Clinical trials: Trauma Blunt
Abdominal Injuries, Physical Abuse
Effectiveness of Contrast-Enhanced Ultrasound
The purpose of the study is to generate pilot data describing test characteristics of contrast enhanced ultrasound in young children with concern for abdominal trauma.
- Conditions
- Abdominal Injuries, Physical Abuse, Accidental Fall, Motor Vehicle Injury
- Trial name
- NCT03473249
- Testing
- Contrast-Enhanced Ultrasound using Lumason
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Ascites, Blunt Abdominal Trauma
Telesonography Adaptation and Use to Improve the Standard of Patient Care Within a Dominican Community
The role of teleradiology has far reaching implications for the health of remote and underserved populations. The ability to coordinate radiographic evaluation and diagnosis from a distance has the potential to raise the standard…
- Conditions
- Ascites, Blunt Abdominal Trauma, Cholelithiasis, Cholecystitis
- Trial name
- NCT00591968
- Testing
- SonoSite Titan portable ultrasound coupled with email telediagnosis
- Where
- Dominican Republic
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Edward Via Virginia College of Osteopathic Medicine
Trauma, Traumatic Injury
ErythroPOietin Alfa to Prevent Mortality and Reduce Severe Disability in Critically Ill TRAUMA Patients
The EPO-TRAUMA study is a prospective, multi-centre, double-blind, phase III, randomised controlled trial evaluating the efficacy of epoetin alfa compared to placebo in reducing mortality and severe disability at six months in…
- Conditions
- Trauma, Traumatic Injury, Traumatic Brain Injury, Wounds and Injuries
- Trial name
- EPO-TRAUMA (NCT04588311)
- Testing
- Epoetin Alfa 40000 UNT/ML, Sodium Chloride 0.9%
- Where
- 41 sites in Australia, Belgium and 7 more
- Volunteers
- 2,500 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Trauma, Blunt Injury
Plasma Cytochrome c as Biomarker of Traumatic Injury and Predictor of Outcome
Cytochrome c is a mitochondrial protein that plays a key role in energy metabolism. When mitochondria are injured, cytochrome c may leave mitochondria and reach the bloodstream.
- Conditions
- Trauma, Blunt Injury, Blunt Trauma, Accident
- Trial name
- NCT02440373
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Wake Forest University Health Sciences
Trauma Injury, Trauma Blunt
Extremity Trauma At a Level 1 Trauma Center
Blunt vascular trauma to the lower extremity has been associated with injuries to the anteroposterior tibial arteries or popliteal artery in the form of transection, occlusion, or intimal injury.
- Conditions
- Trauma Injury, Trauma Blunt, Vascular Trauma
- Trial name
- NCT06402669
- Testing
- Packed Red Blood Cell Administration
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Arrowhead Regional Medical Center
Minor Head Injury
Outcome of Patients With Mild Head Injury and Presence of an Acute Traumatic Abnormality on CT Scan of Head
Background: Patients with mild blunt traumatic brain injury (TBI) are frequently transferred to Level 1 trauma centers (L1TC) if they have any positive finding of any acute intracranial injury identified on a CT scan of the head.
- Trial name
- NCT04143347
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Massachusetts General Hospital
Post-traumatic Facial Edema
Lymphedema Treatment for Blunt Facial Trauma
Injuries to the face caused by traumatic events such as motor vehicle collisions, assault, and falls can result in facial trauma, which can result in swelling and disfiguration that impairs the important functions of the face…
- Trial name
- NCT02977182
- Testing
- Complete Decongestive Therapy (CDT)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Our Lady of the Lake Hospital
Contusions
Phase III Trial to Assess the Safety and Efficacy of TK-254RX in Patients With Contusions
This study is an open-label, multi-centric clinical trial to evaluate the safety and efficacy of TK-254RX in patients with contusions. The primary objective of this study is to assess the safety of TK-254RX.
- Trial name
- NCT06871046
- Testing
- Esflurbiprofen Topical System (EFTS)
- Where
- 5 sites in Germany
- Volunteers
- 221 people
- Sponsor
- Teikoku Seiyaku Co., Ltd.
Spleen Injury
Observation vs Embolization in Severe Splenic Injury: A Randomized Controlled Trial
Nonoperative management (NOM) of blunt splenic injuries has been the standard of care for decades. While many splenic injuries can be successfully observed, studies have demonstrated increased failure rates for higher grade…
- Trial name
- NCT05008172
- Testing
- Splenic Artery Embolization
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Medical College of Wisconsin
Multiple Rib Fractures, Isolated Blunt Thoracic Trauma
GNRI and PNI for Predicting Short-Term Outcomes in Older Adults With Multiple Rib Fractures
This prospective observational cohort study will evaluate whether the Geriatric Nutritional Risk Index (GNRI) and Prognostic Nutritional Index (PNI) can predict short-term clinical outcomes in adults aged 65 years or older with…
- Trial name
- NCT07823712
- Where
- Turkey (Türkiye)
- Volunteers
- 294 people
- Sponsor
- Ankara Etlik City Hospital
Chest Injuries, Respiratory Failure
Early Non-invasive Ventilation and High-flow Nasal Oxygen Therapy for Preventing Delayed Respiratory Failure in Hypoxemic Blunt Chest Trauma Patients.
In blunt chest trauma patients without immediate life-threatening conditions, delayed respiratory failure and need for mechanical ventilation may still occur in 12 to 40% of patients, depending on the severity of the trauma, the…
- Trial name
- OptiTHO (NCT03943914)
- Testing
- Preventive strategy, Standard of care
- Where
- 14 sites in France
- Volunteers
- 144 people
- Sponsor
- University Hospital, Bordeaux
Trauma, Adrenal Gland Injury
Blunt ADrenal Gland injUrY (BAD GUY) Project
Type: retrospective observational multicenter trial. Population of interest: adult patients suffering from thoraco-abdominal trauma undergoing both non-operative and operative management.
- Trial name
- BADGUY (NCT06220448)
- Where
- Italy
- Volunteers
- 5,000 people
- Sponsor
- Niguarda Hospital
Soft Tissue Injuries, Contusions
Efficacy and Safety of Esflurbiprofen Hydrogel Patch in the Treatment of Local Acute Pain
Objective of this study is: to determine efficacy and safety of a Esflurbiprofen Hydrogel Patch compared to placebo in patients with acute strains, sprains or bruises of the extremities following blunt trauma, e.g.
- Conditions
- Soft Tissue Injuries, Contusions, Strains, Sprains
- Trial name
- NCT04908748
- Testing
- Esflurbiprofen Hydrogel Patch
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Teikoku Seiyaku Co., Ltd.
Sepsis, Septic Shock
Nucleosome Monitoring Relevance for Outcome Prediction in Critically Ill Patients
NUROPI is a single-centre, prospective, non-interventional study in the Intensive Care Unit (ICU) of Erasme Hospital (Hôpital Universitaire de Bruxelles, Brussels, Belgium).
- Conditions
- Sepsis, Septic Shock, Cardiac Arrest (CA), Pancreatitis
- Trial name
- NuROPI (NCT07184593)
- Testing
- Plasma H3.1 nucleosome measurement
- Volunteers
- 1,000 people
- Sponsor
- Erasme University Hospital
Wounds and Injuries
Splenic Injury Embolization - the Question About NOM (SInE Qua NOM)
The primary objective is to compare the failure rate due to splenic bleeding between the patients undergoing pre-emptive splenic arterial embolization (SAE) as part of non-operative management (NOM) and the patients not…
- Trial name
- NCT03231202
- Testing
- Embolization
- Where
- 12 sites in United States, Australia and 7 more
- Volunteers
- 224 people
- Sponsor
- Oslo University Hospital
Chest Trauma
Sedation for Non-invasive Ventilation in Blunt Chest Trauma
Effectiveness of sedation using dexmedetomidine and ketamine to facilitate non-invasive ventilation sessions which improve overall outcome after blunt chest trauma
- Trial name
- NCT05175781
- Testing
- Dexmedetomidine Hydrochloride, Ketamine Hydrochloride
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Aswan University Hospital
Head Injuries, Closed
Head Injury Retrieval Trial
The study hypothesis is that advanced interventions as provided by a physician at an accident scene will decrease the death rate and the rate of severe disability in survivors of severe head injury.
- Trial name
- NCT00112398
- Testing
- Extended interventions by advanced level prehospital providers
- Where
- Australia
- Volunteers
- 338 people
- Sponsor
- CareFlight
Chest Trauma
High Flow Nasal Oxygenation Versus Non-invasive Ventilation for Patients With Blunt Chest Trauma
Chest trauma remains an issue for health services for both severe and apparently mild trauma management. Severe chest trauma is associated with high mortality and is liable for 25% of mortality in multiple traumas.
- Trial name
- NCT05342103
- Testing
- high flow oxygenation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Huda Fahmy Mahmoud, PhD
Orthopaedic Injury
Socio-Economic Survey in Uganda
This study will be conducted at Mulago Teaching Hospital. Patients coming to the ER with an orthopaedic injury will be approached. If a patient consents to be part of the study, they will complete a questionnaire.
- Trial name
- NCT01971697
- Where
- 2 sites in United States, Uganda
- Volunteers
- 30 people
- Sponsor
- Duke University
Aortic Rupture
Analysis of Risk Factors for Death After Blunt Traumatic Rupture of the Thoracic Aorta
Aortic injuries after blunt thoracic trauma are compared to the great incidence of accidents relatively rare, but potentially serious leading to death at scene in most of the cases.
- Trial name
- NCT01632774
- Where
- Switzerland
- Volunteers
- 85 people
- Sponsor
- University of Zurich