Clinical trials: Vitreoretinal Lymphoma
Primary Vitreoretinal Lymphoma
A Clinical Trial Evaluating Patients With Primary Vitreoretinal Lymphoma
A prospective, randomized, double-masked, dosing-frequency-controlled, multicenter clinical trial evaluating the safety and activity of intravitreally injected ADX-2191 (methotrexate injection USP) in patients with primary…
- Trial name
- NCT07402876
- Testing
- ICM ADX-2191 injection, Monthly ADX-2191 injection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Vitreoretinal Lymphoma
Multicentre Implementation and Validation of a Molecular Diagnostic for VitreoRetinal Lymphoma
The goal of this observational study is to gain new insights into the changes in proteins, genes and other molecular biological substances in the aqueous humour, vitreous humour, blood serum and, in rare cases, retina/choroid…
- Trial name
- DecodeVRL (NCT05841914)
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- Vinodh Kakkassery, MD
Primary Vitreoretinal Lymphoma
Construction of Diagnosis and Treatment System for Primary Vitreoretinal Lymphoma
This study intends to apply for the establishment of research beds, establish a Chinese PVRL research cohort, and carry out a to achieve the following research objectives: The goal of this prospective observational study is to…
- Trial name
- NCT05950490
- Testing
- Intravitreal injection of methotrexate
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Primary Central Nervous System Lymphoma and Primary Vitreoretinal Lymphoma
Efficacy of Lenalidomide Maintenance in Primary Central Nervous System Lymphoma and Primary Vitreoretinal Lymphoma: a Phase II, Open-label, Single-arm Study
Therefore, we intend to conduct a phase II study to evaluate the efficacy of maintenance therapy with lenalidomide as the maintenance therapy for patients with PCNSL or PVRL who have achieved CR or partial response after…
- Trial name
- NCT05901324
- Testing
- intensity-modulated radiotherapy (IMRT)
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Recurrent Nervous System Lymphoma, Recurrent Primary Vitreoretinal DLBCL
Nivolumab and Pomalidomide in Treating Patients With Relapsed or Refractory Central Nervous System Diffuse Large B Cell Lymphoma or Primary Vitreoretinal Diffuse Large B Cell Lymphoma
This phase I trials studies side effects and best dose of pomalidomide when given together with nivolumab in treating patients with primary central nervous system diffuse large B cell lymphoma or primary vitreoretinal diffuse…
- Conditions
- Recurrent Nervous System Lymphoma, Recurrent Primary Vitreoretinal DLBCL, Refractory Nervous System Lymphoma, Refractory Primary Vitreoretinal DLBCL
- Trial name
- NCT03798314
- Testing
- Nivolumab, Pomalidomide
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Vitreoretinal Lymphoma, Uveitis
Mutation Detection for VRL
Vitreoretinal lymphoma (VRL) is a rare but aggressive masquerade syndrome, which would be easily confused with uveitis. The diagnostic gold standard remains the pathologic examination of ocular specimen with invasiveness and low…
- Trial name
- NCT05102994
- Testing
- mutation test
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sun Yat-sen University
Primary Vitreoretinal Lymphoma
Intravitreal MTX and ZR Regimen in Newly Diagnosed PVRL
This is a prospective single-arm phase II study, and the purpose of this study is to evaluate the efficiency of ZR regimen (rituximab \& Zanubrutinib) combined with intravitreal methotrexate and followed by Zanubrutinib…
- Trial name
- NCT04899453
- Testing
- Methotrexate, Rituximab, Zanubrutinib
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Peking Union Medical College Hospital