Clinical trials: Tuberculosis Active, active
TUBERCULOSIS
Clinical Evaluation of an IGRA Test for the Diagnosis of Active and Latent Tuberculosis
Methodology This is a single-center study carried out as part of routine patient care. The aim of the study is to determine the performance of the 2nd generation TB-IGRA test in the diagnosis of tuberculosis.
- Trial name
- TUBIGRA (NCT06485895)
- Testing
- test IGRA, TEST QUATIFERON TB Gold Plus
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Single Cell Sequencing Technology, Gene Expression Profiling
Host Response to Infection by Direct Analysis of Leukocyte Single Cell-type Gene Expression/transcript Abundance, Direct LS-TA. a Prospective Study Will Evaluate the Performance of Direct LS-TA in Triage Febrile Patients Into Major Categories of Infections: Viral, Bacterial or Active Tuberculosis.
Febrile illness is a common condition and it is crucial to have an early triage of patients according to various aetiologies to enable appropriate treatment.
- Conditions
- Single Cell Sequencing Technology, Gene Expression Profiling, Gene Expression, Infection
- Trial name
- NCT06846645
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- Chinese University of Hong Kong
Pulmonary Tuberculoses, Aspergillosis
Pulmonary Aspergillosis in Tuberculosis Patients
Pulmonary tuberculosis (PTB) is the most common cause of lung destruction, contributing to coinfections development, and Aspergillosis spp. is one of the most important.
- Conditions
- Pulmonary Tuberculoses, Aspergillosis, Old Tuberculosis, Active Tuberculosis
- Trial name
- NCT05045391
- Testing
- Aspergillus IgG detection
- Where
- Uzbekistan
- Volunteers
- 200 people
- Sponsor
- Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan
MDR-TB, Tuberculosis Multi Drug Resistant Active
Feasibility of the Application of a New Six-month Treatment for Multidrug-resistant Tuberculosis (MDR-TB) Patients in France (FAST-MDR)
The FAST-MDR trial is an externally-controlled, multicentre trial with one prospective arm, evaluating the non-inferiority of the effectiveness of BPaLM in the interventional arm versus the effectiveness of the long, conventional…
- Conditions
- MDR-TB, Tuberculosis Multi Drug Resistant Active, Antibiotic Resistance, Mycobacterium Tuberculosis
- Trial name
- FAST-MDR (NCT07486024)
- Testing
- Bedaquiline Oral Tablet
- Where
- 5 sites in France
- Volunteers
- 55 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tuberculosis, Inflammation Biomarkers
Effects of Adjunct Omega-3 Long Chain Polyunsaturated Fatty Acids in Pulmonary Tuberculosis Patient: an Early Bactericidal Activity and Inflammatory Trial
The goal of this randomized controlled trial is to evaluate the early bactericidal activity, early inflammatory response, and safety of omega-3 long chain polyunsaturated fatty acid (n-3 PUFA) supplementation in adult patients…
- Conditions
- Tuberculosis, Inflammation Biomarkers, Liver Function Tests, Iron Status
- Trial name
- TREAT 3 (NCT07118059)
- Testing
- Omega-3 (EPA+DHA)
- Where
- South Africa
- Volunteers
- 40 people
- Sponsor
- North-West University, South Africa
Drug Susceptible Pulmonary Tuberculosis
Bactericidal Activity of TBD09 in Combination With Other Drugs in Pulmonary Tuberculosis
The purpose of this study is to evaluate if TBD09 in combination with other active agents in adults with drug sensitive pulmonary tuberculosis has potential to be safe and effective.
- Trial name
- NCT07525427
- Testing
- Bedaquiline, pretomanid and TBD09, Bedaquiline, pretomanid and linezolid
- Where
- 13 sites in South Africa
- Volunteers
- 150 people
- Sponsor
- Gates Medical Research Institute
Tuberculosis
Effects of the Active Cycle of Breathing Technique With and Without Balloon Blowing Therapy in Tuberculosis
The study design will be a randomized controlled trial. The data will be collected from Gulab Devi Teaching Hospital, Lahore. 34 kids aged 8 to 14 years will be randomly assigned either to an experimental group or a control…
- Trial name
- NCT07484490
- Testing
- Active cycle of breathing with Balloon therapy, Active Cycle of breathing
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Tuberculosis, Tuberculosis (TB)
Shaping a Community-based Pathway to Improve TB Surveillance Among African and Hindustan Immigrants Experiencing Vulnerabilities
This two-phase, mixed-methods approach project aims to develop a community-based, participatory, and co-created TB/TB infection (TBI) screening care pathway for African and Hindustan immigrants, who often face socioeconomic…
- Conditions
- Tuberculosis, Tuberculosis (TB), Tuberculosis Active, Tuberculosis Infection, Latent
- Trial name
- AFROHINDU-MIGT (NCT07687121)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
TB - Tuberculosis, HIV/AIDS
Pre- and Post-treatment Lung Microbiota, Metabolome and Immune Signatures at the Site of Disease in Patients With Active Pulmonary Tuberculosis
The diverse microbial communities in different parts of the human body (microbiome) are important for health but understudied in pulmonary tuberculosis (TB), which is the single biggest infectious cause of death in the world.
- Trial name
- TB-LUNG (NCT04700579)
- Where
- 3 sites in South Africa
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Stellenbosch
Gene Expression, Gene Expression Profiling
Host Response to Infection by Direct Analysis of Leukocyte Single Cell-type Gene Expression/transcript Abundance, Direct LS-TA
Febrile illness is a common condition, particularly among young patients and it is crucial to have an early triage of patients according to various aetiologies to enable appropriate treatment.
- Conditions
- Gene Expression, Gene Expression Profiling, Infection, Viral Diseases
- Trial name
- NCT06838780
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Rifampin-resistant Tuberculosis, Drug-resistant Tuberculosis
Therapeutic Drug Monitoring for Linezolid in the Treatment of Rifampin-resistant Tuberculosis
This study is a two-arm, pragmatic, open-label, randomized clinical trial to determine the efficacy of Therapeutic Drug Monitoring (TDM) in preventing premature discontinuation of Linezolid (LZD) in participants with…
- Trial name
- THERMOL (NCT06590428)
- Testing
- Therapeutic Drug Monitoring for Linezolid
- Where
- South Africa
- Volunteers
- 280 people
- Sponsor
- Albert Einstein College of Medicine
Tuberculosis Diagnosis
Evaluation of New TB Diagnostic Tests (NATs) in Pakistan
This study evaluates two portable molecular tests for tuberculosis (TB), Pluslife MTBC and Ustar PortNAT, during community-based active case-finding activities in Pakistan.
- Trial name
- TB (NCT06984887)
- Testing
- Paired tongue-swab and sputum-based molecular testing for tuberculosis
- Where
- 2 sites in Pakistan
- Volunteers
- 6,100 people, healthy volunteers welcome
- Sponsor
- Mercy Corps Pakistan
Pulmonary Tuberculosis
Short Course Regimen in Low Risk Active Tuberculosis- a Multicenter, Randomized, Active-controlled, Trial
Tuberculosis remains an important global health problem, and the world is currently not on track to end the TB epidemic by 2030.
- Trial name
- NCT06727864
- Testing
- 4-month regimen (2HERZ/2HRE), 6-month (2HERZ/4HRE)
- Where
- 8 sites in Taiwan
- Volunteers
- 270 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Rifampin-Resistant Pulmonary Tuberculosis, Tuberculosis, Multidrug-Resistant (MDR-TB)
A Phase III Study of Oral Sudapyridine (WX-081) Tablets in Rifampicin-Resistant Pulmonary Tuberculosis Patients
This is a multicenter, randomized, double-blind, active-controlled Phase III study to evaluate the efficacy and safety of Sudapyridine (WX-081) combined with a background regimen (BR) in patients with rifampicin-resistant…
- Trial name
- WISH (NCT05824871)
- Testing
- Sudapyridine, Bedaquiline
- Where
- 2 sites in China
- Volunteers
- 450 people
- Sponsor
- Shanghai Jiatan Pharmatech Co., Ltd
Tuberculosis, Pulmonary, Drug-Susceptible Pulmonary Tuberculosis
Short-Course Regimen With Bedaquiline, Moxifloxacin and Pyrazinamide for Early Bactericidal Activity in Drug-Susceptible Tuberculosis
# Brief Summary This study aims to evaluate the early bactericidal activity (EBA), safety, and tolerability of 4-month short-course regimens containing bedaquiline, moxifloxacin, and pyrazinamide in patients with drug-susceptible…
- Trial name
- Beams (NCT07129629)
- Testing
- Bedaquiline (B), Moxifloxacin, Pyrazinamide (PZA)
- Volunteers
- 45 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Chronic Obstructive Pulmonary Disease (COPD), TB - Tuberculosis
COPD-PTB Screening Trial in Henan, China
The goal of this trial is to evaluate the effectiveness of an active case-finding (ACF) strategy for detecting pulmonary tuberculosis (PTB) among patients with chronic obstructive pulmonary disease (COPD) in primary care settings…
- Trial name
- NCT07706972
- Testing
- ACF strategy
- Volunteers
- 25,000 people
- Sponsor
- Henan Provincial People's Hospital
Tuberculosis, COVID-19
Evaluating the Impact of Computer-assisted X-ray Diagnosis and Other Triage Tools to Optimise Xpert Orientated Community-based Active Case Finding for TB and COVID-19
Tuberculosis (TB) is now the commonest cause of death in many African countries. Globally, ~35% (almost 1 in 3) of TB cases are 'missed' (remain undiagnosed or undetected).
- Conditions
- Tuberculosis, COVID-19, HIV Infections
- Trial name
- NCT05220163
- Testing
- CAD, Xpert
- Where
- 3 sites in South Africa, Zambia and 1 more
- Volunteers
- 26,200 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
Tuberculosis (TB)
Optimal Treatment Duration for Radiographically Apparent, Bacteriologically Unconfirmed TB, Identified Through Active Case Finding (RADIO-TB Trial)
People living in high TB burden communities who undergo active case finding for TB may have chest X-ray changes suggestive of TB but their sputum test can be negative for the TB bacteria or they are unable to provide a sputum…
- Trial name
- RADIO-TB (NCT07163143)
- Testing
- Isoniazid (H), Rifampicin (R), Pyrazinamide (Z)
- Where
- 4 sites in Pakistan, South Africa and 1 more
- Volunteers
- 784 people
- Sponsor
- University College, London
Pulmonary Tuberculosis
Channa Striata and Curcuma Domestica Supplementation in Patients With Active Pulmonary Tuberculosis
This study aims to evaluate the effect of combined supplementation with Channa striata extract and Curcuma domestica rhizome on nutritional status, inflammatory markers, and quality of life in patients with active pulmonary…
- Trial name
- NCT07887724
- Testing
- CHANA STRIATA AND CURCUMA
- Where
- 2 sites in Indonesia
- Volunteers
- 80 people
- Sponsor
- DINA KEUMALA SARI
Tuberculosis
Precision Rifampin Trial for Personalized Dosing
Individual pharmacokinetic variability is an important driver of tuberculosis (TB) treatment failure particularly among undernourished populations, and that suboptimal serum drug concentrations are associated with delayed…
- Trial name
- P-RIF (NCT06318416)
- Testing
- urine spectrophotometry for rifampin absorbance
- Where
- Tanzania
- Volunteers
- 200 people
- Sponsor
- University of Virginia