Clinical trials: Traumatic Brain Injuries
Traumatic Brain Injury
A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury
The study is intended to cover two purposes: first, to develop a blood-based biomarker test for aiding the diagnosis of traumatic brain injury (TBI) in adult participants and for prognosis of outcome of TBI (CLIN12.1); and…
- Trial name
- NCT07455136
- Testing
- Blood sample collection
- Where
- 14 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Hoffmann-La Roche
Traumatic Brain Injury
hCG Treatment for Rehabilitation From a TBI
The COGNI-REHAB Trial is a single-site, phase O/I, randomized, double-blind, placebo-controlled study of human chorionic gonadotropin (hCG; choriogonadotropin alfa, Ovidrel®) in men with post-acute, moderate to severe traumatic…
- Trial name
- COGNI-REHAB (NCT07557615)
- Testing
- Ovidrel
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Upper Extremity
Transcutaneous Auricular Vagus Nerve Stimulation to Improve Upper Extremity Recovery After Traumatic Brain Injury
Upper extremity weakness, impaired coordination, reduced dexterity, and limited arm and hand use may continue after TBI. Repetitive, task-specific rehabilitation may improve function, but recovery can remain incomplete.
- Trial name
- taVNS (NCT07867015)
- Testing
- taVNS, FTP
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Craig Hospital
Disorder of Consciousness, Minimally Conscious State
Temporal Interference Stimulation for Disorders of Consciousness
This study aims to investigate whether a new non-invasive brain stimulation technique, called temporal interference stimulation, can influence brain activity and potentially improve signs of consciousness in patients with severe…
- Conditions
- Disorder of Consciousness, Minimally Conscious State, Vegetative State, Unresponsive Wakefulness Syndrome
- Trial name
- NCT07874178
- Testing
- Temporal Interference
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Adult, Traumatic Brain Injury
Effects of Rapid-Resisted Exercise and Bright Light Therapy on Ambulatory Adults With Traumatic Brain Injury
Background: Traumatic brain injury may have a range of effects, from severe and permanent disability to more subtle functional and cognitive deficits that often go undetected during initial treatment.
- Conditions
- Adult, Traumatic Brain Injury, fMRI
- Trial name
- NCT01175993
- Testing
- Elliptical exercise
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Traumatic Brain Injury
Group Lifestyle Balance™ for Individuals With Traumatic Brain Injury (GLB-TBI)
The purpose of this RCT is to examine the efficacy of a Group Lifestyle Balance™ (GLB) program adapted for people with traumatic brain injury (TBI) on primary (weight) and secondary outcomes at 3, 6, 12, and 18 months from…
- Trial name
- NCT03594734
- Testing
- Group Lifestyle Balance™, Attention Control Group
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Baylor Research Institute
Mild Traumatic Brain Injury, Post Traumatic Stress Disorder
Neuromodulation and Neurorehabilitation for mTBI
This study will determine (i) the magnitude of immediate and sustained effects of a current clinical standard interactive computer attention processing training (APT) when combined with intermittent theta burst stimulation…
- Trial name
- NCT03819608
- Testing
- real iTBS, real APT
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Northwestern University
MTBI - Mild Traumatic Brain Injury, Concussion, Mild Traumatic Brain Injury
Positive Assurance and mTBI
This study will develop and validate a new educational video that provides positive assurance about mild traumatic brain injury (mTBI) recovery for patients with mTBI.
- Trial name
- NCT04982731
- Testing
- Positive Assurance
- Where
- United States
- Volunteers
- 229 people
- Sponsor
- Inova Health Care Services
Traumatic Brain Injury
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for TBI
This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells for the treatment of traumatic brain injury
- Trial name
- NCT05018832
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells
- Where
- Antigua and Barbuda
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Spina Bifida, Cerebral Palsy
The Impact of Community-based Wellness Programs on The Triple Aim
People with disabilities experience a staggering incidence of secondary conditions that can result in death or negatively impact their health, participation in the community, and quality of life.
- Conditions
- Spina Bifida, Cerebral Palsy, Spinal Cord Injury, Traumatic Brain Injury
- Trial name
- NCT02938130
- Testing
- Wellness Programs
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- University of Pittsburgh
Traumatic Brain Injury
Evaluation of the Abbott i-STAT TBI Biomarker Test
According to the Centers for Disease Control and Prevention, approximately 200,000 hospitalizations occurred in 2020 related to Traumatic Brain Injury (TBI), which does not include many TBIs treated only in emergency departments…
- Trial name
- NCT06766435
- Testing
- i-STAT TBI Test
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Traumatic Brain Injury
Overground Virtual Reality (VR) Gait Rehabilitation for Traumatic Brain Injury (TBI)
The purpose of this study is to evaluate a new virtual reality (VR)-based rehabilitation program designed to help individuals with traumatic brain injury (TBI) improve their walking abilities in real-world settings.
- Trial name
- NCT07038889
- Testing
- C-Mill VR+ by Motek, Walk-over-Ground
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Traumatic Brain Injury (TBI) Patients, Cognitive Impairment
Mindfulness-Integrated Neuropsychotherapy for Traumatic Brain Injury: A Mixed-Methods Evaluation of Cognitive and Psychosocial Recovery
The goal of this clinical trial is to test the effectiveness of Integrative Mindfulness Enhanced Neuropsychotherapy (IMENP) in improving neurocognitive functioning and wellbeing among adults aged 18 to 44 years with mild to…
- Conditions
- Traumatic Brain Injury (TBI) Patients, Cognitive Impairment, Depression Disorder, Fatigue Severity Scale
- Trial name
- IMENP (NCT07874685)
- Testing
- Integrative Mindfulness Enhanced Neuropsychotherapy (IMENP)
- Where
- India
- Volunteers
- 68 people
- Sponsor
- University of Madras
Traumatic Brain Injury
Control Network Neuromodulation to Enhance Cognitive Training in Complex Traumatic Brain Injury
The CONNECT-TBI Trial aims to develop safe, effective treatments for complex mTBI that improve cognitive functioning. Based on the compelling preliminary data generated by our study team, the objective of this study is to conduct…
- Trial name
- CONNECT-TBI (NCT05236010)
- Testing
- rTMS, HD-tDCS, Attention Process Training
- Where
- 5 sites in United States
- Volunteers
- 108 people
- Sponsor
- University of New Mexico
mTBI - Mild Traumatic Brain Injury, Posttraumatic Stress Disorder
Mindful RAVANS Study
This pilot study is testing a new treatment for people who still have frequent headaches months after a mild traumatic brain injury, with about half of the participants coming from military or veteran backgrounds.
- Conditions
- mTBI - Mild Traumatic Brain Injury, Posttraumatic Stress Disorder, Posttraumatic Headache
- Trial name
- RAVANS (NCT07872761)
- Testing
- Cala-RAVANS (Model CR-2)
- Volunteers
- 20 people
- Sponsor
- Spaulding Rehabilitation Hospital
Head Injury, Traumatic Brain Injury
Outcomes of Early Versus Late Tracheostomy in Critically Ill Patients Due to Head Injury: A Randomized Controlled Trial
Tracheostomy is a surgical procedure that involves creating an opening in the trachea and bringing it to the skin surface to form a stoma. It may be performed as an emergency or elective operation.
- Trial name
- NCT07872865
- Testing
- Tracheostomy
- Where
- Iraq
- Volunteers
- 100 people
- Sponsor
- University Of Anbar
Spinal Cord Injury (=3 Years), Traumatic Brain Injury (TBI) Patients
Evaluation of a Voice-Activated Call Light System for Clients With Limited Upper-Extremity Mobility
The goal of this study is to evaluate whether a voice-activated call light system enables people in a rehabilitation facility who have limited use of their arms and hands to call for help more independently and reliably than with…
- Conditions
- Spinal Cord Injury (=3 Years), Traumatic Brain Injury (TBI) Patients, Healthy Adult Participants
- Trial name
- NCT07873151
- Testing
- voice-activated call light
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Quality Living, Inc.
Adult Growth Hormone Deficiency, Mild Traumatic Brain Injury
Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD)
The purpose of this study is to determine whether growth hormone replacement therapy (GHRT) is effective versus placebo in the improvement of Quality of Life in patients with adult growth hormone deficiency (AGHD) and mild…
- Trial name
- GRIT (NCT04867317)
- Testing
- Somatropin
- Where
- 16 sites in United States
- Volunteers
- 172 people
- Sponsor
- VA Office of Research and Development
Fluid Balance
Caval Aorta Index for Fluid Optimization in Traumatic Brain Injury
Traumatic brain injury is a leading cause of death and disability in trauma patients. As the primary injury cannot be reversed; management strategies must focus on preventing secondary injury by avoiding hypotension and hypoxia…
- Trial name
- CAI for fluids (NCT06940258)
- Testing
- ultrasound measurement of caval aorta index, control group
- Where
- Egypt
- Volunteers
- 92 people
- Sponsor
- Mansoura University
Traumatic Brain Injury (TBI) Patients
Home-Based Walking for Thinking Skills in Persons With TBI
The purpose of this research study is to investigate the effects of a home-based 3-month long walking exercise program on cognitive (thinking) performance in persons with TBI.
- Trial name
- SWEAT-TBI (NCT07733284)
- Testing
- Walking
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Kessler Foundation