Clinical trials: Troponin
Wilms Tumor, Neuroblastoma
Pharmacokinetic Study of Doxorubicin in Children With Cancer
Analyze pharmacokinetics of doxorubicin in children with cancer. Furthermore investigate the predictive role of troponin and natriuretic peptides for anthracycline-induced cardiotoxicity .
- Conditions
- Wilms Tumor, Neuroblastoma, Soft Tissue Sarcoma, Acute Lymphoblastic Leukemia
- Trial name
- Doxo (NCT01095926)
- Testing
- doxorubicin
- Where
- 23 sites in France, Germany and 2 more
- Volunteers
- 101 people
- Sponsor
- University Hospital Muenster
Non-ST-elevation Myocardial Infarction (NSTEMI)
Hs-cTnI Diagnosis of NSTE-ACS Patients in China
This study is to validate 1-hour and 3-hours diagnostic strategy using Architect high-sensitivity cardiac troponin I (hs-cTnI) in Chinese patients with suspected Non-ST-elevation Myocardial Infarction (NSTEMI).
- Trial name
- HEADLINES (NCT03734796)
- Where
- China
- Volunteers
- 2,400 people
- Sponsor
- China National Center for Cardiovascular Diseases
Stable Coronary Artery Disease (CAD), Unstable Angina (Troponin Negative)
Safety of Argatroban Infusion in Conduction Disturbances
To determine change of QTc interval during intravenous argatroban infusion in patients undergoing percutaneous coronary intervention (PCI)
- Trial name
- SAICoDis (NCT05740371)
- Testing
- Argatroban
- Where
- 2 sites in Germany
- Volunteers
- 50 people
- Sponsor
- Tanabe Pharma GmbH
End-stage Renal Disease
Study of High Sensitive Troponin-I Level in End-stage Renal Disease Patients Receiving Hemodialysis
This study objective is to compare the high sensitive troponin-I level in end-stage renal disease patients received hemodialysis without acute cardiovascular event with healthy population.
- Trial name
- NCT02572466
- Testing
- Hemodialysis
- Where
- Thailand
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Acute Coronary Syndrome
A2 AR as a Novel Biomarkers for Physician Decision-making Improvement Evaluation's Patients With Suspected Acute Coronary Syndrome But Negative Troponin.
One proposed strategy is the stratification of troponin-negative patients with biomarker testing at presentation to facilitate the clinically-appropriate rapid discharge from the emergency department of patients who present with…
- Trial name
- NCT03218007
- Testing
- blood samples
- Where
- France
- Volunteers
- 83 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Acute Coronary Syndrome Without ST Elevation on Electrocardiogram
Calibration Study PREDICT - Prehospital Triage for Suspected Acute Coronary Syndrome Without ST-segment Elevation
The PREDICT calibration study is a prospective, non-interventional trial aiming to adapt and calibrate the ACS-Pathfinder algorithm for prehospital triage of patients with suspected non-ST-elevation acute coronary syndrome…
- Trial name
- PREDICT (NCT07419139)
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Leipzig Heart Science gGmbH
Acute Myocardial Infarction
Effect of the Biomarker Copeptin in Managing Patients With Suspected Acute Coronary Syndrome (ACS)
Acute chest pain is commonly known to be the classic symptom of acute myocardial infarction. Of the many patients which visit the Emergency Department because of chest pain, less than half do actually suffer from an acute…
- Trial name
- BiC-8 (NCT01498731)
- Testing
- Discharge home
- Where
- 6 sites in Austria, Germany and 1 more
- Volunteers
- 902 people
- Sponsor
- Charite University, Berlin, Germany
Influenza, Human, Myocardial Injury
Cardiac Injury in Patients With Influenza
This study investigate the prevalence of elevated biomarkers of cardiac injury in patients with suspected influenza infection and the prognostic implication on the composite endpoint of death of any cause, hospitalization due to…
- Trial name
- NCT03339180
- Where
- Sweden
- Volunteers
- 466 people
- Sponsor
- Örebro University, Sweden
Acute Myocardial Infarction
Hemorrhagic Myocardial Infarction Detection by Post-reperfusion Troponin Kinetics
Pilot trial to determine diagnostic efficacy of post-reperfusion troponin kinetics in detection of hemorrhagic myocardial infarction
- Trial name
- MIRON-TROP (NCT05872308)
- Where
- 2 sites in United States, India
- Volunteers
- 227 people
- Sponsor
- Rohan Dharmakumar
Chest Pain, Coronary Artery Disease
Trial of Cardiac CT in Acute Chest Patients With Intermediate Level Initial High-sensitivity Cardiac Troponin
Patients who present to the emergency department (ED) with acute chest pain (ACP) possibly due to Coronary artery disease (CAD), with a normal heart tracing (ECG), need to have further troponin blood tests to confirm or exclude a…
- Conditions
- Chest Pain, Coronary Artery Disease, Acute Coronary Syndrome, Ischemic Heart Disease
- Trial name
- PROTECCT (NCT03583320)
- Testing
- Cardiac CT angiogram
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Heart Failure
Sacubitril/Valsartan Versus Valsartan in Heart Failure
The objective of this study was to identify potential prognostic factors of sacubitril/valsartan vs Valsartan treatment response.
- Trial name
- NCT05881720
- Testing
- Sacubitril / Valsartan Oral Tablet, Valsartan 80 mg
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Damanhour University
Peripheral Arterial Occlusive Disease
Troponin T as Risk Stratification Tool in Peripheral Arterial Occlusive Disease
Study hypothesis: elevated Troponin T is a marker of increased mortality in patients with peripheral arterial occlusive disease (PAOD).
- Trial name
- NCT01087385
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University Heart Center Freiburg - Bad Krozingen
Hip Fracture, Perioperative Myocardial Injury
Nerve Block and Perioperative Myocardial Injury in Elderly Hip Fracture
This single-center, retrospective cohort study evaluates whether a single preoperative peripheral nerve block can reduce the risk of perioperative myocardial injury in elderly patients undergoing delayed hip fracture surgery…
- Conditions
- Hip Fracture, Perioperative Myocardial Injury, Myocardial Injury After Noncardiac Surgery
- Trial name
- PNB-CARD (NCT07751146)
- Testing
- PNB, Non-PNB
- Volunteers
- 500 people
- Sponsor
- Tongji Hospital
Acute Coronary Syndrome, Myocardial Infarction
Use of Abbott High Sensitivity Troponin I Assay In Acute Coronary Syndromes
Hypothesis: High sensitivity cTnI assays will have improved diagnostic accuracy for type 1 MI compared to contemporary cTnI assays.
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Troponin
- Trial name
- UTROPIA (NCT02060760)
- Where
- United States
- Volunteers
- 1,927 people
- Sponsor
- Hennepin Healthcare Research Institute
Myocardial Infarction
Accelerated Rule Out of Myocardial Infarction
Every year > 50.000 people in Denmark are hospitalized with a suspected acute myocardial infarction (AMI). The majority has other explanations of their chest discomfort and most are discharged again without any initiation of…
- Trial name
- AROMI (NCT02666326)
- Testing
- Accelerated, combined biomarker rule-out strategy for MI
- Where
- 3 sites in Denmark
- Volunteers
- 4,516 people
- Sponsor
- Aarhus University Hospital Skejby
Acute Coronary Syndrome, Chest Pain
PARA-HEART Pilot Implementation
Approximately 8-10 million patients complaining of chest pain present to an Emergency Department (ED) annually in the United States.
- Trial name
- PARA-HEART (NCT02709135)
- Where
- United States
- Volunteers
- 511 people
- Sponsor
- Wake Forest University Health Sciences
Acute Coronary Syndrome, Chest Pain
Li-Hep vs. Non-Li-Hep Coated Transfer Device
This study is a prospective, diagnostic, cohort study within the standard care of acute coronary syndrome (ACS) patients. It compares the analytical performance of Siemens® point-of-care high sensitive troponin I testing in…
- Conditions
- Acute Coronary Syndrome, Chest Pain, Myocardial Infarction, Cardiac Ischemia
- Trial name
- NCT04458155
- Testing
- Siemens® Point-of-care high sensitive troponin I analyzer
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- VieCuri Medical Centre
ACS - Acute Coronary Syndrome
Magnetocardiography (MCG) Device Use in Patients With Elevated Troponin
This prospective device study will examine the feasibility of MCG data collection in a hospital setting using the SandboxAQ MCG device as a potential method to more accurately and quickly quantify cardiac disease of patients with…
- Trial name
- DUET (NCT06620744)
- Testing
- Sponsor MCG deivce
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- SB Technology, Inc.
Acute Myocardial Infarction, Acute Coronary Syndrome
Safe Emergency Department DIscharGE Rate (SEIGE)
The Siemens POC High Sensitivity Troponin-I Test System is an in vitro diagnostic test for the quantitative measurement of cardiac troponin I (cTn-I) in fresh human capillary (fingerstick) whole blood, and lithium-heparinized…
- Trial name
- SEIGE (NCT04772157)
- Testing
- Cardiac Troponin Testing
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Hennepin Healthcare Research Institute
Healthy Individuals (Controls)
Healthy Adult Reference Biobank for Cardiovascular Biomarkers in China
Establishing reference intervals for high-sensitivity cardiac troponin in the apparently healthy population in China.
- Trial name
- HARBOR (NCT07136675)
- Where
- China
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases