Clinical trials: Volume Targeted Ventilation
Acute Hypoxemic Respiratory Failure, Mechanical Ventilation Complication
Targeting prEssure-Muscle-index to Avoid Ventilatory Over-Assistance During Pressure Support Ventilation
The TEMA study (Targeting prEssure-Muscle-index to avoid ventilatory over-Assistance during pressure support ventilation) is a prospective, interventional crossover trial investigating the relationship between pressure support…
- Trial name
- TEMA (NCT06921655)
- Testing
- Variation of Pressure Support Levels
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Centre for Medical Sciences
Prematurity, BPD - Bronchopulmonary Dysplasia
Feasibility and Impact of Volume Targeted Ventilation in the Delivery Room
Despite significant improvement in preterm infant survival, the incidence of bronchopulmonary dysplasia (BPD) in infants born < 28 weeks gestational age (GA) has been relatively stable at ~40%, with 10,000-15,000 new cases…
- Conditions
- Prematurity, BPD - Bronchopulmonary Dysplasia, Respiratory Distress Syndrome, Newborn
- Trial name
- NCT03938532
- Testing
- Volume Targeted Ventilation (VTV) using the Philips Respironics NM3 monitor, Tidal Volume Measurement using the Philips Respironics NM3 monitor
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baystate Medical Center
Coronary Artery Disease, Aortic Valve Disease
Dexamethasone, Olanzapine, Hemodynamics, and Ventilation in Cardiac Surgery
Open heart surgery, including coronary artery bypass grafting (CABG) and/or aortic valve replacement (AVR) is associated with a significant risk of mortality.
- Trial name
- GLORIOUS-II (NCT05635227)
- Testing
- Dexamethasone phosphate, Isotonic sodium chloride (0.9%), Olanzapine 10 MG
- Where
- Denmark
- Volunteers
- 1,200 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Respiratory Failure, Hypercapnic Respiratory Failure
Efficacy of Volume Ventilation in Patients With Acute Respiratory Failure at Risk of Obstructive Apneas or Obesity Hypoventilation
This study compares a volume targeted pressure support non-invasive ventilation with an automatic PEP regulation (AVAPS-AE mode) to a pressure support non-invasive ventilation (S/T mode) in patients with acute hypercapnic…
- Conditions
- Acute Respiratory Failure, Hypercapnic Respiratory Failure, Respiratory Acidosis, Obesity
- Trial name
- VONIVOO (NCT04131660)
- Testing
- AVAPS-AE mode during NIV, S/T mode during NIV
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Rouen
Respiratory Distress Syndrome, Newborn, Respiratory Failure
Cerebral and Circulatory Effects of Neonatal Volume Targeted Ventilation
The aim of the study was to assess the effect of volume targeted vs. pressure-controlled mechanical ventilation (MV) on circulatory parameters and cerebral oxygenation in the extremely preterm infants.
- Conditions
- Respiratory Distress Syndrome, Newborn, Respiratory Failure, Premature Birth
- Trial name
- NCT04391634
- Testing
- volume guarantee, pressure-controlled
- Where
- Poland
- Volunteers
- 25 people
- Sponsor
- Poznan University of Medical Sciences
Acute Hypercapnic Respiratory Failure
Volume-targeted Versus Pressure-limited Noninvasive Ventilation in Patients With Acute Hypercapnic Respiratory Failure
Volume-targeted noninvasive ventilation (VT-NIV), a hybrid mode that targets a preseted tidal volume (VT) by automated adjustment of pressure support, could guarantee the delivered VT over pressure-limited noninvasive ventilation…
- Trial name
- NCT02538263
- Testing
- Volume-targeted noninvasive ventilation
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Beijing Chao Yang Hospital
Neuromuscular Diseases
Assessment of Volume-targeted Ventilation in Patients With Neuromuscular Disease
Assessment of safety and efficacy of volume-targeted ventilation in patients with neuromuscular disease.
- Trial name
- VT-NMD (NCT06339580)
- Testing
- Volume-targeted non-invasive ventilation
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Respiratory Insufficiency
Pressure-limited Ventilation Versus Volume-targeted Ventilation in Term Newborns
A randomised controlled trial comparing volume-targeted ventilation to pressure-limited ventilation in infants born at or near term.
- Trial name
- NCT02358460
- Testing
- Ventilation delivered by SLE5000 ventilator
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- King's College London
Neonatal Respiratory Failure
Pressure-limited Ventilation Versus Volume-targeted Ventilation in Preterm Newborns
Aims: There is increasing evidence that volume-targeted ventilation (VTV) holds benefits for preterm infants in comparison to pressure-limited ventilation. This study aims to compare pressure-limited to VTV in preterm infants.
- Trial name
- NCT01531010
- Testing
- Ventilation protocol delivered by the SLE5000 ventilator
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- King's College London
Obesity Hypoventilation Syndrome
Target Volume Mode Controlled Ventilator in Obesity Hypoventilation Syndrome
The purpose of this study is to investigate the evolution of daytime partial pressure of carbon dioxide in the blood (PaCO2) after 6 weeks of noninvasive ventilation-pressure support ventilation (NIV-PSV) with target volume…
- Trial name
- OVO (NCT01104610)
- Testing
- Breas Vivo 40
- Where
- 2 sites in France
- Sponsor
- Breas Medical S.A.R.L.
Carcinoma Breast, Radiation Therapy for Primary Breast Cancer
Dosimetric Comparison of Target Volume, Heart and Left Lung in Post Mastectomy Radiotherapy (RT) of Left Sided Breast Cancer by Free Breathing (FB) Versus Deep Inspiration Breath Hold (DIBH) Technique
Breast cancer is a leading cancer among Bangladeshi female. For breast cancer, there are different available treatment options according to the stage of disease. One of the important ones is radiotherapy (RT).
- Conditions
- Carcinoma Breast, Radiation Therapy for Primary Breast Cancer, Radiation Tolerance, Radiation Induced Cardiac Damage
- Trial name
- FB DIBH RT (NCT06746142)
- Testing
- Deep inspiration breath hold radiotherapy, Free breathing radiotherapy
- Where
- 4 sites in Bangladesh
- Volunteers
- 50 people
- Sponsor
- Nishat Tasnim
Emphysema
Ventilation-Perfusion Discrepancy Index Versus Conventional Anatomic-Physiologic Assessment for Target Lung Lobe Selection in Endobronchial Valve Placement: A Multicenter, Randomised Controlled Trial
The goal of this clinical trial is to learn if a Ventilation-Perfusion Discrepancy Index (VQDI)-guided strategy for selecting the target lung lobe can improve outcomes compared to the standard strategy in patients with severe…
- Trial name
- NCT07403617
- Testing
- VQDI-assisted target lung lobe selection strategy, Conventional target lung lobe selection strategy
- Where
- China
- Volunteers
- 285 people
- Sponsor
- China-Japan Friendship Hospital
Neonatal Respiratory Distress
Volume Targeted Mask Ventilation Versus Pressure Ventilation in Preterm Infants
This is a pilot trial to assess the feasibility of volume Targeted Ventilation in the Delivery Room. Preterm infants will be randomized to pressure guided or volume targeted ventilation during respiratory support in the delivery…
- Trial name
- VOLT (NCT05144724)
- Testing
- Volume targeted ventilation, Pressure targeted ventilation
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- University of Alberta
Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
Pragmatic Investigation of Volume Targeted Ventilation-1
This proposal will test the feasibility of implementing an assist volume control ventilation protocol in patients receiving mechanical ventilation in the medical intensive care unit.
- Conditions
- Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS), Ventilator Lung
- Trial name
- PIVOT-1 (NCT03909854)
- Testing
- mode of mechanical ventilation
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- Wake Forest University Health Sciences
Obesity Hypoventilation Syndrome
Target Volume in Noninvasive Positive Pressure Ventilation
Patients with OHS are efficiently managed with long term home-based nocturnal noninvasive positive pressure ventilation (NIPPV).
- Trial name
- CIBLE (NCT01748656)
- Testing
- IVAPS, AVAPS
- Where
- France
- Volunteers
- 12 people
- Sponsor
- AGIR à Dom
Amyotrophic Lateral Sclerosis, Respiratory Failure
Volume Mode Non-invasive Ventilation in Amyotrophic Lateral Sclerosis
The purpose of this study is to assess the efficacy of using intelligent volume assured pressure support (iVAPS-AE) versus spontaneous timed (ST) modes of non-invasive ventilation (NIV) in patients diagnosed with amyotrophic…
- Conditions
- Amyotrophic Lateral Sclerosis, Respiratory Failure, Respiratory Insufficiency, Sleep-Disordered Breathing
- Trial name
- NCT05328492
- Testing
- iVAPS-AE, ST-mode
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
High Frequency Oscillation, Volume Targeted Ventilation
Optimising HFO&VTV in Newborn Infants
Mechanical ventilation (MV) is life saving for infants requiring respiratory support in the newborn period but its use has been associated with complications.
- Trial name
- NCT06719284
- Testing
- HFO&VTV at targeted tidal volumes of 1.5, 2.0 and 2.5 ml/kg in random order, HFOV at the settings applied prior to the study
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- King's College Hospital NHS Trust