Clinical trials: Vascular Cognitive Impairment
Dementia, Mild Cognitive Impairment
SAMi Intervention Study to Evaluate Smartwatch Interventions in Persons With MCI and Dementia
Assistive Technologies (ATs) can help people living with dementia (PwD) maintain their everyday activity. Still, there is a gap between potential and supply. Involving future users can close the gap.
- Conditions
- Dementia, Mild Cognitive Impairment, Alzheimer Disease, Dementia With Lewy Bodies
- Trial name
- SAIN_UMR (NCT05885620)
- Testing
- drinking reminder and cognitive task (smartwatch-based application)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Rostock
Dementia, Cognitive Impairment, Mild
Cognitive Stimulation Therapy for Dementia: A Two-Armed Pragmatic Trial
Cognitive Stimulation Therapy (CST) is an evidence-based non-pharmacological group therapy shown to benefit people with mild to moderate dementia.
- Conditions
- Dementia, Cognitive Impairment, Mild, Dementia, Vascular, Dementia, Mixed
- Trial name
- NCT05860127
- Testing
- Referral for Cognitive Stimulation Therapy, No change to Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 133 people
- Sponsor
- University of Massachusetts, Amherst
Cerebrovascular Disorders
Daphnetin Capsule In the Treatment of VaScular COgnitive Impairment Without Dementia
The purpose of this clinical trial is to understand and evaluate the clinical efficacy and safety of Daphnetin Capsule in patients with vascular cognitive impairment.
- Trial name
- DISCO (NCT06507488)
- Testing
- Daphnetin Capsule
- Where
- China
- Volunteers
- 206 people
- Sponsor
- First People's Hospital of Shenyang
Cognitive Decline, Stroke
Identification of Epigenetic Risk Factors for Ischemic Complication During the TAVR Procedure in the Elderly
Over the past ten years, the number of endovascular procedures has increased by 5% per year in Europe with the development of interventional cardiology, such as percutaneous coronary angioplasty, aortic valve replacements (TAVR)…
- Trial name
- METHYSTROKE (NCT02972008)
- Where
- France
- Volunteers
- 542 people
- Sponsor
- University Hospital, Lille
Vascular Cognitive Impairment, Post-stroke Depression
Cognition and Affect After Stroke: a Prospective Evaluation of Risks
Stroke is a leading cause of disability, affecting about 34,000 to 41,000 individuals in the Netherlands of middle and old age every year.
- Conditions
- Vascular Cognitive Impairment, Post-stroke Depression, Post-stroke Apathy, Post-stroke Dementia
- Trial name
- CASPER (NCT02585349)
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- Maastricht University Medical Center
Stroke Sequelae, Cognitive Impairment
Remote Bimanual Virtual Rehabilitation Post CVD
The aim of the study is to develop the BrightBrainer G (grasp), a game-based upper-extremity motor and cognitive rehabilitation system using custom virtual reality simulations.
- Conditions
- Stroke Sequelae, Cognitive Impairment, Depression
- Trial name
- NCT04713384
- Testing
- Integrative tele-rehalitation of chronic stroke survivors using custom therapeutic games
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Grigore Burdea
Aging, Parkinson Disease
Beam Walking Across the Lifespan for Falls Prediction
Background: Dynamic balance keeps the vertical projection of the center of mass within the base of support while the center of mass moves. The age-related decrease in dynamic balance is a risk factor for falls.
- Conditions
- Aging, Parkinson Disease, Stroke, Dementia
- Trial name
- BEAM (NCT03532984)
- Testing
- Beam test to predict falls
- Where
- 5 sites in Brazil, Germany and 3 more
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Dysphagia, Cerebral Small Vessel Diseases
Stellate Ganglion Block in Patients With Cerebral Small Vessel Disease
A prospective study was conducted on 84 CSVD patients with dysphagia and cognitive impairment. They were divided into the comparison group and observation group evenly.
- Conditions
- Dysphagia, Cerebral Small Vessel Diseases, Cognitive Impairment
- Trial name
- NCT06176404
- Testing
- Stellate ganglion block, Rehabilitation therapy
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Zeng Changhao
Stroke, Cognitive Impairment
The Treatment Effectiveness of Combined tDCs and Neurofeedback (NF) for Patients With Cognitive Deficits After Stroke
This is a double blinded, randomized control trial with a pretest-posttest control and interventional groups design. Both the assessor and participants are blinded to all assessments and evaluations.
- Trial name
- NCT03093142
- Testing
- tDCS & neurofeedback, neurofeedback
- Where
- Hong Kong
- Volunteers
- 45 people
- Sponsor
- Kowloon Hospital, Hong Kong
Brain Metastases, Meningiomas
Measuring and Mapping Cognitive Decline After Brain Radiosurgery
Background Stereotactic Radiosurgery (SRS) is a localised radiotherapy treatment for patients with brain metastases or other benign tumours in the brain, like meningiomas.
- Conditions
- Brain Metastases, Meningiomas, Stereotactic Radiosurgery, Cognitive Decline
- Trial name
- CoDeB-Rad (NCT06466720)
- Testing
- Neurocognitive testing, Quality of Life questionnaire, Stereotactic radiosurgery
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Nottingham
Cerebral Small Vessel Diseases, Cognitive Impairment
Lacunar Intervention Trial 1 (LACI-1)
Phase II pilot randomised, factorial, short term dose escalation, open label, blinded intermediary endpoint trial, in two hospital centres in the UK, of tolerability and safety of cilostazol, isosorbide mononitrate, both or…
- Conditions
- Cerebral Small Vessel Diseases, Cognitive Impairment, Stroke
- Trial name
- Prevent-SVD (NCT02481323)
- Testing
- isosorbide mononitrate, cilostazol
- Where
- 2 sites in United Kingdom
- Volunteers
- 57 people
- Sponsor
- University of Edinburgh
Sturge-Weber Syndrome
Novel Cognitive Treatment Targets for Epidiolex in Sturge- Weber Syndrome
The purpose of this study is to better understand the utility of cannabidiol (CBD/ Epidiolex) for improving the treatment of cognitive impairments in Sturge-Weber syndrome (SWS).
- Trial name
- NCT04447846
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Anne Comi, MD
Vascular Dementia, Cerebral Small Vessel Diseases
Trial of Remote Ischemic Pre-conditioning in Vascular Cognitive Impairment
Cerebral small vessel disease is a common cause of cognitive impairment. Remote ischemic pre-conditioning (RIC) is a technique to induce brief periods of limb ischemia-reperfusion that is hypothesized to increase tolerance of the…
- Conditions
- Vascular Dementia, Cerebral Small Vessel Diseases, Cerebral Small Vessel Ischaemic Disease, Vascular Cognitive Impairment
- Trial name
- TRIC-VCI (NCT04109963)
- Testing
- Remote ischemic conditioning
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of Calgary
Ischemic Stroke, Blood Pressure
Optimal Blood Pressure for the prevenTIon of Major vAscuLar Events in Stroke Patients
Elevated blood pressure (BP) consists of a major public health concern especially in low and middle income countries. Besides being a highly prevalent condition, it is also a risk factor for several major cardiovascular events…
- Conditions
- Ischemic Stroke, Blood Pressure, Cognitive Impairment, Vascular Diseases
- Trial name
- OPTIMAL Stroke (NCT04036409)
- Testing
- Intensive Control of Systolic Blood Pressure (SBP), Standard control of Systolic Blood Pressure (SBP)
- Where
- 30 sites in Brazil
- Volunteers
- 4,368 people
- Sponsor
- Hospital Israelita Albert Einstein
Carotid Artery Stenosis
Effect of Carotid Artery Stent on Evoked Cerebral Blood Oxygenation and Neurocognitive Functioning
Cerebral hemodynamic compromise from internal carotid artery stenosis may be a cause of vascular cognitive impairment that is amenable to treatment by revascularization.
- Trial name
- NCT04651998
- Testing
- MMSE, MoCA, functional near-infrared spectroscopy
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Stroke
Effects of Combined Cognitive Training With Aerobic Exercise in Stroke Patients With MCI
Cognitive impairments have severe impact on functional recovery and quality of life after stroke. Current evidence indicated that combining exercise and cognitive training may provide additional benefits on cognition in stroke.
- Trial name
- NCT04012866
- Testing
- Aerobic exercise training, Computerized cognitive training, Control training
- Where
- 4 sites in Taiwan
- Volunteers
- 75 people
- Sponsor
- Chang Gung Memorial Hospital
Subarachnoid Aneurysm Hemorrhage, Microsurgery
Structural and Clinical Predictors of Cognitive Impairment After Surgical Treatment for Ruptured Cerebral Aneurysms
This study investigates the clinical and structural predictors of long-term cognitive impairment in patients who underwent microsurgical clipping for aneurysmal subarachnoid hemorrhage.
- Conditions
- Subarachnoid Aneurysm Hemorrhage, Microsurgery, Cognitive Impairment
- Trial name
- SCOPE-aSAH (NCT07723131)
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- University of Campinas, Brazil
Depression, Intracranial Atherosclerosis
Intracranial Atherosclerosis and Depression After Coronary Artery Bypass Graft
The purpose of the study is to examine if blood flow in the brain before coronary artery bypass graft surgery has an effect on depression after surgery.
- Conditions
- Depression, Intracranial Atherosclerosis, Coronary Artery Disease
- Trial name
- NOAHS (NCT01838356)
- Where
- 2 sites in United States
- Volunteers
- 169 people
- Sponsor
- Yale University
Carotid Stenosis, Postoperative Cognitive Dysfunction
Neurocognitive Function After Carotid Thrombendarterectomy
Previous studies did not reach a consensus on the influence of the type of anesthesiologic procedure and monitoring, during carotid thrombendarterectomy, on perioperative complications and cognitive outcomes.
- Conditions
- Carotid Stenosis, Postoperative Cognitive Dysfunction, Neurological Impairment
- Trial name
- NCT05739357
- Testing
- NIRS, EEG
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- Clinical Hospital Centre Zagreb
Activities of Daily Living, Accidental Fall
Bingocize: A Novel Mobile Application for Older Adult Health
This study tests the effectiveness of using a new mobile application (Bingocize®) to improve older adults' (a) adherence to an engaging exercise program, and (b) aspects of functional performance, health knowledge, dietary…
- Conditions
- Activities of Daily Living, Accidental Fall, Sarcopenia, Arteriosclerosis
- Trial name
- Bingocize (NCT03629912)
- Testing
- Socially-Based Exercise Intervention for Older Adults
- Where
- 4 sites in United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Western Kentucky University