Clinical trials: Tuberculous Meningitis
Tuberculosis, Meningeal
Adjunctive Linezolid for the Treatment of Tuberculous Meningitis
This is a phase II randomized open-label trial of high versus standard dose rifampin (RIF) with or without linezolid (LZD) for the first 4 weeks of treatment for Tuberculosis Meningitis (TBM) at Masaka Regional Referral Hospital…
- Trial name
- ALTER (NCT04021121)
- Testing
- LZD, High dose RIF, Standard dose RIF
- Where
- Uganda
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
AIDS-Related Opportunistic Infections, Meningo-encephalitis
Driving Reduced AIDS-associated Meningo-encephalitis Mortality
The DREAMM project is investigating whether the DREAMM interventions (1) Health system strengthening, 2) Co-designed education programs tailored to frontline healthcare workers, 3) Implementation of a diagnostic and treatment…
- Conditions
- AIDS-Related Opportunistic Infections, Meningo-encephalitis, Cryptococcal Meningitis, Bacterial Meningitis
- Trial name
- DREAMM (NCT03226379)
- Testing
- DREAMM
- Where
- 5 sites in Cameroon, Malawi and 1 more
- Volunteers
- 495 people
- Sponsor
- St George's, University of London
Meningitis, Tuberculous, Pharmacokinetics
Intensified Treatment Regimens for TB Meningitis: PK, PD and Tolerability Study
Tuberculous meningitis (TBM) is the most lethal form of tuberculosis infection, and is diagnosed in approximately 5-10% of TB patients.
- Conditions
- Meningitis, Tuberculous, Pharmacokinetics, Pharmacodynamics, Tolerability
- Trial name
- NCT01158755
- Testing
- Moxifloxacin
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Padjadjaran
Tuberculosis Meningitis
Phase 2a Trial of Alpibectir Plus Ethionamide for Tuberculosis Meningitis
AlpE is a novel drug combination under development for the treatment of TB, with several positive attributes for TBM, including rapid bactericidal activity.
- Trial name
- NCT07350174
- Testing
- HRZE, HRZE plus Alpe375, HRZE plus AlpE500
- Volunteers
- 64 people
- Sponsor
- BioVersys AG
Tuberculous Meningitis
The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis
The study aimed to evaluate the relationships between the gene polymorphisms of leukotriene A4 hydrolase(LTA4H) and Dexamethasone treatment for tuberculous meningitis in Chinese patients.
- Trial name
- NCT02588196
- Testing
- Dexamethasone acetate
- Volunteers
- 200 people
- Sponsor
- Hui Bu
Tuberculosis, Meningeal, Tuberculosis; Meningitis (Etiology)
Adjunctive Doxycycline for Central Nervous System Tuberculosis
Although tuberculosis is now considered a treatable disease, central nervous system tuberculosis (CNS-TB) when managed with the current standard-of-care (SOC), still has mortality rates ranging from 30-50% even in tertiary…
- Conditions
- Tuberculosis, Meningeal, Tuberculosis; Meningitis (Etiology), Tuberculosis, Central Nervous System, Tuberculosis; Meningoencephalitis (Etiology)
- Trial name
- DIRECT (NCT06446245)
- Testing
- Doxycycline, Anti Tuberculosis Drug, Adjunctive corticosteroid
- Where
- 6 sites in Indonesia, Malaysia and 1 more
- Volunteers
- 200 people
- Sponsor
- National University Hospital, Singapore
Tuberculosis, Tubercular Meningitis
Cyclophosphamide in the Treatment of Refractory Proliferative Arachnoiditis in CNS Tuberculosis
Tubercular meningitis occurs in around 10% of those with extrapulmonary tuberculosis and is a major cause of mortality and morbidity.
- Conditions
- Tuberculosis, Tubercular Meningitis, Arachnoiditis; Tuberculous (Etiology)
- Trial name
- NCT04620772
- Testing
- Cyclophosphamide injection
- Volunteers
- 40 people
- Sponsor
- All India Institute of Medical Sciences
Tuberculosis, Meningeal
Optimizing Treatment to Improve TBM Outcomes in Children
In this open-labeled, randomized clinical trial, the Investigator will assess the safety and pharmacokinetics (PK) of model-optimized doses of rifampicin (RIF) with or without levofloxacin (LEVO) given to children as part of…
- Trial name
- TBM-KIDS (NCT02958709)
- Testing
- High-dose: RIF, INH, PZA, EMB, High dose: RIF, INH, PZA, LEVO, Standard of care: RIF, INH, PZA, EMB
- Where
- 3 sites in India, Malawi
- Volunteers
- 38 people
- Sponsor
- Johns Hopkins University
Tuberculous Meningitis, HIV I Infection
Tnf Inhibitors to Reduce Mortality in HIV-1 Infected PAtients With Tuberculosis meNIngitis
Randomized phase II clinical trial which aims to assess the impact on 3-month mortality and safety of adding adalimumab to standard treatment (anti-tuberculosis drugs and corticosteroids) in HIV patients with tuberculosis…
- Trial name
- TIMPANI (NCT05590455)
- Testing
- Adalimumab Injection
- Where
- 3 sites in Brazil, Mozambique and 1 more
- Volunteers
- 130 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Tuberculous Meningitis
Intrathecal Therapy for Adult Tuberculous Meningitis: Impact on Clinical Outcomes
Tuberculous meningitis (TBM) is the most lethal form of tuberculosis (TB). While anti-TB regimens remain the cornerstone of treatment, spinal injection of dexamethasone is considered a potentially effective adjuvant therapy.
- Trial name
- NCT06811792
- Testing
- Intrathecal Therapy
- Volunteers
- 837 people
- Sponsor
- Beijing Chest Hospital
Neurological Disorders, Cerebral Malaria
Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC
The impact of neurological disorders is enormous worldwide, and it is increased in poor settings, due to lack of diagnosis and treatment facilities as well as delayed management.
- Conditions
- Neurological Disorders, Cerebral Malaria, Bacterial Meningitis, Central Nervous System Tuberculosis
- Trial name
- Nidiag-Neuro (NCT01589289)
- Testing
- Immunochromatographic HAT tests (DSD), Card Agglutination Trypanosoma Test, TB POC Nucleic Acid Amplification Test (Molbio Diagnostics)
- Where
- Democratic Republic of the Congo
- Volunteers
- 352 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Tuberculosis Meningitis
Study Of The Long Term Outcome Of Tuberculous Meningitis In Vietnamese Adults Treated With Adjunctive Dexamethasone
All patients who were alive at the end of the dexamethasone treatment trial conducted by Oxford University CLinical Research Unit from 2001-2005 (n=340) will be eligible to participate in this long-term follow-up study.
- Trial name
- ES (NCT01317654)
- Testing
- Observation
- Volunteers
- 340 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Tuberculosis, Meningitis
Phase II Clinical Study of Contezolid for the Treatment of Tuberculous Meningitis
Contezolid is a novel oxazolidinone antibiotic developed by Shanghai Mengke Pharmaceutical Co., Ltd., which successfully went public in 2021.
- Trial name
- NCT06811025
- Testing
- Contezolid, Linezolid (LZD)
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Beijing Chest Hospital
Tuberculous Meningitis
Intensified Short Course Regimen for TBM in Adults
Tuberculous meningitis (TBM) is the most lethal form of extra pulmonary tuberculosis. This devastating disease kills almost a third of its sufferers and disables a significant proportion of the survivors.
- Trial name
- INSHORT (NCT05917340)
- Testing
- High dose rifampicin (25mg/kg), Moxifloxacin 400mg, Aspirin 150 mg
- Where
- India
- Volunteers
- 372 people
- Sponsor
- Indian Council of Medical Research
Tuberculous Meningitis
Intensified Tuberculosis Treatment to Reduce the Mortality of Patients With Tuberculous Meningitis
INTENSE-TBM is randomized controlled, phase III, multicenter, 2 x 2 factorial plan superiority trial assessing the efficacity of two interventions to reduce mortality from tuberculous meningitis (TBM) in adolescents and adults…
- Trial name
- INTENSE-TBM (NCT04145258)
- Testing
- Aspirin, WHO TBM treatment, Intensified TBM treatment
- Where
- 13 sites in Côte d’Ivoire, Madagascar and 2 more
- Volunteers
- 768 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Tuberculous Meningitis, HIV
BPaLMZ for TB Meningitis
This two-stage study will compare consented research participants with tuberculous meningitis receiving experimental Bedaquiline (B), Pretomanid (Pa), Linezolid (L); Moxifloxacin (M), Pyrazinamide (Z) known as (BPaLMZ) to…
- Conditions
- Tuberculous Meningitis, HIV, Meningitis, TB - Tuberculosis
- Trial name
- BPaLMZ (NCT07227779)
- Testing
- BPaLMZ Regimen
- Where
- 2 sites in Uganda
- Volunteers
- 312 people
- Sponsor
- David Boulware
Tuberculous Meningitis
Retrospective Real-word Study of Linezolid for the Treatment of Tuberculous Meningitis
Tuberculous meningitis (TBM) is the most serious form of Mycobacterium tuberculosis infection, causing mortality and disability in more than half of the patients.
- Trial name
- NCT03898635
- Testing
- Linezolid
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Huashan Hospital
Tuberculosis, Tuberculous Meningitis
Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial)
The investigators will conduct a randomized, double blind, placebo controlled trial of adjunctive dexamethasone in the initial (6-8 weeks) treatment of tuberculous meningitis in Vietnamese adults.
- Conditions
- Tuberculosis, Tuberculous Meningitis, Drug-Induced Liver Injury, HIV
- Trial name
- NCT03092817
- Testing
- Dexamethasone
- Where
- 6 sites in Indonesia, Vietnam
- Volunteers
- 520 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Tuberculous Meningitis
Diagnosis of Tuberculous Meningitis by ESAT-6 in CSF
Early and reliable diagnosis of tuberculous meningitis (TBM) still poses a great challenge. One of the underlying difficulties is due to the fact that tubercle bacilli are mainly not present in the cerebrospinal fluid (CSF) but…
- Trial name
- NCT01371916
- Where
- China
- Volunteers
- 316 people
- Sponsor
- Xijing Hospital
Tuberculosis, Meningeal, Linezolid
Pharmacokinetic Study of Linezolid for TB Meningitis
Tuberculosis meningitis (TBM) is the most severe manifestation of TB, resulting in death or neurological disability in up to 50% of affected patients, despite antibacterial treatment.
- Trial name
- SIMPLE (NCT03537495)
- Testing
- Linezolid
- Where
- Indonesia
- Volunteers
- 36 people
- Sponsor
- Universitas Padjadjaran