Clinical trials: Upper Limb Hypertonia
Spasticity
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.
The purpose of the study is to assess the safety and efficacy of increasing doses of Corabotase (also known as IPN10200) with the aim to evaluate the Pharmacodynamics (PD) profile of Corabotase and to establish the total…
- Trial name
- LANTIMA (NCT04752774)
- Testing
- Corabotase, Dysport
- Where
- 81 sites in United States, Austria and 12 more
- Volunteers
- 240 people
- Sponsor
- Ipsen
Cerebral Palsy, Muscle
How Are the Muscles Affected in Cerebral Palsy? A Study of Muscle Biopsies Taken During Orthopaedic Surgery.
Cerebral palsy (CP) is a motor disorder caused by an injury to the immature brain. Even though the brain damage does not change, children with CP will have progressively weaker, shorter and stiffer muscles that will lead to…
- Conditions
- Cerebral Palsy, Muscle, Muscle Contracture, Muscle Spasticity
- Trial name
- CPTDBiopsy (NCT05506228)
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Eva Ponten
Spasticity
ETREAT Study on Effectiveness of Botulinum Toxin Type A Injections to Treat Post-stroke Upper and/or Lower Limb Spasticity
The objective of this study is to evaluate the effectiveness of BoNT-A on functional improvement in patients with post-stroke upper and/or lower limb spasticity in the early stage of spasticity development, according to routine…
- Trial name
- ETREAT (NCT02275312)
- Where
- 17 sites in Spain
- Volunteers
- 110 people
- Sponsor
- Ipsen
Upper and/or Lower Limb Focal Spasticity
A Study to Review Treatment Outcomes From Treatment With Dysport® Injections in Adults for Upper and/or Lower Limb Focal Spasticity
The aim of this retrospective study is to describe the real-world outcomes with the treatment of adult patients with Dysport® injections for focal upper limb spasticity (ULS) and/or focal lower limb spasticity (LLS) in NHS…
- Trial name
- DYSCOVER (NCT04604379)
- Where
- 3 sites in United Kingdom
- Volunteers
- 123 people
- Sponsor
- Ipsen
Stroke, Spastic Hemiplegia
Effects of Neuromuscular Electrical Stimulation on Flexor Spasticity and Function in Stroke Patients
In this study, the investigators aimed to determine the effects of botulinum neurotoxin type A injections for wrist and finger flexor spasticity and neuromuscular electrical stimulation therapy applied to wrist and finger flexors…
- Trial name
- NCT06725069
- Testing
- Neuromuscular Electrical Stimulation, Control (Standard treatment)
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Cerebrovascular Accident, Muscle Spasticity
Effects on Quality of Life Following Dysport Treatment in Post-stroke Spasticity of the Arm
The main purpose of this study is to assess the effect on Quality of Life of two cycles of Dysport treatment on post-stroke spasticity of the upper limb. The effect of treatment on spasticity and function will also be measured.
- Trial name
- NCT00216411
- Testing
- Botulinum toxin type A
- Where
- 6 sites in Australia
- Volunteers
- 96 people
- Sponsor
- Ipsen
Muscle Spasticity, Stroke
Study Evaluating MyoRegulator® Treatment in Post-Stroke Upper Limb Spasticity
This is a multi-center, randomized, double-blind (patient and evaluator), sham-controlled study to be conducted in stroke patients with upper-extremity spasticity.
- Trial name
- RECOVER (NCT04742257)
- Testing
- MyoRegulator® device
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- PathMaker Neurosystems Inc.
Stroke
Evaluation of the Effect of Repetitive Peripheral Magnetic Stimulation on Upper Extremity Spasticity After Stroke
Spasticity is a frequent problem in post-stroke patients. It can negatively affect the functional recovery of patients and impair their quality of life.
- Trial name
- NCT05141695
- Testing
- therapeutic repetitive peripheral magnetic stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Ankara University
Spasticity
Study Assessing Adult Subjects Affected With Upper and/or Lower Limb Spasticity Treated With Botulinum Neurotoxin Type A
The aim of the study is to describe the long term use of Botulinum Neurotoxin Type A (BoNT-A) in adult subjects affected with upper and/or lower limb spasticity who received treatment with BoNT-A for a minimum of three injections…
- Trial name
- RESULT (NCT04340336)
- Where
- 3 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Ipsen
Spinal Cord Injury, Spasticity
Shockwave for Elbow and Wrist Spasticity in People With Spinal Cord Injury
Approximately 305,000 people live with a spinal cord injury (SCI) in the United States. Sixty percent of these individuals have tetraplegia, which can cause significant dysfunction of the arms and hands.
- Conditions
- Spinal Cord Injury, Spasticity, Shockwave Therapy
- Trial name
- NCT07501429
- Testing
- Focused extracorporeal shockwave therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Kessler Foundation
Stroke, Muscle Spasticity
Altering Activation Patterns Post-stroke
This study evaluates a new rehabilitation approach for stroke survivors in the chronic phase of recovery in which the combination of drug therapy (cyproheptadine) and active movement practice (AMP) is used to encourage increased…
- Conditions
- Stroke, Muscle Spasticity, Hemiparesis
- Trial name
- NCT02418949
- Testing
- Cyproheptadine, Active Movement Practice (AMP), Passive Cyclical Stretching
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Shirley Ryan AbilityLab
Muscle Spasticity, Stroke
Long-Term Study of OnabotulinumtoxinA Treatment in Adult Patients With Upper Limb Spasticity
This is a long-term safety and efficacy study of onabotulinumtoxinA in poststroke patients with upper limb spasticity.
- Trial name
- NCT02145689
- Testing
- onabotulinumtoxinA
- Sponsor
- Allergan
Stroke, Hemiplegia
Functional Outcome of Hemiplegic Upper Extremity in Patients With Subacute Stroke After Kinesiotaping and Rehabilitation
1. To explore the role of sonoelastography with shear wave velocity to assess poststroke spasticity of affected arm and forearm muscles in patients with stroke. 2.
- Trial name
- NCT04027985
- Testing
- Kinesiotaping, Hand rehabilitation program
- Where
- Taiwan
- Volunteers
- 41 people
- Sponsor
- Chang Gung Memorial Hospital
Muscle Spasticity, Spinal Cord Injury
Comparing Upper Limb Surgery and Botulinum Toxin for Spasticity: A Paired Design Study
Spasticity is a common complication following central nervous system injuries. Left untreated, spasticity can lead to various complications, hindering activities of daily living and diminishing independence.
- Conditions
- Muscle Spasticity, Spinal Cord Injury, Stroke, Traumatic Brain Injuries
- Trial name
- NCT06733025
- Testing
- Tendon lengthening surgery, BoNT Injections
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Vastra Gotaland Region
Stroke
Morphological Characteristics of the Upper and Lower Extremities Using Ultrasound Examination After Stroke.
Introduction A large number of stroke patients develop spasticity in the upper and lower extremities, which is one of the clinical signs of damage to motor neuron 1, causing abnormal postures and movement patterns due to motor…
- Trial name
- Spasticity (NCT07156760)
- Testing
- Ultrasound diagnostics
- Where
- 2 sites in Chile
- Volunteers
- 80 people
- Sponsor
- Universidad de La Frontera
Stroke
Acute Effects of Wearable Electrical Stimulation in Stroke
The goal of this clinical trial is to learn if the EXOPULSE Mollii Suit Wearable Electrical Stimulation works to reduce spasticity and improve functional capacity in individuals with stroke.
- Trial name
- NCT07459361
- Testing
- EXOPULSE Mollii Suit
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Hacettepe University
Stroke, Spasticity
Upper Extremity Rehabilitation Using Robot and Botulinum Toxin
Concomitant use of botulinum toxin and robot would make better results regarding upper extremity function compared to robot, botulinum toxin, or no intervention.
- Trial name
- NCT02228863
- Testing
- Early Inmotion and Botox, Botox, then Inmotion, Inmotion, then Botox
- Where
- South Korea
- Volunteers
- 348 people
- Sponsor
- National Rehabilitation Center, Seoul, Korea
Neurological Rehabilitation, Stroke
Evaluation of Hand Strength and Spasticity in Hemiplegic Patients
The aim in this study is to evaluate spasticity and hand grip strength with a finger hand robot in the Turkish population.
- Conditions
- Neurological Rehabilitation, Stroke, Upper Extremity Problem
- Trial name
- NCT05662878
- Testing
- Assessment of Hand Strength and Spasticity
- Where
- Turkey (Türkiye)
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Spasticity
MEDITOXIN® Versus BOTOX® in the Treatment of Post-stroke Spasticity of the Upper Limb Spasticity
This study is a randomized, double blind, multi-center, active drug controlled, phase III clinical trial to compare the efficacy and safety of MEDITOXIN® versus BOTOX® in treatment of post stroke upper limb(wrist, finger, thumb)…
- Trial name
- NCT01313767
- Testing
- Botulinum toxin type A
- Where
- South Korea
- Volunteers
- 196 people
- Sponsor
- Medy-Tox
Cerebrovascular Accident
Botulinim Toxin Type A Injections by Different Guidance in Stroke Patients With Spasticity on Upper Extremities
The aims of this study were to compare the injection locations of key spastic muscles on upper extremity by three different guidance localization methods ( surface anatomy landmark, ultrasonography, electric stimulation) and the…
- Trial name
- NCT02557737
- Testing
- Botulinum Toxin Type A
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital