Clinical trials: Vaso-occlusive Crisis
Sickle Cell Disease
Comparing Acute Pain Management Protocols for Patients With Sickle Cell Disease
The goal of this pilot study is to improve emergency department (ED) pain management for adults with sickle cell disease. Sickle cell disease (SCD) is the most common genetic disorder in the United States, and occurs primarily…
- Trial name
- NCT02222246
- Testing
- Hydromorphone (Standardized, weight-based dosing), Morphine Sulfate (Standardized, weight-based dosing), Hydromorphone (Patient Specific dosing)
- Where
- 2 sites in United States
- Volunteers
- 106 people
- Sponsor
- Duke University
Anemia, Sickle Cell
Effectiveness of Arginine as a Treatment for Sickle Cell Anemia
Sickle cell disease (SCD), also known as sickle cell anemia, is an inherited genetic disease that can cause intense pain episodes.
- Trial name
- Arginine (NCT00513617)
- Testing
- Arginine
- Where
- 17 sites in United States
- Volunteers
- 128 people
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Vaso-Occlusive Crises, Sickle Cell Disease
Evaluation of the Efficacy of Iloprost in the Management of Vaso-occlusive Crises in Adult Patients With Sickle Cell Disease
Sickle cell disease is a severe monogenic genetic disorder caused by an autosomal recessive mutation of the β-globin gene, leading to production of abnormal hemoglobin (HbS).
- Trial name
- PROSTASICKLE (NCT07498309)
- Testing
- Iloprost
- Where
- France
- Volunteers
- 144 people
- Sponsor
- University Hospital, Rouen
Sickle Cell Disease
Cohort Study of Sickle Cell Patients Evaluating Analgesic Strategies and Their Consequences
To date, there is no comprehensive data among adults with sickle cell disease concerning the prevalence of consumption of level 2 and 3 analgesics at home and the use of cannabis or CBD for analgesic use.
- Trial name
- DDAM (NCT06650059)
- Testing
- Questionnaire
- Where
- 3 sites in France
- Volunteers
- 257 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anemia, Sickle Cell
Efficacy and Safety of Rivipansel (GMI-1070) in the Treatment of Vaso-Occlusive Crisis in Hospitalized Subjects With Sickle Cell Disease
This is a clinical study evaluating the efficacy and safety of rivipansel (GMI-1070) in treating subjects with sickle cell disease (SCD) who are 6 years of age or older experiencing a pain crisis necessitating hospitalization.
- Trial name
- NCT02187003
- Testing
- Rivipansel
- Where
- 142 sites in United States, Canada
- Volunteers
- 345 people
- Sponsor
- Biossil Inc.
Sickle Cell Disease, Vaso-occlusive Crisis
Adaptive Platform Trial for Pain Management in Sickle Cell Vaso-Occlusive Crisis
Sickle cell disease (SCD) is a severe hemoglobinopathy, characterized by recurrent vaso-occlusive crises (VOC) causing intense pain and frequent hospitalizations in adult patients.
- Trial name
- PAMAVOC (NCT07826988)
- Testing
- Group 02 Paracetamol + Morphine + Ketamine, Group 01 Control: Paracetamol + Morphine, Group 03 : Paracetamol + Morphine + Nefopam
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sickle Cell Crisis
Ketamine for Acute Painful Crisis in Sickle Cell Disease Patients
Investigators hypothesize that administration of ketamine for pain relief in sickle cell patients with vaso-occlusive crisis early on will lead to a more rapid improvement in pain score and less narcotic requirement.
- Trial name
- NCT03431285
- Testing
- Morphine Group, Ketamine Group, standard IV hydration
- Where
- Saudi Arabia
- Volunteers
- 278 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
SCD, Vaso Occlussive Crisis
Efficacy of Liberal Versus Restricted IV Fluid Approach in the Management of Sickle Cell Vaso-Occlusive Crisis
Sickle cell disease (SCD) is a prevalent inherited blood disorder characterized by vaso-occlusive crises (VOCs), which lead to severe pain and complications.
- Trial name
- FLASC (NCT07188766)
- Testing
- Sodium Chloride (NaCl) 0.9 %
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 394 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Sickle Cell Disease, Sickle Cell Crisis
Ketorolac for Acute Vaso-Occlusive Crisis in Pediatric Sickle Cell Disease
Pediatric patients who present with acute vaso-occlusive pain crisis may have equivalent pain reduction scores at lower dosing of intravenous Ketorolac compared to standard dosing of 0.5 mg/kg/dose IV (<16yo max 15mg, >16yo max…
- Conditions
- Sickle Cell Disease, Sickle Cell Crisis, Veno-occlusive Disease
- Trial name
- NCT06579703
- Testing
- Ketorolac
- Volunteers
- 102 people
- Sponsor
- Children's Blood and Cancer Center at Dell Children's Medical Center
Sickle Cell Crisis, Sickle Cell Disease
Mindfulness and Yoga Therapy for Acute Pain in Sickle Cell Disease
Patients with sickle cell disease suffer from acute and chronic pain that diminishes their quality of life. The purpose of this study is to assess the feasibility and acceptability of mindfulness meditation, breathing exercises…
- Trial name
- NCT05572294
- Testing
- Mindfulness meditation, breathing exercises (including incentive spirometry), and yoga therapy
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Texas Southwestern Medical Center
Anemia, Sickle Cell, Pain
Intranasal Fentanyl for Initial Treatment of a Vaso-occlusive Crisis
The purpose of this study is to determine if intranasal fentanyl can decrease the pain of patients with sickle cell disease who present to the pediatric emergency department with a vaso-occlusive crisis.
- Trial name
- NCT01482091
- Testing
- Fentanyl Citrate, Normal Saline
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Montefiore Medical Center
Sickle Cell Disease
Sleep Apnea in Sickle Cell Disease
Despite the fact that obstructive sleep apnoea (OSA) is highly prevalent in the sickle cell population, studies focusing on the associations of the two diseases and their common pathophysiological mechanisms are scarce.
- Trial name
- DREPAPNEE (NCT03753854)
- Testing
- polysomnography and oxygen saturation exam, calculation of VOC frequency between the first polysomnography and the end of the first year of continuous positive airway pressure treatment, Blood samples
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Sickle Cell Disease, Vaso-Occlusive Pain Episode in Sickle Cell Disease
Intranasal Ketamine for Pain Control in Patients with Sickle Cell Disease and Vaso-occlusive Episode (VOE) in the PED
This will be a descriptive cohort study of intranasal ketamine as the initial analgesic for children with sickle cell disease who present to the pediatric emergency department with vaso-occlusive crisis and are awaiting…
- Conditions
- Sickle Cell Disease, Vaso-Occlusive Pain Episode in Sickle Cell Disease, Vaso-occlusive Crisis, Ketamine
- Trial name
- NCT04150757
- Testing
- Intranasal ketamine
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Abigail Nixon
Anemia, Sickle Cell
Far Infrared Radiation for Sickle Cell Pain Management
Most patients with sickle-cell disease have periodic intensely painful episodes. To manage this pain, we are proposing the drinking of at least 500 mL of water followed by far infrared radiation.
- Trial name
- NCT00599482
- Testing
- Far Infrared Radiation (5μm to 20μm wavelength)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- GAAD Medical Research Institute Inc.
Sickle Cell Disease
Ketamine as an Adjuvant Therapy for Acute Vaso Occlusive Crisis in Pediatric Patients With Sickle Cell Disease
The primary objective of the proposed study is to determine the potential role of Ketamine as an analgesic agent in pediatric sickle cell disease patients with refractory symptoms in acute (VOC).
- Trial name
- KSickle (NCT02801292)
- Testing
- Ketamine
- Volunteers
- 20 people
- Sponsor
- Augusta University
Vaso-occlusive Crisis, Sickle Cell Anemia Crisis
Hyperbaric Oxygen Therapy in Sickle Cell Pain
Sickle cell anemia is a genetic blood disorder where red blood cells are abnormally shaped, crescent- or sickle-shaped, instead of the normal, round shape.
- Trial name
- HAVOC (NCT03412045)
- Testing
- hyperbaric oxygen therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Nebraska
Sickle-Cell Disease Nos With Crisis
Pulmonary Ultrasound in the Diagnosis of Acute Thoracic Syndrome in Vaso-occlusive Sickle Cell Crisis
ATS (acute thoracic syndrome) refers to acute pulmonary involvement in a sickle cell patient. The diagnosis is based on the association of clinical signs (fever or respiratory symptoms) with a recent pulmonary infiltrate on the…
- Trial name
- ECHO-STA (NCT03971136)
- Testing
- pulmonary ultrasound
- Where
- 4 sites in France
- Volunteers
- 190 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Sickle Cell Disease
Evaluation of Left Ventricular Function by Speckle Tracking Echocardiography in Patient Hospitalised in Intensive Care Unit for Vaso-occlusive Crisis
Vaso-occlusive crisis in Sickle cell disease might alter myocardial function through micro vascular obstruction. Evaluation of strain alteration using speckle tracking echocardiography is a non invasive technique that may allow…
- Trial name
- NCT04864041
- Testing
- Evaluation of global longitudinal strain using routinely recorded echocardiography images
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Bicetre Hospital
Sickle Cell Crisis
Low Dose Ketamine and Acute Pain Crisis
BACKGROUND: Current treatment standard for acute pain crisis in sickle cell disease (SCD) is largely supportive care: opioid analgesics, hydration, oxygen, and blood transfusion.
- Trial name
- LDK-SCD (NCT04330183)
- Testing
- Ketamine, Normal Saline
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Rhode Island Hospital
Sickle Cell Disease
Pilot Study on the Value of Bedside Pleuropulmonary Ultrasound in Patients With Sickle Cell Disease Presenting With Vaso-occlusive Crisis
Describe the proportion of patients with major sickle cell syndrome in vaso-occlusive crisis presenting at least one pleuropulmonary ultrasound abnormality during one of the ultrasounds performed at D0, between D2 and D5 during…
- Trial name
- DREPP (NCT06755385)
- Testing
- Pleuropulmonary ultrasound
- Volunteers
- 25 people
- Sponsor
- University Hospital, Grenoble