Clinical trials: Type 2 DM
Diabetes Mellitus, Type 2
Glufast On Insulin Glargine Trial in Type 2 DM
We will evaluate the efficacy and safety of combination therapy of 10 mg mitiglinide or 0.2mg voglibose with insulin glargine for 16 weeks after single administration of insulin glargine for 4 weeks in type 2 diabetic patients…
- Trial name
- GLORIA (NCT00663884)
- Testing
- Mitiglinide, Voglibose
- Where
- South Korea
- Volunteers
- 167 people
- Sponsor
- JW Pharmaceutical
Diabetes Mellitus, Type 2
RF Vapor Ablation Retreatment of Duodenal Mucosa in Non-responders With Type-2 Diabetes Mellitus
The purpose of this study is to test the hypothesis that re-treatment of the duodenal mucosa with RF vapor ablation will result in improvement in glycemic parameters, without complications (bleeding/ stricture / perforation)…
- Trial name
- NCT06724822
- Testing
- RF Vapor Ablation
- Where
- Chile
- Volunteers
- 12 people
- Sponsor
- Aqua Medical, Inc.
Vitamin D Deficiency, Diabetes
Vitamin D and Inflammatory Markers of Cardiovascular Disease in African Americans With Type 2 Diabetes
Recent clinical trials in non diabetics showed that vitamin D supplementation markedly reduced serum levels of C-reactive protein (CRP), interleukin-6, and tissue matrix metallo-proteinases.
- Trial name
- NCT01153243
- Testing
- Ergocalciferol
- Volunteers
- 117 people
- Sponsor
- Cook County Health
sRAGE Level, SUV and TBR Levels in FDG PET
Association Between Arterial Wall Uptake of Fluorodeoxyglucose on PET Imaging and sRAGE
Arteriosclerosis is a dynamic inflammatory disorder. Recently, FDG-PET CT is emerging diagnostic tool of non-invasive technique to detect vulnerable atherosclerotic plaque.
- Trial name
- NCT01021514
- Volunteers
- 82 people
- Sponsor
- Korea University
Type 2 Diabetes Mellitus (DM)
Community-based, eHealth Supported Type 2 Diabetes Care by Lay Village Health Workers in Rural Lesotho
This cluster-randomized intervention is embedded in the ComBaCaL (Community-Based Chronic disease care Lesotho) cohort study (EKNZ ID AO_2022-00058, clinicaltrials.gov ID NCT05596773, Lesotho NH-REC ID 210-2022), a platform for…
- Trial name
- ComBaCaL DM (NCT05743387)
- Testing
- DM care package, Referral to the responsible health facility
- Where
- 2 sites in Lesotho, Switzerland
- Volunteers
- 252 people
- Sponsor
- University Hospital, Basel, Switzerland
Type-2 Diabetes, Diabetic Retinopathy
Phenotypes of Nonproliferative Diabetic Retinopathy in DM 2 Patients Identified by OCT, CFP, RLA and mfERG (DIAMARKER)
To characterise phenotypes of Non Proliferative Diabetic Retinopathy (NPDR) progression using multimodal testing/imaging procedures.
- Trial name
- NCT01440660
- Where
- Portugal
- Volunteers
- 20 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Kidney Transplant, Type 2 Diabetes
Sitagliptin Treatment in Patients With Type 2 DM After Kidney Transplant
This study is designed to look at the effect sitagliptin has on tacrolimus and sirolimus drug levels in kidney transplant patients. It is also designed to look at the side effects experienced in the transplant population.
- Trial name
- NCT00466518
- Testing
- Administration of sitagliptin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Oklahoma
Type 2 Diabetes Mellitus, Diabetic Nephropathy
Study of FibroGen (FG)-3019 in Subjects With Type 2 Diabetes Mellitus and Kidney Disease on ACEi and/or ARB Therapy
The purpose of this study is to evaluate the effect of FG-3019 on diabetic kidney disease or diabetic nephropathy.
- Conditions
- Type 2 Diabetes Mellitus, Diabetic Nephropathy, Diabetic Kidney Disease
- Trial name
- NCT00913393
- Testing
- FG-3019
- Where
- 28 sites in United States
- Volunteers
- 46 people
- Sponsor
- Kyntra Bio
Type 2 Diabetes Mellitus (DM)
Tolerability and Safety of Nano-Tocotrienols
The goal of this randomised controlled trial is to determine the long term safety and tolerability of nano-tocotrienols (50 - 400 mg/day for 6-months duration) to be used as a health supplement in both healthy individuals and…
- Trial name
- NCT07888426
- Testing
- Nano-tocotrienols
- Where
- Malaysia
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Diabetes Mellitus
BIOD-531 vs. Humalog Mix 75/25 vs. Humulin R U-500 Post-Meal Glucose Control in Patients With Severe Insulin Resistance
The study is designed to compare meal time glucose control associated with BIOD-531, a rapidly absorbed concentrated insulin to that associated with Humalog Mix 75/25 and Humulin R U-500 in patients with diabetes and severe…
- Trial name
- NCT02324309
- Testing
- BIOD-531, Humalog Mix 75/25, Humulin R U-500
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Biodel
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
AI-Predicted Disease Trajectories in Diabetes: A Retrospective Study
The study explores the utilization of artificial intelligence (AI) to predict disease progression trajectories in patients with diabetes.
- Trial name
- AI-TRYDIA (NCT06280729)
- Testing
- AI-Analyis
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- IRCCS San Raffaele
Type 2 Diabetes
Relationship Between Insulin Resistance and Vitamin D in Type 2 Diabetes Mellitus (DM)
The primary aim of the study is to evaluate the association between vitamin D levels and triglyceride-glucose index as a marker of insulin resistance in patients with type 2 DM.
- Trial name
- DM (NCT07467161)
- Volunteers
- 165 people
- Sponsor
- Assiut University
Diabetes Mellitus, Vitamin D Deficiency
Does Vitamin D Improve Glycemic Control in Type II DM?
Vitamin D status has been negatively associated with the presence of type II DM and glycemic control. However, a cause-effect relationship between vitamin D deficiency and glycemic control has not been established.
- Trial name
- NCT01170442
- Testing
- vitamin D3 2000 IU, vitamin D3 5000 IU
- Where
- Saudi Arabia
- Volunteers
- 25 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Type 2 Diabetes Mellitus (T2DM), Atherosclerosis
Colchicine for Primary Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes
This study will test whether a low-cost anti-inflammatory medicine called colchicine can help protect the blood vessels of people with type 2 diabetes.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Atherosclerosis, Cardiovascular Diseases
- Trial name
- Col-DM (NCT07837934)
- Testing
- Colchicine 0.5 MG Oral Tablet Once Daily
- Where
- Singapore
- Volunteers
- 300 people
- Sponsor
- Tan Tock Seng Hospital
Vascular Function, Exercise Training
Evaluation of Effects of Exercise Training and ARB in DM Patients
The aims of this clinical trial are to assess the impacts on vascular function tests and circulating biomarkers of a short-term (12-week) low-to-median intensity exercise training or ARBs treatment in patients with DM and…
- Trial name
- NCT01053026
- Testing
- olmesartan
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- National Taiwan University Hospital
Chronic Kidney Disease(CKD), Type 2 DM
Implementation pRogram to Improve Screening and Management for CKD in Diabetes (IRIS-CKD) (Program 2)
IRIS-CKD is a two-program implementation study to improve guideline-recommended screening and treatment of chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D) in the United States.
- Conditions
- Chronic Kidney Disease(CKD), Type 2 DM, Type 2 Diabetes Mellitus (T2DM)
- Trial name
- IRIS-CKD (NCT06906640)
- Testing
- (IRIS-CKD Management Program): Education, (IRIS-CKD Management Program): GDMT
- Where
- 7 sites in United States
- Volunteers
- 212 people
- Sponsor
- Duke University
Depression, Major Depressive Disorder
eIMPACT-DM Pilot Trial: Depression Treatment to Reduce Diabetes Risk
This pilot randomized controlled trial seeks: (1) to determine the preliminary efficacy of our modernized collaborative care intervention for depression in improving the diabetes risk markers of hemoglobin A1c and insulin…
- Conditions
- Depression, Major Depressive Disorder, Dysthymic Disorder, Depressive Symptoms
- Trial name
- NCT04437485
- Testing
- Good Days Ahead (GDA), Problem Solving Treatment in Primary Care (PST-PC), Antidepressant Medications
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Indiana University
Diabete Mellitus, T2 Diabetes and Fatty Liver Disease (Non-alcoholic Origin)
Duodenal pulsENDO as an Early Treatment for Type 2 DM
This study is designed to evaluate the efficacy and safety of endoscopic duodenal re-cellularization therapy using pulsed electric field in individuals with in patients with a recent diagnosis of type 2 diabetes mellitus (T2DM).
- Trial name
- DREAM-1 (NCT07376486)
- Testing
- pulsENDO treatment
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Type 2 Diabetes Mellitus
Effect of Internet Therapeutic Intervention on A1C Levels in Type 2 Diabetes Mellitus (DM) on Combination Oral Therapy
This project will test the effectiveness of an Internet based glucose monitoring system on the A1C levels of patients with type 2 diabetes.
- Trial name
- NCT01060241
- Testing
- Internet Intervention
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Endocrine Research Society
Type 2 Diabetes
Self-care Management Programme for Type 2 Adult DM Patients With Poor Glycemic Control
Type 2 diabetes becomes the most prevalence chronic disease worldwide. Most type 2 diabetes patient are under the care in public general out-patient clinic in Hong Kong.
- Trial name
- T2DM (NCT04092023)
- Testing
- nursing education
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- Chinese University of Hong Kong