Clinical trials: Vomiting, Postoperative
Osteoarthritis, Knee
Efficacy and Safety of Single, Low-dose Dexamethasone in Patients After Total Knee Arthroplasty
This study was conducted to determine the efficacy of an additional preemptive, single, low-dose dexamethasone in terms of incidence and severity of postoperative nausea/vomiting (PONV), pain level, and the safety in terms of…
- Trial name
- NCT01612702
- Testing
- Dexamethasone
- Where
- South Korea
- Volunteers
- 291 people
- Sponsor
- Tae Kyun Kim
Post-Operative Nausea and Vomiting, Breast Cancer
Intraoperative Acupoint Stimulation to Prevent Post-Operative Nausea and Vomiting (PONV)
The goal of this clinical research study is to learn if light electrical stimulation to the wrist area during surgery is feasible in women having breast surgery.
- Trial name
- NCT02473042
- Testing
- Electrical Stimulation, Zofran, Dexamethasone
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- M.D. Anderson Cancer Center
Post-operative Nausea and Vomiting
Mass-balance Study of [14C]-APD421 in Healthy Volunteers
Open-label, non-randomised, single dose study in 6 healthy male subjects to assess the mass balance recovery, metabolite profile, metabolite identification and pharmacokinetics of 14C-labelled APD421
- Trial name
- NCT02881840
- Testing
- 14C-APD421
- Where
- Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Acacia Pharma Ltd
Postoperative Nausea
Effect of Fosaprepitant on Motor Evoked and Somatosensory Evoked Potentials Under General Anesthesia
The purpose of this study is to determine if intravenous fosaprepitant can interfere with nervous system monitoring signals in patients having surgery under general anesthesia.
- Trial name
- NCT03197064
- Testing
- Fosaprepitant 150 mg
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Stanford University
Postoperative Nausea and Vomiting
Use of Baxter Animated Retching Faces (BARF) Scale to Measure Nausea in Children Who Speak Spanish
Pediatric research in the management of nausea has been limited by the absence of a reliable method to quantify the intensity of this subjective symptom.
- Trial name
- NCT02007109
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Pregnancy Related, Cesarean Delivery
Accupressure of P6 to Reduce Nausea During Cesarean Section
The purpose of this study is to evaluate if the addition of P6 pressure point stimulation as opposed to sham-point stimulation will decrease intraoperative and postoperative nausea and vomiting (IONV and PONV) for patients…
- Conditions
- Pregnancy Related, Cesarean Delivery, Nausea, Vomiting
- Trial name
- NCT04799587
- Testing
- Magnet at P6, Magnet applied to arm not at P6 pressure point.
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Northwestern University
Nausea and Vomiting Post-foregut Surgery
Reletex Versus Standard of Care Therapy for Post-Operative Nausea Control in Patients Undergoing Foregut Surgery
The effect a ReletexTM device has on postoperative nausea and vomiting when used with ondansetron after foregut surgery will be studied.
- Trial name
- Reletex (NCT01510379)
- Testing
- Reletex, IV ondansetron 4 mg q 6 hours for a total of 4 doses, IV promethazine 25 mg q 6 hours prn
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Kyle A Perry
Vomiting, Nausea
Post-Operative Therapy for Nausea or Vomiting
This is a single site, prospective, randomized controlled study designed to evaluate the impact of acupressure when used as an initial treatment before rescue medications in the treatment of post-operative nausea and/or vomiting…
- Trial name
- NCT03075163
- Testing
- Acupressure, Ondansetron
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of California, Davis
Postoperative Nausea and Vomiting
Aprepitant for PONV Prophylaxis in Outpatient Plastic Surgery
Hypothesis: Aprepitant plus ondansetron is more effective than ondansetron plus placebo for prevention of postoperative emesis in patients at moderate-to-high risk for PONV for up to 48 hours after surgery.
- Trial name
- NCT00659945
- Testing
- Aprepitant plus Ondansetron
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Post-Operative Nausea and Vomiting
A Study of Kytril (Granisetron) in the Prevention of Post-Operative Nausea and Vomiting (PONV) in Pediatric Subjects Undergoing Tonsillectomy or Adenotonsillectomy
This 2 arm study will evaluate the efficacy and safety of a single intravenous injection of Kytril in preventing postoperative nausea and vomiting (PONV) in children.
- Trial name
- NCT00231478
- Testing
- granisetron
- Where
- 11 sites in United States
- Volunteers
- 171 people
- Sponsor
- Hoffmann-La Roche
Postoperative Nausea and Vomiting
Prevention of Postoperative Nausea and Vomiting (PONV) in Surgical Patients
This study will compare two different drug regimens (oral dronabinol versus intravenous ondanseteron) for the prevention of post-operative nausea and vomiting (PONV).
- Trial name
- PONV (NCT00757822)
- Testing
- Dronabinol, Ondansetron
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Postoperative Nausea and Vomiting
Safety and Efficacy of Palonosetron IV to Prevent Postoperative Nausea and Vomiting in Pediatric Patients
The primary objective of this study is to evaluate the efficacy of a single palonosetron IV dose compared to a single ondansetron IV dose in the prevention of postoperative nausea and vomiting through 24 hours after surgery in…
- Trial name
- NCT01395901
- Testing
- Palonosetron, Ondansetron
- Where
- 44 sites in United States, Argentina and 6 more
- Volunteers
- 670 people
- Sponsor
- Helsinn Healthcare SA
Nausea, Vomiting
Comparison of Oral Aprepitant and Transdermal Scopolamine for Preventing Postoperative Nausea and Vomiting
Recent evidence suggests multiple drug therapy is superior to single agents. The study compares the incidence of nausea, vomiting, need for rescue medication, prolonged PACU time, and unplanned hospital admission in patients with…
- Trial name
- NCT00659737
- Testing
- Aprepitant, Scopolamine
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Drexel University College of Medicine
Postoperative Nausea and Vomiting
Clinical Use of Baxter Animated Retching Faces (BARF) Scale in Children
Pediatric research in the management of nausea has been limited by the absence of a reliable method to quantify the intensity of this subjective symptom.
- Trial name
- BARF (NCT02421952)
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Postoperative Vomiting and Nausea
Acupuncture and Nausea/Vomiting in Pediatric Patients
The purpose of this study is to investigate the effects of intraoperative P6 acupuncture plus standard therapy on postoperative nausea and vomiting in pediatric patients undergoing tonsillectomy with or without adenoidectomy.
- Trial name
- NCT01417741
- Testing
- Acupuncture Needle
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Oregon Health and Science University
Post-operative Nausea, Post-operative Vomiting
A Study to Evaluate Aprepitant for the Prevention of Post-Operative Nausea and Vomiting in Children (MK-0869-219)
The purpose of this study is to evaluate the pharmacokinetics (PK), safety, and tolerability of aprepitant for the prevention of post-operative nausea and vomiting (PONV) in pediatric participants.
- Trial name
- NCT01732458
- Testing
- Aprepitant, Ondansetron
- Volunteers
- 229 people
- Sponsor
- Merck Sharp & Dohme LLC
Postoperative Nausea and Vomiting
Safety and Efficacy of Palonosetron IV to Prevent Postoperative Nausea and Vomiting in Pediatric Patients
The objective of the study is to assess the safety and efficacy of two doses of IV palonosetron each administered as a single dose for the prevention of postoperative nausea and vomiting through 72 hours postoperatively in…
- Trial name
- NCT00828295
- Testing
- palonosetron
- Where
- 13 sites in Russia, Ukraine
- Volunteers
- 150 people
- Sponsor
- Helsinn Healthcare SA
PONV
Phase IIIb Study of APD421 in Combination as PONV Prophylaxis
A comparison of the efficacy of APD421 and placebo when combined with a standard anti-emetic in the prevention of PONV in patients at high risk of Post-operative Nausea and Vomiting (PONV).
- Trial name
- NCT02337062
- Testing
- APD421
- Where
- 25 sites in United States, France and 1 more
- Volunteers
- 1,147 people
- Sponsor
- Acacia Pharma Ltd
Post Operative Pain
Comparison of Side Effects of Morphine and Hydromorphone Patient-Controlled Analgesia (PCA)
Both morphine and hydromorphone are pain medications commonly used after surgery. It is thought at the institution that hydromorphone causes less side effects but this has not been studied.
- Trial name
- NCT00385541
- Testing
- Morphine PCA, Hydromorphone PCA
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Postoperative Nausea and Vomiting
A Study of Aprepitant (MK-0869) in Pediatric Participants Undergoing Surgery (MK-0869-148)
This two part study will determine the appropriate dosing regimen of aprepitant for the prevention of postoperative nausea and vomiting (PONV) in pediatric participants 6 months to 17 years of age, by assessing pharmacokinetic…
- Trial name
- NCT00819039
- Testing
- Aprepitant, Ondansetron
- Where
- 6 sites in United States, Brazil and 3 more
- Volunteers
- 98 people
- Sponsor
- Merck Sharp & Dohme LLC