Clinical trials: Uncomplicated Infections
Cystitis Acute, Antibiotic Resistant Infection
Dipsticks and Microscopy to Reduce Antibiotic Use in Women's Urinary Tract Infections: a Pilot Trial (MicUTI)
With the aim to pilot a full-scaled trial to reduce unnecessary antibiotics in women with suspected uncomplicated urinary tract infections, twenty general practices in Bavaria, Germany, will be randomized to deliver patient…
- Conditions
- Cystitis Acute, Antibiotic Resistant Infection, Medication Adherence, Urinary Tract Infection Bacterial
- Trial name
- MicUTI (NCT05667207)
- Testing
- Point-of-care microscopy and dipstick guided management
- Where
- 2 sites in Germany
- Volunteers
- 154 people
- Sponsor
- Wuerzburg University Hospital
Pulmonary TB
A Phase 1/2 Trial of Multiple Oral Doses of OPC-167832 for Uncomplicated Pulmonary Tuberculosis
This trial will evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of multiple oral doses of OPC-167832 in participants with uncomplicated, smear-positive, drug-susceptible pulmonary tuberculosis (TB).
- Trial name
- NCT03678688
- Testing
- 10 mg OPC-167832, 30 mg OPC-167832, 90 mg OPC-167832
- Where
- 3 sites in South Africa
- Volunteers
- 122 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Malaria
Dihydroartemisinin- Piperaquine Versus Artemether- Lumefantrine in the Treatment Uncomplicated Plasmodium Falciparum Malaria in Sudan
Dihydroartemisinin- Piperaquine is not inferior to artemether-lumefantrine
- Trial name
- NCT01075945
- Testing
- Dihydroartemisinin- piperaquine, artemether- lumefantrine
- Where
- Sudan
- Volunteers
- 140 people
- Sponsor
- University of Khartoum
Urinary Tract Infections
Symptomatic Therapy of Uncomplicated Lower Urinary Tract Infections in the Ambulatory Setting.
We propose to perform a randomized controlled patient and assessor blind trial in women between the ages of 18 to 70 years with acute uncomplicated UTI to evaluate initial symptomatic treatment for 3 days with the non-steroidal…
- Trial name
- NCT01039545
- Testing
- Diclofenac, Norfloxacin
- Where
- Switzerland
- Volunteers
- 253 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Malaria
In Vivo Efficacy of Artemether-lumefantrine and Amodiaquine-artesunate in Mozambican Children
This is a classical in vivo clinical trial, following World Health organization's recommendations, ran as a multisite study within Mozambique trying to assess the efficacy and safety in 5 sites of the two oral ACTS…
- Trial name
- MEFI (NCT02168569)
- Testing
- Coartem™ (Artemether-lumefantrine combination), Coarsucam™ (Amodiaquine-artesunate combination)
- Where
- 5 sites in Mozambique
- Volunteers
- 700 people
- Sponsor
- Centro de Investigacao em Saude de Manhica
Skin Diseases, Infectious
A Study of the Safety and Effectiveness of Oral Levofloxacin Compared With Oral Ciprofloxacin in the Treatment of Adults With Uncomplicated Infections of the Skin and the Supportive Layers Beneath the Skin
The purpose of this study is to evaluate the safety and effectiveness of levofloxacin, an antibiotic, compared with another antibiotic, ciprofloxacin, in the treatment of adults with uncomplicated infections of the skin and the…
- Trial name
- NCT00257062
- Testing
- Levofloxacin
- Volunteers
- 361 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Rhinosinusitis
Efficacy and Safety of Acetylcysteine for the Treatment of Acute Uncomplicated Rhinosinusitis
The trial was conducted as a prospective, randomized, multinational, multicenter, double-blind study in 4 parallel groups of patients.
- Trial name
- NCT04123405
- Testing
- acetylcysteine
- Where
- 37 sites in Bulgaria, Germany and 2 more
- Volunteers
- 944 people
- Sponsor
- Sandoz
Gonorrhea
Zoliflodacin in Uncomplicated Gonorrhoea
This trial is a multi-center, open label, randomized controlled, non-inferiority phase III trial evaluating the safety and efficacy of a 3 g oral dose of zoliflodacin compared to a combination of a single intra-muscular 500 mg…
- Trial name
- NCT03959527
- Testing
- zoliflodacin, ceftriaxone, azithromycin
- Where
- 17 sites in United States, Belgium and 3 more
- Volunteers
- 1,011 people
- Sponsor
- Global Antibiotics Research and Development Partnership
Acute Appendicitis
Optimizing the Antibiotic Treatment of Uncomplicated Acute Appendicitis
Appendicectomy has been the treatment of acute appendicitis for over a hundred years. Appendicectomy, however, includes operative and postoperative risks despite being a routine procedure.
- Trial name
- APPACII (NCT03236961)
- Testing
- Ertapenem, Moxifloxacin
- Where
- Finland
- Volunteers
- 552 people
- Sponsor
- Turku University Hospital
Falciparum Malaria
Effectiveness of the Association Artesunate and Mefloquine in the Treatment of Malaria by Plasmodium Falciparum
The purpose of this study was to evaluate the effectiveness of the fixed combination of artesunate+mefloquine in the treatment of uncomplicated malaria caused by Plasmodium falciparum in the municipality of Cruzeiro do Sul, Juruá…
- Trial name
- NCT01144702
- Testing
- artesunate & mefloquine combination
- Where
- 2 sites in Brazil
- Volunteers
- 163 people
- Sponsor
- Oswaldo Cruz Foundation
Influenza
A Study to Evaluate the Efficacy and Safety of Intravenous Peramivir in Subjects With Uncomplicated Influenza.
This is a study to evaluate the efficacy and safety of a single dose of intravenous peramivir versus placebo in adolescents and adults with acute uncomplicated influenza.
- Trial name
- NCT01224795
- Testing
- Peramivir
- Where
- 96 sites in United States
- Sponsor
- BioCryst Pharmaceuticals
Urinary Tract Infections
Observational Follow-up Study of REGATTA
Observational follow-up study of patients included in the clinical trial REGATTA.
- Trial name
- REGATTA II (NCT03176563)
- Testing
- Arctuvan, Fosfomycin
- Where
- 47 sites in Germany
- Volunteers
- 398 people
- Sponsor
- University Medical Center Goettingen
Malaria (Uncomplicated)
Efficacy of Artemether-Lumefantrine in the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Children Under 12 Years at Four Sentinel Sites in Mozambique
This is a classical in vivo clinical trial, following World Health organization's recommendations, ran as a multisite study within Mozambique trying to assess the efficacy and safety in four sites of artemether-lumefantrine (AL)…
- Trial name
- NCT06970600
- Testing
- Artemether-lumefantrine (Coartem)
- Where
- 4 sites in Mozambique
- Volunteers
- 352 people
- Sponsor
- Centro de Investigacao em Saude de Manhica
Pelvic Inflammatory Disease
Uncomplicated Pelvic Inflammatory Disease. Treatment With Moxifloxacin.
Comparison of various antibiotics in treatment of uncomplicated pelvic inflammatory disease
- Trial name
- MAIDEN (NCT00683865)
- Testing
- Ofloxacin, Avelox (Moxifloxacin, BAY12-8039)
- Where
- 77 sites in Denmark, Finland and 11 more
- Volunteers
- 749 people
- Sponsor
- Bayer
Febrile Urinary Tract Infection
Individualized Antibiotic Therapy in Children With Acute Uncomplicated Febrile Urinary Tract Infection
An investigator-initiated, open-label, multi-center, randomized, non-inferiority trial of children aged 3 months to 13 years with acute uncomplicated febrile urinary tract infection.
- Trial name
- NCT05301023
- Testing
- Individualized antibiotic therapy, Standard antibiotic therapy
- Where
- 8 sites in Denmark
- Volunteers
- 408 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Vivax Malaria
Study of ACTs Plus Primaquine for Uncomplicated Plasmodium Vivax Malaria
This randomized clinical trial will be conducted in subjects with uncomplicated Plasmodium vivax malaria during November 2010 to March 2012.
- Trial name
- ACTPQ (NCT01288820)
- Testing
- Dihydroartemisinin/piperaquine + primaquine, Artesunate-amodiaquine + primaquine
- Where
- Indonesia
- Volunteers
- 331 people
- Sponsor
- University of Oxford
Skin Infections, Bacterial
Pharmacokinetics of Retapamulin in Pediatric Subjects With Uncomplicated Skin Infections.
A study to evaluate the pharmacokinetics of Retapamulin Ointment, 1%, in pediatric subjects (2-24 months) with secondarily-infected traumatic lesions, secondarily-infected dermatoses, or impetigo (bullous and non-bullous).
- Trial name
- NCT00555061
- Testing
- Retapamulin Ointment, 1%
- Where
- 25 sites in United States, Argentina and 7 more
- Volunteers
- 60 people
- Sponsor
- GlaxoSmithKline
Appendicitis, Other and Unspecified Acute Appendicitis
The Optimization of a Low-dose Computed Tomography Protocol in Patients With Suspected Uncomplicated Acute Appendicitis
This study focuses on the use of contrast enhanced low-dose CT imaging as a modality to differentiate between uncomplicated and complicated acute appendicitis.
- Conditions
- Appendicitis, Other and Unspecified Acute Appendicitis, Acute Disease, Gastrointestinal Diseases
- Trial name
- OPTICAP (NCT02533869)
- Testing
- Low-dose CT, Laparoscopic appendectomy
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Turku University Hospital
Malaria
Efficacy, Safety, Tolerability and Pharmacokinetics of KAE609 in Adult Patients With Acute, Uncomplicated Plasmodium Falciparum or Vivax Malaria Mono-infection
This study will assess efficacy, safety , tolerability and PK in uncomplicated adult malaria patients with P. vivax or P. falciparum infection after 3 day dosing with KAE609 at 30 mg/day
- Trial name
- NCT01524341
- Testing
- KAE609
- Where
- 3 sites in Thailand
- Volunteers
- 27 people
- Sponsor
- Novartis Pharmaceuticals
Malaria
Kintampo Trial of Combination Therapy for Malaria
Case management is one of the key strategies for malaria control in most endemic countries. Plasmodium falciparum malaria is becoming resistant to commonly used and cheap antimalarial drugs such as chloroquine, amodiaquine, and…
- Trial name
- NCT00119145
- Testing
- artesunate-amodiaquine, coartem, artesunate-lapdap
- Where
- Ghana
- Volunteers
- 510 people
- Sponsor
- London School of Hygiene and Tropical Medicine