Clinical trials: Vascular Reactivity
Cardiovascular Diseases, Heart Diseases
Social Dominance, Gender, and Cardiovascular Reactivity
To examine biopsychosocial processes that might contribute to the associations among social dominance, gender, and cardiovascular reactivity,.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease
- Trial name
- NCT00005522
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
Use of a Point-of-Care Platelet Function Assay for the Prediction of Atherothrombotic Events
1. To evaluate the role of VerifyNow test as prognostic marker in routine clinical practice using drug-eluting stents. 2. To determine the add-on-effect of VerifyNow test beyond on conventional risk factors (clinical, lesions, or…
- Trial name
- ASAN-VERIFY (NCT01183754)
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- CardioVascular Research Foundation, Korea
Coronary Artery Disease
Pharmacodynamic Comparison of Rosuvastatin Versus Atorvastatin on Platelet Reactivity in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy With New P2Y12 Inhibitors (Trial gRANADa)
Statin interference has been suggested among the mechanisms of reduction of the antiplatelet effect of clopidogrel. The purpose of this study is to evaluate pharmacodynamic effects of rosuvastatin and atorvastatin on platelet…
- Trial name
- gRANADa (NCT02030054)
- Testing
- Atorvastatin, Rosuvastatin
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Roma La Sapienza
Coronary Disease
Impact of Pumps on Internal Thoracic Arteries (IPITA)
Cardiopulmonary bypass (CPB) induces a systemic inflammatory response and affects the organ vascular bed. Experimentally, the lack of pulsatility alters myogenic tone of resistance arteries and increases the parietal inflammatory…
- Trial name
- IPITA (NCT04168853)
- Testing
- vascular reactivity of internal thoracic arteries
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Acute Coronary Syndrome
Genotype Guided Versus Conventional Approach in Selection of Oral P2Y12 Receptor Blocker in Chinese Patients Suffering From Acute Coronary Syndrome
This study aims to compare the outcome between genotype guided versus clinical guided approach in selection of oral P2Y12 receptor blocker in Chinese patients suffering from acute coronary syndrome.
- Trial name
- NCT01994941
- Testing
- Clopidogrel, Ticagrelor
- Where
- Hong Kong
- Volunteers
- 133 people
- Sponsor
- The University of Hong Kong
Peripheral Arterial Disease (PAD), Amputation
Personalizing Thromboprophylaxis for Patients With Peripheral Artery Disease
The goal of this clinical trial is to determine whether a personalised blood clot prevention plan is more effective than standard treatment in adults with peripheral artery disease (PAD) who have undergone a procedure to restore…
- Conditions
- Peripheral Arterial Disease (PAD), Amputation, Thrombosis, Thrombosis (Stent Thrombosis)
- Trial name
- NCT07613840
- Testing
- Aspirin, Clopidogrel, Ticagrelor
- Where
- 2 sites in United States
- Volunteers
- 484 people
- Sponsor
- Massachusetts General Hospital
Inflammation
Effect of Pioglitazone on Oxidative Load, Inflammatory End-Points and Vascular Reactivity in Obese Non-Diabetic Patients: A Dose Ranging Study
Pioglitazone decreases oxidative load, inflammatory end points and improves vascular reactivity in obese patients in a dose dependent manner and that this effect is independent of its glucose lowering effects.
- Trial name
- NCT01161394
- Testing
- Pioglitazone 15mg, pioglitazone 30mg
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Acute Coronary Syndrome, Antiplatelet Therapy
Platelet Reactivity And Clinical ThrombotIC Events Study
Platelet function testing has been considered for DAPT strategy adjustments to reduce the patient's risk of ischemia and bleeding.
- Conditions
- Acute Coronary Syndrome, Antiplatelet Therapy, Platelet Reactivity
- Trial name
- PRACTICE (NCT03525145)
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Shenyang Northern Hospital
Diabetes, Hypertension
Effects of Quinapril 40 mg With Alpha Lipoic Acid or Placebo on Diabetes and Hypertension
We will evaluate the combination of quinapril and alpha lipoic acid in patients with diabetes mellitus and hypertension. We will determine whether the combination of quinapril and lipoic acid as compared to quinapril and placebo…
- Trial name
- QUALITY (NCT00795262)
- Testing
- Quinapril (Accupril) plus Alpha Lipoic Acid, accupril, alpha lipoic acid
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- InVasc Therapeutics, Inc.
Ischemia/Reperfusion Injury After Neonatal Cardiac Surgery, Inflammatory Reaction After Neonatal Cardiac Surgery
Efficacy of Nitric Oxide Administration in Attenuating Ischemia/Reperfusion Injury During Neonatal Cardiopulmonary Bypass
Around 7500 neonates born yearly in the United States have complex congenital heart disease that require surgical repair in the first few days of life.
- Trial name
- NCT02151877
- Testing
- Inhaled Nitric Oxide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wake Forest University Health Sciences
Cardiovascular Diseases, Heart Diseases
Regulation of Placental Vascular Reactivity in Pregnancy-induced Hypertension
To elucidate the role of an imbalance in vasodilator prostacyclin (PGI2) and vasoconstrictor thromboxane (TxA2) in pregnancy-induced hypertension
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Pregnancy Toxemias
- Trial name
- NCT00005208
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
Effect of Cocoa Flavanols on Vascular Function
Endothelial dysfunction is associated with a higher incidence of adverse cardiovascular events in patients with coronary artery disease (CAD).
- Trial name
- Cocoa (NCT00553774)
- Testing
- Cocoa Flavanols
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Francisco
Microcirculatory Dysfunction, Tissue Hypoperfusion
Submental Tissue Oxygenation and Arterial Lactate in Major Surgery
During major surgical procedures performed under general anesthesia, changes in blood flow and oxygen delivery to tissues may occur due to blood loss, hemodynamic fluctuations, and anesthesia-related physiological effects.
- Conditions
- Microcirculatory Dysfunction, Tissue Hypoperfusion, Microcirculatory Status, Microvascular Circulation
- Trial name
- NCT07399275
- Testing
- No intervention. This is a prospective observational study. Near-infrared spectroscopy measurements are performed for monitoring purposes only and do not influence clinical management.
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Bursa Sevket Yilmaz Training and Research Hospital
Intracerebral Hemorrhage
Non-invasive Evaluation of Cerebrovascular Reactivity in Spontaneous Intracerebral Hemorrhage
Spontaneous intracerebral hemorrhage (ICH) remains a significant cause of morbidity and mortality around the globe. The most common etiology of nontraumatic spontaneous ICH is hypertensive arteriopathy (HA), while cerebral…
- Trial name
- NCT03815513
- Testing
- brain MRI
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Coronary Artery Disease
Effects of Almonds On Endothelial Function In Patients With Coronary Artery Disease
The vascular endothelium (inner lining of cells in blood vessels) normally prevents vasospasm and thrombosis by production of a variety of regulatory substances, including nitric oxide.
- Trial name
- NCT01038362
- Testing
- NCEP Step 1 diet plus Almonds, No Almonds
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Boston University
Ischemic Stroke, Anticoagulant Adverse Reaction
Evaluataion of NOAC Levels in Acute Stroke
Non-vitamin K antagonist oral anticoagulants (NOACs) are recommended over warfarin in preventing stroke and thromboembolism among patients with atrial fibrillation (AF) in several guidelines.
- Trial name
- NCT06144866
- Testing
- Dabigatran, rivaroxaban, apixaban, edoxaban
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- National Taiwan University Hospital
Blood Clots, Infection and Inflammatory Reaction
Cobas® Lumira Collection of Venous and Capillary Blood Samples for the Research, Optimization and Calibration of New Diagnostic Devices
This study is a blood sample collection study, collecting venous and capillary blood samples from adult patients in the UK, with a range of health conditions.
- Conditions
- Blood Clots, Infection and Inflammatory Reaction, Heart Disease, Kidney Disease
- Trial name
- EVOLVE (NCT07378514)
- Testing
- Blood samples are obtained and pseudonymized, prior to use for the development, optimization and calibration of diagnostic tests
- Volunteers
- 30,000 people
- Sponsor
- LumiraDx UK Limited
Stroke, Spinal Cord Injury
Robotic Assisted Balance and Exoskeleton Training (REACTION) in Neurorehabilitation: a Feasibility Study
The goal of this clinical trial is to explore the effect on walking speed of a new robotic assisted balance and gait trainer (REACTION) and their subsystems in individuals with neurological disorders.
- Trial name
- REACTION (NCT06805500)
- Testing
- REACTION, ABLE Regain, GABLE Core
- Where
- 2 sites in Netherlands
- Volunteers
- 7 people
- Sponsor
- Roessingh Research and Development
Chronic Kidney Diseases
miRNA in Chronic Kidney Diseases
Oxidative stress and endoplasmic reticulum (ER) stress play a key role in tubular damage in both acute kidney injury and chronic kidney disease (CKD).
- Trial name
- NCT06316284
- Where
- Croatia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Chronic Urticaria
Quality of Life in Patients With Chronic Urticaria
Urticaria is one of the most frequent presenting complaints in dermatology, allergy, and emergency departments. The term chronic urticaria (CU) is understood as the appearance of recurrent wheals more than twice a week for over 6…
- Trial name
- NCT03163875
- Testing
- Hospital Anxiety and Depression Scale
- Volunteers
- 30 people
- Sponsor
- Assiut University