference Questionnaire. The adolescents will be asked to answer a series of questions about their food preferences by selecting their favorite foods from a selection of images during a 10-min computer exercise. During this exercise, they are asked to use a visual analog scale to estimate how much they would like to eat certain foods presented. Based on their choices and the time taken to respond, the LFPQ assesses the adolescents' degree of "liking" and "wanting." The adolescents will be asked to complete this exercise 15 minutes before and after the evening test meal. To avoid influencing food intake at the next meal, the foods presented during the test are not the same as those presented during the meal. As the aim of this exercise is to assess the response of "liking" and "wanting" to food intake, it is necessary to carry it out before and after the meal.
Measured: 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Sep 2026
- Study start1 Sep 2026 (estimated)
- Primary completion1 Jul 2028 (estimated)
- Study completion30 Sep 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Weight GainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 18 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Emile Roux
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07844330
- Sponsor's protocol ID
- RIPH2_GADEA_LipoxAPP
- Other IDs
- 2026-A01076-45
- Acronym
- LipoxAPP
- Status last verified
- Sep 2026
- First submitted
- 22 Sep 2026
- Last updated
- 28 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 28 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Nutritional Responses to Acute Exercise Performed on the LipoxMax in Obese Adolescents
- ClinicalTrials.gov ID
- NCT07844330
- Acronym / sponsor ID
- LipoxAPP / RIPH2_GADEA_LipoxAPP
- Conditions
- Weight Gain, Weight Loss, Eating Attitudes, Obese Adolescents
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 18 participants (estimated)
- Lead sponsor
- Centre Hospitalier Emile RouxUniversity, hospital or other
- Study start
- 1 Sep 2026 (estimated)
- Primary completion
- 1 Jul 2028 (estimated)
- Study completion
- 30 Sep 2029 (estimated)
- First posted
- 28 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Primarily over the past 20 years, it has been shown that physical activity not only leads to energy expenditure but can also indirectly influence energy intake and feelings of hunger in both lean and obese adults, suggesting that physical activity has a dual effect on energy balance.
Studies in children and adolescents are less common, but it now seems clear that their energy intake is affected by physical exercise ) depending on their weight status.
Detailed description
Our team has indeed demonstrated the appetite-suppressing effects of moderate- to vigorous-intensity exercise (>65% of maximum capacity) in obese adolescents, regardless of gender. While research conducted to date has primarily focused on identifying the characteristics of exercise that can influence food intake in these adolescents-such as the type, intensity, or duration of exercise-it appears that, beyond physical exercise itself, the energy substrates utilized during exercise may play a crucial role.
In adults-whether of normal weight, overweight, or obese-the scientific literature highlights not only the energy expenditure generated by physical exercise but also the vital role played by the type of energy substrate used to fuel this expenditure. Indeed, while physical exercise that primarily promotes lipid oxidation does not appear to significantly impact eating behavior at the next meal, carbohydrate utilization, on the other hand, appears to have a rather appetite-stimulating effect. Although this nutritional impact of the types of energy substrates utilized during physical exercise is crucial for better guiding our recommendations for adapted physical activity, it remains unexplored in adolescents at this time. Recently, based on a secondary analysis, our team suggested a positive correlation between energy expenditure during a 30-minute cycling exercise and subsequent food intake in adolescents with obesity. In that study, carbohydrate oxidation in particular showed a positive relationship with the adolescents' food intake at the next meal. These preliminary results led to a study dedicated to this question; however, that study unfortunately did not replicate this relationship and appears to indicate that carbohydrate utilization during acute exercise is not involved in short-term dietary regulation in these adolescents.
However, that study had focused its design on an exercise regimen that promotes carbohydrate utilization, and the potential role of fat oxidation remains unexplored in this population. In overweight adults, Javernaud and colleagues previously demonstrated that exercise targeting the maximum lipid oxidation point (known as Lipoxmax) reduced feelings of hunger in the hours following the workout while improving participants' satiety. While prescribing physical exercise as a key component of pediatric obesity management is considered essential for optimizing treatment outcomes, the potential impact of exercise performed at Lipoxmax on food intake remains unexplored in this population.
Thus, in this context, the objective of this study is to explore the effects of a single session of exercise performed at the maximum lipid oxidation point (Lipoxmax) on dietary control in adolescents with obesity.
Study design
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Intervention | Other | Other: The participants in this study are adolescents with obesity (with a Body Mass Index above the 95th percentile on international growth charts)The participants in this study are adolescents with obesity (with a Body Mass Index above the 95th percentile on international growth charts). |
Who may qualify
- Ages
- 12 to 16 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
Key inclusion criteria (4 listed)
- Adolescents aged 12 to 16 (inclusive), at Tanner stage 3-5,
- With obesity defined as a body mass index (BMI) above the 95th percentile according to international growth charts,
- Adolescents enrolled in the social security system or an equivalent program,
- Adolescents who have been informed and have provided written consent to participate in the study
Key exclusion criteria (15 listed)
- Refusal to participate in the study,
- Refusal of consent by legal guardians,
- Regular use of tobacco or alcohol,
- Special dietary restrictions,
- Participation in regular and intense physical and sports activities,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| The participants in this study are adolescents with obesity (with a Body Mass Index above the 95th percentile on international growth charts)This study aims to understand how physical exercise performed at a specific intensity that promotes fat utilization (called LipoxMax) influences food intake, hunger, and food preferences in adolescents with obesity. Following an initial screening visit to verify eligibility criteria and assess dietary habits, participants undergo a measurement visit at Clermont-Ferrand University Hospital, which includes anthropometric assessments (height, weight, waist and hip circumferences), body composition measurements (body fat, muscle mass, bone structure), and a bicycle ergometer test to determine their LipoxMax intensity. The adolescents then undergo two experimental visits at the AME2P laboratory in Clermont-Ferrand, conducted in random order and spaced at least five days apart. At each visit, they arrive having fasted, consume a standardized breakfast, and then rest until 11:00 a.m. They then either rest for 40 minutes (control condition) or perform a 40-minute exercise session at LipoxMax. | Other | Intervention |
Primary outcome
ad libitum food intake in response to exercise
Time frame: 3 months
Method: Meta-Max Indirect Calorimetry The following will be measured here: energy expenditure in kcal/min based on oxygen consumption, as well as fat and carbohydrate utilization based on the respiratory quotient (VCO2/VO2), in mg/min.
2 secondary outcomes
Feelings of hunger in response to exercise
Time frame: 3 months
Hedonic response as measured by food liking and wanting
Time frame: 3 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Sep 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing The participants in this study are adolescents with obesity (with a Body Mass Index above the 95th percentile on international growth charts) in people with Weight Gain and Weight Loss, run by Centre Hospitalier Emile Roux at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 15 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 28 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact David THIVEL (00 33 4 73405486, david.thivel@uca.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
ad libitum food intake in response to exercise (time frame: 3 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Sep 2026.