Clinical trials: Upper Extremity
Peripheral Arterial Disease
BEST SFA Pilot Study - Best Endovascular STrategy for Complex Lesions of the Superficial Femoral Artery
Prospective, multi-center 1:1 randomized trial to compare efficacy and safety of a stent-avoiding (using drug coated balloons) versus a stent-preferred (using drug eluting or interwoven stents) approach for treatment of complex…
- Trial name
- NCT03776799
- Testing
- Stent-avoiding, Stent-based
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University of Leipzig
Lymphomas
Selinexor, High-dose Methotrexate, and Rituximab Combined With Radiotherapy for Newly Diagnosed, Transplant-ineligible Patients With Central Nervous System Lymphoma: An Open-label, Single-arm, Multicenter Phase II Study
This phase II clinical trial is designed to evaluate a novel combination treatment for patients with newly diagnosed central nervous system lymphoma (CNSL) who are not candidates for stem cell transplantation.
- Trial name
- NCT07002099
- Testing
- Selinexor + High-dose Methotrexate + Rituximab + WBRT
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Fistula Stenosis
Paclitaxel for the Treatment of Upper-Extremity Arteriovenous Access Fistula Stenosis
The objective of this study is to evaluate the safety and effectiveness of the use of intravascular paclitaxel, in addition to standard therapy, for the treatment of arteriovenous dialysis access fistula stenosis.
- Trial name
- PaciFIST-1 (NCT01868984)
- Testing
- Paclitaxel, Standard Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Englewood Hospital and Medical Center
Lymphoma Diffuse Large B-cell, Leukemia and Lymphoma
Study of Allo-QuadCAR01-T, an Allogeneic CAR-T Targeting CD19/CD20, in Patients With Relapsed or Refractory B-Cell Malignancies
This study is testing Allo-QuadCAR01-T, a new off-the-shelf CAR-T therapy for people with hard-to-treat B-cell cancers. Unlike current CAR-T treatments that use a patient's own cells, this therapy uses donor cells that are ready…
- Conditions
- Lymphoma Diffuse Large B-cell, Leukemia and Lymphoma, Leukemia Relapse, Lymphoma Receiving CAR-T Therapy
- Trial name
- QUADvance (NCT07284433)
- Testing
- Cyclophosphamide (Non-IMP, Lymphodepletion), Fludarabine (Non-IMP, Lymphodepletion), Allo-QuadCAR01-T
- Where
- 13 sites in United States, Germany
- Volunteers
- 178 people
- Sponsor
- AvenCell Therapeutics, Inc.
Bladder Dysfunction, Neurogenic Bladder Dysfunction
Feasibility Study of Transcutaneous Tibial Nerve Stimulation for Urinary Symptoms in People With Multiple Sclerosis
Neurogenic lower urinary tract dysfunction is common among people with Multiple sclerosis with a pooled prevalence of 68.41% using self-report measures and 63.95% using urodynamic studies.
- Conditions
- Bladder Dysfunction, Neurogenic Bladder Dysfunction, Urinary Incontinence, Urinary Bladder, Overactive
- Trial name
- NCT04528784
- Testing
- Transcutaneous tibial nerve stimulation
- Where
- Ireland
- Volunteers
- 23 people
- Sponsor
- University of Limerick
Breast Cancer
Surgical Intervention and Physiotherapy in Breast Cancer: Effects in Scapular Kinematics, Pain and Upper Limb Function
Our objective is to identify the possible changes of three-dimensional scapula movement during arm elevation in women after breast cancer surgery and subjected to a physical therapy intervention.
- Trial name
- NCT02604030
- Testing
- Upper limb function
- Where
- Brazil
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sao Carlos
Squamous Cell Carcinoma of the Head and Neck
FRAIL-IMMUNE (GORTEC 2018-03) - Combination of Durvalumab With Carboplatin/Paclitaxel
The primary objective of the phase II trial is to determine the efficacy and safety of a combination of Durvalumab with the Carboplatin/Paclitaxel as first line treatment in patients with recurrent/metastatic SCCHN not eligible…
- Trial name
- FRAIL-IMMUNE (NCT03723967)
- Testing
- Durvalumab with Carboplatin/Paclitaxel
- Where
- 17 sites in France
- Volunteers
- 104 people
- Sponsor
- Centre Leon Berard
Hemiplegic Cerebral Palsy
Bimanual Task Training and Constraint-Induced Movement Therapy in Hemiplegic Cerebral Palsy Children
Various studies have been done comparing the individual effects of the two interventions of Constraint-Induced Movement Therapy and Bimanual Task Training in Hemiplegic Cerebral Palsy Children, but this study will compare the…
- Trial name
- NCT05380011
- Testing
- Constraint Induced Movement Therapy and Bimanual Task Training, Bimanual Task Training
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
Ulnar Neuropathies
The Effect of Ulnar Nerve Entrapment Localization on Ipsilateral Upper Extremity Functions. The Effect of Ulnar Nerve Entrapment Localization on Ipsilateral Upper Extremity Functions. The Effect of Ulnar Nerve Entrapment Localization on Ipsilateral Upper Extremity Functions.
Regardless of the cause of ulnar nerve entrapment neuropathy, investigators are planning to explore the relationship between the ipsilateral upper extremity dysfunction that may develop due to ulnar neuropathy and the level of…
- Trial name
- NCT05175209
- Testing
- EMG
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Yuzuncu Yil University
Healthy
The Effect of Load Carriage on Upper Limb Performance
Purpose: Quantify the relationship between brachial plexus deformations caused by backpack carriage and upper extremity performance.
- Trial name
- NCT02337998
- Testing
- load carriage
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma
Cisplatin, Nab-Paclitaxel, and Cetuximab (CACTUX) in Patients With Incurable Head and Neck Squamous Cell Carcinoma
The purpose of this research study is to look at the effect of a treatment regimen called CACTUX on head and neck cancer. The CACTUX regimen is a combination of three drugs called cisplatin, nab-paclitaxel, and cetuximab…
- Conditions
- Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma, Cancer of the Head and Neck
- Trial name
- CACTUX (NCT02270814)
- Testing
- nab-paclitaxel, Cisplatin, Carboplatin
- Where
- 5 sites in United States
- Volunteers
- 74 people
- Sponsor
- Washington University School of Medicine
Hepatocellular Carcinoma, Immune Checkpoint Inhibitors
A Study of Camrelizumab Combined Apatinib in Hepatocellular Carcinoma Previously Treated With Immune Checkpoint Inhibitors (ICIs).
The purpose of this study is to observe and preliminary explore the efficacy and safety of the combination of Camrelizumab and Apatinib regimen in treating advanced hepatocellular carcinoma (HCC) participants who have progressed…
- Trial name
- NCT04826406
- Testing
- Camrelizumab combined Apatinib regimen
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Hunan Cancer Hospital
Upper Extremity Dysfunction
Effects of Different Stimuli on Muscle Activation, Hand Grip Strength, Reaction Time, and Hand Function
The study will include three separate intervention groups: an ice application group, a vibration application group, and a control group. Accordingly, three groups were randomly generated using the Research Randomizer software.
- Trial name
- NCT07407114
- Testing
- Ice, Vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lokman Hekim University
Metastatic Non Small Cell Lung Cancer
Dacomitinib for Treatment of Patients in India With Metastatic Non Small Cell Lung Cancer With EGFR Activating Mutations
This is a Phase 4, open label, single arm, multi-center, prospective clinical trial of dacomitinib that will be performed in India.
- Trial name
- NCT04511533
- Testing
- Dacomitinib
- Where
- 15 sites in India
- Volunteers
- 101 people
- Sponsor
- Pfizer
Physical Fatigue
Effects of Upper Extremity Flywheel Exercises on Skills, Muscle Oxygenation, and Fatigue in Adolescent Basketball
This study will investigate the effects of flywheel exercises targeting the upper extremities on athletic performance, muscle oxygenation, physical fatigue, and muscle strength in adolescent basketball players.
- Trial name
- Flywheel (NCT07331012)
- Testing
- Flywheel Exercises, Traditional Resistance Training
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Istinye University
Idiopathic Pulmonary Fibrosis
Safety and Tolerability Study of Macitentan in Patients With Idiopathic Pulmonary Fibrosis
The MUSIC OL study is an open-label extension study, in which all eligible patients having completed the double-blind AC-055B201/MUSIC study as scheduled receive macitentan 10 mg once daily.
- Trial name
- MUSIC OL (NCT01346930)
- Testing
- Macitentan
- Sponsor
- Actelion
Cholangiocarcinoma Non-resectable, Non-metastatic
Hepatic Arterial Infusion of Gemcitabine-oxaliplatin for Second-line Therapy in Non-metastatic Unresectable Intra-hepatic Cholangiocarcinoma
We hypothesized that intra-arterial gemcitabine/oxaliplatin administered as second-line treatment could strongly improve objective response rate at 4 months after inclusion in patient with non-metastatic unresectable…
- Trial name
- GEMOXIA-02 (NCT03364530)
- Testing
- Gemcitabine-Oxaliplatin Regimen, Hepatic intra arterial chemotherapy
- Where
- 7 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
PARKINSON DISEASE (Disorder)
Effect of Botulinum Toxin on Resting Tremor of the Refractory Upper Limb in Parkinsonians
Tremor is one of the most common symptoms in Parkinson Disease (PD), affecting almost 60% of patients. There is currently no specific treatment for tremor in PD, and 30% of patients develop drug-resistant tremor, making its…
- Trial name
- TOX PARK (NCT07822893)
- Where
- 2 sites in France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Toulouse
Esophageal Cancer
Study of Adebrelimab Combined With Thymalfasin and Chemotherapy for Neoadjuvant Treatment of Esophageal Cancer
This is a prospective, single-arm, multicenter clinical study conducted in China. Patients with pathologically or cytologically confirmed resectable esophageal squamous cell carcinoma will be enrolled to explore the efficacy and…
- Trial name
- NCT07780721
- Testing
- Adebrelimab, Thymalfasin, Chemotherapy
- Where
- China
- Volunteers
- 31 people
- Sponsor
- The Affiliated Hospital of Putian University
Central Venous Catheter Thrombosis, Central Venous Catheter Associated Bloodstream Infection
t-PA Prophylaxis to Prevent Catheter-associated Thrombosis and Infection
The purpose of this pilot study is to test feasibility of concept, consent and enrollment rates, and mechanics of study designed to assess if intra-catheter dwells of tissue plasminogen activator (t-PA) is effective in decreasing…
- Trial name
- TOPCAT (NCT03672006)
- Testing
- alteplase (recombinant t-PA), Heparin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical College of Wisconsin