Clinical trials: Tuberculosis, Latent
Children LTBI
A Multicentre, Cohort Study of Screening and Preventive Intervention for Latent Tuberculosis Infection in Children
The management of latent Mycobacterium tuberculosis infection is a new priority action for the WHO End Tuberculosis (TB) Strategy.
- Trial name
- NCT04156568
- Testing
- INH、RFT
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Children's Hospital
Tuberculosis, Pulmonary, Tuberculosis Infection
Short-course Regimens for the Treatment of Pulmonary Tuberculosis
The purpose of this study is to determine whether one or two 17-week regimens of tuberculosis treatment bedaquiline (B or BDQ), moxifloxacin (M), pyrazinamide (Z)-- (BMZ) plus either Rifabutin (Rb) or Delamanid (D or DLM) are as…
- Trial name
- CRUSH-TB (NCT05766267)
- Testing
- Rifabutin, Delamanid, Bedaquiline
- Where
- 8 sites in United States, Canada and 4 more
- Volunteers
- 288 people
- Sponsor
- Centers for Disease Control and Prevention
Tuberculosis Infection
Tuberculosis In Children Visiting Friends and Relatives
In countries with a low incidence of Tuberculosis (TB), the incidence remains higher among the immigrant population than among the autochthonous population beyond the first years after arrival in the host country.
- Trial name
- NCT04236765
- Testing
- TB infection-screening benefiting group
- Where
- Spain
- Volunteers
- 492 people, healthy volunteers welcome
- Sponsor
- Hospital Mutua de Terrassa
Advanced Cancer
Latent Tuberculosis Infection in Cancer Patients
Primary Objective: 1. To evaluate the performance of the new T-SPOT.TB test and the conventional TST for screening of Latent Tuberculosis infections in patients with cancer and those undergoing Hematopoietic Stem Cell Transplant.
- Trial name
- NCT00507754
- Testing
- T-SPOT TB test
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- M.D. Anderson Cancer Center
Latent Tuberculosis
Promoting Adherence to Treatment for Latent TB Infection Through Text Messaging
The purpose of this pilot study is to determine whether regularly scheduled medication reminder text messages (SMS) are effective in increasing latent tuberculosis infection (LTBI) treatment completion.
- Trial name
- TXT4MED (NCT02690818)
- Testing
- Regularly scheduled LTBI medication reminder text messages
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Tuberculosis Infection
Multicenter Italian Cohort Study on Tuberculosis in Pediatric Age
According to the WHO report of 2021, approximately 10 million new cases were reported in 2020, of which 1 million occurred in the pediatric population.
- Trial name
- NCT06289660
- Where
- 17 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- Meyer Children's Hospital IRCCS
Tuberculin Skin Test
Self-Assessment Tuberculin Skin Test
The research team/investigator/nurse/professional health care workers will teach the participants how to read the results for TST test.
- Trial name
- ISAT (NCT03835832)
- Testing
- The participants do not receive any intervention for this study
- Where
- 2 sites in Thailand
- Volunteers
- 215 people
- Sponsor
- The HIV Netherlands Australia Thailand Research Collaboration
Active Tuberculosis
Characterization and Evaluation of Diagnostic Biomarkers for Tuberculosis
There was no sensitive and specific biomarker for tuberculosis infection, disease progression and predicting the prognosis of treatment.
- Trial name
- NCT01269268
- Where
- South Korea
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Pediatric HIV Infection, Latent Tuberculosis
Dolutegravir Pharmacokinetics During Weekly Rifapentine/Isoniazid for TB Prevention
Tuberculosis (TB) is the leading cause of death among children living with HIV, yet insufficient data are available on the pharmacokinetics of newer TB prevention strategies in children.
- Trial name
- NCT06281834
- Testing
- Rifapentine, Dolutegravir
- Where
- Nigeria
- Volunteers
- 25 people
- Sponsor
- Brigham and Women's Hospital
Latent Tuberculosis Infection
Phase IV Clinical Study of Recombinant Mycobacterium Tuberculosis Fusion Protein
Cohort 1 was a randomized, double-blind, controlled clinical trial with a planned enrollment of 500 patients. Cohort 2 is a non-randomized, open-label clinical trial with a planned enrollment of approximately 60000 patients.
- Trial name
- NCT05746611
- Testing
- Recombinant Mycobacterium tuberculosis fusion protein for injection, TB-PPD was injected
- Where
- China
- Volunteers
- 7,500 people, healthy volunteers welcome
- Sponsor
- Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.
Latent Tuberculosis
Determining Risk in Latent Tuberculosis
Background: Tuberculosis (TB) is a leading cause of death worldwide. Those who are exposed to the TB bacteria but have not become sick are said to have latent TB.
- Trial name
- NCT01571739
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis, Latent Tuberculosis
Use TST and QFT-RD1 Test to Monitor the Tuberculous Infection in Patients, Close Contact People and Health Care Workers
Tuberculosis is still the most common infectious disease in Taiwan. The infants in Taiwan have been vaccinated at birth with BCG -Tokyo 171 strain since 1951.
- Conditions
- Tuberculosis, Latent Tuberculosis, Tuberculosis Contact, Elderly
- Trial name
- NCT00311220
- Testing
- tuberculin for skin test
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
Monitoring, Immunologic, Active Tuberculosis
New Generation IGRA in Immunocompromised Individuals
Evaluation of a new ELISA based interferon-gamma release assay (QuantiFERON TB plus In-tube test) in immunocompromized patients
- Conditions
- Monitoring, Immunologic, Active Tuberculosis, Tuberculosis in Solid Organ Transplant Recipients, Tuberculosis in Marrow Transplant Recipients
- Trial name
- TBnet#54 (NCT02639936)
- Where
- 16 sites in Denmark, Germany and 8 more
- Volunteers
- 2,663 people, healthy volunteers welcome
- Sponsor
- Tuberculosis Network European Trialsgroup
Latent Tuberculosis Infection, Tuberculosis Infection, Latent
Evaluation of a Novel Microbiological Diagnostic Test for Latent Mycobacterium Tuberculosis Infection
Tuberculosis (TB) is an infectious disease that is caused by bacteria (bugs). The infection is passed on when a patient with active lung TB coughs bugs into the air, which are then breathed in by an uninfected person.
- Trial name
- MICRO-LTBI (NCT06728930)
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Queen Mary University of London
Tuberculosis Infection
Immunization With BCG Vaccine to Prevent Tuberculosis Infection
The purpose of this research is to find out if a single dose of pre-travel vaccination with BCG can lessen tuberculosis (TB) infection by producing an immune response when given to adults traveling to countries with a high or…
- Trial name
- TIPI (NCT04453293)
- Testing
- BCG (Tokyo 172) vaccine
- Where
- 7 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Tuberculosis Infection
Evaluating Diagnostics for Paediatric Tuberculosis by Blood Culture
Detection of M. tuberculosis in clinical specimens of children has a low sensitivity because specimens are either difficult to collect or contain low levels of M. tuberculosis.
- Trial name
- NCT01434758
- Where
- Vietnam
- Volunteers
- 560 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Tuberculosis, Psoriasis
Sensitivity and Specificity of QuantiFeron -TB Gold Test (QFT-G)in Patients With Psoriasis
The purpose of this study is to determine the level of agreement between QuantiFeron -TB Gold test (QFT-G)and Tubeculin skin test (TST)for screening of latent tuberculosis in patients suffering from psoriasis.
- Trial name
- NCT01223976
- Testing
- Tuberculin skin test and Quantiferon -TB Gold test
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Tuberculosis (TB), Tuberculosis Infection, Latent
Burden of Tuberculosis Among Pregnant and Postpartum Women in Guinea-Bissau
This study aims to address critical diagnostic and data gaps in tuberculosis (TB) care among pregnant and postpartum women in Guinea-Bissau, a high-burden, resource-limited setting.
- Conditions
- Tuberculosis (TB), Tuberculosis Infection, Latent, Pregnancy, Tuberculosis Diagnosis
- Trial name
- TIPP (NCT07419568)
- Testing
- Enhanced protocol
- Where
- Guinea-Bissau
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Tuberculosis
Latent Tuberculosis Infection in Bone Marrow Transplant Recipients
The aim of this study is to estimate the usefulness of a T cell-based assay (i.e. Quantiferon-Gold In-Tube assay) for diagnosis of latent tuberculosis infection (LTBI) in bone marrow transplant recipients.
- Trial name
- NCT01021124
- Where
- South Korea
- Volunteers
- 409 people
- Sponsor
- Asan Medical Center
HIV, Tuberculosis
Medical and Economical Impact of IGRAs Diagnosis of Latent Tuberculosis in HIV-infected Patients
Tuberculosis is a current infection during HIV infection. After infectious contact, some patients will develop tuberculosis some will only be infected without symptoms, they have Latent Tuberculosis Infection (LTBI) which can…
- Conditions
- HIV, Tuberculosis, Latent Tuberculosis Infection
- Trial name
- IGRAVIH (NCT00805272)
- Testing
- QTF-TB Gold and T-SPOT TB
- Where
- France
- Volunteers
- 536 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris