Clinical trials: Traumatic Brain Injuries
Traumatic Brain Injury
Deployment of a Novel National Institute of Neurological Disorders and Stroke Clinical, Biomarker, Imaging, and Modifiers (CBI-M) Classification Framework for Emergency Department Patients With Glasgow Coma Scale 15 Traumatic Brain Injury (PIONEER-Prognosis)
This study is being done to learn how information from blood tests, medical records, and wearable devices that track sleep, activity, and heart rate can help predict how people recover after a concussion.
- Trial name
- NCT07858266
- Where
- 5 sites in United States
- Volunteers
- 500 people
- Sponsor
- University of Michigan
Traumatic Brain Injury
Sovateltide for the Treatment of Acute Traumatic Brain Injury
Traumatic brain injury (TBI) remains a leading cause of global disability, yet current clinical management is limited to supportive care and pressure stabilization using hyperosmolar therapies like mannitol and hypertonic saline.
- Trial name
- RESTORE-TBI (NCT07861126)
- Testing
- Sovateltide
- Volunteers
- 214 people
- Sponsor
- Pharmazz, Inc.
Traumatic Brain Injury
Music Therapy for Comatose Brain Injured Patients
The goal of this single-arm observational study is to determine whether alpha music therapy, initiated early in the recovery period, can improve cognitive function for severe traumatic brain injury patients when compared to…
- Trial name
- NCT07544602
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Mercy Health Ohio
Fibrinogen, Albumin
Fibrinogen-to-Albumin Ratio as a Predictor of Acute Respiratory Distress Syndrome in Traumatic Brain Injury
this study aims to assess the ability of fibrinogen-to-albumin ratio to predict the development of Acute respiratory distress syndrome in traumatic brain injury patients.
- Conditions
- Fibrinogen, Albumin, ARDS, TBI (Traumatic Brain Injury)
- Trial name
- FARDS (NCT07664358)
- Testing
- Fibrinogen-to-albumin ratio
- Where
- Egypt
- Volunteers
- 350 people
- Sponsor
- Tanta University
Traumatic Brain Injuries
Therapeutic Benefits of Pareidolia in Acute Traumatic Brain Injury Patients
This study will investigate whether viewing and identifying meaningful shapes or images hidden within nature pictures (pareidolia) can improve motivation and engagement in rehabilitation therapy for adults with mild to moderate…
- Trial name
- NCT07867119
- Testing
- Therapeutic Benefits of Pareidolia, Active Comparator #1
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Shirley Ryan AbilityLab
Traumatic Brain Injury, Mild Traumatic Brain Injury
Memantine Targeting Neurovascular Dysfunction After Mild and Moderate Traumatic Brain Injury (MEND)
The goal of this pilot clinical trial is to learn whether memantine can be given safely and successfully to adults in hospital with a mild or moderate traumatic brain injury (TBI).
- Conditions
- Traumatic Brain Injury, Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury (TBI), TBI
- Trial name
- MEND (NCT07867210)
- Testing
- Memantine
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Nova Scotia Health Authority
Exercise, Fatigue
Effect of Aerobic Exercise Training on Cardiorespiratory Function in Patients With Traumatic Brain Injury
Background: Many people who have traumatic brain injury (TBI) have low levels of physical fitness. Low physical fitness causes severe fatigue that reduces the ability to perform routine daily activities, and may also cause…
- Conditions
- Exercise, Fatigue, Physical Fitness, Traumatic Brain Injury
- Trial name
- NCT01294332
- Testing
- Aerobic Exercise Training
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
MTBI - Mild Traumatic Brain Injury
Retraining Neural Pathways Improves Cognitive Skills After A Mild Traumatic Brain Injury
The proposed study tests the efficacy (Phase II) of 36 or 54 30-minute training sessions of PATH neurotraining followed by digit memory exercises to improve working memory, processing speed and attention in mTBI patients rapidly…
- Trial name
- NCT03655782
- Testing
- PATH + DigitMemory (DM) neurotraining
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Perception Dynamics Institute
Mild Traumatic Brain Injury, Dizziness
Vestibular Rehabilitation App for Adults With Dizziness Related to mTBI
The goal of this clinical trial is to compare outcomes for standard vestibular rehabilitation home program to a digital vestibular rehabilitation home program in adults with dizziness related to mild traumatic brain injury…
- Trial name
- NCT06222450
- Testing
- Vestibular Rehabilitation Therapy (VRT)
- Where
- 3 sites in United States
- Volunteers
- 68 people
- Sponsor
- Mountain Home Research & Education Corporation
Traumatic Brain Injury, Acquired Brain Injury
Feasibility and Outcomes of 3D-printed External Cranial Orthosis After Craniectomy
This study will compare the outcomes of a current clinical implementation of PEACO designed for one-handed donning and doffing with carer-monitoring with a previous prototype (HPPD) requiring carer-donning and doffing with…
- Conditions
- Traumatic Brain Injury, Acquired Brain Injury, Brain Tumor, Stroke
- Trial name
- NCT07122752
- Where
- Singapore
- Volunteers
- 32 people
- Sponsor
- Tan Tock Seng Hospital
Traumatic Brain Injury, Neurogenic Communication Disorders
Narrative Discourse Treatment Development
Discourse impairments are breakdowns in meaningful communication beyond the level of single sentences and have a functional impact on the lives of Veterans with traumatic brain injury (TBI), disrupting return to work…
- Trial name
- NCT05008419
- Testing
- Narrative discourse treatment
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Traumatic Encephalopathy
Ketamine in Severe Traumatic Brain Injury
Traumatic brain injury (TBI) accounts for approximately 2.5 million visits to emergency departments in the United States each year.
- Trial name
- NCT06062628
- Testing
- Ketamine Hydrochloride
- Sponsor
- University of Texas Southwestern Medical Center
Stroke, Acquired Brain Injury
Machine Learning to Predict Factors Affecting Rehabilitation Length of Stay and Healthcare Costs for Neurological Rehabilitation
The aim of this retrospective study is to ascertain total direct costs, rehabilitation length of stay (RLOS) and factors associated with RLOS for neurological inpatient rehabilitation at the tertiary care hospital.
- Conditions
- Stroke, Acquired Brain Injury, Traumatic Brain Injury, Brain Tumor
- Trial name
- NCT06704997
- Where
- Singapore
- Volunteers
- 10,000 people
- Sponsor
- Tan Tock Seng Hospital
Traumatic Brain Injury, Aging Disorder
Carbon Dioxide Administration and Brain Waste Clearance
The current study tests whether different exposures to carbon dioxide (CO2) can safely result in the increased movement of proteins from the brain into the blood.
- Conditions
- Traumatic Brain Injury, Aging Disorder, Magnetic Resonance Imaging (MRI)
- Trial name
- COPETBI (NCT07357090)
- Testing
- Hypercapnia task performed during fMRI
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Andrew Mayer
Traumatic Brain Injury (TBI) Patients
Transcutaneous Vagus Nerve Stimulation for Attention and Memory
This clinical trial aims to evaluate whether transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive brain stimulation method, can improve attention and memory in veterans with traumatic brain injury (TBI) and…
- Trial name
- taVNS (NCT06723743)
- Testing
- Transcutaneous vagus nerve stimulation for attention in veterans with TBI, Soterix Medical Vagus Nerve Stimulation mini-CT
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine
Traumatic Brain Injury
Modulating Inflammation in Neuro-Trauma
MINT is a single-site, prospective, randomized, double-blind, sham-controlled pilot trial evaluating the safety and feasibility of transcutaneous auricular vagus nerve stimulation (taVNS) in patients with moderate to severe…
- Trial name
- MINT (NCT07510074)
- Testing
- Nurosym taVNS
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Traumatic Brain Injury
Evaluation, Pathogenesis, and Outcome of Subjects With or Suspected Traumatic Brain Injury
Background: Traumatic brain injury may have a range of effects, from severe and permanent disability to more subtle functional and cognitive deficits that often go undetected during initial treatment.
- Trial name
- NCT01132937
- Where
- United States
- Volunteers
- 886 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Brain Injury, Post Traumatic Stress Disorder
Innovative Multimodal and Attention Training to Improve Emotion Communication in Veterans With TBI and PTSD
Poor emotion recognition has been associated with poor quality of interpersonal relationships, loss of employment, behavioral problems, reduced social reintegration, social isolation and even suicide.
- Trial name
- NCT05478759
- Testing
- Multimodal affect recognition training, Attention Training, Brain Health Workshop
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Venous Thromboembolism
Evaluation of the SCALED (SCaling AcceptabLE cDs)
This project will adapt a currently deployed Clinical Decision Support (CDS) system to deliver a VTE prevention guideline for adult patients with traumatic brain injury (TBI).
- Trial name
- NCT05628207
- Testing
- Observational, Observational-control
- Where
- United States
- Volunteers
- 15,000 people
- Sponsor
- University of Minnesota
Stroke, Traumatic Brain Injury
Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention
The aging population and its accompanying burden from non-communicable chronic diseases predicts an increasing impact imposed by frailty on healthcare systems.
- Conditions
- Stroke, Traumatic Brain Injury, Knee Osteoarthritis, Breast Cancer
- Trial name
- OPTIMA-C (NCT06073106)
- Where
- Singapore
- Volunteers
- 500 people
- Sponsor
- Tan Tock Seng Hospital