Clinical trials: VA-ECMO
Cardiopulmonary Arrest, VA-ECMO
Optimized CT-imaging Protocol in VA-ECMO Patients After CPR
Veno-arterial (VA) extracorporal membrane oxygenation (ECMO) is an increasingly applied method in patients under cardiopulmonary resuscitation (CPR), who are regularly examined with a contrast-enhanced computed tomography to…
- Trial name
- NCT05290805
- Testing
- ECMO flow rate reduction
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Individualized or Conventional Transfusion Strategies During Peripheral VA-ECMO
This multicenter randomized controlled trial compare two transfusion strategies of red blood cells transfusion in patients supported by veno-arterial extracorporeal membrane oxygenation for refractory cardiogenic shock.
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation, Transfusion Related Complication, Anemia
- Trial name
- ICONE (NCT05699005)
- Testing
- Packed Red Blood Cells (PRBCs)
- Where
- 4 sites in France
- Volunteers
- 236 people
- Sponsor
- University Hospital, Lille
Covid-19
Bicentric Study on the Use of ECMO-VV or VA for Severe ARDS Associated With Covid-19
Describes the cohort of patients receiving ECMO-VV or ECMO-VA in the management of severe ARDS refractory to SARS-CoV-2 in the Strasbourg and Louvain centres
- Trial name
- ECMO-SL-CoV-2 (NCT04446286)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Cardiac Arrest, Cardiopulmonary Arrest
ECMELLA vs. ECMO on 30-day Mortality
This international, multicenter cohort study aims to investigate outcomes after treatment with extracorporeal cardiopulmonary resuscitation (eCPR) during cardiac arrest.
- Conditions
- Cardiac Arrest, Cardiopulmonary Arrest, Extracorporeal Membrane Oxygenation Complication, Cardiogenic Shock
- Trial name
- NCT05175898
- Testing
- VA-ECMO, ECMELLA
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Cardiac Dysfunction
Population Pharmacokinetics of Teicoplanin, Levofloxacin, Piperacillin/Tazobactam, Meropenem, Vancomycin, Remifentanil, Cefepime, Cefpirome, Sufentanil, Midazolam, Clopidogrel, Ticagrelor, Prasugrel During Veno-arterial Extracorporeal Membrane Oxygenation (VA ECMO)
Extracorporeal membrane oxygenation (ECMO) is the device which increases the supply of oxygen to the body tissues in vitro and to assist in heart and lung function.
- Trial name
- NCT02581280
- Testing
- Residual blood
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Yonsei University
Microcirculation, Extracorporeal Membrane Oxygenation
Effects of Microcirculation-assisted Adjustment of Blood Flow of VA-ECMO on Prognosis
One of the key factors of survival of patients with extra-corporeal membrane oxygenation (ECMO) life support system is whether the blood flow supplied by ECMO can meet the need of perfusion of each organ.
- Trial name
- NCT03470792
- Testing
- Microcirculation examination
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Extracorporeal Life Support, Hypotension
Hypotension During Extracorporeal Circulatory Support Indicated for Cardiogenic Shock
The cardiogenic shock is characterized by an alteration of organs function following a decrease in cardiac output linked to an impairment of cardiac performance. The prognosis remains poor with mortality between 40 and 50%.
- Conditions
- Extracorporeal Life Support, Hypotension, Vasoplegia
- Trial name
- RetroECMO-VP (NCT03968926)
- Testing
- Arterial pressure management during circulatory support by VA-ECMO
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Montpellier
Cardiogenic Shock Acute
Early Preventive Left Ventricle Unloading After VA-ECMO for Refractory Cardiogenic Shock
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly being used worldwide to treat severe cardiogenic shock.
- Trial name
- EULODIA (NCT07027202)
- Testing
- Early Left Ventricle unloading
- Where
- 12 sites in France
- Volunteers
- 298 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiogenic Shock
Early Left Ventricular unLoading by Impella vs Intra-aortic Balloon Pump
Over the past decade, VA-ECMO has become the main mechanical support for cardiogenic shock (CS) unresponsive to medical therapy.
- Trial name
- ELLIPSE1 (NCT06645990)
- Testing
- Impella, IABP
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Cardiogenic Shock
Physiology of Unloading VA ECMO Trial
The goal of this clinical trial is to compare the use of veno-arterial extracorporeal membrane oxygenation (VA ECMO) with and without left ventricular (LV) unloading in patients being treated for cardiogenic shock (CS).
- Trial name
- NCT06336655
- Testing
- IABP
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Utah
Cardiogenic Shock
Establishing Physiologic Outcomes for Ventricular Unloading on VA ECMO
Aim 1: Prospective, observational analysis of the association between echocardiographic measures of cardiac function and left ventricular unloading on VA ECMO.
- Trial name
- NCT05658276
- Where
- 2 sites in United States, Canada
- Sponsor
- University of Utah
Cardiogenic Shock Acute, Bypass, Cardiopulmonary
Prognosis of Patients With Mixed Cardiogenic-Vasoplegic Shock
Mixed cardiogenic-vasoplegic shock (M-CS) represents a distinct and severe phenotype of cardiogenic shock characterized by concomitant myocardial dysfunction and inappropriate systemic vasodilation.
- Conditions
- Cardiogenic Shock Acute, Bypass, Cardiopulmonary, Septic Shock, Mechanical Circulatory Support
- Trial name
- PROMIX (NCT07354568)
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Out-Of-Hospital Cardiac Arrest
Rapid Response VA-ECMO in Refractory Out-of-hospital Cardiac Arrest
A selected group of patients with refractory cardiac arrest may benefit from inhospital treatment and this may warrant transfer to the hospital with ongoing CPR.
- Trial name
- RESuSCITATe (NCT03658759)
- Testing
- Extracorporeal Cardiopulmonary Resuscitation
- Where
- Netherlands
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Myocardial Infarction, Cardiogenic Shock
Assessment of ECMO in Acute Myocardial Infarction Cardiogenic Shock
Data from case series and large retrospective trials suggest that the early treatment of cardiogenic shock AMI patients with the association of VA-ECMO and IABP may significantly decrease mortality, which is still unacceptably…
- Trial name
- ANCHOR (NCT04184635)
- Testing
- VA-ECMO
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Hypertension of the Newborn (PPHN)
Circulatory Changes During Venovenous (VV)- and Venoarterial (VA) Extracorporeal Membrane Oxygenation (ECMO)
Rationale: Persistent pulmonary hypertension of the newborn (PPHN) is a life threatening disease with a high mortality rate. Extracorporeal Membrane Oxygenation (ECMO) with veno-arterial (V-A) or veno-venous (V-V) cannulation can…
- Trial name
- ECMO (NCT00622492)
- Testing
- echocardiography Doppler sonography, blood and urine sampling
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Cardiogenic Shock
A Study on the Effects of Left Ventricular Unloading in the Setting of VA ECMO Support
REMAP ECMO is a registry based platform in which multiple response adaptive randomized clinical trials (trial domains) will be embedded.
- Trial name
- REMAP ECMO (NCT05913622)
- Testing
- Intra-aortic balloon pump
- Where
- 14 sites in Belgium, Netherlands
- Volunteers
- 430 people
- Sponsor
- Erasmus Medical Center
ECMO, Mplementation of a Veno-venous VV or Veno-arterial VA
EVOLUTION OF D-DIMER AS A MARKER OF BLEEDING RISK ON ECMO
ECMO (extracorporeal membrane oxygenation) is a life-saving device, used in intensive care to treat severe respiratory or cardiac failure. However, it carries a high risk of serious life-threatening bleeding.
- Conditions
- ECMO, Mplementation of a Veno-venous VV or Veno-arterial VA, INTENSIVE CARE
- Trial name
- ECMOstase2 (NCT07039513)
- Testing
- Blood sampling collection
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Extracorporeal Membrane Oxygenation
The Consistency of Cardiac Output Measurements by Different Methods in VA-ECMO Patients
Objective： 1. To evaluate the consistency of cardiac output measured by different hemodynamic monitoring methods in patients with VA-ECMO 2.
- Trial name
- NCT04102072
- Testing
- Trendelenburg Maneuver, dobutamine stress test
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Zhongshan Hospital
EMCO-VA
Vaso-inotropic Score and ECMO-VA Support in Post-cardiotomy Cardiogenic Shock.
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a well-established lifesaving treatment for refractory cardiogenic shock, with or without concomitant respiratory failure.
- Trial name
- ECMOVIS (NCT05412303)
- Testing
- data collection
- Where
- France
- Volunteers
- 2,769 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Cardiac Rhythm Disorder
Incidence and Morbidity of Cardiac Rhythm Disorders in Patients Assisted by ECMO-VA for Refractory Cardiogenic Shock
Brief Summary : Rhythm disorders are a frequent and potentially serious complication of critical patients in the ICU and postoperative cardiac surgery.
- Trial name
- CAVA-ECMO (NCT05788120)
- Testing
- Follow up by phone call
- Where
- 20 sites in France
- Volunteers
- 600 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris