Clinical trials: Type1diabetes
Type1diabetes, Insulitis
Pancreas Ultrasound Imaging in type1 Diabetes
The overall goal of this study is to develop and test a novel method involving ultrasound imaging, in order to detect the development of type 1 diabetes.
- Conditions
- Type1diabetes, Insulitis, Pancreas Inflamed
- Trial name
- NCT05482321
- Testing
- Definity Suspension for Injection
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
type1diabetes, Hunger
Postprandial Gut Hormone Responses in Patients With Type 1 Diabetes Mellitus
The study will compare the postprandial responses to a test meal between subjects with type 1 diabetes and healthy control subjects, in terms of gut hormone levels, meal induced thermogenesis, hunger and satiety perception, as…
- Conditions
- type1diabetes, Hunger, Obesity
- Trial name
- NCT04430946
- Testing
- Standardized test meal
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Type1diabetes
Crosstalk Between Mucosal-Associated Invariant T (MAIT) Cells and the Gut Microbiota and Mucosa in the Development of Type 1 Diabetes in Children
To investigate in a prospective way changes in Mucosal-Associated Invariant T (MAIT) cells frequency, phenotype and function in link with the gut microbiota, gut integrity and the presence of Coxsackie virus B in two cohorts of…
- Trial name
- MAIT-DT1 (NCT05054361)
- Testing
- MAIT cells analysis, MAIT cytokines production analysis, Lactulose/Mannitol Test
- Where
- 2 sites in France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Type1diabetes
Thrive With Type 1 Diabetes 2026
This study aims to learn whether a cognitive behavioral intervention can improve lifestyle and glucose targets for adults with type 1 diabetes.
- Trial name
- NCT07522866
- Testing
- TranS-C Intervention Arm, Attention Control Enhanced Usual Care (EUC) Arm
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Emory University
Type1diabetes
Metabolic Adaptation to High-frequent Hypoglycaemia in Type 1 Diabetes
An experimental mechanistic study. The overall objective is to gain new knowledge about mechanisms involved in adaptation to recurrent hypoglycaemia in diabetes by investigating patients with type 1 diabetes and healthy controls.
- Trial name
- HypoADAPT (NCT05095259)
- Testing
- insulin human, Epinephrin, Muscle biopsy
- Where
- 2 sites in Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nordsjaellands Hospital
Type1diabetes
CGMIS 48-hour Feasibility Study
This is a single center, single arm non-randomized study of 48-hour CGMIS wear duration incorporating two meal-challenge tests to explore the performance of a single insertion combined glucose-sensing insulin delivery cannula.
- Trial name
- NCT05562206
- Testing
- CGMIS (Continuous Glucose Monitoring Infusion Set)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pacific Diabetes Technologies
Type1diabetes
Fasted Exercise in People With Type 1 Diabetes
This study aims to compare the effect of a bout of high-intensity interval training (HIT) with a bout of moderate-intensity continuous training (MICT) on glucose concentrations over the subsequent 24h period.
- Trial name
- NCT03544684
- Testing
- Effects of the type of exercise on blood glucose concentrations
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Type1diabetes, Hypoglycemia
Introducing CGM at Type 1 Diabetes Diagnosis
Diabetes technology is changing and has quickly become an integral part of diabetes care and management. The study team plans to study the effects of introducing technology to newly diagnosed type 1 diabetes patients.
- Trial name
- NCT03736083
- Testing
- Freestyle Libre Blood Glucose Monitor
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Type 1 Diabetes, Hypoglycemia
Neuronostatin - a Glucagonotropic Agent in Humans?
With the present study the investigators wish to delineate the effects of neuronostatin-13 (NST) on glucose-dependent glucagon secretion in humans.
- Conditions
- Type 1 Diabetes, Hypoglycemia, Type1diabetes
- Trial name
- NSTCLAMP (NCT06143267)
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
type1diabetes, Type2 Diabetes
Efficacy and Safety of Recombinant Human Insulin Patch ZJSRM2021
The aim of this study is to investigate the efficacy，safety， and tolerability of the recombinant human insulin patch ZJSRM2021 in healthy subjects, type 1diabetes mellitus and type 2diabetes mellitus patients
- Trial name
- NCT05089942
- Testing
- Recombinant Human Insulin Patch ZJSRM2021
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Zhejiang Provincial People's Hospital
Type1diabetes
Gluten and Amylase Trypsin Inhibitors (ATI) Free Diet
Siblings of those with type 1 diabetes are at an increased risk of developing the disease themselves. Through prior research, the investigators have found that siblings as well as those with type 1 diabetes have a general level…
- Trial name
- NCT03443180
- Testing
- Gluten and Amylase Trypsin Inhibitors (ATI)-free diet
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Type1diabetes, Diabetes Mellitus, Type 1
Genetics Of Autoimmunity In Type I Diabetes
The purpose of this study is to gain more information about the step-by-step process that causes someone to develop type 1 diabetes.
- Conditions
- Type1diabetes, Diabetes Mellitus, Type 1, Type1 Diabetes Mellitus, Diabetes Mellitus
- Trial name
- NCT03648918
- Testing
- Blood Collection
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Type1diabetes, Depressive Symptoms
Type 1 Diabetes and Depression: Role of Brain Glutamate
The goal of this study is to examine the effect of chronic and acute hyperglycemia in type 1 diabetes mellitus (T1DM) on brain glutamate levels using magnetic resonance spectroscopy (MRS), and associations of brain glutamate with…
- Conditions
- Type1diabetes, Depressive Symptoms, Major Depressive Disorder
- Trial name
- NCT05355285
- Testing
- Glucose Clamp
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Type1diabetes, Therapeutic Play
The Effect of Therapeutic Play on Anxiety and Fear Levels in Children With Diabetes
The study will be conducted using a randomized controlled method. Children with type 1 diabetes who are admitted to the Pediatric Endocrinology Service will be divided into two groups by randomization method.
- Conditions
- Type1diabetes, Therapeutic Play, Fear State, Anxiety State
- Trial name
- NCT06418269
- Testing
- Therapeutic Play
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Type1diabetes
HIT on Hypoglycaemic Risk in T1D
There is clear evidence that regular exercise improves wellbeing and reduces the risk of diabetes related complications in people with type 1 diabetes. However, many people with type 1 diabetes do not exercise regularly.
- Trial name
- NCT05044442
- Testing
- moderate intensity continous training, high intensity interval training
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Type1diabetes, Type1 Diabetes Mellitus
Modulation of Type 1 Diabetes Susceptibility Through the Use of Probiotics
Investigators aim to further the understanding of environmental factors that underlie the progression to Type 1 diabetes (T1D). Dysbiosis, defined as alterations in intestinal microbiota composition and function, has been…
- Trial name
- NCT03423589
- Testing
- VSL#3
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Type1diabetes
The Relationship of RAGE Gene Polymorphism With Type I Diabetes in Egyptian Patients
Type I Diabetes Mellitus (TIDM) is a chronic metabolic disorder caused by the immune-mediated T-cell and macrophages that typically affects insulin-producing β-cells of Langerhans leading to cell destruction and absolute insulin…
- Trial name
- NCT05874323
- Testing
- Detection of RAGE gene polymorphism (rs1800625)
- Where
- Egypt
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Type1diabetes, Parents
Parents of Young Adults With Type 1 Diabetes: An Exploratory Study
The purpose of this mixed-methods study is to explore the lived experience of parents of young adults ages 18 to 25 years with type 1 diabetes who are transitioning to independence, and to test the preliminary efficacy of a…
- Trial name
- NCT03158415
- Testing
- T1DToolkit.org mobile diabetes education
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Florida
Type1diabetes
School Readiness in Children with Type 1 Diabetes
It is known that motor and sensory functions are affected in children with type 1 diabetes (T1DM).This may cause children to have restrictions in their daily lives and decrease their participation in activities.Motor and sensory…
- Trial name
- NCT06673251
- Testing
- motor and sensory assessments, surveys
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- arife akbulut
Type1diabetes
Food Literacy and Type 1 Diabetes
The objective of the current study is to assess the prevalence of poor food literacy in young adults with type 1 diabetes through a national on-line survey.
- Trial name
- NCT03588234
- Where
- Canada
- Volunteers
- 427 people, healthy volunteers welcome
- Sponsor
- McGill University