Clinical trials: Trauma Associated Hemorrhage
Trauma Associated Hemorrhage
Prehospital Transfusion Outcomes in Traumatic Hemorrhage: a Prospective Cohort Study
Traumatic injuries can cause severe bleeding, which causes a lot of deaths worldwide that could be prevented. Starting treatment as early as possible has been shown to improve survival, which makes fast care very important.
- Trial name
- PRONTO (NCT07883252)
- Where
- Netherlands
- Volunteers
- 750 people
- Sponsor
- Erasmus Medical Center
Skin Lesion, Traumatic Ulcer
Clinical Investigation EUCLIDES-01 for the Calculation of the Area of Skin Lesions
The aim of this clinical investigation is to collect skin lesion area data for the comparison of the agreement among the results obtained between the following three wound area measurement methods: Ruler using the Kundin method…
- Conditions
- Skin Lesion, Traumatic Ulcer, Hematoma, Pressure Ulcer
- Trial name
- NCT05729334
- Testing
- Clinicgram Euclides
- Where
- Spain
- Volunteers
- 65 people
- Sponsor
- Skilled Skin S.L.
Myocardial Injury After Noncardiac Surgery (MINS), Bleeding Independently Associated With Mortality After Noncardiac Surgery (BIMS)
Vascular Events in Noncardiac Surgery Patients Cohort Evaluation Study 2
VISION-2 is an international, multi-site, prospective observational cohort study of 20,000 patients undergoing noncardiac surgery.
- Conditions
- Myocardial Injury After Noncardiac Surgery (MINS), Bleeding Independently Associated With Mortality After Noncardiac Surgery (BIMS), Sepsis, Infection Without Sepsis
- Trial name
- VISION-2 (NCT07300579)
- Testing
- Continuous vital signs measurement device
- Where
- 3 sites in Canada
- Volunteers
- 20,000 people
- Sponsor
- Hamilton Health Sciences Corporation
Major Trauma
Trauma Associated Bleeding: Effectiveness of an Early Coagulation Support Protocol
In severe trauma patients, uncontrolled bleeding is a major cause of death, partly caused by trauma-induced coagulopathy (TIC).TIC represents a severe post-traumatic complication associated with increased transfusion requirements…
- Trial name
- NCT03354559
- Volunteers
- 235 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Shock Hemorrhagic
Pre-hospital Administration of Lyophilized Plasma for Post-traumatic Coagulopathy Treatment (PREHO-PLYO)
In severe bleeding due to trauma, a decrease in coagulation factors maintains and promotes bleeding. The plasma allows, through its contribution of coagulation factors, early prevention or correction of this post-trauma induced…
- Trial name
- PREHO-PLYO (NCT02736812)
- Testing
- French Lyophilized Plasma, Normale Saline Solution
- Where
- 22 sites in France
- Volunteers
- 140 people
- Sponsor
- French Defence Health Service
Cerebral Palsy (CP), Intraventricular Hemorrhage Neonatal
Intelligent Physiological Monitoring to Predict Preterm Brain Injury
Cerebral palsy (CP) remains prevalent among very (28-31 weeks) and extremely (<28 weeks) preterm infants. Prematurity-related brain injuries (high-grade intraventricular haemorrhage, IVH or periventricular leukomalacia, PVL)…
- Conditions
- Cerebral Palsy (CP), Intraventricular Hemorrhage Neonatal, Periventricular Leukomalacia, Neurodevelopmental Delay
- Trial name
- AI4NICU (NCT07880431)
- Testing
- EEG, NIRS
- Where
- Ireland
- Volunteers
- 413 people
- Sponsor
- University College Cork
Iliofemoral Artery Injury, Shock
Posterior Tibial Artery Bypass for Iliofemoral Artery Injury Associated With Massive Blood Loss and Shock
Traumatic disruption of iliofemoral arterial segment is often associated with multiple injuries, massive hemorrhage, state of shock, and loss of blood supply to the ipsilateral lower extremity, as well as with high mortality.
- Trial name
- NCT00900848
- Volunteers
- 8 people
- Sponsor
- The Second Hospital of Qinhuangdao
Ventilator Associated Pneumonia
Study of Povidone Iodine to Reduce Pulmonary Infection in Head Trauma and Cerebral Hemorrhage in Intensive Care Unit
Head trauma and severe cerebral hemorrhage are major risk factors for development of ventilator-associated pneumonia. In a previous open labelled, single center study the investigators showed that repeated oropharyngeal…
- Trial name
- SPIRIT-ICU (NCT00950027)
- Testing
- povidone iodine
- Where
- 7 sites in France
- Volunteers
- 179 people
- Sponsor
- Rennes University Hospital
Infection Wound, Gastrointestinal Complication
Tranexamic Acid to Reduce Infection After Gastrointestinal Surgery
This international, multicentre, pragmatic, double-blind, placebo-controlled, randomised trial of TxA versus placebo will enrol 3,300 patients throughout Australia and internationally.
- Conditions
- Infection Wound, Gastrointestinal Complication, Anesthesia, Bleeding
- Trial name
- TRIGS (NCT04192435)
- Testing
- Tranexamic Acid
- Where
- Australia
- Volunteers
- 3,300 people
- Sponsor
- Bayside Health
Osteoarthritis, Hip, Joint Deformities, Acquired
Efficacy of Aquamantys for Reducing Transfusions With Anterior Supine Intermuscular Approach Total Hip Arthroplasty
The purpose of this study is to establish whether or not there is a clinical advantage to the use of Aquamantys® System from Medtronic Advanced Energy (formerly Salient Surgical Technologies) in patients undergoing primary total…
- Conditions
- Osteoarthritis, Hip, Joint Deformities, Acquired, Hip Dislocation, Congenital, Osteonecrosis
- Trial name
- Aquamantys (NCT01583465)
- Testing
- Aquamantys, standard electrocautery (Bovie)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Joint Implant Surgeons, Inc.
Bleeding, Cardiac Defect
ZEPLAST- PED: ZEro_PLASma Trial in Small Infants Undergoing Cardiac Surgery
In pediatric patients (newborns and infants weighing less than 10 kg) undergoing cardiac surgery with extracorporeal circulation postoperative bleeding represents a known complication with a significant impact on outcome.
- Conditions
- Bleeding, Cardiac Defect, Surgery--Complications, Fibrinogenopenia; Acquired
- Trial name
- ZEPLAST-PED (NCT04434001)
- Testing
- Fibrinogen Concentrate Human, Prothrombin Complex Concentrate, Fresh Frozen Plasma
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Policlinico S. Donato
Hypothermia, Hemorrhage, Postpartum
Complications Associated With Intraoperative Hypothermia.
Maintaining intraoperative normothermia and temperature measurement is a marker of quality of care. We know that intraoperative hypothermia is associated with an increased risk of cardiovascular events, infection of the surgical…
- Conditions
- Hypothermia, Hemorrhage, Postpartum, Infection Surgical Wound, Transfusion-dependent Anemia
- Trial name
- NCT05203016
- Testing
- Hipotermia/Normotermia
- Where
- Spain
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Hypofibrinogenemia, Hemorrhage
Cryo-FIRST: Effectiveness of INTERCEPT Fibrinogen Complex (IFC) for Trauma-Associated Hemorrhage
The objective of this multicenter, single-arm, observational study is to determine the feasibility and effectiveness of early administration of FDA-approved, pre-thawed Pathogen Reduced Cryoprecipitated Fibrinogen Complex…
- Conditions
- Hypofibrinogenemia, Hemorrhage, Trauma Associated Hemorrhage, Hemorrhagic Shock
- Trial name
- CRYO-FIRST (NCT07218185)
- Testing
- Pathogen Reduced Cryoprecipitated Fibrinogen Complex
- Where
- 4 sites in United States
- Volunteers
- 320 people
- Sponsor
- Cerus Corporation
Massive Blood Transfusion in Trauma Patients
Comparing TASH Score and Modified TBSS in Trauma Patients in Need for Massive Blood Transfusion
Evaluate And Compare predictive value of TASH Score And MTBBS In need for Massive Blood Transfusion
- Trial name
- NCT06128057
- Testing
- Blood products
- Volunteers
- 140 people
- Sponsor
- Assiut University
Subarachnoid Hemorrhage, Severe Traumatic Brain Injury
Outcomes Associated With Application of a Normothermia Protocol in Patients With Severe Neurological Insult and Fever
When fever is present in patients with stroke, traumatic brain injury (TBI), or brain hemorrhage, it has been associated with worse outcomes including larger areas of tissue death, increased length of stay, worse degree of coma…
- Trial name
- SNIF (NCT00890604)
- Testing
- Stepwise normothermia protocol, Ibuprofen, Acetominophen
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Washington