VapingENDSNCT05454267
Early Detection of Vaping-related Vascular Diseases
An observational study of Vaping and Blood Vessel Injury, run by University of Miami at 1 site in United States.
Trial summary
The purpose of this study is to determine how vaping affects blood vessels, in particular if early damage occurs in the lung vessels. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Vaping, Blood Vessel Injury
- How many people
- 90 participants
- Where
- 1 siteUnited States
- Study dates
- 12 Sep 2022to 31 Dec 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Study population: Healthy non smokers and vapers residing in Florida
Who may be able to join
- Vapers Group:
- Current electronic cigarette (EC) Puff Bar users defined as using EC either daily or occasionally in the past 30 days for at least 6 months, and with 5% nicotine concentration pods.
- Adults aged 18-40 years
- Healthy Group:
- Healthy never smokers, never vapers
- Adults aged 18-40 years
Who cannot join
- Current or past smoking of tobacco cigarette (TC) or other tobacco/nicotine products (e.g., smokeless tobacco, Hookah) or marijuana will be excluded from the study.
- Subjects with self-reported history of chronic health problems including asthma, chronic obstructive pulmonary disease (COPD), morbid obesity (BMI>40 kg/m2), hypertension or diabetes
- Pregnant or breastfeeding women
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
University of Miami Health System
Miami, Florida, 33136
Michael Campos, MD, 3052436388, mcampos1@med.miami.edu
Adam Wanner, MD
About this study
The purpose of this study is to determine how vaping affects blood vessels, in particular if early damage occurs in the lung vessels.
- Conditions
- Vaping, Blood Vessel Injury
- Medical subject headings
- Vaping, Vascular System Injuries
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Healthy Volunteer Group | Participants who have never smoked or vaped | |
| High Frequency Vaping Group | Participants who vape >20 days per month. | |
| Low-Frequency Vaping Group | Participants who vape < 20 days per month |
What is being measured
The primary outcome is the main question the study is designed to answer.
Airway blood flow reactivity (QAW)
QAW will be measured via soluble gas uptake method
Measured: Up to 1 week
Pulmonary vascular resistance (PVR)
PVR will be measured via echocardiography
Measured: Up to 4 weeks
Flow-mediated vasodilation (FMD)
FMD will be measured by blood pressure cuff deflation using ultrasound
Measured: Up to 4 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Jul 2022
- Study start12 Sep 2022
- Primary completion30 Jun 2027 (estimated)
- Study completion31 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for VapingStudies of the same condition, open and under way.
- More trials run by University of MiamiThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 90 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Miami
- Sponsor type
- University, hospital or other
- Collaborators
- Florida Department of Health
- Responsible party
- Principal investigator, Adam Wanner, University of Miami
- Investigators
- Adam Wanner, MD, Principal investigator, University of Miami
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05454267
- Sponsor's protocol ID
- 20211060
- Acronym
- ENDS
- Status last verified
- May 2026
- First submitted
- 30 Jun 2022
- Last updated
- 15 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Early Detection of Vaping-related Vascular Diseases
- ClinicalTrials.gov ID
- NCT05454267
- Acronym / sponsor ID
- ENDS / 20211060
- Conditions
- Vaping, Blood Vessel Injury
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 90 participants (estimated)
- Lead sponsor
- University of MiamiUniversity, hospital or other
- Collaborators
- Florida Department of Health
- Study start
- 12 Sep 2022 (actual)
- Primary completion
- 30 Jun 2027 (estimated)
- Study completion
- 31 Dec 2027 (estimated)
- First posted
- 12 Jul 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to determine how vaping affects blood vessels, in particular if early damage occurs in the lung vessels.
Study design
- Observational model
- Other
- Time perspective
- Cross-sectional
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Healthy Volunteer Group | – | –Participants who have never smoked or vaped |
| High Frequency Vaping Group | – | –Participants who vape >20 days per month. |
| Low-Frequency Vaping Group | – | –Participants who vape < 20 days per month |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- Healthy non smokers and vapers residing in Florida
Key inclusion criteria (6 listed)
- Current electronic cigarette (EC) Puff Bar users defined as using EC either daily or occasionally in the past 30 days for at least 6 months, and with 5% nicotine concentration pods.
- Adults aged 18-40 years
- Healthy never smokers, never vapers
- Adults aged 18-40 years
Key exclusion criteria (3 listed)
- Current or past smoking of tobacco cigarette (TC) or other tobacco/nicotine products (e.g., smokeless tobacco, Hookah) or marijuana will be excluded from the study.
- Subjects with self-reported history of chronic health problems including asthma, chronic obstructive pulmonary disease (COPD), morbid obesity (BMI>40 kg/m2), hypertension or diabetes
- Pregnant or breastfeeding women
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Airway blood flow reactivity (QAW)
Time frame: Up to 1 week
QAW will be measured via soluble gas uptake method
Pulmonary vascular resistance (PVR)
Time frame: Up to 4 weeks
PVR will be measured via echocardiography
Flow-mediated vasodilation (FMD)
Time frame: Up to 4 weeks
FMD will be measured by blood pressure cuff deflation using ultrasound
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 May 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Adam Wanner, MD principal investigator
University of Miami
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Vaping and Blood Vessel Injury, run by University of Miami at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 15 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Adam Wanner, MD ((305)243-2568, awanner@med.miami.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Airway blood flow reactivity (QAW) (time frame: Up to 1 week). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 May 2026.