Clinical trials: VRE Colonization
Infection Due to Resistant Organism
FMT for MDRO Colonization After Infection in Renal Transplant Recipients
Transplant patients are at increased risk of colonization and infection with Multidrug Resistant Organisms (MDROs) due to medications that modify their immune systems, increased healthcare and antibiotic exposure, and surgical…
- Trial name
- PREMIX (NCT02922816)
- Testing
- Fecal Microbiota Transplant (FMT), Bowel preparation, Stool or perirectal swab sampling
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Emory University
MRSA Colonization, VRE Colonization
The Effect of Chlorhexidine Bathing on MRSA and VRE Colonization Among Haematology-Oncology ICU Patients
Hospital-acquired infections (HIs) are defined as an infection developed within 48-72 hours of admission to hospital in whom the infection was not incubating at the time of admission to the hospital or an infection acquired in…
- Trial name
- NCT04347057
- Testing
- Bed bathing with 2% CHG solution, Bed bathing with soap and water
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Hacettepe University
VRE Colonization, CRE Colonization
Human Clinical Trial to Evaluate the Decolonization Efficacy of BM111 Against Carbapenem-Resistant Enterobacteriaceae (CRE) and Vancomycin-Resistant Enterococcus (VRE)
A clinical study to eliminate intestinal colonization in subjects harboring microorganisms resistant to carbapenem and vancomycin antibiotics, thereby treating infections caused by these microorganisms.
- Trial name
- NCT07525089
- Testing
- BM111
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- BioMe Inc.
Antimicrobial Resistance, Colonization
Fecal Microbiota Transplantation for CRE/VRE
Multidrug-resistant organisms (MDRO) present an increasingly serious public health threat to the global community.The prevalence of various MDRO, including carbapenem-resistant Enterobacteriaceae (CRE) and vancomycin-resistant…
- Trial name
- NCT03479710
- Testing
- FMT infusion
- Where
- Hong Kong
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Intestinal Multi-drug Resistant Organism Colonization
Further MT for Antibiotic-Resistant Bacterial Colonization
The purpose of this study is to better understand the effectiveness and safety of microbiome therapies (MT) as a treatment for patients with Multidrug Resistant Organism (MDRO) colonization after an infection.
- Trial name
- FAIR (NCT05835206)
- Testing
- Microbiome Therapeutic
- Where
- 6 sites in United States
- Volunteers
- 40 people
- Sponsor
- Emory University
Liver Diseases
Vancomycin Resistant Enterococci in Patients Awaiting Liver Transplantation at the University of Michigan: Prevalence, Risk Factors, Natural History and Outcome of Colonization
Enterococci, especially vancomycin resistant enterococci (VRE), are increasing in prevalence in many hospitals in the United States.
- Trial name
- NCT00005667
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Antimicrobial Drug Resistance, Antibiotic Resistant Infection
Dynamics of Colonization and Infection by Multidrug-Resistant Pathogens in Immunocompromised and Critically Ill Patients
The goal of this observational study is to investigate how bacterial populations from the intestine and mouth of patients change during the hospitalization period and evaluate if some populations of specific bacteria increase or…
- Conditions
- Antimicrobial Drug Resistance, Antibiotic Resistant Infection, Clostridium Difficile, Carbapenem-Resistant Enterobacteriaceae Infection
- Trial name
- DYNAMITE (NCT06258551)
- Where
- 2 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
Multidrug Resistant Bacterial Infection, Enterobacteriaceae Infections
PMT for MDRO Decolonization
This is a randomized, open label, comparative Phase II trial being conducted to determine whether fecal microbiota transplant using Penn Microbiome Therapy (PMT) products helps standard therapy eradicate antibiotic-resistant…
- Conditions
- Multidrug Resistant Bacterial Infection, Enterobacteriaceae Infections, Pseudomonas Aeruginosa, VRE Infection
- Trial name
- NCT05632315
- Testing
- PMT
- Where
- 3 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of Pennsylvania
Nosocomial Bacteremia, MRSA Colonization
Multicenter Trial of Daily Chlorhexidine Bathing to Reduce Nosocomial Infections
To determine if daily bathing with chlorhexidine impregnated washcloths will reduce the incidence of MRSA and VRE within an Intensive Care Unit (ICU) or ward setting.
- Conditions
- Nosocomial Bacteremia, MRSA Colonization, MRSA Infection, VRE Colonization
- Trial name
- CBET (NCT00502476)
- Testing
- Bathing with Chlorhexidine Impregnated Washcloths
- Where
- 7 sites in United States
- Volunteers
- 14,000 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Hematopoietic Stem Cell Transplantation, Vancomycin-Resistant Enterococci
Theraworx Bath Wipes Versus Standard Bath Wipes in the Reduction of Vancomycin-Resistant Enterococci
Healthcare-associated infections (HAI) are associated with substantial morbidity, mortality and health-care costs in children undergoing hematopoietic stem cell transplantation (HSCT).
- Trial name
- NCT02241005
- Testing
- Theraworx™ bath wipes, Standard bath wipes
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- St. Jude Children's Research Hospital
Anti-biotic Resistance
A Pilot Trial to Determine the Efficacy of VSL#3 for Reducing Colonization by VRE
The purpose of this study is to investigate the feasibility, safety and efficacy of oral probiotic, VSL#3 versus oral placebo for reducing colonization by VRE.
- Trial name
- PROVE (NCT00933556)
- Testing
- VSL#3
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Wisconsin, Madison
Vancomycin-Resistant Enterococcal Colonization
Safety and Efficacy of Oral Administration of the Phage Cocktail, VRELysin™, In Healthy and VRE-Colonized Subjects
The study is a first-in-human Phase 1/2a randomized, double-blind, placebo-controlled trial to assess the clinical safety and efficacy of VRELysin in healthy and VRE-colonized adults.
- Trial name
- NCT05715619
- Testing
- VRELysin™
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Intralytix, Inc.
Infection
Reduction of Nosocomial Vancomycin -Resistant Enterococci (VRE) Colonization and Infection by Active Surveillance and Intervention of Infection Control
Vancomycin -resistant enterococci(VRE) has emerged as one of the most common nosocomial pathogen of health-care associated infection since 1988.
- Trial name
- NCT01201031
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Medical University WanFang Hospital
Vancomycin Resistant Enterococci Infection, Clostridium Difficile Infection
Hospital Design and Risk of Nosocomial Infections: A Prospective Controlled Trial
With the construction of a new medical teaching ward with features designed to reduce hospital-acquired infections, we hypothesized that the design of the new ward was the major factor that contributed to the improved outcomes…
- Conditions
- Vancomycin Resistant Enterococci Infection, Clostridium Difficile Infection, Nosocomial Infection, Methicillin Resistant Staphylococcus Aureus Infection (MRSA)
- Trial name
- NCT00563186
- Testing
- Admission to a novel hospital ward
- Where
- Canada
- Volunteers
- 1,514 people
- Sponsor
- University of Calgary
VRE Colonization
Microbiologic Effect of Selective Decontamination of the Digestive Tract With Colistin, Gentamicin and Nystatin
Selective decontamination of the digestive tract (SDD) is a prophylactic measure aimed at reducing Gram negative flora in the gut with an aim to reduce nosocomial infections such as ventilator-associated pneumonia.
- Trial name
- NCT00250133
- Testing
- Blood draws
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pittsburgh
VRE Colonization
Probiotic Efficacy in VRE Eradication
This study will evaluate the efficacy of a probiotic lactobacillus strain in eradicating VRE in non-symptomatic carriers after 4 weeks of treatment. It will also evaluate the long-term efficacy after 8,16 and 24 weeks.
- Trial name
- PROVE (NCT03560700)
- Testing
- lactobacillus probiotic strain
- Where
- Denmark
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
GI Colonization of Vancomycin-resistant Enterococcus
The Influence of Probiotics on Vancomycin-Resistant Enterococcus
Drinking probiotics in a the form of a yogurt drink will restore normal gastrointestinal (GI) bacteria in patients whose colon are colonized with vancomycin-resistant enterococcus (VRE).
- Trial name
- NCT00591474
- Testing
- probiotics, yogurt
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Oregon Health and Science University
Eluted Swab
Comparison of Elution Swab (ESwab) and Amies Transport Swabs for Screening Patients for Methicillin Resistant Staphylococcus Aureus (MRSA) and Vancomycin Resistant Enterococci (VRE) Colonization
1.To assess whether the Elution swab (ESwab) is superior to Amies transport swabs for the detection of Methicillin Resistant Staphylococcus aureus (MRSA) and Vancomycin Resistant Enterococci (VRE) in colonized patients and to…
- Trial name
- MRSA VRE (NCT00941122)
- Testing
- Eluted Swab
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Hamilton Health Sciences Corporation
Vancomycin (Glycopeptide) Resistant Enterococcus (VRE), Cancer
Cohort Study of German Hematological / Oncological Wards to Assess the Effect of Contact Precautions on Nosocomial Colonization With Vancomycin Resistant Enterococci
The study aims to evaluate the impact of contact precautions on the rate of VRE- the rate of colonization and infection aand hospital-acquired VRE transmissions.
- Trial name
- CONTROL (NCT02623413)
- Volunteers
- 950 people
- Sponsor
- University of Cologne
Vancomycin Resistant Enterococcal Colonization
Probiotic Lactobacillus GG to Eliminate VRE Colonization
The use of LGG will be associated with elimination of VRE colonization. The primary comparison will be VRE elimination rates among those patients that receive LGG compared to those that receive placebo.
- Trial name
- VRE (NCT00756262)
- Testing
- Lactobacillus GG or Culturelle
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Tufts Medical Center