Clinical trials: Urethroplasty
Urethral Stricture
9000 URETHRA STUDY: a Study About Urethroplasty for Urethral Stricture Disease
It has been demonstrated that urethroplasty should be considered the gold standard treatment for urethral stricture disease as it yields higher long-term success rates than endoscopic treatment options such as direct vision…
- Trial name
- NCT04071925
- Testing
- Urethroplasty
- Where
- 2 sites in Belgium
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Ghent
Urethral Stricture, Anterior, Urethral Stricture Disease
Outcomes of Double-face Augmentation Urethroplasty
Combined dorsal and ventral onlay augmentation for bul¬bar urethral reconstruction. Nontraumatic near-obliterative bulbar urethral strictures (BUS) of <2 cm in length can be managed with non-transecting anastomotic bulbar…
- Trial name
- BMG (NCT07436819)
- Testing
- Double-face augmentation urethroplasty
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Menoufia University
Trauma;Pelvis
Urological Outcome of Posterior Urethroplasty in Patients in Assuit University
The management of posterior urethral disruption secondary to blunt pelvic injury remains controversial. While many groups have recommended early realignment of urethral distraction injuries, Classic reports advocate a suprapubic…
- Trial name
- NCT03533270
- Testing
- Urethroplasty
- Volunteers
- 30 people
- Sponsor
- Assiut University
Urethral Stricture
Liquid Buccal Mucosa Graft Urethroplasty
Study Objectives The current definitive treatment options for urethral stricture disease include endoscopic urethrotomy known as Direct Vision Internal Urethrotomy (DVIU) or open reconstruction known as urethroplasty (1-6).
- Trial name
- LBMG (NCT03061344)
- Testing
- DVIU treated with liquid buccal mucosal graft
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- State University of New York - Upstate Medical University
Urethral Stricture
Dorsal vs. Ventral Buccal Graft Dorsal vs. Ventral Buccal Graft
This is a randomized non-blinded comparison of dorsal vs. ventral approach for buccal mucosa graft urethroplasty in the bulbar urethra. Buccal mucosa graft is a common method of repairing the strictured urethra.
- Trial name
- DoVeBuG (NCT02551783)
- Testing
- Urethroplasty with buccal mucosa graft, Ventral Buccal
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Minnesota
Hypospadias
Local Oestrogen Versus Placebo as Preoperative Treatment in Patients With Severe Hypospadias: Effects on Post-operative Complications
Hypospadias is a congenital abnormality of the penis that is caused by incomplete development of the anterior urethra. This pathology is one of the most common genital anomalies in paediatric urology .The incidence is reported to…
- Trial name
- HYPOSPADES (NCT01370798)
- Testing
- promestriene, Urethroplasty, Wrist X ray
- Where
- 4 sites in France
- Volunteers
- 244 people
- Sponsor
- Hospices Civils de Lyon
Urethra Stenosis, Urethral Stricture
Multi-stage Urethroplasty with Augmentation Using a Dorsal Graft Inlay Technique Comparing Graft Use in First or Second Stage
The principal aim of this pilot study is to directly compare both approaches and analyze the failure rate after one year of follow-up.
- Trial name
- MAGIC I (NCT04965025)
- Testing
- Multi-stage urethroplasty with graft inlay in first stage, Multi-stage urethroplasty with graft inlay in second stage
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University Hospital, Ghent
Urethral Stricture
Scandinavian Urethroplasty Study
A multicentre, prospective, randomized study comparing bulbar urethroplasty with excision and primary anastomosis or with an onlay grafting procedure using buccal mucosa.
- Trial name
- SUPS (NCT02321670)
- Testing
- End-to-end, Graft
- Where
- 4 sites in Finland, Norway and 1 more
- Volunteers
- 151 people
- Sponsor
- Oslo University Hospital
Urethral Stricture, Male
Small Intestinal Submucosa Graft for Repair of Anterior Urethral Strictures
The field of research for this study is tissue engineering and the utilization of a small intestinal submucosa graft as a substitute biomaterial for conventional buccal mucosa in substitution urethroplasty of anterior urethral…
- Trial name
- NCT06192654
- Testing
- Small intestinal submucosa (SIS) graft urethroplasty, Autologous oral bucal mucosa graft urethroplasty
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xiaoyong Zeng
Urethral Stricture
Bioengineered Collagen Implant for Urethral Stricture Repair
The field of research for this study is tissue engineering and the utilization of a bioengineered collagen implant as a substitute biomaterial for conventional buccal mucosa in substitution urethroplasty of distal urethral…
- Trial name
- NCT05463991
- Testing
- Bioengineered collagen implant
- Where
- Malaysia
- Volunteers
- 5 people
- Sponsor
- Regenosca SA
Failed Anastomotic Urethroplasty
Radiological Re-evaluation of Failed Anastomotic Uretheroplasty for PFUDDI Using Computed Tomographic Urethrography.
Estate vlue of CTU in evaluation of failed anastomotic urethroplasty for pelvic fracture urethral distraction defect injury [PFUDDI] combared to retrograde urethrography and voiding cysto-urethrography .
- Trial name
- NCT03328000
- Testing
- CTU and MR urethrography
- Volunteers
- 20 people
- Sponsor
- Assiut University
Urethrocutaneous Fistulas
2-octyl Cyanoacrylate for Closure of Urethrocutaneous Fistula.
Urethrocutaneous fistulae (UCF) represent one of the most frequent causes of morbidity after urethroplasty. Hypospadias can be repaired using different surgical techniques, but regardless of technique, the incidence of UCF ranges…
- Trial name
- NCT02115191
- Testing
- 2-octylcyanoacrylate, Surgical reintervention
- Where
- Mexico
- Volunteers
- 42 people
- Sponsor
- Instituto Mexicano del Seguro Social
PRF, Hypospadias
A Multicenter Randomized Controlled Trial Comparing Platelet-Rich Fibrin and Ventral Dartos Flap as Intermediate Layers in Tabularized Incised Plate (TIP) Urethroplasty for Distal Hypospadias With Mild Penile Curvature
Distal hypospadias is the most common form of hypospadias. The Tubularized Incised Plate (TIP) repair is the standard surgical technique for this condition; however, complications such as fistula formation and meatal stenosis…
- Conditions
- PRF, Hypospadias, Distal Hypospadias, Hypospadias Repair
- Trial name
- PRF (NCT07045545)
- Testing
- - Group A: Platelet-rich fibrin membrane prepared intraoperatively and applied over neourethra, Group B: Ventral dartos flap rotated over neourethra
- Where
- Uzbekistan
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- National Children's Medical Center, Uzbekistan
Distal Penile Hypospadias (Disorder)
Hybrid Mathieu Urethroplasty
the aim is to study the results of simple modification of classic Mathieu urethroplasty to increase the scope of cases candidates for that procedure.
- Trial name
- NCT04946058
- Testing
- hyebrid Mathieu Urethroplasty
- Volunteers
- 43 people
- Sponsor
- Tanta University
Completed
Preputial Graft Urethroplasty in Primary Repair of Hypospadias
Introduction: Hypospadias repair is debated. There has been no perfect procedure until this moment. A graft is sometimes needed to fundamentally strengthen the narrow urethral plate.
- Trial name
- Hypospadias (NCT05660564)
- Testing
- DIGU Dorsal inlay preputial graft urethroplasty
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sarah Magdy Abdelmohsen
Urethral Stricture, Urethral Diseases
REDUCER Trial (TXA in Urethroplasty)
This study will test whether tranexamic acid (TXA), a medication used to reduce bleeding, can decrease blood loss in patients having urethroplasty.
- Trial name
- REDUCER (NCT07501884)
- Testing
- Tranexamic Acid, Urethroplasty
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Amjad Alwaal, MD, MSc, FRCSC, FACS
Urethral Stricture
A Comparative Study of the Antibacterial Effects of Two Preoperative Hair Removal Methods in Male Patients With Urethral Stricture
Male urethral stricture is one of the common diseases in urology, with risk factors including a history of hypospadias surgery, indwelling urinary catheterization or instrumental manipulation, trauma, transurethral surgery, and…
- Trial name
- NCT07508566
- Testing
- Wiping with wet wipes containing 2% chlorhexidine gluconate (CHG).
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Proximal Hypospadias, Modified Duckett Urethroplasty
Hybrid Duckett vs Modified Duckett Urethroplasty for Proximal Hypospadias
proximal hypospadias presents a serious anomaly for both infants and their care givers. a variety of techniques were described through decades. None of them is completely curable.
- Trial name
- NCT06598215
- Testing
- Duckett urethroplasty
- Where
- Egypt
- Volunteers
- 43 people
- Sponsor
- Tanta University
Hypospadias, Penoscrotal, Chordee
Transverse Preputial Island Flap Versus Double Faced Preputial Flap for Repair of Penoscrotal Hypospadias With Chordee
The purpose of this study is to compare the outcomes and complications of the transverse preputial island flap (Duckett's procedure) to those of double-faced preputial flap (DFPF) for one-stage repair of penoscrotal hypospadias…
- Trial name
- DuckettvDFPF (NCT04605068)
- Testing
- Transverse preputial island flap (Duckett's technique), Double-faced preputial flap (DFPF)
- Volunteers
- 144 people
- Sponsor
- dr. Muhammad Abdelhafez Mahmoud, MD
Distal Hypospadias, Hypospadias
Fibrin-Enhanced TIP Versus Grafted TIP Urethroplasty in Distal Hypospadias
Hypospadias is a common congenital condition in boys in which the opening of the urethra is located on the underside of the penis.
- Trial name
- FTIP-RCT (NCT07319780)
- Testing
- Fibrin-Enhanced TIP Urethroplasty, Grafted TIP Urethroplasty
- Where
- 2 sites in Indonesia, Uzbekistan
- Volunteers
- 100 people
- Sponsor
- National Children's Medical Center, Uzbekistan