Clinical trials: Urolithiasis, Calcium Oxalate
Kidney Stones, Urolithiasis
Pilot Study to Evaluate the Contribution of Gene Variants to Idiopathic Urolithiasis
Recent investigations from this group have identified that genetic variants of genes associated with monogenic forms of nephrolithiasis are expressed in idiopathic calcium oxalate kidney stone patients and could influence stone…
- Conditions
- Kidney Stones, Urolithiasis, Calcium Oxalate Urolithiasis
- Trial name
- NCT01127854
- Where
- United States
- Volunteers
- 2,900 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Calcium Oxalate Urolithiasis
Mineral Water for Prevention of Renal Stones
The investigators would like to assess if the intake of high bicarbonate mineral water would not only increase total fluid intake but will also be able to give patients the additional benefit of correcting the urinary…
- Trial name
- NCT04638166
- Testing
- Mineral water, Plain water
- Where
- Singapore
- Volunteers
- 58 people
- Sponsor
- Singapore General Hospital
Kidney Stones, Urolithiasis, Hypocitraturia, Nephrolithiasis
Sodium Bicarbonate as an Alternative to Potassium Citrate for Kidney Stones
Kidney stones affect 1 in every 11 people in the US each year. In patients with kidney stones who are prescribed medications for stone management, only 30.2% are adherent to a medication regime and even fewer, only 13.4 % are…
- Trial name
- NCT07408076
- Testing
- Potassium Citrate, Sodium Bicarbonate
- Where
- 6 sites in United States, Canada and 1 more
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
Urolithiasis, Calcium Oxalate, Ureteroscopy
Clinical Trial of VISOR vs fURS for Upper Urinary Tract Stone
This prospective randomized controlled clinical study aims to evaluate the safety and efficacy of a novel Vortex Intelligence Stone Optimized Removal (VISOR,The experimental group) system compared to a single-use ureterorenoscope…
- Conditions
- Urolithiasis, Calcium Oxalate, Ureteroscopy, Therapeutic Irrigation, Intraoperative Complications
- Trial name
- VISOR (NCT07181759)
- Testing
- VISOR, fURS
- Volunteers
- 100 people
- Sponsor
- Ningbo No. 1 Hospital
Cystinuria, Nephrolithiasis, Calcium Oxalate
Use of an Herbal Preparation to Prevent and Dissolve Kidney Stones
We will investigate the safety and effectiveness of a mixture of 9 east Indian herbs known as Cystone regarding their ability to dissolve existing kidney stones and prevent formation of new ones.
- Trial name
- NCT00381849
- Testing
- Cystone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Renal Calculi
Evaluation of Prevalence, Molecular and Genetic Backgrounds of Calcium-Based Stones Among Patients With Renal Calcular Disease in Mansoura Urology and Nephrology Center
Evaluation of Prevalence, Molecular and Genetic Backgrounds of Calcium-Based stones among Patients with Renal Calcular Disease in Mansoura Urology and Nephrology Center
- Trial name
- NCT05972408
- Testing
- percutaneous nephrlolithotomy, VDR gene, CASR gene
- Where
- Egypt
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Primary Hyperoxaluria, Nephrocalcinosis
International Registry for Primary Hyperoxaluria
The purpose of this study is to collect medical information from a large number of patients in many areas of the world with primary hyperoxaluria.
- Conditions
- Primary Hyperoxaluria, Nephrocalcinosis, Kidney Stones
- Trial name
- NCT00875823
- Where
- 4 sites in United States
- Sponsor
- Mayo Clinic
Secondary Hyperoxaluria, Nephrolithiasis
Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Hyperoxaluria and Kidney Stones
The purpose of this study is to evaluate the safety, tolerability, and efficacy of different doses of ALLN 177 for reducing urinary oxalate excretion in patients with secondary hyperoxaluria and recurrent kidney stones.
- Conditions
- Secondary Hyperoxaluria, Nephrolithiasis, Kidney Stones, Hyperoxaluria
- Trial name
- NCT02503345
- Testing
- ALLN-177 low dose, ALLN-177 mid dose, ALLN-177 high dose
- Where
- 16 sites in United States
- Volunteers
- 32 people
- Sponsor
- Allena Pharmaceuticals
Nephrolithiasis
Mature Vinegar Prophylaxis Against Recurrent Calcium Oxalate Nephrolithiasis
Kidney stones are one of the most common disorders of the urinary tract and cause a great deal of morbidity and economic loss. Because of the high recurrence rate, researchers are interested in finding medicinal therapies to…
- Trial name
- NCT03092908
- Testing
- mature vinegar
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Primary Hyperoxaluria Type 1
A Study of DCR-PH1 in Patients With Primary Hyperoxaluria Type 1 (PH1)
A phase 1 study of DCR-PH1 in patients with primary hyperoxaluria type 1 (PH1) to determine the safety, tolerability, pharmacokinetic (PK) and pharmacodynamics (PD) effects of DCR-PH1 administered via-intravenous infusion (IV)
- Trial name
- NCT02795325
- Testing
- DCR-PH1
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 41 people
- Sponsor
- Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Kidney Calculi
Efficacy of Potassium Sodium Hydrogen Citrate Therapy on Renal Stone Recurrence and/or Residual Fragments After Shockwave Lithotripsy and Percutaneous Nephrolithotomy in Calcium Oxalate Urolithiasis
Extracorporeal shock wave lithotripsy (ESWL) and Percutaneous nephrolithotomy (PCNL) become the therapy of choice for renal stone.
- Trial name
- NCT01329042
- Testing
- Potassium-sodium citrate
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ouiheng International Healthcare Co., Ltd
Renal Injury, Kidney Injury
Efficacy and Safety of Renalof® in the Removal of Calculi Smaller Than 10 mm Located in the Reno-Ureteral Tract
Given the high recurrence of urolithiasis in patients, the search for less aggressive and preventive treatments is increasingly necessary.
- Conditions
- Renal Injury, Kidney Injury, Kidney Calculi, Ureteral Obstruction
- Trial name
- NCT04695951
- Testing
- Renalof
- Where
- Nicaragua
- Volunteers
- 155 people
- Sponsor
- Catalysis SL
Urolithiasis, Calcium Oxalate
What Lies Beneath the Stone? Metabolic Insights From Composition-Based Analysis of Kidney Stones
This retrospective observational study investigates the metabolic abnormalities associated with different types of kidney stones by analyzing their composition.
- Trial name
- Kidney stone (NCT06992206)
- Testing
- Metabolik taş analizi ile retrospektif gözlem
- Volunteers
- 506 people
- Sponsor
- Hisar Intercontinental Hospital
Renal Stones, Urolithiasis, Calcium Oxalate
Comparison of Trifecta Analysis of Standard Versus Mini Percutaneous Nephrolithotomy in the Management of Urolithiasis
Introduction: Urolithiasis is a common urological condition, and percutaneous nephrolithotomy (PCNL) is a widely used treatment option.
- Trial name
- Trifecta (NCT06836700)
- Testing
- Mini PCNL
- Where
- Pakistan
- Volunteers
- 180 people
- Sponsor
- Hayat Abad Medical Complex, Peshawar
Urolithiasis, Calcium Oxalate, Kidney Stone
A Single-Center Clinical Study on the Efficacy and Safety of VISOR
Goal of this trial: To test a new tool called VISOR in adults (aged 18-80) with 1-3 cm kidney or ureter stones. We want to see: 1. If it's safe and works well 2.
- Trial name
- NCT07071948
- Testing
- Multifunctional Integrated Flexible Ureteroscope
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Calcium Oxalate Urolithiasis
Oxalobacter Formigenes Colonization and Urinary Oxalate Excretion
The purpose of this research study is to assess the efficacy of ingesting a small amount of the harmless bacterium Oxalobacter formigenes in establishing residence in the guts of healthy participants and to determine whether this…
- Trial name
- NCT03752684
- Testing
- Moderately high oxalate/low calcium diet non-colonized, Oxalobacter formigenes, Moderately high oxalate/low calcium diet colonized
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Kidney Stone
Oxalate Formation From Ascorbic Acid
The purpose of this basic research study is to determine the contribution of endogenous ascorbic acid (AA) turnover to urinary oxalate excretion in both normal BMI and obese adult non-stone formers and calcium oxalate stone…
- Trial name
- NCT04603898
- Testing
- Low Oxalate Diet, Carbon-13 Ascorbic Acid Oral Load
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Kidney Stone, Urolithiasis, Calcium Oxalate
Heterozygous Individuals for AGXT and Kidney Stones
This study seeks to examine the effects of a heterozygous mutation of the AGXT gene in a stone forming population on endogenous oxalate production.
- Trial name
- NCT04430426
- Testing
- Controlled Diet
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Alabama at Birmingham
Hyperoxaluria, Nephrolithiasis
Evaluating ALLN-177 for Reducing Urinary Oxalate Excretion in Calcium Oxalate Kidney Stone Formers With Hyperoxaluria
The purpose of this study is to evaluate the effect of ALLN-177 to reduce urinary oxalate excretion in patients with recurring kidney stones and enteric or idiopathic hyperoxaluria.
- Trial name
- NCT02289755
- Testing
- ALLN-177
- Where
- 4 sites in United States
- Volunteers
- 16 people
- Sponsor
- Allena Pharmaceuticals
Kidney Calculi, Calcium Oxalate Kidney Stones
Bryophyllum Pinnatum Tea as a Novel Treatment for Recurrent Kidney Stone Formers
The aim of this randomized placebo-controlled double-blind crossover clinical trial is to test the ability of a traditional tea made from the leaf of the Bryophyllum pinnatum (B.
- Conditions
- Kidney Calculi, Calcium Oxalate Kidney Stones, Calcium Phosphate Kidney Stones
- Trial name
- NCT06987084
- Testing
- Bryophyllum pinnatum tea
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Indra Gupta