Clinical trials: Type I Chiari Malformation
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Chiari Malformation Type I, Proprioceptive Disorders
Investigation of the Effects of Exercise on Patients With Chiari Malformation
Chiari Malformation (CM) is a posterior brain anomaly caused by the displacement of the brain stem and cerebellum into the cervical spinal canal.
- Conditions
- Chiari Malformation Type I, Proprioceptive Disorders, Coordination and Balance Disturbances, Syringomyelia
- Trial name
- NCT04220541
- Testing
- Motor learning based exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Hacettepe University
Type I Chiari Malformation, Cerebral Hemodynamic
Analysis of Disturbances in Neurofluid Dynamics in Type I Chiari Malformations
A global analysis of craniospinal hemodynamics and hydrodynamics is necessary to better understand the pathophysiology of Chiari malformations.
- Conditions
- Type I Chiari Malformation, Cerebral Hemodynamic, Craniospinal Hydrodynamic, Phase Contrast MRI
- Trial name
- NEUROFLUX-C (NCT06502431)
- Testing
- phase contrast sequences
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Chiari Malformation Type I, Syringomyelia
Abnormality of the Central Canal of the Spinal Cord in Syringomyelia in a Patient With a Basal Skull Malformation
The aim of this study is to analyze the association between a deformity of the cranial portion of the central spinal canal and syringomyelia in patients with a Chiari-type malformation of the craniocervical junction.
- Trial name
- SYRCANAL (NCT07720206)
- Testing
- MRI
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Syringomyelia, Type I Arnold Chiari Malformation
Genetic Analysis of the Chiari I Malformation
The purpose of this study is to better understand the genetic factors related to the Chiari I malformation. In people with this abnormality, the lower part of the skull is smaller than normal.
- Trial name
- NCT00004738
- Where
- 2 sites in United States, Russia
- Volunteers
- 152 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Chiari Malformation Type I, Tonsillectomy
PFDD Versus PFDRT in Chiari Decompression Surgery
The purpose of this study is to determine whether a posterior fossa decompression and duraplasty with or without tonsil manipulation results in better patient outcomes with fewer complications and improved quality of life in…
- Trial name
- NCT06079125
- Testing
- Posterior fossa decompression with duraplasty, PFDD with tonsillar resection/reduction
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Xuanwu Hospital, Beijing
Arnold Chiari Malformation
Investigation of the Effects of Exercise Program in Patients With Chiari Type 1 Malformation
This study will be conducted in Hacettepe University Faculty of Medicine Neurosurgery Department and Hacettepe University Faculty of Physical Therapy and Rehabilitation. The study was designed as a randomized controlled trial.
- Trial name
- NCT04073667
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 8 people
- Sponsor
- Hacettepe University
Chiari Malformation, Type 1
Modalities of Surgical Treatment of Chiari Malformation Disease : Clinical Study and Outcomes
Evaluation of postoperative outcomes of Chiari type I Malformation Patients at Department of Neurosurgery Assiut University Hospital .
- Trial name
- NCT06029101
- Testing
- posterior fossa craniectomy with or without duraplasty
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Assiut University
Arnold-Chiari Malformation, Type 1, Chiari Malformation Type I
Posterior Fossa Decompression With or Without Duraplasty for Chiari Type I Malformation With Syringomyelia
The purpose of this study is to determine whether a posterior fossa decompression or a posterior fossa decompression with duraplasty results in better patient outcomes with fewer complications and improved quality of life in…
- Conditions
- Arnold-Chiari Malformation, Type 1, Chiari Malformation Type I, Type I Arnold-Chiari Malformation, Syringomyelia
- Trial name
- NCT02669836
- Testing
- Posterior fossa decompression, Dural Augmentation
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Washington University School of Medicine
Chiari Malformation Type I
Health-related Quality of Life in Chiari Malformation Type 1 - A National Cross-Sectional Patient Survey
The goal of this observational survey study is to investigate factors that may affect the health-related quality of life (HRQoL) in adults with Chiari malformation type 1 (CM1).
- Trial name
- NCT07818122
- Where
- Sweden
- Volunteers
- 1,004 people
- Sponsor
- Karolinska Institutet
Chiari I Malformation, Pediatric
Postual Control in Pediatric Chiari I Malformation
BACKGROUND: Chiari I malformation is a rare disease characterized by cerebellar amygdalae descent under the level of the foramen magnum.
- Trial name
- NCT04679792
- Testing
- Dynamic posturography
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Central Hospital, Nancy, France
Tethered Cord, Chiari I Malformation
Magnetic Resonance Imaging of the Spine
Diffusion-weighted (DW) magnetic resonance imaging (MRI) imaging is a well established method for detecting acute injury to the brain and is used on all children undergoing an MRI brain scan at Children's Healthcare of Atlanta.
- Trial name
- MRIS (NCT01382290)
- Testing
- MRI
- Where
- United States
- Sponsor
- Children's Healthcare of Atlanta
Chiari Type I Malformation
The Genetics of Chiari Type I Malformation
Duke University Medical Center is investigating the hereditary basis of Chiari type I malformations with or without syringomyelia (CM1/S).
- Trial name
- NCT01060800
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Duke University
Chiari Malformation, Type 1
Identification of Genetic Mutations Involved in Chiari Type I Malformations
Although most cases of Chiari malformation type I (CM1) are sporadic, familial cases of CM1, with or without syringomyelia, suggest a genetic cause in the pathogenesis of these malformations.
- Trial name
- ChiariGene (NCT05165030)
- Testing
- Blood Sample
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Arnold-Chiari Malformation, Type 1
Arnold Chiari Malformation: the Otological Assessment as an Objective Criteria for Surgical Treatment
The aim of this study is to compare the value of multifrequency tympanometry between patients with surgical indication of treatment for a Chiari type I malformation and healthy volunteers.
- Trial name
- MCoto (NCT03295864)
- Testing
- Multifrequency tympanometry at Inclusion, Multifrequency tympanometry 6 month after surgery
- Where
- France
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux