Clinical trials: Type A Aortic Dissection
Aortic Dissection, Left Subclavian Artery Occlusion
Endovascular Repair With In Situ nEedle feNestration of Left Subclavian Artery to Treat AoRtic Dissection(RISEN STAR):A Multicenter Prospective Trial.
Background: Aortic dissection (AD) is a common emergency in vascular surgery, which seriously threatens human life and health. The rupture of Stanford type B dissection is located in aortic arch and the dissection range is from…
- Conditions
- Aortic Dissection, Left Subclavian Artery Occlusion, Vascular Diseases, Interventional Therapy
- Trial name
- NCT05186181
- Testing
- In situ fenestration
- Where
- China
- Volunteers
- 217 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Acute Type A Dissection
Mechanical Characterization of Ascending Aorta in Patients With and Without Aortic Dissection
Acute type A aortic dissection is a frequent (3 cases per 100 000 people per year) and severe (spontaneous mortality 70%), needing an emergency surgical treatment.
- Trial name
- NCT02860182
- Testing
- measure the elastic properties of aortic wall
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Vascular Ehlers Danlos Syndrome
An Exercise and Lifestyle Programme for Adults With Vascular Ehlers-Danlos Syndrome: A Feasibility Study
Vascular Ehlers-Danlos syndrome (vEDS) is a rare, life-threatening connective tissue disorder. People with vEDS have often been advised to limit physical activity, yet the safety and feasibility of structured exercise in this…
- Trial name
- NCT07697573
- Testing
- Co-designed exercise-based lifestyle intervention
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Sheffield Hallam University
Type A Aortic Dissection
iNO as Salvage Treatment of Hypoxemia After TAAD Surgery
The purpose of this study was to clarify the possible mechanism of hypoxemia after surgical treatment of type A acute aortic dissection and the possible mechanism of the treatment role of inhaled nitric oxide in refractory…
- Trial name
- NCT04032366
- Testing
- inhaled nitric oxide, PEEP
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Zhongshan Hospital
Aortic Dissection Type B
WeFlow-EndoSeal™ Aorta Vascular Plug System for the Treatment of Stanford Type B Aortic Dissection
The goal of this prospective, multicenter, randomized controlled clinical trial is to evaluate the safety and efficacy of the WeFlow-EndoSeal™ vAorta Vascular Plug System combined with thoracic endovascular aortic repair (TEVAR)…
- Trial name
- NCT07658651
- Testing
- WeFlow-EndoSeal™ Aorta Vascular Plug System, Thoracic Endovascular Aortic Repair（TEVAR）
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Hangzhou Endonom Medtech Co., Ltd.
Hypoxemia, Ventilator Lung
Driving Pressure-guided Lung Protective Ventilation
The study, named as "The Efficacy of Driving Pressure-guided Lung Protective Ventilation in Surgical Repair of Acute Type A Aortic Dissection: an open-label, randomized control clinical trial", aims to investigate whether driving…
- Trial name
- DPV (NCT06361420)
- Testing
- Driving pressure-guided positive end expiratory pressure, Optimal oxygenation-guided positive end expiratory pressure, Ventilation strategy
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Yong Lin, PhD
Aortic Dissection
Hemiarch vs Extended Arch in Type 1 Aortic Dissection
HEADSTART is a prospective, open-label, non-blinded, multicenter, randomized controlled trial that compares a composite of mortality and re-intervention in patients undergoing hemiarch and extended arch repair for acute DeBakey…
- Trial name
- HEADSTART (NCT03885635)
- Testing
- Hemiarch repair, Extended arch repair
- Where
- 5 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Acute Aortic Syndrome, Aortic Dissection Type A
Protective Effect of Thymosin α1 Against Negative Immune Dysregulation and Organ Dysfunction After Acute Aortic Dissection Surgery (PANDA II)
Systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) are the major causes of death in patients with acute aortic syndrome (AAS).
- Trial name
- PANDA (NCT05339529)
- Testing
- Thymosin Alpha1, 28A-Glycine-28B-L-Arginine-28C-L-Glutamic Acid-28D-L-Alanine-28E-L-Proline-28F-L-Alanine-28G-L-Asparagine-, Blank control
- Where
- 15 sites in China
- Volunteers
- 600 people
- Sponsor
- Nanjing Medical University
Type B Aortic Dissection
Korean Registry of Thoracic Endovascular Aortic Repair Timing for Type B Aortic Dissection (K-TEAM Study): A Prospective Multicenter Registry
Prospective, single-arm, multi-center registry study A total of 50 subjects with Type B aortic dissection who meet all inclusion and exclusion criteria will be included.
- Trial name
- NCT02816333
- Sponsor
- Yonsei University
Aortic Dissection Type B
EndoVascular Aortic Dissection Early vs Delayed
This is a prospective, multicenter, non-inferior, parallel-controlled observational study. This study aims to compare clinical outcomes of endovascular treatment for acute high-risk type B aortic dissection in the acute phase…
- Trial name
- EVADE (NCT07143071)
- Testing
- Acute Phase, Subacute Phase
- Where
- China
- Volunteers
- 4,068 people
- Sponsor
- Shanghai Zhongshan Hospital
Aortic Dissection, Stroke
Neurological Complications and ICU Workload After Emergency Repair of Acute Type A Aortic Dissection
Single-center retrospective cohort at China Medical University Hospital (Taichung, Taiwan) using fully de-identified electronic health records.
- Conditions
- Aortic Dissection, Stroke, Paraplegia, AKI - Acute Kidney Injury
- Trial name
- ATAAD-ICU (NCT07167628)
- Where
- Taiwan
- Volunteers
- 274 people
- Sponsor
- China Medical University Hospital
Acute Aortic Dissection
A Triple-branched Stent Graft for Aute Debakey Type I Dissection Surgery
Prospective, multicenter, randomized controlled clinical trial plan to evaluate the effectiveness and safety of intraoperative stent system in the treatment of acute type I aortic dissection
- Trial name
- NCT06492980
- Testing
- triple-branched stent graft
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Fujian Medical University
Aortic Dissection
Optimized Strategies for Malperfusion Syndrome
An investigator-initiated, randomized, multicenter, two-arm, open-label study of consecutive patients presenting with acute type A aortic dissection (ATAAD) and malperfusion syndrome (MPS).
- Trial name
- NCT06532838
- Testing
- Optimized treatment strategies, Traditional treatment strategies
- Where
- China
- Volunteers
- 236 people
- Sponsor
- Xiamen Cardiovascular Hospital, Xiamen University
Penetrating Ulcer of Aorta, Aneurysm Aortic
Evaluation of the Valiant Captivia Physician Fenestrated Stent Graft System in Aortic Arch and Descending Thoracic Aorta Pathologies
The study objectives are to assess safety and effectiveness, measured acutely and at the 30-day visit after implantation of the Valiant Captivia physician fenestrated Stent Graft.
- Conditions
- Penetrating Ulcer of Aorta, Aneurysm Aortic, Type B Aortic Dissection, Residual Dissection After Type A Repair
- Trial name
- EVERGREEN (NCT05479305)
- Testing
- The Valiant Captivia Stent Graft
- Where
- 4 sites in France
- Volunteers
- 30 people
- Sponsor
- Ceric Sàrl
Type B or Non-A Non-B Aortic Dissection;Thoracic Aortic Aneurysm
Aspirin for Prevention of Stroke After Endovascular Aortic Arch Repair: a Multicenter, Double-Blind, Randomized Controlled Trial
ABSTRACT Introduction Endovascular aortic arch repair (EAAR) and the endovascular reconstruction of arch branch vessels represent a new trend in managing aortic arch pathologies, due to advantages such as minimal invasiveness…
- Trial name
- NCT07205250
- Testing
- enteric-coated aspirin tablets (100 mg once daily, Bayer Healthcare, specification: 100 mg/tablet)
- Volunteers
- 224 people
- Sponsor
- The General Hospital of Western Theater Command
Methylprednisolone, Glucocorticoid
Glucocorticoids for Post-operative Patients With Acute Type A Aortic Dissection (The GLAD Trial)
This study is designed to evaluate the effects of glucocorticoid(GC) on improving post-operative organ dysfunction in patients with acute type A aortic dissection(aTAAD).
- Conditions
- Methylprednisolone, Glucocorticoid, Aortic Dissection, Organ Dysfunction
- Trial name
- NCT05329740
- Testing
- Methylprednisolone Injection
- Where
- China
- Volunteers
- 212 people
- Sponsor
- Shanghai Zhongshan Hospital
Acute Type A Aortic Dissection
Efficacy of Bilateral Modified Catheter Antegrade Cerebral Perfusion in Acute Type A Aortic Dissection Surgery
This retrospective cohort study aims to evaluate the efficacy of a Bilateral Modified Catheter Antegrade Cerebral Perfusion (Modified bACP) technique in acute Type A aortic dissection surgery.
- Trial name
- NCT06943716
- Testing
- Modified Catheter Antegrade Cerebral Perfusion (Modified bACP), Conventional Brain Perfusion
- Where
- Taiwan
- Volunteers
- 273 people
- Sponsor
- China Medical University Hospital
Aortic Dissection
Percutaneous Plug-based Femoral Arteriotomy Closure Device Use in Surgery for Acute Type A Aortic Disection
A single-center prospective study. Patients undergoing surgery for acute type A aortic dissection with femoral arterial cannulation between 2017 and 2022 at the Karolinska University Hospital in Stockholm, Sweden are eligible.
- Trial name
- NCT05482555
- Testing
- Percutaneous arteriotomy closed using a plug-based arteriotomy closure device, Surgical cut-down and arterial puncture under direct vision
- Where
- Sweden
- Volunteers
- 171 people
- Sponsor
- Karolinska University Hospital
Hypofibrinogenemia
A Point-of-care Electrochemical-based Device for Rapid Detection of Fibrinogen on Type A Aortic Dissection Surgery
This study compares the results of the existing fibrinogen concentration monitoring technology to the Electrochemical-based device, a point-of-care and rapid method,using a small amount of extra blood obtained in Type A Aortic…
- Trial name
- NCT06434389
- Testing
- the Electrochemical-based device
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Proximal Aortic Dissection
Safety and Efficacy of Fibrinogen Concentrate in Aortic Arch Surgery Involving Moderate Hypothermic Circulatory Arrest
Bleeding is a common complication of cardiac surgery, especially aortic arch surgery involving moderate hypothermic circulatory arrest.
- Trial name
- SEFC (NCT02542306)
- Testing
- fibrinogen concentrate
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Hongjia Zhang