Clinical trials: Type 2 Diabetes Mellitus Remission
Diabetes Mellitus, Type 2, Bariatric Surgery
Comparisons of Metabolic Effect of Sleeve Gastrectomy With Duodenojejunal Bypass and Sleeve Gastrectomy (MEDUSA): A Multicenter Randomized Controlled Trial
In this study, the effects of SG with DJB and SG alone for the treatment of type 2 diabetes mellitus (T2DM) will be compared in patients other than the two groups at both extremes who are expected to show excellent effects of…
- Conditions
- Diabetes Mellitus, Type 2, Bariatric Surgery, Surgical Procedures, Operative, Asians
- Trial name
- NCT05211375
- Testing
- Duodenojejunal bypass, Sleeve gastrectomy
- Where
- South Korea
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Type2 Diabetes, Complication of Bariatric Procedure
Efficacy and Safety of One-anastomosis Versus Roux-en-Y Gastric Bypass for Type 2 Diabetes Remission
Diabetes mellitus (T2DM) is the most common complication of obesity patients. According to previous literature reports, weight loss and metabolic surgery are powerful means to treat obesity complicated with T2DM.
- Trial name
- ORDER (NCT05015283)
- Testing
- The laparoscopic One-anastomosis gastric bypass will consist of:, The laparoscopic Roux-en-Y gastric bypass will consist of:
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Beijing Friendship Hospital
Case-control Study
GENETIC SUSCEPTIBILITY FACTOR AS A PREDICTOR OF TYPE 2 DIABETES REMISSION AND WEIGHT LOSS AFTER BARIATRIC SURGERY
Obesity is directly related to an increased risk of diabetes mellitus, hypertension, dyslipidemia, cardiovascular disease, and overall mortality. Weight loss is effective in decreasing these risks and to reduce disease severity.
- Trial name
- OBEGEN (NCT02405949)
- Testing
- Genetic test
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Type 2 Diabetes, Obesity
Diabetes Data-Assisted Remission Trial (DDART)
The study team will study the efficacy of a high intensity medical weight loss intervention paired with a digital platform to create weight loss and induce remission of type 2 diabetes mellitus (T2DM) compared to a diabetes…
- Trial name
- NCT04663061
- Testing
- Medical weight loss, Diabetes education, Continuous glucose monitoring
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Wake Forest University Health Sciences
Type 2 Diabetes
Pancreas Lipotoxicity in T2D: Edinburgh Diabetes Remission Study (EDRS)
This study aims to investigate how fat accumulation in the pancreas contributes to the development of type 2 diabetes (T2D), and how weight loss may reverse this process.
- Trial name
- EDRS (NCT07364045)
- Testing
- Total Diet Replacement (TDR) Program
- Where
- United Kingdom
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Type 2 Diabetes
The Effects of Glycemic Optimization Before Gastric Bypass Surgery
Metabolic surgery such as gastric bypass, gastric banding or sleeve gastrectomy operations can cause rapid and uncontrolled reductions in blood glucose.
- Trial name
- GLUCOSURG2 (NCT01353118)
- Testing
- gastric bypass
- Where
- 2 sites in United Kingdom
- Volunteers
- 41 people
- Sponsor
- Imperial College London
Diabetes Mellitus, Type 2
The eHealth Diabetes Remission Trial
Overweight patients with type 2 diabetes are offered a total diet replacement with the goal of weight loss and diabetes remission.
- Trial name
- eDIT (NCT05491005)
- Testing
- Total diet replacement, eHealth, Face-to-face
- Where
- 3 sites in Sweden
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Umeå University
Type 2 Diabetes
Effect on Beta Cell Function and Glycaemic Control After Insulin and Exenatide Sequential Therapy
Whether GLP-1 receptor agonists sequential therapy in newly diagnosed type 2 diabetic patients can further improve glycemic control, diabetes remission rate and β-cell function after the short-term insulin intensive therapy.
- Trial name
- T2DMRS (NCT02129985)
- Testing
- Exenatide, Metformin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- xiaolong zhao
Type 2 Diabetes Mellitus
Remission Evaluation of a Metabolic Intervention for Type 2 Diabetes With IDegLira
The purpose of the study is to determine whether in patients with early type 2 diabetes, a short-term intensive metabolic intervention comprising IDegLira, metformin, and lifestyle approaches will be superior to standard diabetes…
- Trial name
- REMITiDegLira (NCT03862716)
- Testing
- IDegLira, insulin degludec, Metformin
- Where
- 8 sites in Canada
- Volunteers
- 159 people
- Sponsor
- Population Health Research Institute
Diabetes Mellitus, Type 2, Obesity
Calorie Reduction Or Surgery: Seeking Remission for Obesity And Diabetes
The escalating pandemics of obesity and type 2 diabetes mellitus (T2DM) are among the most significant contributors to morbidity and mortality worldwide.
- Trial name
- CROSSROADS (NCT01295229)
- Testing
- laparoscopic Roux-en-Y gastric bypass (RYGB) procedure, Lifestyle Intervention
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- University of Washington
Type 2 Diabetes
Development of Minimally Invasive Methodology for Diabetyping to Personalise Treatment to Realise Remission and Reversal of Type 2 Diabetes
Rationale: Lifestyle changes in diet and exercise can reverse type 2 diabetes (T2D), also referred to as T2D remission. Although combined lifestyle interventions for T2D remission are promising, not all persons react similarly to…
- Trial name
- 2DIAREM (NCT06125119)
- Where
- Netherlands
- Volunteers
- 57 people
- Sponsor
- TNO
Obesity, Diabetes Mellitus, Type 2
Weight Management for the Remission of Type 2 Diabetes Using a Proprietary Meal Replacement System- Diabetes Remission Study (DRS)
A three month meal replacement dietary system which combines meal replacements and self-prepared meals which hypothetically will result in Diabetes remission in >30% of intervention subjects To assess the efficacy of which…
- Trial name
- DRS (NCT05397028)
- Testing
- Meal replacement system, Intensive lifestyle Intervention
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Loma Linda University
Bariatric Surgery Candidate, Diabetes
Surgery Versus Best Medical Management for the Long Term Remission of Type 2 Diabetes and Related Diseases (REMISSION)
Bariatric surgery procedures induce weight loss through restriction and/or malabsorption. The mechanisms underlying type 2 diabetes remission and others metabolic improvements after Roux-en-Y Gastric Bypass (RYGB), sleeve…
- Trial name
- REMISSION (NCT02390973)
- Testing
- Sleeve Gastrectomy, Roux-en-Y Gastric Bypass, Biliopancreatic Diversion with Duodenal Switch
- Where
- Canada
- Volunteers
- 408 people
- Sponsor
- Laval University
Type2diabetes, Disordered Eating
ARIADNE: A Study of Weight Loss for Diabetes Treatment and Wellbeing
The NHS has started a trial-run of a weight loss programme replacing food with 800-calorie shakes and soups for 3 months, offered to people with newly diagnosed type 2 diabetes (T2D) to lose weight and put their diabetes into…
- Conditions
- Type2diabetes, Disordered Eating, Obesity, Overweight and Obesity
- Trial name
- NCT05744232
- Testing
- Low calorie total diet replacement, Usual care
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Diabetes, Type 2, Obesity &Amp; Overweight
Calorie Restricted Dietary Intervention in Type 2 Diabetes Patients With Obesity for Remission
This study aims to induce remission of type 2 diabetes through dietary intervention for weight reduction.
- Trial name
- K-Direct2 (NCT07753447)
- Testing
- Contrave ER, Low-calorie meal box
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Yeouido St. Mary's Hospital
Type 2 Diabetes
Identification of Human Biomarkers Predictive of Diabetes Remission in Type 2 Diabetes Patient (BARIAKINES)
This study focuses on identifying potentially predictive human circulating adipocyte and muscle biomarkers of diabetes remission after bariatric surgery in obese type 2 diabetic (T2D) subjects.
- Trial name
- BARIAKINES (NCT05472883)
- Testing
- blood samples, collection of body tissues, routine care procedure
- Where
- France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Toulouse
Type 2 Diabetes (T2DM)
Remission Evaluation of Metabolic Interventions in Type 2 Diabetes in Primary Care (REMIT-Prime)
The Remission Evaluation of Metabolic Interventions in Type 2 diabetes (REMIT) program incorporates a non-surgical-remission-inducing therapeutic approach, pairing health coaching with physician-led pharmacotherapy.
- Trial name
- REMIT-Prime (NCT07665567)
- Where
- Canada
- Volunteers
- 118 people
- Sponsor
- McMaster University
Severe Obesity, Diabetes Mellitus, Type 2
Diabetes Remission and Hypoabsorptive Bariatric Surgery
Bariatric surgery is the most effective treatment to achieve type 2 Diabetes Mellitus (DM) remission in patients with severe obesity.
- Conditions
- Severe Obesity, Diabetes Mellitus, Type 2, Bariatric Surgery Candidate
- Trial name
- DIABAR-3 (NCT06043245)
- Testing
- Duodenal Switch, SADI-S, Minigastric Bypass
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Hospital Universitari de Bellvitge
Diabetes Mellitus Type 2
Effects on Remission of Type 2 Diabetes Mellitus Following Gastric Bypass Alone vs Gastric Bypass Combined With Truncal Vagotomy
This randomized, triple-blind clinical trial investigates whether adding truncal vagotomy to Roux-en-Y gastric bypass (RYGB) enhances remission of type 2 diabetes mellitus (T2DM) in patients with obesity.
- Trial name
- VagusSx (NCT07278115)
- Testing
- Roux-en-Y Gastric Bypass plus Truncal Vagotomy, Roux-en-Y Gastric Bypass
- Where
- 2 sites in Greece
- Volunteers
- 40 people
- Sponsor
- University Research Institute for the Study of Genetic & Malignant Disorders in Childhood
Type 2 Diabetes Mellitus Remission
Type 2 Diabetes Remission
The study aims to establish a cohort of patients with type 2 diabetes (T2D) who have achieved remission through lifestyle intervention or bariatric surgery.
- Trial name
- NCT06177210
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia