Clinical trials: Venous Leg Ulcers
Venous Leg Ulcer
Effect of rhGM-CSF on the Healing of Venous Leg Ulcers
The objective of this study is to examine whether local administration of the growth factor rhGM-CSF incorporated into a hydrogel, can accelerate wound healing when applied to venous leg ulcers, and whether this is safe.
- Trial name
- NCT04823962
- Testing
- rhGM-CSF + hydrogel, Standard care
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- Reponex Pharmaceuticals A/S
Venous Leg Ulcers, Venous Leg Ulcers (VLUs)
Modified Platform Trial Assessing Multiple Umbilical Cord-based CAMPs and SOC v SOC Alone in the Treatment of Hard-to-Heal VLUs
The purpose of this study is to evaluate the efficacy of two dehydrated human umbilical cord-based medical devices, also defined as Cellular, Acellular, Matrix-like Products/skin substitutes, plus SOC versus SOC alone in…
- Conditions
- Venous Leg Ulcers, Venous Leg Ulcers (VLUs), Venous Leg, Leg Ulcers
- Trial name
- CORDSTIM-VLU (NCT07449988)
- Testing
- Standard of Care (SOC), Corplex P, Theracor
- Volunteers
- 272 people
- Sponsor
- StimLabs
Venous Ulcer, Venous Ulcer of Leg
Venous Ulcers and Hyaluronic Acid Phonophoresis
Venous leg ulcers are severe manifestations of chronic venous insufficiency and account for a large proportion of lower limb ulcers.
- Trial name
- NCT07626203
- Testing
- Phonophoresis group (A), Ultrasound-preceded gel (hyaluronic acid gel) group (B):
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Cairo University
Venous Ulcer
Monitoring of Venous Ulcers Using a Bioimpedance Measurement Based Method and System
The purpose of this study is to investigate the functionality of a new type of wound monitoring method and measurement system for monitoring healing of venous ulcers.
- Trial name
- WoundWatch® (NCT05805137)
- Testing
- WoundWatch® wound monitoring system
- Where
- 2 sites in Finland, Poland
- Volunteers
- 20 people
- Sponsor
- CutoSense Oy
Diabetic Foot Ulcer, Pressure Ulcer
A Prospective, Open Label, Multicenter Trial for Evaluating the Efficacy of Treating and Managing Wounds in Elderly Population in Specialized Nursing Facilities Using RD1
The study is a prospective, single arm, multicenter efficacy study, consisting of 60 subjects who will complete the study (note: if any patients are lost to follow-up or withdrawn, enrollment will increase to compensate for loss…
- Conditions
- Diabetic Foot Ulcer, Pressure Ulcer, Venous Leg Ulcer, Trauma Injury
- Trial name
- NCT04577183
- Testing
- RD1 System
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- RedDress Ltd.
Diabetic Foot, DFU
Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers
The purpose of this study is to evaluate the efficacy of human placental membrane products and standard of care versus standard of care alone in the management of nonhealing diabetic foot ulcers and venous leg ulcers.
- Conditions
- Diabetic Foot, DFU, Diabetic Foot Ulcer, Foot Ulcer, Diabetic
- Trial name
- BIOCAMP (NCT07089602)
- Testing
- Standard of Care DFU, Tri-Membrane Wrap™ DFU, Membrane Wrap™ DFU
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- BioLab Holdings
Venous Leg Ulcer, Venous Stasis Ulcers
Dose Finding Study of HP802-247 in Venous Leg Ulcers
This is a 16-week study for subjects with a venous leg ulcer between the knee and ankle. This research is being done to determine the effectiveness of two dosing frequencies and two different concentrations of HP802-247, together…
- Trial name
- NCT00852995
- Testing
- HP802-247
- Where
- 30 sites in United States, Canada
- Volunteers
- 228 people
- Sponsor
- Healthpoint
Venous Stasis, Deep Vein Thrombosis
Blood Flow Stimulation in the Lower Limbs by Application of Different External Devices
In this study, four different devices which stimulate the blood in the lower extremities are used in ten healthy persons while measuring the blood flow with ultrasound.
- Trial name
- NCT03420625
- Testing
- Foot IPC, Rapid calf IPC, Slow calf IPC
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Venous Ulcer of Leg
Dose-Response Structured Calf Muscle Pump Activation Strategies Versus Unsupervised Home Walks
investigates the comparative effectiveness of two interventions aimed at promoting the healing of venous leg ulcers-a common chronic condition characterized by impaired venous return and poor wound healing in the lower…
- Trial name
- Ulcer (NCT07763782)
- Testing
- Dose-Response Structured CMP Activation, Active Control
- Where
- Jordan
- Volunteers
- 80 people
- Sponsor
- MTI University
Diabetic Ulcers, Venous Leg Ulcer
PMCF Study of Debridement Pad
The design of the study is a clinical trial of Debridement Pad in subjects with superficial, chronic and acute wounds consisting of Diabetic ulcers, Arterial and Venous Leg ulcers, Pressure ulcers, Postoperative wounds healing by…
- Conditions
- Diabetic Ulcers, Venous Leg Ulcer, Arterial Leg Ulcer, Pressure Ulcer
- Trial name
- NCT07255937
- Testing
- Debridement Pad
- Where
- Spain
- Volunteers
- 184 people
- Sponsor
- Advanced Medical Solutions Ltd.
Venous Leg Ulcer (VLU), Diabetic Foot Ulcer (DFU)
Effectiveness of Silicone Superabsorbent Polymer Dressings for Chronic Wound Management
The purpose of this single arm clinical study is to find out how well two Silicone superabsorbent polymer dressings, RespoSorb Silicone (also known as Zetuvit Plus Silicone) and RespoSorb Silicone Border (also known as Zetuvit…
- Trial name
- NCT07549737
- Testing
- RespoSorb Silicone (RSSil), RespoSorb Silicone Border (RSSB)
- Where
- 8 sites in Poland
- Volunteers
- 80 people
- Sponsor
- HARTMANN GROUP
Heart Failure，Congestive, Leg Edema
The ROle of Compression StocKings in Heart Failure Patients
Congestive heart failure (CHF) occurs when the heart is weak and not able to effectively pump blood to the body. One of the common manifestations of CHF is fluid overload and swelling of the legs.
- Conditions
- Heart Failure，Congestive, Leg Edema, Venous Insufficiency, Venous Ulcers
- Trial name
- ROCK-HF (NCT06350695)
- Testing
- low grade compression stockings (10-15 mmHg), high grade compression stockings (20-30 mmHg)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Maryland, Baltimore
Stasis Ulcer
Safety And Efficacy Of Topical Platelet Rich Plasma And Thrombin Coagulum
The aim of this study is to To evaluate the safety and tolerability of Platelet Rich plasma(PRP)/Thrombin mixture in treating chronic venous ulcers To evaluate efficacy of PRP/Thrombin mixture in treating chronic venous ulcers
- Trial name
- NCT02802995
- Testing
- PRP/thrombin mixture
- Where
- South Africa
- Volunteers
- 15 people
- Sponsor
- University of Witwatersrand, South Africa
Venous Leg Ulcer
A Study to Evaluate the Safety and the Efficacy of EscharEx (EX-02 Formulation) in Debridement of Venous Leg Ulcers
This study is a multicenter, prospective, randomized, placebo controlled, adaptive design study performed to assess the safety and the efficacy of 5% EscharEx (EX-02) compared to Gel Vehicle (placebo) and non-surgical standard of…
- Trial name
- NCT03588130
- Testing
- EscharEx (5% EX-02 formulation), Gel Vehicle, Non-surgical standard of care (NSSOC)
- Where
- 22 sites in United States, Switzerland
- Volunteers
- 120 people
- Sponsor
- MediWound Ltd
Venous Leg Ulcer
Investigation of the Clinical Performance of Biatain Fiber Ag on Venous Leg Ulcers
The goal of this study is to test a new gelling fiber wound dressing with silver on patients with a venous leg ulcer Participants will be asked to wear the test dressing in a four weeks period (+/- 2 days) consisting of 6 study…
- Trial name
- NCT05873257
- Testing
- Biatain Fiber Ag applied to participants
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Coloplast A/S
Venous Leg Ulcer, Venous Stasis Ulcer
Evaluation of Bilayered Cellular Matrix (OrCel) for the Treatment of Venous Ulcers
This study was designed to evaluate the clinical benefits and safety of OrCel in the treatment of venous ulcers. OrCel and standard care were compared to standard care alone.
- Trial name
- NCT00270946
- Testing
- Bilayered Cellular Matrix (OrCel)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Ortec International
Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU)
Evaluation of the Safety and Efficacy of Dehydrated Human Placenta Tissue (dHPT) for Wound Healing
The retrospective trial is observational, intended to stand alone, complement and integrate data collected in ongoing clinical studies to aid in establishing payor coverage in the United States (U.S.) for Cellution Biologics…
- Conditions
- Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU), Pressure Ulcer (PU)
- Trial name
- RETRO-PLAST (NCT07375160)
- Testing
- dHPT, AIC
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Cellution Biologics
Venous Insufficiency, Venous Reflux
Effects of Non Contact Low Frequency Ultrasound in Healing Venous Leg Ulcers
This trial is a prospective, randomized, controlled, multi-center study of subjects presenting with chronic lower extremity venous ulcers.
- Conditions
- Venous Insufficiency, Venous Reflux, Lower Extremity Ulcer
- Trial name
- NCT01549860
- Testing
- MIST Therapy
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Celleration, Inc.
Venous Thromboses, Venous Stasis
Evaluation of the OsciPulse Rapid Cycling Compression Device Effects on Venous Blood Flow
This study will evaluate the effects on venous blood flow of the investigational device, OsciPulse system, which is an external intermittent limb compression device.
- Trial name
- NCT05087108
- Testing
- OsciPulse system, Reference Therapy 1, Refence Therapy 2
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- OsciFlex LLC
Chronic Venous Disease, Varicose Ulcer
Effects of Local Insulin on Varicose Ulcers for Wound Healing
A randomized, split-plot, double-blind, placebo-controlled trial. The varicose ulcer is divided into two (side A and B). Half of the wound's surface is treated locally with insulin (Glargine) applied at an approx depth of 3-4 mm.
- Conditions
- Chronic Venous Disease, Varicose Ulcer, Wound Healing, Insulin
- Trial name
- NCT04310280
- Testing
- Insulin Glargine, Saline
- Where
- Mexico
- Volunteers
- 13 people
- Sponsor
- Hospital Central "Dr. Ignacio Morones Prieto"