Clinical trials: Traumatic Hemorrhage
Multiple Trauma, Polytrauma
Development and Internal Validation of a Multimodal Prediction Score for Early Hemodynamic Deterioration in Adult Polytrauma Patients
Severe traumatic injury involving multiple body regions (polytrauma) carries a high risk of rapid bleeding, tissue hypoperfusion, and circulatory collapse.
- Conditions
- Multiple Trauma, Polytrauma, Hemodynamic Instability, Traumatic Shock
- Trial name
- NCT07850427
- Volunteers
- 300 people
- Sponsor
- Assiut University
Trauma, Acute Hemorrhage
Evaluation of a Transfusion Therapy Using Whole Blood in the Management of Coagulopathy in Patients With Acute Traumatic Hemorrhage
The prognosis of traumatized hemorrhages is correlated with the nature of transfusion therapy: a 50% reduction in mortality for an early and massive supply of plasma, and 20% for an early and massive supply of platelets.
- Conditions
- Trauma, Acute Hemorrhage, Coagulopathy
- Trial name
- T-STORHM (NCT04431999)
- Testing
- Whole blood transfusion, Fractionated blood products transfusion
- Where
- 6 sites in France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Chronic Subdural Hematomas
PHIL™ Middle Meningeal Artery Embolization for First-Line Treatment of Chronic Subdural Hematoma IDE Trial
This is a prospective, randomized, controlled, open-label, blinded endpoint (PROBE) clinical investigation in which patients with non-emergent chronic subdural hematoma (cSDH) requiring treatment will be randomized (1:1) to…
- Trial name
- PHILFIRST (NCT07576998)
- Testing
- PHIL™ (Precipitating Hydrophobic Injectable Liquid), Surgical evacuation
- Volunteers
- 475 people
- Sponsor
- Microvention-Terumo, Inc.
The Efficacy of Percutaneous Catheter vs. Open Chest Tube, Traumatic Hemothorax
Multi-center:The Small (14F) Percutaneous Catheter vs. Large (28-40F) Open Chest Tube for Traumatic Hemothorax (P-CAT)
After sustaining severe trauma to the chest, patients will often bleed into the chest cavity (pleural space) which is called hemothorax or they may also experience air leakage within the chest cavity in combination with the…
- Trial name
- P-CAT (NCT03546764)
- Testing
- Percutaneous catheter
- Where
- 4 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Trauma Associated Hemorrhage
Prehospital Transfusion Outcomes in Traumatic Hemorrhage: a Prospective Cohort Study
Traumatic injuries can cause severe bleeding, which causes a lot of deaths worldwide that could be prevented. Starting treatment as early as possible has been shown to improve survival, which makes fast care very important.
- Trial name
- PRONTO (NCT07883252)
- Where
- Netherlands
- Volunteers
- 750 people
- Sponsor
- Erasmus Medical Center
Brain Injury, Coma, Cardiac Arrest (CA)
Prediction for Coma Recovery With Comaweb
The general objective of the comaScore project is to provide an external validation of the accuracy of the comaScore, a score derived from magnetic resonance imaging (MRI), to predict 1 year outcome of patients unresponsive to…
- Conditions
- Brain Injury, Coma, Cardiac Arrest (CA), Traumatic Brain Injury (TBI), Aneurysmal Subarachnoid Hemorrhages (aSAH)
- Trial name
- COMASCORE (NCT03874208)
- Testing
- MRI sequence, MRI
- Where
- France
- Volunteers
- 611 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Subdural Hematoma
High Concentration Oxygen Therapy for Pneumocephalus in Chronic Subdural Haematoma: A Prospective Observational Study
Normobaric oxygen therapy was shown to be effective in reducing post craniotomy pneumocephalus. Theoretical assessment of normobaric oxygen therapy in treating pneumocephalus has shown that a higher level of oxygen concentration…
- Trial name
- NCT05143216
- Testing
- Low concentration oxygen group: Room air (0-2Litre Oxygen via Nasal Canula), High concentration oxygen group: Room air (12-15Litre Oxygen via Non-rebreather Mask)
- Where
- Hong Kong
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Dr. David Yuen Chung CHAN
Traumatic Intracranial Hemorrhage
Restart TICrH AP Pilot Trial
A Prospective Randomized Open-Label Blinded Endpoint (PROBE) Pilot Trial of restarting antiplatelet therapy at 1 week versus 3 weeks after traumatic intracranial hemorrhage with a primary composite endpoint of major bleeding and…
- Trial name
- NCT05000060
- Testing
- Timing/1 week, Timing/3 weeks
- Volunteers
- 100 people
- Sponsor
- University of Texas at Austin
Middle Meningeal Artery Embolization, Chronic Subdural Hematomas
Middle Meningeal Artery Embolization in Patients With Chronic Subdural Hematoma
Primary : to evaluate the efficacy of MMAE on resolution and recurrence of hematoma in patients with CSDH. Secondary : evaluate the effect of MMAE on functional outcome, radiological changes, the need to repeat surgery, duration…
- Trial name
- NCT07806552
- Testing
- middle meningeal artery embolization
- Volunteers
- 35 people
- Sponsor
- Assiut University
Acute Subdural Hematoma
Scandinavian Multicentre Acute Subdural Hematoma (SMASH) Study
In a multi-national population-based cohort, the investigators want to compare the clinical course and clinical outcome of elderly patients (≥70 y/o) compared with younger patients (< 70 y/o) with acute subdural hematoma treated…
- Trial name
- SMASH (NCT03284190)
- Testing
- Surgery
- Volunteers
- 1,600 people
- Sponsor
- Karolinska University Hospital
Chronic Subdural Hematoma
Puerto Rico Embolization of the Middle Meningeal Artery for the Treatment of Chronic Subdural Hematoma Trial (PREMMA)
Puerto Rico Embolization of the Middle Meningeal Artery (PREMMA) trial is a multi-center, parallel, prospective, superiority, randomized controlled trial with concealed allocation comparing reoperation rates and neurological…
- Trial name
- PREMMA (NCT06466733)
- Testing
- Embolization of the middle meningeal artery, Surgical Evacuation via burr hole or craniotomy
- Volunteers
- 658 people
- Sponsor
- Juan M. Ramos Acevedo
Stroke, Traumatic Brain Injury
Validation of the FOUR Coma Scale in Russia.
The purpose of this study is to examine the validity of the Russian version of the FOUR Full Outline of UnResponsiveness (hereafter FOUR) scale in adult ICU patients with an acute cerebral insufficiency clinic (hereinafter…
- Conditions
- Stroke, Traumatic Brain Injury, Subarachnoid Hemorrhage
- Trial name
- FOUR-RUS (NCT04018989)
- Where
- 3 sites in Russia
- Volunteers
- 260 people
- Sponsor
- Russian Federation of Anesthesiologists and Reanimatologists
Acute Subdural Hematoma, Acquired Brain Injury
A Comparative Analysis of Prognostic Factors for Functional Outcomes in Patients With Acute Subdural Hematoma
Acute subdural hematoma (ASDH) is the most common intracranial traumatic lesion that requires surgical intervention. Although there is extensive published research on acute subdural, there remains uncertainty regarding mortality…
- Trial name
- NCT06364059
- Testing
- Decompressive craniectomy with evacuation of subdural hematoma
- Where
- Czechia
- Volunteers
- 175 people
- Sponsor
- Charles University, Czech Republic
Shock, Hemorrhagic
Pre-Hospital Use of Plasma for Traumatic Hemorrhage
Type A Thawed Plasma (TP) will be compared in polytrauma patients who receive only Normal Saline (NS) (standard of care) before arrival at the hospital.
- Trial name
- PUPTH (NCT02303964)
- Testing
- Plasma, Normal saline
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Trauma, Brain, Hemorrhage Cerebral
Research of Optimal Cerebral Perfusion Pressure Diagnosis
The research will investigate the hypothesis that timely identification of the optimal value of the cerebral perfusion pressure (optCPP) or optimal arterial blood pressure (optABP) is possible after detecting informative episodes…
- Trial name
- optCPP (NCT06028906)
- Testing
- Multimodal physiological monitoring and cerebral autoregulation monitoring
- Where
- Lithuania
- Volunteers
- 80 people
- Sponsor
- Vilnius University
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Chronic Subdural Hematoma
Middle Meningeal Artery Embolization for Chronic Subdural Hematoma
Endovascular middle meningeal artery (MMA) embolization is an emerging treatment for chronic subdural hematoma (cSDH). There is preliminary data to suggest that this minimally invasive therapy may be more efficacious and equally…
- Trial name
- NCT04065113
- Testing
- Middle Meningeal Artery Embolization with polyvinyl alcohol particles (PVA), Drainage of Subdural Hematoma
- Where
- United States
- Sponsor
- Washington University School of Medicine
Subdural Hematoma, Subdural Hematoma, Chronic
Study On Histoacryl Used For Embolization Of Middle Meningeal Artery (MMA) In Chronic Subdural Hematoma (CSDH) (HARMONY)
The aim of the study is to proof the effectiveness of Histoacryl® on preventing recurrence or progression of subdural hematoma after embolization of the middle meningeal artery.
- Trial name
- HARMONY (NCT07258069)
- Testing
- Histoacryl®
- Where
- 6 sites in Japan
- Volunteers
- 178 people
- Sponsor
- Aesculap AG
Chronic Subdural Hematoma
Outcome of Single Burr Hole Under Local Anaesthesia in the Management of Chronic Subdural Hematoma
Aim of the work: Is to evaluate the prognosis of single burr hole under local anesthesia in management of CSDH according to clinical picture, risk factors, and age.
- Trial name
- NCT03447327
- Testing
- single burr hole
- Volunteers
- 67 people
- Sponsor
- Zagazig University
Obstructive Hydrocephalus, Subarachnoid Hemorrhage
VisAR Augmented Reality Navigation of Ventriculostomy
This study is intended to evaluate the feasibility of using VisAR augmented reality surgical navigation during placement of an external ventricular drain (EVD).
- Conditions
- Obstructive Hydrocephalus, Subarachnoid Hemorrhage, Brain Trauma
- Trial name
- NCT06132139
- Testing
- VisAR
- Volunteers
- 50 people
- Sponsor
- Dartmouth-Hitchcock Medical Center