Clinical trials: Vaping, open to volunteers
Nicotine Use Disorder
Real-time eCounselling for Nicotine Addiction
The goal of this clinical trial is to pilot an eHealth intervention (real-time telecounselling) in nicotine addiction. The main questions it aims to answer are: Is the intervention likely to be efficacious in preventing an…
- Trial name
- NCT06544057
- Testing
- CBT-MI
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Overcome
Vaping, Blood Vessel Injury
Early Detection of Vaping-related Vascular Diseases
The purpose of this study is to determine how vaping affects blood vessels, in particular if early damage occurs in the lung vessels.
- Trial name
- ENDS (NCT05454267)
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Miami
Vaping
A Virtual Reality Vaping Prevention Intervention for Adolescents
This study will examine E-Invite Only VR, a novel school-based universal e-cigarette prevention intervention that uses virtual reality (VR) to deliver prevention and emotion regulation skills-building content to middle school…
- Trial name
- NCT07362069
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yale University
Tobacco Use Disorder, Nicotine Dependence
TUBSIS 2.0 - Tobacco Use Behavioral Support and Intervention System
Background: Tobacco smoking and vaping remains public health concern, with many adults continuing to experience difficulties accessing appropriate support for smoking cessation in Switzerland and Türkiye.
- Conditions
- Tobacco Use Disorder, Nicotine Dependence, Vaping, Smoking Tobacco
- Trial name
- TUBSIS_2_0 (NCT07568483)
- Testing
- TUBSIS 2.0
- Where
- Switzerland
- Volunteers
- 406 people
- Sponsor
- University of Zurich
Vaping, Addiction
The Use of tDCS for Vaping Reduction
Project Summary - tDCS for Vaping Reduction Background: While the prevalence of tobacco smoking has plateaued over the last several years, the prevalence of nicotine vaping (e-cigarettes) continues to increase exponentially in…
- Conditions
- Vaping, Addiction, Transcranial Direct Current Stimulation(tDCS)
- Trial name
- NCT06885606
- Testing
- Active tDCS
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Addiction and Mental Health
Tobacco Smoking, Harm Reduction
Smoking Harm Reduction Using E-cigarettes and Cytisine
Smoking remains the leading cause of preventable death globally, with high prevalence in disadvantaged populations despite access to free nicotine replacement therapy (NRT) and counseling through Ontario's STOP Program.
- Conditions
- Tobacco Smoking, Harm Reduction, Nicotine
- Trial name
- SHRECC (NCT07274475)
- Testing
- E-cigarette e-liquid, Cytisine
- Volunteers
- 6,000 people
- Sponsor
- Centre for Addiction and Mental Health
E-cigarette Use
Sex Differences in the Vascular Effects of E-cigarette Use
The use of electronic nicotine delivery systems, or e-cigarettes - colloquially referred to as "vaping" - in the United States has increased exponentially since their introduction to the US market in 2007.
- Trial name
- NCT06159608
- Testing
- Local heating + L-NAME (NG-nitro-L-arginine methyl ester; nitric oxide synthase inhibitor), Chronic estrogen exposure
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Vaping
E-cigarette Social Media Marketing and Its Perceptions by Youth
The proposed study will conduct two randomized between-subject experiments among 6,000 adolescents (per each experiment) recruited nationwide to test the effects of audio-visual features of e-cigarette influencer marketing on…
- Trial name
- NCT07694739
- Testing
- Exposure to Influencer Age and Context Variations in E-Cigarette Marketing
- Where
- United States
- Volunteers
- 6,000 people
- Sponsor
- University of Southern California
Nicotine, Vaping
Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine and Nicotine Analogues
Electronic cigarettes are battery-operated devices that can produce an aerosol by heating a liquid which commonly contains nicotine.
- Conditions
- Nicotine, Vaping, Synthetic Nicotine, Nicotine Analogues
- Trial name
- NCT07348224
- Testing
- Vaping of synthetic S-nicotine, Vaping of racemic nicotine (S-/R-nicotine), Vaping of 6-methylnicotine
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
E-cigarette, Alcohol
Flavored Ready-to-Drink Alcohol Restriction in Young Adults: Behavioral and Biomarker Outcomes
This pilot randomized behavioral study evaluates the feasibility, adherence, and acceptability of an intervention to restrict flavored ready-to-drink (RTD) alcoholic beverages among young adults who regularly use both alcohol and…
- Trial name
- NCT07840625
- Testing
- Flavored Ready-to-Drink alcoholic beverage use restriction
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Nicotine Labeling for E-cigarettes
Survey to Test the Nicotine Concentration and Nicotine Flux Labels for E-cigarettes
Current labels for the nicotine in e-cigarette/vaping products do not sufficiently convey information to the public. The aims of this study include developing and validating two new types of labels for the nicotine in vaping…
- Trial name
- NCT07553585
- Testing
- Updated Labeling
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Yale University
Vaping Cessation
Phase 3 Trial Evaluating the Efficacy and Safety of Cytisinicline for Vaping Cessation in Adults Using Nicotine-Containing E Cigarettes
This will be a multi-center, double-blind, randomized, placebo-controlled, Phase 3 study conducted in male or female adults who are daily nicotine e-cigarette users only.
- Trial name
- ORCA-V2 (NCT07392125)
- Testing
- Cytisinicline, Behavioral Support
- Volunteers
- 800 people
- Sponsor
- Achieve Life Sciences
Electronic Cigarette Related Lung Damage
Dissolved Phase HXe-129 MRI: A Novel Biomarker to Quantify Pulmonary Pathology
A two-center, longitudinal assessment of 40 electronic cigarette users and 40 healthy controls at the initial visit and a follow-up visit 12 months later.
- Trial name
- ECig (NCT06856525)
- Testing
- Hyperpolarized xenon 129, Cardiopulmonary Stress Test, Pulmonary Function Test
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Y. Michael Shim, MD
Tobacco Use Disorder
Nicotine Regulation for Dual Users of E-cigarettes and Cigarettes
Cigarette smoking remains the leading cause of preventable morbidity and mortality in the US. Use of multiple tobacco products is becoming increasingly prevalent, with dual use of e-cigarettes and cigarettes representing the most…
- Trial name
- RDEC (NCT06614504)
- Testing
- Varying the nicotine content of cigarettes, Varying the nicotine content of e-cigarettes
- Where
- 2 sites in United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Vaping Cessation
Nicotine Patch Plus Nicotine Mouth Spray Versus Nicotine Reduction for Vaping Cessation
This research focuses on maximizing the chances of successfully quitting vaping. A large, pragmatic community-based clinical trial is planned in New Zealand to build on existing evidence from previous vaping and smoking cessation…
- Trial name
- EQUIT3 (NCT06832098)
- Testing
- Nicotine patches plus nicotine mouth spray, Nicotine Tapering Plan
- Where
- New Zealand
- Volunteers
- 774 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Vaping Behaviors, Message Exposure
A Text Messaging Trial to Test Vaping Health Messages Optimized to Young Adults' Vaping Status
The goal of this study is to examine if e-cigarette education messages delivered using a source and presentation tailored to one's vaping status influences young adults' vaping behaviors.
- Conditions
- Vaping Behaviors, Message Exposure, Young Adults
- Trial name
- NCT07038317
- Testing
- Intervention, Control
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Cannabis Use, Tobacco
Lung Health and Breath Biomarkers: Acute Effects of Inhaled Cannabis
This outpatient study examines how inhaled cannabis, combustible or vaporized, alters lung health and breath biomarkers compared to a tobacco cigarette.
- Conditions
- Cannabis Use, Tobacco, Biomarkers
- Trial name
- NCT07694466
- Testing
- Cannabis (THC), Tobacco Cigarette
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hannah Harris
Cannabis Use, Tobacco Use
Effect of Cannabis on E-Cigarette Use Behavior
The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of electronic cigarettes.
- Conditions
- Cannabis Use, Tobacco Use, Electronic Cigarette Use
- Trial name
- NCT06609109
- Testing
- THC High Dose, THC Low Dose, THC 0mg
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
E Cigarette Use, Cessation, Tobacco
Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette Use
This study aims to improve understanding of how people who use electronic cigarettes (ECIGs or e-cigarettes) respond when they try to stop using them and whether nicotine replacement therapy (NRT) can make that process easier.
- Conditions
- E Cigarette Use, Cessation, Tobacco, Cessation, Nicotine
- Trial name
- NCT07786896
- Testing
- Nicotine Replacement Therapies, Brief Behavioral Counseling
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- West Virginia University
Cigarette Smoking-Related Carcinoma, E-Cig Use
Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use Cigarettes, E-cigarettes and Cannabis (Co-Tox Study)
This study evaluates the amount of nicotine, cannabis, and toxicants linked to the use of nicotine e-cigarette and/or cannabis products in the blood and urine of young adult users as well as the cannabis and nicotine use…
- Trial name
- NCT07167225
- Testing
- Effectiveness of different recruitment approaches, Choice of study completion locations, Cannabis Engagement Assessment
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute