Clinical trials: Vascular Dysfunction, active
Hypertension, Cognitive Decline
Implementation of Multifaceted Patient-Centered Treatment Strategies for Intensive Blood Pressure Control in Minimize Cognitive Decline
The study will test a multifaceted strategy for implementing an intensive blood pressure intervention protocol targeting systolic BP <120 mmHg on cognitive decline in racial minority and low-income hypertensive patients in…
- Trial name
- IMPACTS-MIND (NCT04797403)
- Testing
- Stepped-care protocol adapted from the SPRINT intensive-treatment algorithm
- Where
- United States
- Volunteers
- 1,306 people, healthy volunteers welcome
- Sponsor
- Tulane University
Non-hodgkin Lymphoma,B Cell, Multiple Myeloma
CAR T-cell Therapy in Patients With Renal Dysfunction
This is a prospective, descriptive study designed to assess the feasibility of administering CAR T therapy among patients with moderate to severe renal impairment using dose adjusted lymphodepleting chemotherapy.
- Conditions
- Non-hodgkin Lymphoma,B Cell, Multiple Myeloma, Acute Lymphoblastic Leukemia, Adult
- Trial name
- NCT05909059
- Testing
- Fludarabine, Cyclophosphamide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northside Hospital, Inc.
Ischemic Stroke, Intracerebral Hemorrhage
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke.
- Conditions
- Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Dementia, Vascular
- Trial name
- DISCOVERY (NCT04916210)
- Where
- 31 sites in United States
- Volunteers
- 8,000 people
- Sponsor
- Massachusetts General Hospital
Moyamoya Disease
Study on the Mechanism of Cognitive Impairment in Patients with Moyamoya Disease
The purpose of this study is to comprehensively evaluate the risk factors for cognitive decline in patients with moyamoya disease, identify imaging target areas associated with cognitive damage in the brain, and explore the…
- Trial name
- NCT06832839
- Testing
- Revascularization
- Where
- China
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Endothelial Dysfunction, Inflammation in Cardiopulmonary and Vascular Disease States
Samples From Human Subjects to Facilitate Basic, Translational and Clinical Research
Background: This study is designed to provide samples to help us study the genes your blood cells are making as well as the proteins, sugars, fats, vitamins and other metabolites found in your blood or urine.
- Conditions
- Endothelial Dysfunction, Inflammation in Cardiopulmonary and Vascular Disease States, Healthy Volunteers
- Trial name
- NCT03253705
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Neuropsychiatric Post-Acute Sequelae of SARS-CoV-2 Infection
Neuropsychiatric Post-Acute Sequelae of SARS-CoV-2 (PASC) Using TSPO Positron Emission Tomography (PET) and MRI
The overarching goal of this study is to develop PET/MR techniques for the diagnosis of neuropsychiatric post-acute sequelae (PASC) of SARS-CoV-2.
- Trial name
- NCT05615415
- Testing
- PET Tracer, MRI Tracer, 3T PET/MRI
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Peripheral Artery Disease (PAD)
Using Near-Infrared Light to Better Understand Peripheral Artery Disease
The goal of this study is to better understand how blood flows and how oxygen is utilized in the lower limbs of people who suffer from peripheral artery disease.
- Trial name
- NCT07313410
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Pregnancy Related, Pelvic Floor Disorders
Effects of Reformer Pilates in Pregnant Women
Pregnancy is known as a period associated with important physiological and psychological changes in women's lives. There is moderately sufficient evidence in the literature to recommend supplementing prenatal physical activity…
- Conditions
- Pregnancy Related, Pelvic Floor Disorders, Pain, Back, Pain, Neck
- Trial name
- NCT06777771
- Testing
- Reformer pilates exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Izmir Democracy University
Mild Cognitive Impairment, Cerebrovascular Disease
EGb 761 in the Syndrome of MCI With Concomitant CVD
EGb 761 has been demonstrated to be useful in improving cognitive and global clinical outcomes in patients with cognitive impairment or dementia, when administered at a daily dosage of 240mg in randomised controlled trials…
- Trial name
- NCT04525144
- Testing
- Tebonin Forte
- Where
- Singapore
- Volunteers
- 134 people
- Sponsor
- National Neuroscience Institute
Hemodialysis Access Failure, Kidney Disease, End-Stage
Low-Dose Apixaban Added to Standard Heparin Lock Versus Heparin Lock Alone to Prevent Tunneled Hemodialysis Catheters Dysfunction (APICATH-HD)
This randomized, single-center, PROBE trial evaluates whether adding low-dose apixaban (2.5 mg orally every 12 hours) to standard intraluminal heparin lock prolongs primary functional patency of tunneled hemodialysis catheters…
- Conditions
- Hemodialysis Access Failure, Kidney Disease, End-Stage, Hemodialysis Catheter
- Trial name
- APICATH-HD (NCT07404345)
- Testing
- Apixaban, Heparin sodium lock solution
- Where
- Mexico
- Volunteers
- 54 people
- Sponsor
- Hospital Civil de Guadalajara
Cognitive Dysfunction, Alzheimer Disease
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults…
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of
- Trial name
- NCT07392723
- Testing
- Alpha-Linolenic Acid (2.6 g/day)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michal Schnaider Beeri, Ph.D.
Stroke
Myofascial Dysfunction in Post Stroke Shoulder Pain
Shoulder pain is extremely common after stroke and occurs in 30-70% of patients. The pain may begin as early as one week after stroke, although peak onset and severity occurs around four months, and persists into the chronic…
- Trial name
- NCT06718413
- Testing
- hyaluronidase plus saline, saline
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Johns Hopkins University
Primary Graft Dysfunction, Lung Transplantation
Risk Factors That Increase the Chance of Developing Primary Graft Dysfunction After Lung Transplantation
Primary graft dysfunction (PGD) is a severe lung complication that can occur in the days after lung transplant surgery. This study will analyze blood samples to determine if high levels of certain chemicals may increase the risk…
- Trial name
- NCT00552357
- Where
- United States
- Volunteers
- 1,150 people
- Sponsor
- University of Pennsylvania
Microvascular Coronary Dysfunction, Cardiovascular Disease
WISE CVD - Continuation (WISE HFpEF)
The Women's Ischemia Study Evaluation (WISE), a cohort study of over 1000 women, has made many contributions to the understanding of cardiovascular disease.
- Trial name
- NCT02582021
- Testing
- Coronary Angiography, Coronary Reactivity Testing, Cardiac Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Cedars-Sinai Medical Center
Arterial Stiffness, White Matter Lesions
Effect of Equol Supplementation on Arterial Stiffness and Cognition in Healthy Volunteers
The ACE Trial, funded by the National Institute on Ageing/National Institutes of Health (NIH), is a multicenter clinical trial. The ACE Trial will determine if taking the dietary supplement Equol could slow the progression of…
- Conditions
- Arterial Stiffness, White Matter Lesions, Cognitive Decline
- Trial name
- ACE (NCT05741060)
- Testing
- S-equol
- Where
- 3 sites in United States
- Volunteers
- 369 people, healthy volunteers welcome
- Sponsor
- Akira Sekikawa
Dyspnea, Cardiopulmonary Dysfunction
Effect of Different Breathing Techniques on Dyspnea and Cardiopulmonary Parameters Among Patients After Open Heart Surgery
Open heart surgery is often associated with postoperative pulmonary complications, reduced lung expansion, dyspnea, and impaired cardiopulmonary function.
- Conditions
- Dyspnea, Cardiopulmonary Dysfunction, Postoperative Respiratory Dysfunction, Coronary Artery Disease
- Trial name
- NCT07591987
- Testing
- Segmental Breathing Exercises, Active Cycle Breathing Technique, Standard postoperative care
- Where
- 3 sites in Iraq
- Volunteers
- 99 people
- Sponsor
- University of Baghdad
Coronary Vasospasm, Coronary Microvascular Dysfunction
The NetherLands Registry of Invasive Coronary Vasomotor Function Testing (NL-CFT)
The goal of this registry is to collect data on patients referred for clinically indicated coronary vasomotor function test (CFT) and answer different questions on prevalence, safety and outcomes. The registry is observational.
- Conditions
- Coronary Vasospasm, Coronary Microvascular Dysfunction, Non-Obstructive Coronary Atherosclerosis
- Trial name
- NL-CFT (NCT06083155)
- Testing
- Coronary Function Test, Patient questionnaires
- Where
- 15 sites in Netherlands
- Volunteers
- 2,000 people
- Sponsor
- Radboud University Medical Center
Coronary Artery Disease, Left Ventricular Systolic Dysfunction
Preoperative Gastric Ultrasound and Left Ventricular Function in Coronary Artery Bypass Surgery
This study aims to investigate whether reduced heart function is associated with differences in stomach contents before elective coronary artery bypass graft (CABG) surgery.
- Conditions
- Coronary Artery Disease, Left Ventricular Systolic Dysfunction, Gastric Contents
- Trial name
- NCT07898215
- Testing
- Gastric Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Adiyaman University
Right Ventricular Dysfunction, Cardiopulmonary Diseases
Right Heart and Lung Blood Flow During Exercise (RIGHT-NET 2.0)
RIGHT-NET 2.0 is a multicenter observational study with a retrospective-prospective design that builds on the original RIGHT-NET study.
- Conditions
- Right Ventricular Dysfunction, Cardiopulmonary Diseases, Pulmonary Hypertension
- Trial name
- RIGHT-NET 2 (NCT07851610)
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- IRCCS SYNLAB SDN
Septic Shock
Effects of Hemoadsorption on Vascular Integrity in Septic Shock
This study aims to investigate the effects of adjunctive CytoSorb hemoadsorption therapy versus standard medical treatment on endothelial dysfunction in patients with refractory septic shock.
- Trial name
- ADSORP-VIP (NCT07711197)
- Testing
- CytoSorb hemoadsorption, Standard Medical Therapy (SMT)
- Where
- Hungary
- Volunteers
- 110 people
- Sponsor
- Semmelweis University