Clinical trials: Venous Insufficiency
Chronic Venous Disease, Chronic Venous Insufficiency, CVI
The ReCAna for Lower ExtremIty Venous OBstructions and In-StEnt Restenosis Registry
The goal of this observational study is to gather additional safety and performance (effectiveness) data on the device for the treatment of symptomatic lower extremity venous obstructions and occlusions.
- Conditions
- Chronic Venous Disease, Chronic Venous Insufficiency, CVI, Venous Thrombosis, Thrombosis (Stent Thrombosis)
- Trial name
- CALIBER (NCT07529756)
- Testing
- Recanalization and debulking
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Intervene, Inc.
Cardiac Rhythm Disorders, Urological Disorders
Product Surveillance Registry
The purpose of the Registry is to provide continuing evaluation and periodic reporting of safety and effectiveness of Medtronic market-released products.
- Conditions
- Cardiac Rhythm Disorders, Urological Disorders, Neurological Disorders, Cardiovascular Disorders
- Trial name
- PSR (NCT01524276)
- Where
- 402 sites in United States, Argentina and 39 more
- Volunteers
- 100,000 people
- Sponsor
- Medtronic
Superficial Venous Insufficiency, Varicose Veins
Pilot Study: Evaluation of the Safety of the Application of Non-thermal HIFU for Varicose Veins Treatment of the Lower Limbs
EASY-VEIN NT is a pilot, prospective, single-center, non-randomized clinical investigation evaluating the safety and feasibility of the application of non-thermal high-intensity focused ultrasound (NT-HIFU) for the treatment of…
- Trial name
- EASY-VEIN NT (NCT07878767)
- Testing
- Non-thermal HIFU application along the saphenous vein of one leg / 3-month follow-up
- Where
- Romania
- Volunteers
- 15 people
- Sponsor
- VeinSound
Total Knee Anthroplasty, Venous Insufficiency (Chronic)(Peripheral)
Impact of Chronic Venous Insufficiency on Outcomes After Total Knee Arthroplasty
Total knee arthroplasty (TKA) is an effective treatment for end-stage knee osteoarthritis; however, postoperative complications-particularly wound healing problems-remain a significant concern.
- Conditions
- Total Knee Anthroplasty, Venous Insufficiency (Chronic)(Peripheral), Doppler Ultrasound Diagnosis
- Trial name
- VENOUS-TKA (NCT07577141)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- SB Istanbul Education and Research Hospital
Non-infected Venous Leg Ulcer, Venous Leg Ulcer
Non-healing Venous Leg Ulcers Treated With Standard Care With or Without BR-AC
This study examines a patient population with a non-healing, non-infected venous leg ulcer (VLU) having adequate arterial perfusion with confirmed venous reflux.
- Conditions
- Non-infected Venous Leg Ulcer, Venous Leg Ulcer, Venous Insufficiency, Venous Stasis
- Trial name
- NCT06811909
- Testing
- BR-AC, Standard Care
- Where
- 22 sites in United States
- Volunteers
- 71 people
- Sponsor
- BioStem Technologies
Venous Insufficiency
Open Label Safety Investigation of Solutio™ Tumescent Catheter
The goal of this clinical investigation is to evaluate safety of the Solutio™ catheter when administering tumescent anesthesia before treatment with endothermal ablation in adults above the age of 18, who suffer from unilateral…
- Trial name
- NCT07823088
- Testing
- Administration of local anesthesia
- Where
- 2 sites in Sweden
- Volunteers
- 30 people
- Sponsor
- MedVasc AB
Venous Leg Ulcer (VLU), Venous Hypertension Ulcers
Effect of Photobiomodulation on Healing of Venous Leg Ulcers
Venous leg ulcers are a significant public health problem because of their prolonged duration, high recurrence rates, and economic, social, and quality-of-life effects.
- Conditions
- Venous Leg Ulcer (VLU), Venous Hypertension Ulcers, Chronic Venous Insufficiency, Chronic Venous Disease
- Trial name
- NCT07123285
- Testing
- Photobiomodulation Therapy, Compression Therapy
- Where
- Brazil
- Volunteers
- 102 people
- Sponsor
- University of Nove de Julho
Lower Extremity Edema, Lower Extremity Edema Chronic
Pedal Pump Clinical Trial on Edema V2
Previous research on the osteopathic manual technique entitled "Pedal Pump" has shown health benefits, specifically increasing lymphatic flow, decreasing lower extremity edema, and decreasing serum lactic acid after maximal…
- Conditions
- Lower Extremity Edema, Lower Extremity Edema Chronic, CHF - Congestive Heart Failure, CHF Exacerbation
- Trial name
- NCT07809516
- Testing
- Pedal Pump
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Hillcrest
Chronic Venous Insufficiency, CVI
Structured Home-Based Exercise and Education for Chronic Venous Insufficiency
The goal of this clinical trial is to learn whether a structured home-based exercise and education program can improve quality of life and leg symptoms in adults with chronic venous insufficiency.
- Trial name
- NCT07777978
- Testing
- Structured Home-Based Exercise and Education Program, Standard Care (in control arm)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Abant Izzet Baysal University
Chronic Venous Insufficiency
Tissue Engineered Veins in Patients With Chronic Venous Insufficiency
This study aims to evaluate the safety (incidence of adverse events including serious adverse events and clinical significant laboratory abnormalities) of personalized tissue engineered veins (P-TEV) with valves implanted in…
- Trial name
- TECVI-1 (NCT03784131)
- Testing
- P-TEV
- Where
- Spain
- Volunteers
- 11 people
- Sponsor
- Verigraft AB
Chronic Venous Insufficiency
Respiratory and Physical Functions in Individuals With Chronic Venous Insufficiency
In the literature, it is still unclear whether individuals with chronic venous insufficiency are affected by edema, pain, respiratory muscle strength, respiratory functions, functional capacity, lower extremity strength and…
- Trial name
- NCT06196541
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Izmir Democracy University
Lower Extremity Edema, Congestive Heart Failure(CHF)
Pedal Pump Clinical Trial on Edema V1
Previous research on the osteopathic manual technique entitled "Pedal Pump" has shown health benefits, specifically increasing lymphatic flow, decreasing lower extremity edema, and decreasing serum lactic acid after maximal…
- Conditions
- Lower Extremity Edema, Congestive Heart Failure(CHF), Chronic Venous Insufficiency (CVI), Kidney Disease
- Trial name
- NCT07760363
- Testing
- Pedal Pump
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- David McVay
Venous Insufficiency of Leg
Therapeutic Efficacy of the Phlebology-oriented Thermal Cure at the Saint-Eloy Thermal Center in the Treatment of Symptoms of Severe Chronic Venous Insufficiency
Chronic venous insufficiency (CVI) is a common progressive vascular disease that affects nearly one-third of the French population.
- Trial name
- AMNEVILLE-PHL (NCT07362719)
- Testing
- Phlebology oriented thermal cure
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Société d'Exploitation des Thermes d'Amnéville
Chronic Venous Insufficiency C2 and Below
Comparison of the Effects of Kinesio Taping and Interval Exercise in Patients Diagnosed With Venous Insufficiency: A Randomised Controlled Trial
This study aims to compare the effects of kinesiology taping and interval exercise on reducing symptoms, improving quality of life, and vital parameters in individuals with venous insufficiency.
- Trial name
- NCT07228585
- Testing
- Kinesio Taping and Lifestyle Advice, Kinesio Taping and Interval Exercise with Lifestyle Advice, Lifestyle Advice for Venous Insufficiency
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Venous Thrombosis Deep (Limbs), Venous Insufficiency (Chronic)(Peripheral)
Apixaban vs Rivaroxaban vs No Anticoagulant to Prevent EHIT After Great Saphenous Vein Laser Ablation
Endothermal heat-induced thrombosis (EHIT) is a thrombotic complication specific to endovenous thermal ablation of the great saphenous vein (GSV), for which no prophylactic regimen is standardized.
- Conditions
- Venous Thrombosis Deep (Limbs), Venous Insufficiency (Chronic)(Peripheral), Varicose Veins Leg, Venous Thrombosis
- Trial name
- NCT07699796
- Testing
- Apixaban, Rivaroxaban
- Where
- United States
- Volunteers
- 564 people
- Sponsor
- Heart, Artery, and Vein Center of Fresno
Lipedema, Venous Insufficiency
Assessment of Venous Insufficiency and Clinical Features in Lipedema
Lipedema is a chronic adipose tissue disorder characterized by disproportionate fat accumulation, pain, tenderness, edema, and functional impairment.
- Conditions
- Lipedema, Venous Insufficiency, Venous Disease, Disability Physical
- Trial name
- NCT07603076
- Testing
- Venous Doppler Ultrasonography, Numeric Rating Scale, Lower Extremity Functional Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Vascular Diseases, Peripheral, Venous Insufficiency of Leg
Observation of Pain During Radiofrequency Ablation of Saphenous Vein，and Analysis of Related Factors
Objective: This study is a single-center prospective observational study, which recorded the pain scores of patients at four time nodes during surgery (puncture and catheterization, injection of swelling fluid, radiofrequency…
- Conditions
- Vascular Diseases, Peripheral, Venous Insufficiency of Leg, Varicose Veins of Lower Limb
- Trial name
- NCT07683871
- Testing
- VAS scores of the puncture
- Where
- China
- Volunteers
- 155 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Chronic Venous Disease, Vein Disease
Randomized, Placebo-crontrolled Clinical Trial Evaluating the Efficacy and Safety of Heparan Sulfate 120 mg Prolonged-Release Tablets Compared With Placebo in Patients With Chronic Venous Disease
This multicenter, randomized, double-blind study is a phase III evaluates the safety and effectiveness of CLR prolonged-release tablets in patients with chronic venous insufficiency, has been shown to be effective in reducing the…
- Conditions
- Chronic Venous Disease, Vein Disease, Venous Insufficiency of Leg
- Trial name
- CLR-18 (NCT07684833)
- Testing
- CLR Tablets - Heparan Sulphate
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Barbara Maglione
Varicose Veins of Lower Limb, Thromboses, Venous
Prospective Cohort Study for Varicose Veins Incidence and Natural Course
A prospective study of individuals without varicose veins and who have primary varicose veins to assess the morbidity, risk factors and natural course of chronic lower limb vein disease.
- Conditions
- Varicose Veins of Lower Limb, Thromboses, Venous, Venous Insufficiency
- Trial name
- VINCI (NCT04546750)
- Where
- Russia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Russian Phlebological Association
Chronic Venous Insufficiency, CVI
The Use of Immersive Virtual Reality as a Method of Treating Anxiety and Procedural Pain During Endovenous Laser Ablation (EVLA) of Lower Varicose Veins Under Tumescent Anesthesia
This is a prospective, single-arm, pre-post interventional study designed to evaluate the feasibility, safety, and impact of immersive virtual reality (VR) as an adjunct to tumescent local anesthesia during endovenous laser…
- Trial name
- EVLA+VR (NCT07624929)
- Testing
- VR (VR-Control)
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Bydgoszcz University of Science and Technology