Clinical trials: Treatment Interruption
Glioma, Malignant, Glioblastoma
Assessment of Safety and Feasibility of ExAblate Blood-Brain Barrier (BBB) Disruption in GBM Patients
The purpose of this study is to evaluate the safety of the Exablate Model 4000 Type 2.0 used as a tool to disrupt the BBB in patients with high grade glioma undergoing standard of care therapy.
- Trial name
- NCT04998864
- Testing
- Magnetic Resonance guided Focused ultrasound (MRgFUS)
- Where
- 2 sites in Italy, Spain
- Volunteers
- 3 people
- Sponsor
- InSightec
HIV
Immunologic and Virologic Parameters During Analytical Treatment Interruption Following Combination bNAb Therapy During Suppressive ART
Background: Recent studies have shown bNAbs may help remove cells that are infected with HIV (HIV reservoir) from the body and may also change how the immune system fights HIV.
- Trial name
- NCT06908083
- Testing
- Analytical Treatment Interruption
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Paraparesis, Gait Disorders, Neurologic
Effect of Electromagnetic Field Therapy on Balance and Gait in Paraparetic Patients
This study will investigate whether adding electromagnetic field therapy (EMT) to a standard physical therapy program is more effective than physical therapy alone for improving balance and walking ability in paraparetic…
- Conditions
- Paraparesis, Gait Disorders, Neurologic, Postural Balance Disorders
- Trial name
- EMT-BG (NCT07196956)
- Testing
- Low-Frequency Electromagnetic Field Therapy (0.5 Hz)
- Where
- Saudi Arabia
- Volunteers
- 30 people
- Sponsor
- MTI University
Disruption or Dehiscence of Closure of Sternum or Sternotomy
Treatment With PTH After Sternotomy in Cardiac Surgery Patients
The aims of this study is to compare healing time and quality of newly formed bone in cardiac surgery patients treated with PTH post-surgically and a control group treated with saline.
- Trial name
- PAATH (NCT01466829)
- Testing
- Parathyroid hormone
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Multiple Closed Pelvic Fractures With Disruption of Pelvic Ring, Fragility Fracture
Early Internal Fixation Versus NonOperative Care With Early Rehabilitation for LC1 Fragility Fractures of the Pelvis
The goal of this randomized pilot study is to assess feasibility of the trial and to collect information to inform the design of a definitive trial.
- Conditions
- Multiple Closed Pelvic Fractures With Disruption of Pelvic Ring, Fragility Fracture, Internal Fixation, Nonoperative Care
- Trial name
- PIVOT-LC1-Pi (NCT06496867)
- Testing
- Early Internal Fixation, Nonoperative Care with Early Rehabilitation
- Where
- 13 sites in United States, Spain
- Volunteers
- 48 people
- Sponsor
- University of Southern California
HIV Infection
Safety, Tolerability, and Efficacy of IL-15 Superagonist (N-803) With and Without Combination Broadly Neutralizing Antibodies to Induce HIV-1 Control During Analytic Treatment Interruption
The purpose of this study is to evaluate the safety, tolerability, and efficacy of N-803, an IL-15 superagonist, with or without combination broadly neutralizing antibodies (bNAbs), to induce HIV-1 control during analytic…
- Trial name
- NCT04340596
- Testing
- N-803 (IL-15 Superagonist), VRC07-523LS, 10-1074
- Where
- 14 sites in United States
- Volunteers
- 118 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Adhesive Capsulitis
Percutaneous Interruption of the Coracohumeral Ligament for the Treatment of Frozen Shoulder
Percutaneous Interruption of the Coracohumeral Ligament for the treatment of Frozen Shoulder.
- Trial name
- CHLTenex (NCT04549051)
- Testing
- Tenex, Local anesthetic
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Albert Einstein College of Medicine
HIV
A Clinical Trial of Analytical Treatment Interruption in People With HIV With a Highly Favourable Profile
A pilot single exploratory clinical trial of ATI in a selected sample of PWH sharing specific genetic, phenotypic and clinical characteristics.
- Trial name
- CLINIC-CURE (NCT07875504)
- Testing
- Treatment interruption
- Volunteers
- 20 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Type 2 Diabetes Mellitus
An Exploratory Study of the Effect of Treatment Interruption on Safety of Exenatide in Patients With Type 2 Diabetes
The primary purpose of this study is to assess the anti-exenatide-antibody response to exenatide re-exposure as measured by anti-exenatide antibodies and incidence of treatment-emergent allergy and hypersensitivity reactions…
- Trial name
- NCT00516048
- Testing
- exenatide
- Where
- 13 sites in Australia, Canada and 3 more
- Volunteers
- 58 people
- Sponsor
- AstraZeneca
Glioblastoma Multiforme
ExAblate Blood-Brain Barrier Disruption for Glioblastoma in Patients Undergoing Standard Chemotherapy
The purpose of this study is to evaluate the safety of the ExAblate Model 4000 Type 2.0 used as a tool to disrupt the BBB in patients with Glioblastoma undergoing standard of care therapy.
- Trial name
- NCT03712293
- Testing
- BBB Disruption with Chemotherapy Arm
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- InSightec
Diabete Mellitus
Hypertension Treatment in Nigeria: Hypertension Diabetes Integration Study- Formative Aim 3
The purpose of the second phase of the Hypertension Treatment in Nigeria (HTN 2.0) Program is to build upon the success of the first phase of the HTN Program (2020-2023), which implemented the WHO HEARTS package across 60 primary…
- Trial name
- HTN2 (NCT07589387)
- Testing
- Implementation of program based on WHO HEARTS-D guidelines, Metformin, Glimepiride
- Where
- 10 sites in Nigeria
- Volunteers
- 2,800 people
- Sponsor
- Washington University School of Medicine
Major Depressive Disorder, Bipolar Disorder II
Long-term Potentiation Disruption Underlying Cognitive Impairment in ECT
Cognitive problems, like memory loss, are common after brain injuries like trauma or stroke. These problems make daily life harder, and the investigators don't yet know the best ways to help the brain recover.
- Trial name
- LTP-DUCIECT (NCT06733558)
- Testing
- Electroconvulsive Therapy
- Where
- United States
- Sponsor
- University of New Mexico
Mild Cognitive Impairment, Alzheimer Disease 1
Safety and Feasibility of Exablate Blood-Brain Barrier Disruption for Mild Cognitive Impairment or Mild Alzheimer's Disease Undergoing Standard of Care Monoclonal Antibody (mAb) Therapy
The purpose of this study is to assess the safety and feasibility of administering standard of care monoclonal antibody (mAb) infusion therapy in combination with opening the blood-brain barrier with the Exablate Model 4000 Type…
- Trial name
- NCT05469009
- Testing
- Aducanumab, Exablate Model 4000 Type 2, Lecanemab
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Ali Rezai
HIV Infections
Therapeutic Vaccination Followed by Treatment Interruption in HIV Infected Patients
The aim of this trial is to find out if immune responses to HIV can be boosted in individuals who start medicines soon after being infected.
- Trial name
- NCT00058734
- Testing
- Dendritic Cells Pulsed with HIV antigens
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pregnancy Related
Pharmacological Voluntary Termination of Pregnancy: Predictors of Pelvic Pain During Treatment
Pharmacological treatment for voluntary termination of pregnancy is a safe and effective practice, but has as its limitation a greater need for analgesic coverage than surgical treatment.
- Trial name
- NCT06800287
- Where
- 2 sites in Italy
- Volunteers
- 13 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Premenstrual Syndrome, PMS
Treatment of Menstrually Related Disorders With Continuous v. Interrupted Oral Contraceptives
This study will determine whether uninterrupted treatment with birth control pills over several menstrual cycles prevents severe premenstrual syndrome (PMDD).
- Conditions
- Premenstrual Syndrome, PMS, Premenstrual Dysphoric Disorder, PMDD
- Trial name
- NCT00089414
- Testing
- Ethinyl Estradiol/Drospirenone, CDB 2914
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Mental Health (NIMH)
Gastrointestinal Stromal Tumors, Resected Gastrointestinal Stromal Tumors
Efficiency of Imatinib Treatment Maintenance or Interruption After 3 Years of Adjuvant Treatment in Patients With Gastrointestinal Stromal Tumours (GIST)
This is a 2 arms study concerning patients with primary GIST who followed an Imatinib adjuvant treatment for 3 years after surgery and who have a high risk of recurrence.
- Conditions
- Gastrointestinal Stromal Tumors, Resected Gastrointestinal Stromal Tumors, Non-metastatic, High Risk of Recurrence
- Trial name
- ImadGist (NCT02260505)
- Testing
- Imatinib maintenance
- Where
- 17 sites in France
- Volunteers
- 136 people
- Sponsor
- Centre Leon Berard
Epiphora
Placement of Three Interrupted Sutures After Triangular Three-snip Punctoplasty
a prospective randomized study conducted upon 40 eyes of 24 patients with lower punctual stenosis (grade 1 or 2 according to Kashkouli scale) attending at Menoufia University hospitals and Kafr Elsheikh ophthalmic eye center.
- Trial name
- NCT04680078
- Testing
- Placement of three interrupted sutures after Triangular Three-snip Punctoplasty of the lower punctum, Conventional Triangular Three-snip Punctoplasty of the lower punctum
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Primary Myelofibrosis
A Phase II Study of Re-treatment of Myelofibrosis Patients With Ruxolitinib/Jakavi After Treatment Interruption Due to Loss of Response and/or Adverse Event (ReTreatment Trial)
The aim of the study is to assess the efficacy and safety of restarting ruxolitinib after treatment interruption due to loss of response and/or adverse events.
- Trial name
- NCT02091752
- Testing
- Ruxolitinib
- Where
- 3 sites in Germany, Italy and 1 more
- Volunteers
- 3 people
- Sponsor
- Novartis Pharmaceuticals
Human Immunodeficiency Virus
The SUSTAIN 2 Study - SUStained HIV Treatment for Adherence After Interruption in Care
The goal of this clinical trial is to learn if the DSD model (SUSTAIN-DSD) is effective in improving participants HIV treatment adherence.
- Trial name
- NCT06554223
- Testing
- SUSTAIN-DSD, Enhanced (guideline-driven) Standard of Care (E-SoC)
- Where
- South Africa
- Volunteers
- 310 people
- Sponsor
- Brigham and Women's Hospital