Clinical trials: Twin; Complicating Pregnancy
Preterm Delivery
Prevention of Preterm Delivery in Twin Pregnancies by 17 Alpha-hydroxyprogesterone Caproate
Preterm birth remains a major cause of perinatal morbidity and mortality in developing as well as in developed countries. Despite major clinical research efforts aimed at reducing the incidence of preterm births in the United…
- Trial name
- NCT00141908
- Testing
- 17-alpha Hydroxyprogesterone Caproate, Castor oil
- Where
- Lebanon
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Complicated Twin Pregnancy
The Value of Prenatal Ultrasound in Complicated Twin Pregnancy and Its Correlation With Chromosomal Anomalies
Recent years, women with infertility have become more and more and thus assisted reproductive technology has been applied in a broad range. And the quantities of twin pregnancies are larger and larger.
- Trial name
- NCT02732717
- Testing
- ultrasound (observation)
- Where
- China
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Twin; Complicating Pregnancy, Postpartum Hemorrhage
Prophylactic Methylergonovine for Twin Cesarean
Obstetrical hemorrhage (excessive bleeding related to pregnancy) is a leading cause of maternal morbidity (disease or symptom of disease) and mortality (death) worldwide with a significantly higher frequency and severity…
- Trial name
- NCT05772156
- Testing
- Methylergonovine
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Columbia University
Twin; Complicating Pregnancy, Psychology
Psychological Screening and Nursing of Twin Pregnancy
Objectives This research will screen the psychological problems of twin pregnant women step by step and detect early and treat early in order to reduce the incidence of mental diseases and promote the health of mother and baby.
- Trial name
- NCT05182541
- Testing
- Guided self help, Problem solving therapy, Face to face PST course
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Preeclampsia/Toxemia
The Prediction of Preeclampsia/Toxemia in Twin Pregnancy
The purpose of this study is to finout whetere uterinae artery flow , PP13 and endogolin levels in the serum and kongo red in the urine can predict preeclamsia toxemia in twin pregnancies.
- Trial name
- NCT01255202
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Twin Pregnancy
Planned Vaginal Delivery vs Planned Cesarean Delivery in Preterm Twins
The incidence of twin pregnancies has increased and currently accounts for 1.8% of all deliveries. 47.5% of twins are born prematurely (vs. 6% for singletons) of which 9.9% before 32SA.
- Trial name
- NCT04232436
- Testing
- Survival at discharge, Survival without severe morbidity
- Where
- France
- Volunteers
- 204 people
- Sponsor
- University Hospital, Montpellier
Preterm Birth, Pregnancy
Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS)
Women pregnant with twins or triplets are at high risk of preterm birth, yet no intervention or approach has served to reduce this risk.
- Conditions
- Preterm Birth, Pregnancy, Multifetal
- Trial name
- NCT00099164
- Testing
- 17 alpha-hydroxyprogesterone caproate (17P)
- Where
- 14 sites in United States
- Volunteers
- 795 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Hematologic Pregnancy Complications
Doubling the Iron Dose to Prevent IDA in Twin Pregnant Women
In twin pregnancies, the maternal iron demands are magnified, estimated at 1.8 times more than in singleton pregnancies due to greater maternal red blood cell mass and plasma volume expansion as well as increased fetal and…
- Trial name
- IDA (NCT03836703)
- Testing
- Feroglobin single daily use, Feroglobin twice daily dose
- Where
- Egypt
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Twin; Complicating Pregnancy, Microwave Ablation
Microwave Ablation vs Radiofrequency Ablation in the Management of Complicated Monochorionic Pregnancies：A RCT Study
Complicated pregnancies refer some special complications, including twin to twin transfusion syndrome(TTTS), twin reverse arterial perfusion(TRAP), selective intrauterine fetal growth restriction(sIUGR), twin anemia-polycythemia…
- Trial name
- MWAvsRFA (NCT04014452)
- Testing
- Microwave ablation, Radiofrequency ablation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Preterm Birth, Intrauterine Growth Retardation
Fish Oil Trials in Pregnancy for the Prevention of Pregnancy Complications ('FOTIP')
The initial trial examined if fish oil supplementation during pregnancy could reduce the risk of pregnancy induced hypertension, intrauterine growth retardation, and preterm birth in pregnancies that were at increased risk of…
- Conditions
- Preterm Birth, Intrauterine Growth Retardation, Pregnancy Induced Hypertension
- Trial name
- FOTIP (NCT02229526)
- Testing
- Low dose fish oil, Low dose olive oil, High dose fish oil
- Volunteers
- 1,619 people
- Sponsor
- Sjurdur Frodi Olsen
Fetal Conditions, Maternal; Procedure
A Prospective Study on the Role of Karl Storz Curved and Straight Fetoscopes (11508AAK and 11506AAK) for Fetoscopic Intrauterine Procedures
In this research study, the investigators want to learn more about the role of new innovative surgical devices, the Karl Storz Curved and Straight Fetoscopes for in-utero surgery.
- Conditions
- Fetal Conditions, Maternal; Procedure, Pregnancy Related, Twin to Twin Transfusion Syndrome
- Trial name
- NCT06056635
- Testing
- Karl Storz Curved Scope, Karl Storz Straight Scope
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Polycystic Ovary Syndrome
Environmental Factors in the Development of Polycystic Ovary Syndrome
Polycystic Ovary Syndrome (PCOS) is manifested as a heterogeneous mixture of clinical and bichemical characteristics that complicate study of its etiology.
- Trial name
- NCT00341731
- Where
- 2 sites in United States
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
EOS, Pregnancy Related
Breech Pelvimetry by EOS® Technique With Change of Maternal Position and Delivery Route
When a patient presents with a fetus in PS after 36+0SA, after acceptance of participation in the study, pelvimetry with evaluation of the height of the fetal presentation by EOS® system in the upright and sitting position will…
- Conditions
- EOS, Pregnancy Related, Fetus Fetus, Breech Fetal Presentation
- Trial name
- PelviEOS (NCT05224908)
- Testing
- EOS
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Renal Failure
Open Label Trial to Establish the Equivalence Between ANDY-Disc® and Ultrabag® in Patients on CAPD.
Apart from haemodialysis, continuous ambulatory peritoneal dialysis (CAPD) is another effective therapy for end stage renal disease (ESRD).
- Trial name
- NCT00255619
- Testing
- Baxter's UltraBag® and FMC Andy·Disc®
- Where
- 6 sites in Malaysia
- Volunteers
- 264 people
- Sponsor
- Ministry of Health, Malaysia
Pregnancy
Transvaginal Ultrasound Cervical Length Measurements in Twin Gestations
The purpose of this study is to determine if the use of routine transvaginal cervical length ultrasound can be used to prevent preterm deliveries in twin gestations.
- Trial name
- NCT02372422
- Testing
- Transvaginal ultrasound determination of cervical length, Routine care
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- William H. Barth, Jr., M.D., Col(ret), USAF, MC
Preterm Birth, Twin Pregnancy With Antenatal Problem
Progesterone and Cervical Pessary in Twins
The aim of this randomized control trial is to determine wheter cervical pessary plus vaginal progesterone (400mg) reduce preterm birth less than 34 weeks of gestacion and improve perinatal outcome, among women presenting…
- Trial name
- PRECEPET (NCT03058536)
- Testing
- Arabin Pessary, Vaginal Progesterone, Arabin Pessary and Progesterone
- Where
- Brazil
- Volunteers
- 312 people
- Sponsor
- Mario Henrique Burlacchini de Carvalho
Preterm Birth, Twin Pregnancy With Antenatal Problem
Prophylactic Cerclage for Twin Pregnancy With Shortened Cervix
This randomized controlled trial is aimed to evaluate pregnancy and neonatal outcomes in twin pregnancies, in which a cervical cerclage is placed due to the shortening of the cervix with or without visible fetal membranes.
- Conditions
- Preterm Birth, Twin Pregnancy With Antenatal Problem, Cervical Shortening
- Trial name
- NCT05338164
- Testing
- cervical cerclage
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Twin Pregnancy With Antenatal Problem, Preterm Birth
Cerclage for Twins With Short Cervical Length ≤ 15mm
This is a multicenter randomized study designed to determine if ultrasound indicated cerclage reduces the incidence of spontaneous preterm birth <34 weeks in asymptomatic women with twin gestations and cervical length ≤15mm…
- Conditions
- Twin Pregnancy With Antenatal Problem, Preterm Birth, Short Cervix
- Trial name
- TWIN-UIC (NCT03340688)
- Testing
- Cervical cerclage
- Where
- 8 sites in United States, Egypt and 2 more
- Volunteers
- 200 people
- Sponsor
- Thomas Jefferson University
Preterm Birth, Twin Pregnancy
Pessary Versus Cerclage With or Without Progesterone in Twins
This study compares the effectiveness of cervical pessary and cervical cerclage with or without vaginal progesterone for prevention of preterm birth in women with a twin pregnancy and a cervix ≤28 mm.
- Conditions
- Preterm Birth, Twin Pregnancy, Short Cervix
- Trial name
- PCP-Twins (NCT03863613)
- Testing
- Pessary, Cervical cerclage, Vaginal progesterone
- Where
- Vietnam
- Volunteers
- 219 people
- Sponsor
- Mỹ Đức Hospital
Twin; Pregnancy, Affecting Fetus or Newborn, Fetal Growth Retardation
Selective Fetal Growth Restriction in Monochorionic Twins - an International Investigation
Optimal diagnostic management and underlying pathophysiological mechanisms of selective fetal growth restriction (sFGR) in monochorionic diamniotic (MCDA) twin pregnancies have not been fully clarified.
- Conditions
- Twin; Pregnancy, Affecting Fetus or Newborn, Fetal Growth Retardation, Twin Monochorionic Diamniotic Placenta, Twin Diseases
- Trial name
- CONTRAST (NCT05952583)
- Testing
- Ultrasound
- Where
- 6 sites in United States, Belgium and 4 more
- Volunteers
- 274 people
- Sponsor
- Leiden University Medical Center