Clinical trials: Uncontrolled Hypertension, active
Uncontrolled or Resistant Hypertension
A Trial of HRS-1780 in Participants With Uncontrolled Hypertension or Resistant Hypertension.
The study is being conducted to evaluate the efficacy and safety of HRS-1780 in participants with uncontrolled hypertension or resistant hypertension.
- Trial name
- NCT07708441
- Testing
- HRS-1780 tablet
- Where
- 2 sites in China
- Volunteers
- 914 people
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Uncontrolled Hypertension
Renal Pelvic Denervation Pilot Trial
The RPD Pilot trial will evaluate the safety and effectiveness of Verve Medical's RPDTM renal denervation system for hypertensive patients with uncontrolled blood pressure despite use of two medications at a therapeutic dose.
- Trial name
- NCT07005050
- Testing
- RPD, Active hypertension medical therapy
- Where
- 9 sites in United States
- Volunteers
- 60 people
- Sponsor
- Verve Medical, Inc
Uncontrolled Hypertension
A Phase IIIb Study to Investigate the Effect of Baxdrostat in Chinese Participants With Uncontrolled Hypertension.
This is a Phase IIIb, multicentre, randomised, double-blind, placebo-controlled, parallel group study to evaluate the effect of baxdrostat 2mg versus placebo, administered QD orally, on the reduction of ambulatory 24-hour average…
- Trial name
- BaxNoD (NCT07686120)
- Testing
- baxdrostat 2mg
- Where
- 51 sites in China
- Volunteers
- 286 people
- Sponsor
- AstraZeneca
Uncontrolled Hypertension
A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension
The purpose of this clinical trial is to measure the safety and efficacy of RTN-001 in adult participants with uncontrolled hypertension versus placebo.
- Trial name
- NCT07142356
- Testing
- RTN-001
- Where
- 34 sites in United States
- Volunteers
- 280 people
- Sponsor
- Retension Pharmaceuticals. Inc.
Hypertension, Resistant Hypertension
A Phase II Study of VB19055 in Uncontrolled or Resistant Hypertension
A multicenter, randomized, double-blind, placebo-controlled, dose-ranging Phase II trial of VB19055 for 12 weeks in 240 adults with uncontrolled hypertension (including resistant hypertension).
- Conditions
- Hypertension, Resistant Hypertension, Uncontrolled Hypertension
- Trial name
- NCT07833098
- Testing
- VB19055 Dose A QD, VB19055 Dose B QD, VB19055 Dose C QD
- Where
- 24 sites in China
- Volunteers
- 240 people
- Sponsor
- Zhejiang Yangli Pharmaceutical Technology Co., Ltd.
Uncontrolled Hypertension, Renal Denervation
Renal Denervation in Chronic Kidney Disease - RDN-CKD Study
RDN-CKD GR Study is a prospective, randomized (1:1), double-blind (unblinded interventionalist and blinded study team), sham controlled study.
- Conditions
- Uncontrolled Hypertension, Renal Denervation, Chronic Kidney Disease (Stage 3)
- Trial name
- RDN-CKD GR (NCT07742787)
- Testing
- Renal denervation
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- Hippocration General Hospital
Chronic Kidney Disease(CKD), Uncontrolled Hypertension
Intensification of Blood Pressure Lowering Therapeutics Based on Diuretics Versus Usual Management for Uncontrolled Hypertension IN Patients With Moderate to Severe Chronic Kidney Disease
Chronic kidney disease (CKD) is a major public health issue worldwide. Hypertension is the first risk factor in patients with CKD for mortality, cardiovascular disease and end-stage renal disease.
- Trial name
- THINK (NCT05732727)
- Testing
- Antihypertensive algorithm, Standard of care
- Where
- 40 sites in France
- Volunteers
- 720 people
- Sponsor
- University Hospital, Tours
Uncontrolled Hypertension
A Phase II Clinical Trial of Efficacy and Safety of SAL0140 at Different Doses in Patients With Uncontrolled Hypertension
This is a multicenter, randomized, double-blind, placebo-controlled phase II study designed to explore the efficacy and safety of different doses of SAL0140 in uncontrolled hypertension.
- Trial name
- NCT07654140
- Testing
- SAL0140
- Where
- China
- Volunteers
- 252 people
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.
Normal Blood Pressure, Controlled Hypertension
Wearable Evaluation of Ambulatory Readings for Blood Pressure
The purpose of this project is to compare the performance and validity of novel wearable technologies that measure blood pressure (BP) and physical activity with a Spacelabs Ambulatory Blood Pressure Monitoring (ABPM) device.
- Conditions
- Normal Blood Pressure, Controlled Hypertension, Uncontrolled Hypertension
- Trial name
- WEAR-BP (NCT06610448)
- Testing
- ABPMPro, Spacelabs Ambulatory Blood Pressure Monitoring, Aktiia Blood Pressure
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Stephen Juraschek
Uncontrolled Hypertension
Remote Hypertension Management for Black Patients
This study will compare two approaches for managing hypertension in Black patients with uncontrolled blood pressure (BP). One approach will include home BP telemonitoring supported by a pharmacist and a community health worker.
- Trial name
- RHYTHM-B (NCT06527794)
- Testing
- RHYTHM (Remote Hypertension Tracking Help Management), Enhanced usual care (UC)
- Where
- United States
- Volunteers
- 864 people
- Sponsor
- Wake Forest University Health Sciences
Uncontrolled Stage 2 Hypertension
REDUCED 1 - Renal Denervation Using Ultrasonic Catheter EmitteD Energy Study /
This is a prospective, multicenter, non-randomized, open-label clinical study of the safety and performance of the TIVUS™ System in subjects with uncontrolled stage 2 hypertension in order to assess the safety and effectiveness…
- Trial name
- REDUCED (NCT05372679)
- Testing
- Renal denervation
- Where
- 9 sites in United States
- Volunteers
- 25 people
- Sponsor
- SoniVie Inc.
Uncontrolled Hypertension
Sequential Multiple Assignment Randomized Trial to Reduce Food Insecurity
Food insecurity affects 20% of the 116 million people in the US with hypertension and is associated with poor adherence to evidence-based treatments and disparities in hypertension outcomes.
- Trial name
- SMART (NCT07031739)
- Testing
- Resource information, Community Health Worker (CHW) assistance, Medically-tailored Meals (MTM)
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Wake Forest University Health Sciences
Uncontrolled Hypertension, Autosomal Dominant Polycystic Kidney Disease
Renal Denervation in ADPKD- RDN-ADPKD Study
RDN-ADPKD is a prospective, randomized (1:1, central randomization), single-center, hypothesis-generating, feasibility study. The purpose of the RDN-ADPKD study is to demonstrate efficacy and document safety of renal denervation…
- Conditions
- Uncontrolled Hypertension, Autosomal Dominant Polycystic Kidney Disease, Renal Denervation
- Trial name
- RDN-ADPKD (NCT05460169)
- Testing
- Renal denervation
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Uncontrolled Hypertension
Implementation of Effective Hypertension Management Approaches: OSF HealthCare
The goal of this observational pragmatic study is to learn about how evidence-based interventions and best practices for management of uncontrolled hypertension can be integrated across a large healthcare system through the use…
- Trial name
- NCT07450222
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Colleen J Klein
Hypertension, Uncontrolled Hypertension
Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Iloperidone for the Treatment of Participants with Uncontrolled Hypertension
- Trial name
- NCT07090161
- Testing
- iloperidone
- Where
- 28 sites in United States
- Volunteers
- 240 people
- Sponsor
- Vanda Pharmaceuticals
Uncontrolled Hypertension
Netrod-Pilot Study of Renal Denervation With NetrodTM Sixelectrode Radiofrequency RDN System
This single-arm, non-randomized, open-label investigation aims to collect safety and efficacy data of the CE-Marked Netrod™ RDN System in treating European patients with primary hypertension in the absence of anti-hypertensive…
- Trial name
- NCT07061054
- Testing
- Netrod™ six-electrode radiofrequency renal denervation system
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Shanghai Golden Leaf MedTec Co. Ltd
Uncontrolled Hypertension
A Food Effect Study of QLS1410 in Healthy Chinese Adults
This study is aimed to evaluate the effect of food on pharmacokinetics of QLS1410 in healthy Chinese adults.
- Trial name
- NCT07358858
- Testing
- QLS1410
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Uncontrolled Hypertension
Engaging Patients in Adherence Interventions Using Behavioral Science
The overarching goal of the proposed research is to prepare an evidence-based clinical pharmacist-delivered medication adherence intervention for sustainable implementation and dissemination.
- Trial name
- ENGAGE-HTN (NCT06543394)
- Testing
- Primer postcard, Control recruitment letter, Behavioral theory-informed recruitment letter
- Where
- United States
- Volunteers
- 584 people
- Sponsor
- Columbia University
Uncontrolled Hypertension
A Phase I Trial of QLS1410 in Healthy Chinese Adults and Participants With Mild Essential Hypertension
The goal of this clinical trial is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and food effect of single and multiple ascending doses of QLS1410 in healthy Chinese adults and participants with mild…
- Trial name
- NCT07152444
- Testing
- QLS1410 (CYP11B2 inhibitor)
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Uncontrolled Hypertension
SAL0140 Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study in a Healthy Chinese Population
The purpose of this study is to evaluate the safety, tolerability pharmacokinetics and pharmacodynamics of SAL0140 healthy Chinese population.
- Trial name
- NCT07051603
- Testing
- SAL0140
- Where
- China
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.