Clinical trials: Updating
Depressive Disorder, Major
Brain Network Dynamics of Depression During Esketamine Treatment
This is a monocentric, observational clinical trial investigating the effect of Esketamine on brain network activity and a belief updating task in people with depression.
- Trial name
- K-BRAINED (NCT06012916)
- Testing
- Esketamine nasal spray
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of North Carolina, Chapel Hill
Epilepsy
A Prospective Diagnostic Belief Updating Study to verIfy the Utility of BioEP in First Seizure Clinics.
The goal of this belief updating study is to assess the utility of BioEP as a complementary support tool in aiding clinical decision making in adults in first seizure clinics.
- Trial name
- PRISTINE (NCT05764252)
- Testing
- BioEP
- Where
- United Kingdom
- Volunteers
- 88 people
- Sponsor
- Neuronostics Ltd
Amputation, Upper Limb
RESCU System for Robust Upper Limb Prosthesis Control
This study will compare the use of RESCU [Experimental] Prosthesis with a [Standard] pattern recognition prosthesis in a clinical setting and in unsupervised daily activity.
- Trial name
- RESCU (NCT04043234)
- Testing
- RESCU, Pattern Recognition
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Infinite Biomedical Technologies
Mild Cognitive Impairment (MCI)
Silver Agri Age: Longevity, Intrinsic Capacity and Cognitive Impairment Into Farmlands and Natural Environments: Updating Contexts Following the "Montessori" Action
This project aims to enhance the intrinsic capacities of elderly individuals with mild cognitive impairment by promoting innovative activities based on the Montessori approach within the context of agricultural…
- Trial name
- Silver Agri Ag (NCT06754202)
- Testing
- Social activities with cognitive stimulation
- Where
- 2 sites in Italy
- Volunteers
- 12 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Post-Traumatic Stress Disorders, Anxiety
fMRI in Posttraumatic Stress Disorder (PTSD) During Working Memory Updating
Neuropsychological studies investigating trauma-exposed and posttraumatic stress disorder (PTSD) subjects have generally underlined the significantly poorer performance of tasks that require attention, concentration, and verbal…
- Conditions
- Post-Traumatic Stress Disorders, Anxiety, Amnesia, Dissociative
- Trial name
- METRAPI (NCT00288314)
- Testing
- Magnetic Resonance Imaging, Functional
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Phase I
Pilot Study on the Effects of Psilocybin on Belief Updating and Insight Formation
The primary aim of this phase I mechanistic pilot study is to evaluate the effects of psilocybin on aspects of cognition in healthy adult volunteers.
- Trial name
- NCT07818564
- Testing
- Psilocybin (Usona Institute)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brown University
Public Speaking Anxiety, Public Speaking Fear
Enhancing Generalization of Virtual Reality Exposure for Public Speaking Anxiety
This randomized controlled trial examines whether imagery-based extinction memory updating following a standardized virtual reality (VR) exposure session improves the generalization of exposure effects to novel public speaking…
- Trial name
- VREX2 (NCT07323498)
- Testing
- VR Exposure, Standard Mental Rehearsal, Mental Rehearsal With Extinction Memory Updating
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Philipps University Marburg
Prader-Willi Syndrome
Effects of Transcutaneous Vagus Nerve Stimulation on Emotion Regulation and Executive Functioning in Prader-Willi Syndrome
The STIM-PRADER study aims to assess the effectiveness of auricular vagal neuromodulation therapy (aVNT) on emotional, behavioral, and cognitive domains impaired in Prader-Willi Syndrome (PWS).
- Trial name
- STIM-PRADER (NCT06720571)
- Testing
- Auricular vagal neuromodulation therapy (aVNT)
- Where
- 4 sites in France
- Volunteers
- 24 people
- Sponsor
- University of Bordeaux
Nicotine Addiction, Smoking Cessation
Extinction Updating in Reconsolidation
Smoking occurs in approximately 21% of the US population, is responsible for an annual mortality rate of approximately 438,000 citizens, and has an associated healthcare economic burden of $167 billion.
- Trial name
- NCT02154685
- Testing
- Retrieval-Extinction, Non-Retrieval Extinction
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Treatment Resistant Depression
Belief Updating in Treatment Resistant Depression
Major depressive disorder (MDD) is characterized by a cognitive triad of negative beliefs about oneself, the future and the world.
- Trial name
- KETABELIEF (NCT05577247)
- Testing
- functional magnetic resonance imaging
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Schizophrenia; Psychosis, Persecutory Delusion
Cognitive Behavioral Therapy (CBT) Study Evaluating the Updating of Persecutory Beliefs
The purpose of this study is to examine how Bayesian belief updating changes throughout psychotherapeutic treatment for persecutory delusions.
- Trial name
- NCT04748679
- Testing
- Worry Intervention, Befriending
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Vanderbilt University Medical Center
Dementia, Mild, Dementia of Alzheimer Type
Adaptation of the Uniform Data Set for Telematic Administration
The present project is an evolution of the previous RIN 2019 study aimed at validating and standardizing the Uniform Data Set (UDS) for dementia, a battery of tests exploring various cognitive domains (memory, language, praxis…
- Trial name
- NCT05785910
- Testing
- IUDS
- Where
- Italy
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Inhibition (Psychology), Updating
Attentional Control Training in Older Adults: Efficacy, Transfer and Brain Substrates
Formal education and cognitively stimulating hobbies and profession have a protective effect against age-related cognitive decline and Alzheimer's disease.
- Conditions
- Inhibition (Psychology), Updating, General Knowledge, No Training
- Trial name
- NCT03532113
- Testing
- Updating, Inhibition, General knowledge
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Breast Cancer Risk
FH-Risk 2.0: Updating Breast Cancer Risk Estimates
In the UK women with a strong family history of breast cancer are eligible for breast cancer risk estimation via Family History Risk and Prevention Clinics (FHRPCs).
- Trial name
- NCT05082740
- Testing
- Notification of a revised breast cancer risk estimate
- Where
- United Kingdom
- Volunteers
- 333 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Mobility Limitations
Experimental Control Investigation of the Impact of Assistive Technology on the User-caregiver Dyad: a Multi-site Trial
The purpose of this study is to determine the effectiveness of an assistive technology updating and tune up intervention on users and their caregivers.
- Trial name
- ATUTI (NCT00927706)
- Testing
- Assistive technology updating and tune up intervention
- Where
- 4 sites in Canada
- Volunteers
- 88 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Autism Spectrum Disorder (ASD)
Cycling Interventions on Cognition in Children With Autism
The goal of this clinical trial was to determine if a specific type of cycling exercise improved executive functions in school-aged children with autism spectrum disorder (both boys and girls, aged 8-10 years, no healthy…
- Trial name
- Cycling&Autism (NCT07295912)
- Testing
- Learning to Bicycle, Bicycle Treadmill, Cycling with Training Wheels
- Where
- Hong Kong
- Volunteers
- 62 people
- Sponsor
- Chinese University of Hong Kong
Schizophrenia Disorders
Volatility in Paranoia (VIP) Trial: An RCT of Changes in Volatility With Psychotherapy
The goal of this clinical trial is to learn whether learning and belief updating change in response to the treatment of persecutory delusions, in individuals with schizophrenia-spectrum disorders. The main questions are: 1.
- Trial name
- VIP (NCT06835556)
- Testing
- Cognitive Behavioral Therapy, TAU
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Vanderbilt University Medical Center
Ovarian Cancer, Quality of Life
Updating the EORTC Quality-of-Life Questionnaire for Ovarian Cancer (QLQ-OV38)
The goal of this observational study is to pre-test the EORTC QLQ-OV39 to identify and resolve potential problems in its administration and to identify missing/redundant items.
- Trial name
- EORTC QLQ-OV39 (NCT07465133)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Helios University Hospital Wuppertal
Parkinson Disease, Cognitive Impairment
Cognitive Training in Parkinson's Disease, the iPARK Study
The aim of the iPARK-study is to investigate the effects of a process-based cognitive training program with focus on working memory in patients with Parkinson's Disease (PD).
- Trial name
- iPARK (NCT03680170)
- Testing
- Working memory updating training
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Umeå University
Obstructive Sleep Apnea, Obstructive Sleep Apnea-hypopnea
Updating Deep Learning Algorithms for OSA Monitoring
The objective is to enhance the reliability of the algorithm to match that of Level 1 polysomnography by leveraging the diverse data obtained from Level 1 polysomnography to refine the deep learning algorithm.
- Trial name
- NCT06522815
- Testing
- CART-I plus, Polysomnography
- Where
- South Korea
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Sky Labs