Clinical trials: Unruptured Intracranial Aneurysm, active
Intracranial Aneurysms, Unruptured Intracranial Aneurysm
ANEURYSM@RISK: Automatic Intracranial Aneurysm Quantification and Feature Learning Modelling to Optimize Intracranial Aneurysm Rupture Prediction
ANEURYSM@RISK is an observational study aiming to develop and validate an artificial intelligence (AI)-based prediction model for the growth and rupture of intracranial aneurysms (IAs).
- Conditions
- Intracranial Aneurysms, Unruptured Intracranial Aneurysm, Subarachnoid Hemorrhage (SAH) From Ruptured Aneurysm
- Trial name
- NCT07111975
- Where
- Netherlands
- Volunteers
- 3,800 people
- Sponsor
- UMC Utrecht
Aneurysm Cerebral, Bifurcation
LUMENS-1 Canada Early Feasibility Study Clinical Investigation Plan
The primary objective of this clinical investigation is to evaluate the early safety and feasibility of the LuSeed Aneurysm Embolization System for treating unruptured intracranial aneurysms (IA).
- Conditions
- Aneurysm Cerebral, Bifurcation, Unruptured Intracranial Aneurysm, Saccular Aneurysm
- Trial name
- NCT07259018
- Testing
- LuSeed Aneurysm Embolization System
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- LuSeed Vascular LTD.
Intracranial Aneurysms, Subarachnoid Hemorrhage, Aneurysmal
Screening in Relatives With Elevated Risk for Unruptured Intracranial Aneurysms
The purpose of this study is to screen first-degree relatives of patients with aneurysmal subarachnoid hemorrhage using magnetic resonance angiography to detect unruptured intracranial aneurysms.
- Trial name
- SIREN (NCT07387575)
- Where
- Serbia
- Volunteers
- 300 people
- Sponsor
- University of Novi Sad
Intracranial Aneurysm, Postoperative Pain
Effect of Bilateral Greater Occipital Nerve Block on Headache After Intracranial Aneurysm Coiling
Postoperative headache is a common complication following endovascular coil embolization of intracranial aneurysms and may increase analgesic requirements, impair patient comfort, and contribute to hemodynamic instability.
- Trial name
- NCT07910864
- Testing
- Ultrasound-Guided Bilateral Greater Occipital Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Konya City Hospital
Unruptured Intracranial Aneurysm, Indobufen
INdobufen Versus asPirin in Endovascular Unruptured Intracranial Aneurysms Treatment (INPUT)
This project aims to evaluate the safety and efficacy of the antiplatelet regimen combining indobufen and clopidogrel in preventing ischemic events after stent-assisted coiling embolization and flow diverter implantation for…
- Trial name
- NCT07089862
- Testing
- Indobufen treatment, Aspirin treatment
- Where
- China
- Volunteers
- 2,500 people
- Sponsor
- Beijing Tiantan Hospital
Unruptured Intracranial Aneurysm, Intracranial Aneurysm
Surveillance Versus Treatment of Unruptured Intracranial Aneurysms of Fortuitous Discovery
The goal of this clinical trial is to determine whether a watchful waiting strategy with imaging surveillance is superior to immediate aneurysm treatment in adults with incidentally discovered unruptured intracranial aneurysms…
- Trial name
- STAF (NCT07817511)
- Testing
- Clinical and imaging surveillance, Endovascular or neurosurgical aneurysm treatment
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hemorrhagic Stroke, Aneurysm, Intracranial
The Use of p48/64 MW HPC Flow Modulation Device in the Treatment of Wide-necked Intracranial Aneurysms
To determine safety and effectiveness of the p48 MW HPC and p64 MW HPC Flow Modulation Device in the treatment of wide-necked intracranial aneurysms.
- Conditions
- Hemorrhagic Stroke, Aneurysm, Intracranial, Saccular Aneurysm, Fusiform Aneurysm
- Trial name
- PIANO (NCT07143019)
- Testing
- Flow diversion
- Where
- 25 sites in United States
- Volunteers
- 214 people
- Sponsor
- phenox Inc.
Cerebrovascular Disease, Ischemic Stroke
Florida Cerebrovascular Disease Biorepository and Genomics Center
The purpose of this study is to create a state-wide biorepository and resource center for cerebrovascular diseases in Florida, which will include collecting medical history information and blood from subjects affected by…
- Conditions
- Cerebrovascular Disease, Ischemic Stroke, Transient Ischemic Attack, Intracerebral Hemorrhage
- Trial name
- NCT05491980
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Mayo Clinic
Aneurism
Genetic Profile In Patients With Ruptured and Unruptured Intracranial Aneurysms
The project will involve multiple units within our Institute (Neurosurgery, Cerebrovascular Diseases, Neurology IV), as well as additional neurosurgical centers across Italy, for the enrollment of patients with saccular…
- Trial name
- ANEUBIO (NCT07233915)
- Where
- Italy
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Ruptured and Unruptured Intracranial Aneurysms
Safety and EffecTiveness of the Silk Vista Flow DiverteR in the TrEatment of Unruptured IntracrAnial AneurysMs
Intracranial aneurysms (IA) are abnormal outpouchings of cerebral arteries' walls that occur mostly in arteries found in the Circle of Willis and the middle cerebral artery bifurcation with a risk of rupture leading to…
- Trial name
- STREAM (NCT07073118)
- Testing
- Endovascular treatment with placement of a flow-diverting stent
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Bordeaux
Unruptured Intracranial Aneurysm
MRI Analysis in the Growth of Cerebral Aneurysms
An intracranial aneurysm is defined as a localized dilatation of the cerebral arteries, which can potentially lead to rupture and subsequent hemorrhagic stroke. The mechanisms by which aneurysms develop and grow remain unknown.
- Trial name
- EPICAVC (NCT06705452)
- Testing
- Additional 4D Flow MRI or additional 4D Flow sequence
- Where
- France
- Volunteers
- 281 people
- Sponsor
- CHU de Reims
Unruptured Intracranial Aneurysm, Headache
Efficacy and Safety of Transcutaneous Auricular Vagus Nerve Stimulation for Postoperative Headache Following Stent-Assisted Coiling of Unruptured Intracranial Aneurysms
The goal of this clinical trial is to evaluate the efficacy and safety of transcutaneous auricular vagus nerve stimulation (taVNS) in reducing postoperative headache among adults undergoing stent-assisted coiling for unruptured…
- Conditions
- Unruptured Intracranial Aneurysm, Headache, Vagus Nerve Stimulations
- Trial name
- IMPACT-HT (NCT07479082)
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Aneurysm
A Study of Choydar Flow-Directed Mesh Stent in the Treatment of Unruptured Intracranial Aneurysms
The purpose of this study is to assess how safe choydar flow-directed mesh stent is and how well it works in the treatment of unruptured intracranial aneurysms (a condition in which a bulging blood vessel in the brain can burst…
- Trial name
- CROWN (NCT07228312)
- Where
- 8 sites in China
- Volunteers
- 200 people
- Sponsor
- Johnson & Johnson Medical (Shanghai) Ltd.
Cerebral Aneurysm Unruptured
Impact of Life-size 3D Model on Patient Anxiety During Intracranial Aneurysms Embolization in Interventional Neuroradiology.
Intracranial aneurysm is a malformation of the cerebral arteries, identifying with a focal dilatation of the wall of an intracranial artery.
- Trial name
- ANXIFLOW (NCT06914414)
- Testing
- Using the flow model in cerebral aneurysm embolization
- Where
- France
- Volunteers
- 144 people
- Sponsor
- University Hospital, Caen
Unruptured Intracranial Aneurysm
Assessment of the Clinical and Economic Impact of Sim&Size, a Simulation Software for Implantable Devices Used in the Treatment of Intracranial Aneurysms: A Prospective Multicenter Study.
In recent years, endovascular treatment of intracranial aneurysms has seen remarkable growth, now surpassing traditional surgical approaches in terms of frequency of use.
- Trial name
- ESSNAI (NCT07433075)
- Testing
- 3D simulation of placement of neurovascular implantable medical device, Manual planning of endovascular procedure
- Where
- 6 sites in France
- Volunteers
- 576 people
- Sponsor
- Sim&Cure
Aneurysm Cerebral, Bifurcation
LUMENS-1 EU EFS CIP
The primary objective of this clinical investigation is to evaluate the early safety and feasibility of the LuSeed Aneurysm Embolization System for treating unruptured intracranial aneurysms (IA).
- Conditions
- Aneurysm Cerebral, Bifurcation, Unruptured Intracranial Aneurysm, Saccular Aneurysm
- Trial name
- NCT06761365
- Testing
- LuSeed Aneurysm Embolization System
- Where
- 6 sites in Bulgaria, Germany and 2 more
- Volunteers
- 30 people
- Sponsor
- LuSeed Vascular LTD.
Unruptured Intracranial Aneurysm
Unruptured Cerebral Aneurysm: Prediction of Evolution
The protocol has many assets. A prospective nationwide recruitment allows for the inclusion of a large cohort of patients with UIA. It will combine accurate clinical phenotyping and comprehensive imaging with CAWE screening.
- Trial name
- U-CAN (NCT04578808)
- Testing
- Unruptured intracranial aneurysms
- Where
- 29 sites in France, Netherlands and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Nantes University Hospital
Intracranial Aneurysm
AI for Detection of Brain Aneurysm: Low-cost Opportunistic Screening
The goal of this clinical trial is to verify the opportunistic screening potential of the AI software for detection of brain unruptured intracranial aneurysms (UIA) on routinely performed brain NECT scans in a prospective setting…
- Trial name
- AIDALOS-III (NCT07123818)
- Testing
- AI software
- Where
- 4 sites in Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ziekenhuis Oost-Limburg
Intracranial Aneurysm
Pivotal Study of the Silk Vista Baby Flow Diverters in the Treatment of Unruptured Intracranial Aneurysms (PIONEER)
The PIONEER Study is a pivotal, multi-center, prospective, single-arm study designed to evaluate the safety and efficacy of the Silk Vista Baby (SVB) Flow Diverter for the treatment of unruptured aneurysms.
- Trial name
- PIONEER (NCT07225075)
- Testing
- Silk Vista Baby (SVB) Flow Diverter
- Where
- 6 sites in United States, Canada
- Volunteers
- 250 people
- Sponsor
- Balt USA
Unruptured Intracranial Wide-neck Bifurcation Aneurysms
Flow Diverter Versus Conventional Endovascular Treatment for Unruptured Wide-Neck Bifurcation Aneurysms (FD-BWA Trial)
Brief Summary： The goal of this clinical trial is to compare whether the traditional approach (stent-assisted coiling) is associated with a lower complication rate than flow diverter (Pipeline™) treatment for unruptured…
- Trial name
- FD-BWA (NCT07707076)
- Testing
- Flow Diverter Group, Stent Assisted Coiling Group
- Where
- China
- Volunteers
- 266 people
- Sponsor
- Nanfang Hospital, Southern Medical University