Clinical trials: VF
Brugada Syndrome
Brugada Ablation of VF Substrate Ongoing MultiCenter Registry
Current treatment of high-risk Brugada Syndrome (BrS) patients (pts) with recurrent VF is limited. Catheter ablation (CA) has been performed for BrS but a large study with long-term outcomes of CA in BrS ablation are lacking.
- Trial name
- BRAVO (NCT04420078)
- Testing
- Catheter Ablation
- Where
- Thailand
- Volunteers
- 159 people
- Sponsor
- Pacific Rim Electrophysiology Research Institute
Out-Of-Hospital Cardiac Arrest, Ventricular Fibrillation
DOuble SEquential External Defibrillation for Refractory VF
Despite significant advances in resuscitation efforts, there are some patients who remain in refractory ventricular fibrillation (VF) during out-of-hospital cardiac arrest.
- Trial name
- DOSEVF (NCT04080986)
- Testing
- Double Sequential Defibrillation, Vector Change Defibrillation
- Where
- 6 sites in Canada
- Volunteers
- 405 people
- Sponsor
- Sunnybrook Health Sciences Centre
Haemophilia B
A Study to Investigate the Safety and Efficacy of Replenine®-VF in Haemophilia B Patients Under the Age of 6 Years
The objective of this study was to assess the safety and efficacy of Replenine®-VF in children enrolled in the study, under the age of six years, with severe haemophilia B.
- Trial name
- NCT02263469
- Testing
- Replenine®-VF (High Purity Factor IX)
- Where
- 4 sites in Poland, Ukraine
- Sponsor
- Bio Products Laboratory
Brugada Syndrome, Early Repolarization Syndrome
VF Mapping in Brugada and Early Repolarization Syndromes
To determine the values and limitations of ECGI in guiding ablation and risk stratification in patients with BrS and Early Repolarization.
- Trial name
- NCT03764592
- Testing
- radiofrequency ablation
- Where
- 2 sites in Thailand
- Volunteers
- 50 people
- Sponsor
- Pacific Rim Electrophysiology Research Institute
Haemophilia B
A Study to Investigate the Safety and Efficacy of Replenine®-VF in Haemophilia B Patients Undergoing Major Surgery.
The main objective of the study is to investigate the safety and efficacy of Replenine®-VF administered by continuous infusion in appropriate dosage to prevent bleeding and achieve haemostasis in patients with haemophilia B…
- Trial name
- NCT02250560
- Testing
- Replenine®-VF (High Purity Factor IX)
- Where
- 5 sites in United Kingdom
- Sponsor
- Bio Products Laboratory
Cardiomyopathy
Comparison of VF Induction Techniques During Medtronic ICD Implant (VF) (ICD)
As the indications for Implantable Cardioverter Defibrillator implantation expand, minimizing implant time is critical. Also, patients receiving biventricular ICDs are sometimes more unstable and minimization of sedation time is…
- Trial name
- VF (NCT02027883)
- Testing
- Nominal T shock setting, Educated T shock setting
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- James Merrill
Cardiac Arrest, Fibrillation, Ventricular
Early Double Sequential Defibrillation in Out-of-hospital Cardiac Arrest
Some of the patients affected by Out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF)/ventricular tachycardia (VT) do not respond to initial defibrillation.
- Conditions
- Cardiac Arrest, Fibrillation, Ventricular, Sudden Cardiac Death, Sudden Cardiac Arrest
- Trial name
- DOUBLE-D (NCT06447805)
- Testing
- Double Sequential Defibrillation (DSD), Standard defibrillation
- Where
- 3 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Glaucoma, Filtering Surgery
Long-Term IOP Fluctuation and VF Progression After Triple Procedure
Long-term intraocular pressure (IOP) fluctuation may be significantly associated with the progression of glaucomatous visual field loss, even in patients kept always low IOP after triple procedure, an effective approach for…
- Conditions
- Glaucoma, Filtering Surgery, Intraocular Pressure
- Trial name
- NCT00428740
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Ventricular Tachycardia
Bipolar Ventricular Tachycardia (VT) Study
This non-randomized study will examine the safety and efficacy of irrigated bipolar radiofrequency (RF) ablation in the treatment of ventricular tachycardia (VT) in patients for whom standard VT unipolar RF ablation has been…
- Trial name
- NCT02374476
- Testing
- Bipolar Ablation
- Where
- 6 sites in United States
- Volunteers
- 145 people
- Sponsor
- Srinivas Dukkipati
Visceral Obesity
Comparison of Body Mass Index and Metabolic Score for Visceral Adiposity in Evaluation of Visceral Adiposity
Visceral obesity is a major risk factor for cardiometabolic diseases such as type 2 diabetes, hypertension, and coronary artery disease.
- Trial name
- NCT05648409
- Where
- Turkey (Türkiye)
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Goztepe Prof Dr Suleyman Yalcın City Hospital
Brugada Syndrome
Ablation in Brugada Syndrome for the Prevention of VF
This trial aims to develop evidence based curative treatment with optimal net benefit for patients with Brugada syndrome.
- Trial name
- BRAVE (NCT02704416)
- Testing
- Catheter Ablation
- Where
- 6 sites in Netherlands, Thailand
- Volunteers
- 200 people
- Sponsor
- Pacific Rim Electrophysiology Research Institute
Depression - Major Depressive Disorder, Cognitive Flexibility
Cognitive Flexibility in Depression and TMS Response
The primary aim of this study is to determine the level of cognitive flexibility in patients with TRD before treatment and to explore whether there is a relationship with their response to TMS treatment.
- Conditions
- Depression - Major Depressive Disorder, Cognitive Flexibility, Treatment Response, Side Effects
- Trial name
- CogFelx_TMS (NCT06775054)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
Amputation
Validation of the SIGAM/VF Mobility Grade
The objective of this study is to demonstrate the validity, the reproducibility and the coherence of the French version of the Special Interest Group in Amputee medicine (SIGAM) mobility scale questionnaire in adults with…
- Trial name
- SIGAM (NCT02859740)
- Testing
- SIGAM Questionnaire
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Neonatal Respiratory Distress
DIaphragmatic Swing According to Cpap Flow Output in NEOnates (DISCONEO)
The hypothesis behind the study is that the performance of constant flow CPAP (Continuous Positive Airway Pressure) devices (CF-CPAP) is not inferior to that of variable flow CPAP devices (VF-CPAP) in terms of respiratory efforts…
- Trial name
- NCT07513051
- Testing
- CF-CPAP; CF-CPAP; VF-CPAP; VF-CPAP, VF-CPAP; VF-CPAP; CF-CPAP; CF-CPAP, CF-CPAP; VF-CPAP; VF-CPAP; CF-CPAP
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Primary Immune Deficiency Disorders, Common Variable Immunodeficiency
Pharmacokinetics (PK) and Safety of Subgam-VF in Primary Immunodeficiency Diseases
The main objective of the study is to determine the pharmacokinetics profile of Subgam-VF. The secondary objectives are to assess the safety of Subgam-VF and refine the dose adjustment coefficient for Subgam-VF needed for…
- Conditions
- Primary Immune Deficiency Disorders, Common Variable Immunodeficiency, X-linked Agammaglobulinaemia, Hyperimmunoglobulin M Syndrome
- Trial name
- SCIG03 (NCT01884311)
- Testing
- Subgam
- Where
- 16 sites in United States
- Volunteers
- 38 people
- Sponsor
- Bio Products Laboratory
Implantable Cardioverter Defibrillator(ICD)
To Evaluate the Delivery Timing Safety and Efficacy of AntiTachycardia Pacing (BIO|ATP)
To compare Treatment Group (settings of Early Multiple ATP) and Control Group (settings of extended detection time for the conventional ATP) in Japanese patients, and confirm their safety and efficacy
- Trial name
- BIO|ATP (NCT05426785)
- Testing
- 1:1 ratio for Treatment Group and Control Group
- Where
- Japan
- Volunteers
- 398 people
- Sponsor
- Biotronik SE & Co. KG
Ventricular Fibrillation
DOuble SEquential External Defibrillation for Refractory VF Pilot Study
Despite significant advances in resuscitation efforts, there are some patients who remain in refractory ventricular fibrillation (VF) during out-of-hospital cardiac arrest.
- Trial name
- DOSE-VF (NCT03249948)
- Testing
- Vector change defibrillation, Double-sequential defibrillation
- Where
- 4 sites in Canada
- Volunteers
- 173 people
- Sponsor
- Sunnybrook Health Sciences Centre
Cardiac Arrest, Out-Of-Hospital, Ventricular Fibrillation
Ventricular Fibrillation Following Out-of-hospital Cardiac Arrest
The majority of survivors suffering an out-of-hospital cardiac arrest (OHCA) are those who initially present with a shockable rhythm, which is usually ventricular fibrillation (VF).
- Trial name
- NCT05325385
- Testing
- There are no interventions - this is a database study only
- Where
- United Kingdom
- Volunteers
- 15,000 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Ventricular Tachycardia, Ventricular Fibrillation
Unpinning Termination Therapy for VT/VF
This study is intended to develop a better method for stopping potentially lethal heart rhythms than currently available defibrillators.
- Trial name
- NCT03871231
- Testing
- Unpinning Termination Therapy
- Where
- 4 sites in Australia
- Volunteers
- 8 people
- Sponsor
- Cardialen, Inc.
Preterm Birth, Infection
VF Test for Prediction of Extremely PTB After Cerclage
The purpose of this research study is to determine if a vaginal fluid (VF) test can predict very early preterm birth in patients who are scheduled to have an exam indicated cerclage for severe cervical shortening.
- Trial name
- NCT03443154
- Testing
- VF-Test
- Sponsor
- Pediatrix